Protein kinase C and cancer: what we know and what we do not
- Autores
- Garg, R; Benedetti, L. G.; Abera, M. B.; Wang, H.; Abba, Martín Carlos; Kazanietz, M.G.
- Año de publicación
- 2014
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Since their discovery in the late 1970s, protein kinase C (PKC) isozymes represent one of the most extensively studied signaling kinases. PKCs signal through multiple pathways and control the expression of genes relevant for cell cycle progression, tumorigenesis and metastatic dissemination. Despite the vast amount of information concerning the mechanisms that control PKC activation and function in cellular models, the relevance of individual PKC isozymes in the progression of human cancer is still a matter of controversy. Although the expression of PKC isozymes is altered in multiple cancer types, the causal relationship between such changes and the initiation and progression of the disease remains poorly defined. Animal models developed in the last years helped to better understand the involvement of individual PKCs in various cancer types and in the context of specific oncogenic alterations. Unraveling the enormous complexity in the mechanisms by which PKC isozymes have an impact on tumorigenesis and metastasis is key for reassessing their potential as pharmacological targets for cancer treatment.
Fil: Garg, R. University of Pennsylvania; Estados Unidos
Fil: Benedetti, L. G.. University of Pennsylvania; Estados Unidos
Fil: Abera, M. B.. University of Pennsylvania; Estados Unidos
Fil: Wang, H.. University of Pennsylvania; Estados Unidos
Fil: Abba, Martín Carlos. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de La Plata. Facultad de Ciencias Médicas. Centro de Investigaciones Inmunológicas Básicas y Aplicadas; Argentina
Fil: Kazanietz, M.G.. University of Pennsylvania; Estados Unidos - Materia
-
Protein Kinase C (Pkc)
Apoptosis
Survival
Tumorigenesis
Metastasis
Animal Models - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/32893
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Protein kinase C and cancer: what we know and what we do notGarg, RBenedetti, L. G.Abera, M. B.Wang, H.Abba, Martín CarlosKazanietz, M.G.Protein Kinase C (Pkc)ApoptosisSurvivalTumorigenesisMetastasisAnimal Modelshttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Since their discovery in the late 1970s, protein kinase C (PKC) isozymes represent one of the most extensively studied signaling kinases. PKCs signal through multiple pathways and control the expression of genes relevant for cell cycle progression, tumorigenesis and metastatic dissemination. Despite the vast amount of information concerning the mechanisms that control PKC activation and function in cellular models, the relevance of individual PKC isozymes in the progression of human cancer is still a matter of controversy. Although the expression of PKC isozymes is altered in multiple cancer types, the causal relationship between such changes and the initiation and progression of the disease remains poorly defined. Animal models developed in the last years helped to better understand the involvement of individual PKCs in various cancer types and in the context of specific oncogenic alterations. Unraveling the enormous complexity in the mechanisms by which PKC isozymes have an impact on tumorigenesis and metastasis is key for reassessing their potential as pharmacological targets for cancer treatment.Fil: Garg, R. University of Pennsylvania; Estados UnidosFil: Benedetti, L. G.. University of Pennsylvania; Estados UnidosFil: Abera, M. B.. University of Pennsylvania; Estados UnidosFil: Wang, H.. University of Pennsylvania; Estados UnidosFil: Abba, Martín Carlos. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de La Plata. Facultad de Ciencias Médicas. Centro de Investigaciones Inmunológicas Básicas y Aplicadas; ArgentinaFil: Kazanietz, M.G.. University of Pennsylvania; Estados UnidosNature Publishing Group2014-11info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/32893Abera, M. B.; Abba, Martín Carlos; Garg, R; Benedetti, L. G.; Wang, H.; Kazanietz, M.G.; et al.; Protein kinase C and cancer: what we know and what we do not; Nature Publishing Group; Oncogene; 33; 11-2014; 1-130950-9232CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1038/onc.2013.524info:eu-repo/semantics/altIdentifier/url/https://www.nature.com/articles/onc2013524info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:32:46Zoai:ri.conicet.gov.ar:11336/32893instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:32:46.359CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
Protein kinase C and cancer: what we know and what we do not |
title |
Protein kinase C and cancer: what we know and what we do not |
spellingShingle |
Protein kinase C and cancer: what we know and what we do not Garg, R Protein Kinase C (Pkc) Apoptosis Survival Tumorigenesis Metastasis Animal Models |
title_short |
Protein kinase C and cancer: what we know and what we do not |
title_full |
Protein kinase C and cancer: what we know and what we do not |
title_fullStr |
Protein kinase C and cancer: what we know and what we do not |
title_full_unstemmed |
Protein kinase C and cancer: what we know and what we do not |
title_sort |
Protein kinase C and cancer: what we know and what we do not |
dc.creator.none.fl_str_mv |
Garg, R Benedetti, L. G. Abera, M. B. Wang, H. Abba, Martín Carlos Kazanietz, M.G. |
author |
Garg, R |
author_facet |
Garg, R Benedetti, L. G. Abera, M. B. Wang, H. Abba, Martín Carlos Kazanietz, M.G. |
author_role |
author |
author2 |
Benedetti, L. G. Abera, M. B. Wang, H. Abba, Martín Carlos Kazanietz, M.G. |
author2_role |
author author author author author |
dc.subject.none.fl_str_mv |
Protein Kinase C (Pkc) Apoptosis Survival Tumorigenesis Metastasis Animal Models |
topic |
Protein Kinase C (Pkc) Apoptosis Survival Tumorigenesis Metastasis Animal Models |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/1.6 https://purl.org/becyt/ford/1 |
dc.description.none.fl_txt_mv |
Since their discovery in the late 1970s, protein kinase C (PKC) isozymes represent one of the most extensively studied signaling kinases. PKCs signal through multiple pathways and control the expression of genes relevant for cell cycle progression, tumorigenesis and metastatic dissemination. Despite the vast amount of information concerning the mechanisms that control PKC activation and function in cellular models, the relevance of individual PKC isozymes in the progression of human cancer is still a matter of controversy. Although the expression of PKC isozymes is altered in multiple cancer types, the causal relationship between such changes and the initiation and progression of the disease remains poorly defined. Animal models developed in the last years helped to better understand the involvement of individual PKCs in various cancer types and in the context of specific oncogenic alterations. Unraveling the enormous complexity in the mechanisms by which PKC isozymes have an impact on tumorigenesis and metastasis is key for reassessing their potential as pharmacological targets for cancer treatment. Fil: Garg, R. University of Pennsylvania; Estados Unidos Fil: Benedetti, L. G.. University of Pennsylvania; Estados Unidos Fil: Abera, M. B.. University of Pennsylvania; Estados Unidos Fil: Wang, H.. University of Pennsylvania; Estados Unidos Fil: Abba, Martín Carlos. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de La Plata. Facultad de Ciencias Médicas. Centro de Investigaciones Inmunológicas Básicas y Aplicadas; Argentina Fil: Kazanietz, M.G.. University of Pennsylvania; Estados Unidos |
description |
Since their discovery in the late 1970s, protein kinase C (PKC) isozymes represent one of the most extensively studied signaling kinases. PKCs signal through multiple pathways and control the expression of genes relevant for cell cycle progression, tumorigenesis and metastatic dissemination. Despite the vast amount of information concerning the mechanisms that control PKC activation and function in cellular models, the relevance of individual PKC isozymes in the progression of human cancer is still a matter of controversy. Although the expression of PKC isozymes is altered in multiple cancer types, the causal relationship between such changes and the initiation and progression of the disease remains poorly defined. Animal models developed in the last years helped to better understand the involvement of individual PKCs in various cancer types and in the context of specific oncogenic alterations. Unraveling the enormous complexity in the mechanisms by which PKC isozymes have an impact on tumorigenesis and metastasis is key for reassessing their potential as pharmacological targets for cancer treatment. |
publishDate |
2014 |
dc.date.none.fl_str_mv |
2014-11 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/32893 Abera, M. B.; Abba, Martín Carlos; Garg, R; Benedetti, L. G.; Wang, H.; Kazanietz, M.G.; et al.; Protein kinase C and cancer: what we know and what we do not; Nature Publishing Group; Oncogene; 33; 11-2014; 1-13 0950-9232 CONICET Digital CONICET |
url |
http://hdl.handle.net/11336/32893 |
identifier_str_mv |
Abera, M. B.; Abba, Martín Carlos; Garg, R; Benedetti, L. G.; Wang, H.; Kazanietz, M.G.; et al.; Protein kinase C and cancer: what we know and what we do not; Nature Publishing Group; Oncogene; 33; 11-2014; 1-13 0950-9232 CONICET Digital CONICET |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/doi/10.1038/onc.2013.524 info:eu-repo/semantics/altIdentifier/url/https://www.nature.com/articles/onc2013524 |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
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openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
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application/pdf application/pdf |
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Nature Publishing Group |
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Nature Publishing Group |
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Consejo Nacional de Investigaciones Científicas y Técnicas |
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CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
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