Protein kinase C and cancer: what we know and what we do not
- Autores
- Garg, Rachana; Benedetti, Lorena G.; Abera, Mahlet B.; Wang, HongBin; Abba, Martín Carlos; Kazanietz, Marcelo G.
- Año de publicación
- 2014
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión enviada
- Descripción
- Since their discovery in the late 1970’s, protein kinase C (PKC) isozymes represent one of the most extensively studied signaling kinases. PKCs signal through multiple pathways and control the expression of genes relevant for cell cycle progression, tumorigenesis and metastatic dissemination. Despite the vast amount of information concerning the mechanisms that control PKC activation and function in cellular models, the relevance of individual PKC isozymes in the progression of human cancer is still a matter of controversy. Although the expression of PKC isozymes is altered in multiple cancer types, the causal relationship between such changes and the initiation and progression of the disease remains poorly defined. Animal models developed in the last years helped to better understand the involvement of individual PKCs in various cancer types and in the context of specific oncogenic alterations. Unraveling the enormous complexity in the mechanisms by which PKC isozymes impact on tumorigenesis and metastasis is key for reassessing their potential as pharmacological targets for cancer treatment.
- Materia
-
Ciencias Médicas
Protein kinase C (PKC)
mitogenesis
apoptosis
survival
tumorigenesis
metastasis
animal models - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- http://creativecommons.org/licenses/by-nc/4.0/
- Repositorio
- Institución
- Comisión de Investigaciones Científicas de la Provincia de Buenos Aires
- OAI Identificador
- oai:digital.cic.gba.gob.ar:11746/6197
Ver los metadatos del registro completo
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Protein kinase C and cancer: what we know and what we do notGarg, RachanaBenedetti, Lorena G.Abera, Mahlet B.Wang, HongBinAbba, Martín CarlosKazanietz, Marcelo G.Ciencias MédicasProtein kinase C (PKC)mitogenesisapoptosissurvivaltumorigenesismetastasisanimal modelsSince their discovery in the late 1970’s, protein kinase C (PKC) isozymes represent one of the most extensively studied signaling kinases. PKCs signal through multiple pathways and control the expression of genes relevant for cell cycle progression, tumorigenesis and metastatic dissemination. Despite the vast amount of information concerning the mechanisms that control PKC activation and function in cellular models, the relevance of individual PKC isozymes in the progression of human cancer is still a matter of controversy. Although the expression of PKC isozymes is altered in multiple cancer types, the causal relationship between such changes and the initiation and progression of the disease remains poorly defined. Animal models developed in the last years helped to better understand the involvement of individual PKCs in various cancer types and in the context of specific oncogenic alterations. Unraveling the enormous complexity in the mechanisms by which PKC isozymes impact on tumorigenesis and metastasis is key for reassessing their potential as pharmacological targets for cancer treatment.2014-11info:eu-repo/semantics/articleinfo:eu-repo/semantics/submittedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfhttps://digital.cic.gba.gob.ar/handle/11746/6197enginfo:eu-repo/semantics/altIdentifier/doi/10.1038/onc.2013.524info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by-nc/4.0/reponame:CIC Digital (CICBA)instname:Comisión de Investigaciones Científicas de la Provincia de Buenos Airesinstacron:CICBA2025-09-29T13:40:11Zoai:digital.cic.gba.gob.ar:11746/6197Institucionalhttp://digital.cic.gba.gob.arOrganismo científico-tecnológicoNo correspondehttp://digital.cic.gba.gob.ar/oai/snrdmarisa.degiusti@sedici.unlp.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:94412025-09-29 13:40:11.415CIC Digital (CICBA) - Comisión de Investigaciones Científicas de la Provincia de Buenos Airesfalse |
dc.title.none.fl_str_mv |
Protein kinase C and cancer: what we know and what we do not |
title |
Protein kinase C and cancer: what we know and what we do not |
spellingShingle |
Protein kinase C and cancer: what we know and what we do not Garg, Rachana Ciencias Médicas Protein kinase C (PKC) mitogenesis apoptosis survival tumorigenesis metastasis animal models |
title_short |
Protein kinase C and cancer: what we know and what we do not |
title_full |
Protein kinase C and cancer: what we know and what we do not |
title_fullStr |
Protein kinase C and cancer: what we know and what we do not |
title_full_unstemmed |
Protein kinase C and cancer: what we know and what we do not |
title_sort |
Protein kinase C and cancer: what we know and what we do not |
dc.creator.none.fl_str_mv |
Garg, Rachana Benedetti, Lorena G. Abera, Mahlet B. Wang, HongBin Abba, Martín Carlos Kazanietz, Marcelo G. |
author |
Garg, Rachana |
author_facet |
Garg, Rachana Benedetti, Lorena G. Abera, Mahlet B. Wang, HongBin Abba, Martín Carlos Kazanietz, Marcelo G. |
author_role |
author |
author2 |
Benedetti, Lorena G. Abera, Mahlet B. Wang, HongBin Abba, Martín Carlos Kazanietz, Marcelo G. |
author2_role |
author author author author author |
dc.subject.none.fl_str_mv |
Ciencias Médicas Protein kinase C (PKC) mitogenesis apoptosis survival tumorigenesis metastasis animal models |
topic |
Ciencias Médicas Protein kinase C (PKC) mitogenesis apoptosis survival tumorigenesis metastasis animal models |
dc.description.none.fl_txt_mv |
Since their discovery in the late 1970’s, protein kinase C (PKC) isozymes represent one of the most extensively studied signaling kinases. PKCs signal through multiple pathways and control the expression of genes relevant for cell cycle progression, tumorigenesis and metastatic dissemination. Despite the vast amount of information concerning the mechanisms that control PKC activation and function in cellular models, the relevance of individual PKC isozymes in the progression of human cancer is still a matter of controversy. Although the expression of PKC isozymes is altered in multiple cancer types, the causal relationship between such changes and the initiation and progression of the disease remains poorly defined. Animal models developed in the last years helped to better understand the involvement of individual PKCs in various cancer types and in the context of specific oncogenic alterations. Unraveling the enormous complexity in the mechanisms by which PKC isozymes impact on tumorigenesis and metastasis is key for reassessing their potential as pharmacological targets for cancer treatment. |
description |
Since their discovery in the late 1970’s, protein kinase C (PKC) isozymes represent one of the most extensively studied signaling kinases. PKCs signal through multiple pathways and control the expression of genes relevant for cell cycle progression, tumorigenesis and metastatic dissemination. Despite the vast amount of information concerning the mechanisms that control PKC activation and function in cellular models, the relevance of individual PKC isozymes in the progression of human cancer is still a matter of controversy. Although the expression of PKC isozymes is altered in multiple cancer types, the causal relationship between such changes and the initiation and progression of the disease remains poorly defined. Animal models developed in the last years helped to better understand the involvement of individual PKCs in various cancer types and in the context of specific oncogenic alterations. Unraveling the enormous complexity in the mechanisms by which PKC isozymes impact on tumorigenesis and metastasis is key for reassessing their potential as pharmacological targets for cancer treatment. |
publishDate |
2014 |
dc.date.none.fl_str_mv |
2014-11 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/submittedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
submittedVersion |
dc.identifier.none.fl_str_mv |
https://digital.cic.gba.gob.ar/handle/11746/6197 |
url |
https://digital.cic.gba.gob.ar/handle/11746/6197 |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/doi/10.1038/onc.2013.524 |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by-nc/4.0/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
http://creativecommons.org/licenses/by-nc/4.0/ |
dc.format.none.fl_str_mv |
application/pdf |
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reponame:CIC Digital (CICBA) instname:Comisión de Investigaciones Científicas de la Provincia de Buenos Aires instacron:CICBA |
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CIC Digital (CICBA) |
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CIC Digital (CICBA) |
instname_str |
Comisión de Investigaciones Científicas de la Provincia de Buenos Aires |
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CICBA |
repository.name.fl_str_mv |
CIC Digital (CICBA) - Comisión de Investigaciones Científicas de la Provincia de Buenos Aires |
repository.mail.fl_str_mv |
marisa.degiusti@sedici.unlp.edu.ar |
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13.070432 |