Circadian rhythms in bacterial sepsis pathology : what we know and what we should know

Autores
Mul Fedele, Malena Lis; Senna, Camila Agustina; Aiello, Ignacio; Golombek, Diego A.; Paladino, Natalia
Año de publicación
2021
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Fil: Mul Fedele, Malena Lis. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas. Instituto de Investigaciones Biomédicas. Laboratorio de Cronofisiología; Argentina
Fil: Mul Fedele, Malena Lis. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Senna, Camila Agustina. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología. Laboratorio de Cronobiología; Argentina
Fil: Senna, Camila Agustina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Aiello, Ignacio. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología. Laboratorio de Cronobiología; Argentina
Fil: Aiello, Ignacio. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Golombek, Diego A. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología. Laboratorio de Cronobiología; Argentina
Fil: Golombek, Diego A. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Paladino, Natalia. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología. Laboratorio de Cronobiología; Argentina
Fil: Paladino, Natalia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Abstract: Sepsis is a syndrome caused by a deregulated host response to infection, representing the primary cause of death from infection. In animal models, the mortality rate is strongly dependent on the time of sepsis induction, suggesting a main role of the circadian system. In patients undergoing sepsis, deregulated circadian rhythms have also been reported. Here we review data related to the timing of sepsis induction to further understand the different outcomes observed both in patients and in animal models. The magnitude of immune activation as well as the hypothermic response correlated with the time of the worst prognosis. The different outcomes seem to be dependent on the expression of the clock gene Bmal1 in the liver and in myeloid immune cells. The understanding of the role of the circadian systemin sepsis pathology could be an important tool to improve patient therapies.
Fuente
Frontiers in cellular and infection microbiology. 2021, 11
Materia
RITMO CIRCADIANO
SISTEMA INMUNOLOGICO
HIPOTERMIA
SEPSIS
INFECCIONES
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/4.0/
Repositorio
Repositorio Institucional (UCA)
Institución
Pontificia Universidad Católica Argentina
OAI Identificador
oai:ucacris:123456789/13955
Acceder
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oai_identifier_str oai:ucacris:123456789/13955
network_acronym_str RIUCA
repository_id_str 2585
network_name_str Repositorio Institucional (UCA)
spelling Circadian rhythms in bacterial sepsis pathology : what we know and what we should knowMul Fedele, Malena LisSenna, Camila AgustinaAiello, IgnacioGolombek, Diego A.Paladino, NataliaRITMO CIRCADIANOSISTEMA INMUNOLOGICOHIPOTERMIASEPSISINFECCIONESFil: Mul Fedele, Malena Lis. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas. Instituto de Investigaciones Biomédicas. Laboratorio de Cronofisiología; ArgentinaFil: Mul Fedele, Malena Lis. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Senna, Camila Agustina. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología. Laboratorio de Cronobiología; ArgentinaFil: Senna, Camila Agustina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Aiello, Ignacio. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología. Laboratorio de Cronobiología; ArgentinaFil: Aiello, Ignacio. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Golombek, Diego A. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología. Laboratorio de Cronobiología; ArgentinaFil: Golombek, Diego A. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Paladino, Natalia. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología. Laboratorio de Cronobiología; ArgentinaFil: Paladino, Natalia. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaAbstract: Sepsis is a syndrome caused by a deregulated host response to infection, representing the primary cause of death from infection. In animal models, the mortality rate is strongly dependent on the time of sepsis induction, suggesting a main role of the circadian system. In patients undergoing sepsis, deregulated circadian rhythms have also been reported. Here we review data related to the timing of sepsis induction to further understand the different outcomes observed both in patients and in animal models. The magnitude of immune activation as well as the hypothermic response correlated with the time of the worst prognosis. The different outcomes seem to be dependent on the expression of the clock gene Bmal1 in the liver and in myeloid immune cells. The understanding of the role of the circadian systemin sepsis pathology could be an important tool to improve patient therapies.Frontiers2021info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfhttps://repositorio.uca.edu.ar/handle/123456789/139552235-2988 (on line)10.3389/fcimb.2021.77318134956930Mul Fedele, M. L. et al. Circadian rhythms in bacterial sepsis pathology : what we know and what we should know [en línea]. Frontiers in cellular and infection microbiology. 2021, 11. doi: 10.3389/fcimb.2021.773181. Disponible en: https://repositorio.uca.edu.ar/handle/123456789/13955Frontiers in cellular and infection microbiology. 2021, 11reponame:Repositorio Institucional (UCA)instname:Pontificia Universidad Católica Argentinaenginfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/4.0/2025-07-03T10:58:33Zoai:ucacris:123456789/13955instacron:UCAInstitucionalhttps://repositorio.uca.edu.ar/Universidad privadaNo correspondehttps://repositorio.uca.edu.ar/oaiclaudia_fernandez@uca.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:25852025-07-03 10:58:33.797Repositorio Institucional (UCA) - Pontificia Universidad Católica Argentinafalse
dc.title.none.fl_str_mv Circadian rhythms in bacterial sepsis pathology : what we know and what we should know
title Circadian rhythms in bacterial sepsis pathology : what we know and what we should know
spellingShingle Circadian rhythms in bacterial sepsis pathology : what we know and what we should know
Mul Fedele, Malena Lis
RITMO CIRCADIANO
SISTEMA INMUNOLOGICO
HIPOTERMIA
SEPSIS
INFECCIONES
title_short Circadian rhythms in bacterial sepsis pathology : what we know and what we should know
title_full Circadian rhythms in bacterial sepsis pathology : what we know and what we should know
title_fullStr Circadian rhythms in bacterial sepsis pathology : what we know and what we should know
title_full_unstemmed Circadian rhythms in bacterial sepsis pathology : what we know and what we should know
title_sort Circadian rhythms in bacterial sepsis pathology : what we know and what we should know
dc.creator.none.fl_str_mv Mul Fedele, Malena Lis
Senna, Camila Agustina
Aiello, Ignacio
Golombek, Diego A.
Paladino, Natalia
author Mul Fedele, Malena Lis
author_facet Mul Fedele, Malena Lis
Senna, Camila Agustina
Aiello, Ignacio
Golombek, Diego A.
Paladino, Natalia
author_role author
author2 Senna, Camila Agustina
Aiello, Ignacio
Golombek, Diego A.
Paladino, Natalia
author2_role author
author
author
author
dc.subject.none.fl_str_mv RITMO CIRCADIANO
SISTEMA INMUNOLOGICO
HIPOTERMIA
SEPSIS
INFECCIONES
topic RITMO CIRCADIANO
SISTEMA INMUNOLOGICO
HIPOTERMIA
SEPSIS
INFECCIONES
dc.description.none.fl_txt_mv Fil: Mul Fedele, Malena Lis. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas. Instituto de Investigaciones Biomédicas. Laboratorio de Cronofisiología; Argentina
Fil: Mul Fedele, Malena Lis. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Senna, Camila Agustina. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología. Laboratorio de Cronobiología; Argentina
Fil: Senna, Camila Agustina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Aiello, Ignacio. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología. Laboratorio de Cronobiología; Argentina
Fil: Aiello, Ignacio. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Golombek, Diego A. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología. Laboratorio de Cronobiología; Argentina
Fil: Golombek, Diego A. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Paladino, Natalia. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología. Laboratorio de Cronobiología; Argentina
Fil: Paladino, Natalia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Abstract: Sepsis is a syndrome caused by a deregulated host response to infection, representing the primary cause of death from infection. In animal models, the mortality rate is strongly dependent on the time of sepsis induction, suggesting a main role of the circadian system. In patients undergoing sepsis, deregulated circadian rhythms have also been reported. Here we review data related to the timing of sepsis induction to further understand the different outcomes observed both in patients and in animal models. The magnitude of immune activation as well as the hypothermic response correlated with the time of the worst prognosis. The different outcomes seem to be dependent on the expression of the clock gene Bmal1 in the liver and in myeloid immune cells. The understanding of the role of the circadian systemin sepsis pathology could be an important tool to improve patient therapies.
description Fil: Mul Fedele, Malena Lis. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas. Instituto de Investigaciones Biomédicas. Laboratorio de Cronofisiología; Argentina
publishDate 2021
dc.date.none.fl_str_mv 2021
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://repositorio.uca.edu.ar/handle/123456789/13955
2235-2988 (on line)
10.3389/fcimb.2021.773181
34956930
Mul Fedele, M. L. et al. Circadian rhythms in bacterial sepsis pathology : what we know and what we should know [en línea]. Frontiers in cellular and infection microbiology. 2021, 11. doi: 10.3389/fcimb.2021.773181. Disponible en: https://repositorio.uca.edu.ar/handle/123456789/13955
url https://repositorio.uca.edu.ar/handle/123456789/13955
identifier_str_mv 2235-2988 (on line)
10.3389/fcimb.2021.773181
34956930
Mul Fedele, M. L. et al. Circadian rhythms in bacterial sepsis pathology : what we know and what we should know [en línea]. Frontiers in cellular and infection microbiology. 2021, 11. doi: 10.3389/fcimb.2021.773181. Disponible en: https://repositorio.uca.edu.ar/handle/123456789/13955
dc.language.none.fl_str_mv eng
language eng
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/4.0/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/4.0/
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Frontiers
publisher.none.fl_str_mv Frontiers
dc.source.none.fl_str_mv Frontiers in cellular and infection microbiology. 2021, 11
reponame:Repositorio Institucional (UCA)
instname:Pontificia Universidad Católica Argentina
reponame_str Repositorio Institucional (UCA)
collection Repositorio Institucional (UCA)
instname_str Pontificia Universidad Católica Argentina
repository.name.fl_str_mv Repositorio Institucional (UCA) - Pontificia Universidad Católica Argentina
repository.mail.fl_str_mv claudia_fernandez@uca.edu.ar
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score 13.13397

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