Protein kinase C and cancer: what we know and what we do not

Autores
Garg, R; Benedetti, L. G.; Abera, M. B.; Wang, H.; Abba, Martín Carlos; Kazanietz, M.G.
Año de publicación
2014
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Since their discovery in the late 1970s, protein kinase C (PKC) isozymes represent one of the most extensively studied signaling kinases. PKCs signal through multiple pathways and control the expression of genes relevant for cell cycle progression, tumorigenesis and metastatic dissemination. Despite the vast amount of information concerning the mechanisms that control PKC activation and function in cellular models, the relevance of individual PKC isozymes in the progression of human cancer is still a matter of controversy. Although the expression of PKC isozymes is altered in multiple cancer types, the causal relationship between such changes and the initiation and progression of the disease remains poorly defined. Animal models developed in the last years helped to better understand the involvement of individual PKCs in various cancer types and in the context of specific oncogenic alterations. Unraveling the enormous complexity in the mechanisms by which PKC isozymes have an impact on tumorigenesis and metastasis is key for reassessing their potential as pharmacological targets for cancer treatment.
Fil: Garg, R. University of Pennsylvania; Estados Unidos
Fil: Benedetti, L. G.. University of Pennsylvania; Estados Unidos
Fil: Abera, M. B.. University of Pennsylvania; Estados Unidos
Fil: Wang, H.. University of Pennsylvania; Estados Unidos
Fil: Abba, Martín Carlos. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de La Plata. Facultad de Ciencias Médicas. Centro de Investigaciones Inmunológicas Básicas y Aplicadas; Argentina
Fil: Kazanietz, M.G.. University of Pennsylvania; Estados Unidos
Materia
Protein Kinase C (Pkc)
Apoptosis
Survival
Tumorigenesis
Metastasis
Animal Models
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/32893
Acceder
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network_name_str CONICET Digital (CONICET)
spelling Protein kinase C and cancer: what we know and what we do notGarg, RBenedetti, L. G.Abera, M. B.Wang, H.Abba, Martín CarlosKazanietz, M.G.Protein Kinase C (Pkc)ApoptosisSurvivalTumorigenesisMetastasisAnimal Modelshttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Since their discovery in the late 1970s, protein kinase C (PKC) isozymes represent one of the most extensively studied signaling kinases. PKCs signal through multiple pathways and control the expression of genes relevant for cell cycle progression, tumorigenesis and metastatic dissemination. Despite the vast amount of information concerning the mechanisms that control PKC activation and function in cellular models, the relevance of individual PKC isozymes in the progression of human cancer is still a matter of controversy. Although the expression of PKC isozymes is altered in multiple cancer types, the causal relationship between such changes and the initiation and progression of the disease remains poorly defined. Animal models developed in the last years helped to better understand the involvement of individual PKCs in various cancer types and in the context of specific oncogenic alterations. Unraveling the enormous complexity in the mechanisms by which PKC isozymes have an impact on tumorigenesis and metastasis is key for reassessing their potential as pharmacological targets for cancer treatment.Fil: Garg, R. University of Pennsylvania; Estados UnidosFil: Benedetti, L. G.. University of Pennsylvania; Estados UnidosFil: Abera, M. B.. University of Pennsylvania; Estados UnidosFil: Wang, H.. University of Pennsylvania; Estados UnidosFil: Abba, Martín Carlos. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de La Plata. Facultad de Ciencias Médicas. Centro de Investigaciones Inmunológicas Básicas y Aplicadas; ArgentinaFil: Kazanietz, M.G.. University of Pennsylvania; Estados UnidosNature Publishing Group2014-11info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/32893Abera, M. B.; Abba, Martín Carlos; Garg, R; Benedetti, L. G.; Wang, H.; Kazanietz, M.G.; et al.; Protein kinase C and cancer: what we know and what we do not; Nature Publishing Group; Oncogene; 33; 11-2014; 1-130950-9232CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1038/onc.2013.524info:eu-repo/semantics/altIdentifier/url/https://www.nature.com/articles/onc2013524info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-22T12:05:13Zoai:ri.conicet.gov.ar:11336/32893instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-22 12:05:13.99CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Protein kinase C and cancer: what we know and what we do not
title Protein kinase C and cancer: what we know and what we do not
spellingShingle Protein kinase C and cancer: what we know and what we do not
Garg, R
Protein Kinase C (Pkc)
Apoptosis
Survival
Tumorigenesis
Metastasis
Animal Models
title_short Protein kinase C and cancer: what we know and what we do not
title_full Protein kinase C and cancer: what we know and what we do not
title_fullStr Protein kinase C and cancer: what we know and what we do not
title_full_unstemmed Protein kinase C and cancer: what we know and what we do not
title_sort Protein kinase C and cancer: what we know and what we do not
dc.creator.none.fl_str_mv Garg, R
Benedetti, L. G.
Abera, M. B.
Wang, H.
Abba, Martín Carlos
Kazanietz, M.G.
author Garg, R
author_facet Garg, R
Benedetti, L. G.
Abera, M. B.
Wang, H.
Abba, Martín Carlos
Kazanietz, M.G.
author_role author
author2 Benedetti, L. G.
Abera, M. B.
Wang, H.
Abba, Martín Carlos
Kazanietz, M.G.
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv Protein Kinase C (Pkc)
Apoptosis
Survival
Tumorigenesis
Metastasis
Animal Models
topic Protein Kinase C (Pkc)
Apoptosis
Survival
Tumorigenesis
Metastasis
Animal Models
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Since their discovery in the late 1970s, protein kinase C (PKC) isozymes represent one of the most extensively studied signaling kinases. PKCs signal through multiple pathways and control the expression of genes relevant for cell cycle progression, tumorigenesis and metastatic dissemination. Despite the vast amount of information concerning the mechanisms that control PKC activation and function in cellular models, the relevance of individual PKC isozymes in the progression of human cancer is still a matter of controversy. Although the expression of PKC isozymes is altered in multiple cancer types, the causal relationship between such changes and the initiation and progression of the disease remains poorly defined. Animal models developed in the last years helped to better understand the involvement of individual PKCs in various cancer types and in the context of specific oncogenic alterations. Unraveling the enormous complexity in the mechanisms by which PKC isozymes have an impact on tumorigenesis and metastasis is key for reassessing their potential as pharmacological targets for cancer treatment.
Fil: Garg, R. University of Pennsylvania; Estados Unidos
Fil: Benedetti, L. G.. University of Pennsylvania; Estados Unidos
Fil: Abera, M. B.. University of Pennsylvania; Estados Unidos
Fil: Wang, H.. University of Pennsylvania; Estados Unidos
Fil: Abba, Martín Carlos. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de La Plata. Facultad de Ciencias Médicas. Centro de Investigaciones Inmunológicas Básicas y Aplicadas; Argentina
Fil: Kazanietz, M.G.. University of Pennsylvania; Estados Unidos
description Since their discovery in the late 1970s, protein kinase C (PKC) isozymes represent one of the most extensively studied signaling kinases. PKCs signal through multiple pathways and control the expression of genes relevant for cell cycle progression, tumorigenesis and metastatic dissemination. Despite the vast amount of information concerning the mechanisms that control PKC activation and function in cellular models, the relevance of individual PKC isozymes in the progression of human cancer is still a matter of controversy. Although the expression of PKC isozymes is altered in multiple cancer types, the causal relationship between such changes and the initiation and progression of the disease remains poorly defined. Animal models developed in the last years helped to better understand the involvement of individual PKCs in various cancer types and in the context of specific oncogenic alterations. Unraveling the enormous complexity in the mechanisms by which PKC isozymes have an impact on tumorigenesis and metastasis is key for reassessing their potential as pharmacological targets for cancer treatment.
publishDate 2014
dc.date.none.fl_str_mv 2014-11
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/32893
Abera, M. B.; Abba, Martín Carlos; Garg, R; Benedetti, L. G.; Wang, H.; Kazanietz, M.G.; et al.; Protein kinase C and cancer: what we know and what we do not; Nature Publishing Group; Oncogene; 33; 11-2014; 1-13
0950-9232
CONICET Digital
CONICET
url http://hdl.handle.net/11336/32893
identifier_str_mv Abera, M. B.; Abba, Martín Carlos; Garg, R; Benedetti, L. G.; Wang, H.; Kazanietz, M.G.; et al.; Protein kinase C and cancer: what we know and what we do not; Nature Publishing Group; Oncogene; 33; 11-2014; 1-13
0950-9232
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1038/onc.2013.524
info:eu-repo/semantics/altIdentifier/url/https://www.nature.com/articles/onc2013524
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Nature Publishing Group
publisher.none.fl_str_mv Nature Publishing Group
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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