Circadian rhythms in bacterial sepsis pathology: What we know and what we should know

Autores
Mul Fedele, Malena Lis; Senna, Camila Agustina; Aiello, Ignacio; Golombek, Diego Andrés; Paladino, Natalia
Año de publicación
2021
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Sepsis is a syndrome caused by a deregulated host response to infection, representing the primary cause of death from infection. In animal models, the mortality rate is strongly dependent on the time of sepsis induction, suggesting a main role of the circadian system. In patients undergoing sepsis, deregulated circadian rhythms have also been reported. Here we review data related to the timing of sepsis induction to further understand the different outcomes observed both in patients and in animal models. The magnitude of immune activation as well as the hypothermic response correlated with the time of the worst prognosis. The different outcomes seem to be dependent on the expression of the clock gene Bmal1 in the liver and in myeloid immune cells. The understanding of the role of the circadian system in sepsis pathology could be an important tool to improve patient therapies.
Fil: Mul Fedele, Malena Lis. Pontificia Universidad Católica Argentina "Santa María de los Buenos Aires". Instituto de Investigaciones Biomédicas. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas; Argentina
Fil: Senna, Camila Agustina. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología. Laboratorio de Cronobiología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Aiello, Ignacio. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología. Laboratorio de Cronobiología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Golombek, Diego Andrés. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología. Laboratorio de Cronobiología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Paladino, Natalia. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología. Laboratorio de Cronobiología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Materia
SEPSIS
CIRCADIAN RHYTHMS
IMMUNE SYSTEM
HYPOTHERMIA
INFECTION
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/155167
Acceder
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network_name_str CONICET Digital (CONICET)
spelling Circadian rhythms in bacterial sepsis pathology: What we know and what we should knowMul Fedele, Malena LisSenna, Camila AgustinaAiello, IgnacioGolombek, Diego AndrésPaladino, NataliaSEPSISCIRCADIAN RHYTHMSIMMUNE SYSTEMHYPOTHERMIAINFECTIONhttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3Sepsis is a syndrome caused by a deregulated host response to infection, representing the primary cause of death from infection. In animal models, the mortality rate is strongly dependent on the time of sepsis induction, suggesting a main role of the circadian system. In patients undergoing sepsis, deregulated circadian rhythms have also been reported. Here we review data related to the timing of sepsis induction to further understand the different outcomes observed both in patients and in animal models. The magnitude of immune activation as well as the hypothermic response correlated with the time of the worst prognosis. The different outcomes seem to be dependent on the expression of the clock gene Bmal1 in the liver and in myeloid immune cells. The understanding of the role of the circadian system in sepsis pathology could be an important tool to improve patient therapies.Fil: Mul Fedele, Malena Lis. Pontificia Universidad Católica Argentina "Santa María de los Buenos Aires". Instituto de Investigaciones Biomédicas. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas; ArgentinaFil: Senna, Camila Agustina. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología. Laboratorio de Cronobiología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Aiello, Ignacio. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología. Laboratorio de Cronobiología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Golombek, Diego Andrés. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología. Laboratorio de Cronobiología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Paladino, Natalia. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología. Laboratorio de Cronobiología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaBacteria and Host2021-12-09info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/155167Mul Fedele, Malena Lis; Senna, Camila Agustina; Aiello, Ignacio; Golombek, Diego Andrés; Paladino, Natalia; Circadian rhythms in bacterial sepsis pathology: What we know and what we should know; Bacteria and Host; Frontiers in Cellular and Infection Microbiology; 11; 773181; 9-12-2021; 1-82235-2988CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.frontiersin.org/articles/10.3389/fcimb.2021.773181/fullinfo:eu-repo/semantics/altIdentifier/doi/10.3389/fcimb.2021.773181info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:48:10Zoai:ri.conicet.gov.ar:11336/155167instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:48:10.884CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Circadian rhythms in bacterial sepsis pathology: What we know and what we should know
title Circadian rhythms in bacterial sepsis pathology: What we know and what we should know
spellingShingle Circadian rhythms in bacterial sepsis pathology: What we know and what we should know
Mul Fedele, Malena Lis
SEPSIS
CIRCADIAN RHYTHMS
IMMUNE SYSTEM
HYPOTHERMIA
INFECTION
title_short Circadian rhythms in bacterial sepsis pathology: What we know and what we should know
title_full Circadian rhythms in bacterial sepsis pathology: What we know and what we should know
title_fullStr Circadian rhythms in bacterial sepsis pathology: What we know and what we should know
title_full_unstemmed Circadian rhythms in bacterial sepsis pathology: What we know and what we should know
title_sort Circadian rhythms in bacterial sepsis pathology: What we know and what we should know
dc.creator.none.fl_str_mv Mul Fedele, Malena Lis
Senna, Camila Agustina
Aiello, Ignacio
Golombek, Diego Andrés
Paladino, Natalia
author Mul Fedele, Malena Lis
author_facet Mul Fedele, Malena Lis
Senna, Camila Agustina
Aiello, Ignacio
Golombek, Diego Andrés
Paladino, Natalia
author_role author
author2 Senna, Camila Agustina
Aiello, Ignacio
Golombek, Diego Andrés
Paladino, Natalia
author2_role author
author
author
author
dc.subject.none.fl_str_mv SEPSIS
CIRCADIAN RHYTHMS
IMMUNE SYSTEM
HYPOTHERMIA
INFECTION
topic SEPSIS
CIRCADIAN RHYTHMS
IMMUNE SYSTEM
HYPOTHERMIA
INFECTION
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Sepsis is a syndrome caused by a deregulated host response to infection, representing the primary cause of death from infection. In animal models, the mortality rate is strongly dependent on the time of sepsis induction, suggesting a main role of the circadian system. In patients undergoing sepsis, deregulated circadian rhythms have also been reported. Here we review data related to the timing of sepsis induction to further understand the different outcomes observed both in patients and in animal models. The magnitude of immune activation as well as the hypothermic response correlated with the time of the worst prognosis. The different outcomes seem to be dependent on the expression of the clock gene Bmal1 in the liver and in myeloid immune cells. The understanding of the role of the circadian system in sepsis pathology could be an important tool to improve patient therapies.
Fil: Mul Fedele, Malena Lis. Pontificia Universidad Católica Argentina "Santa María de los Buenos Aires". Instituto de Investigaciones Biomédicas. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas; Argentina
Fil: Senna, Camila Agustina. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología. Laboratorio de Cronobiología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Aiello, Ignacio. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología. Laboratorio de Cronobiología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Golombek, Diego Andrés. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología. Laboratorio de Cronobiología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Paladino, Natalia. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología. Laboratorio de Cronobiología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
description Sepsis is a syndrome caused by a deregulated host response to infection, representing the primary cause of death from infection. In animal models, the mortality rate is strongly dependent on the time of sepsis induction, suggesting a main role of the circadian system. In patients undergoing sepsis, deregulated circadian rhythms have also been reported. Here we review data related to the timing of sepsis induction to further understand the different outcomes observed both in patients and in animal models. The magnitude of immune activation as well as the hypothermic response correlated with the time of the worst prognosis. The different outcomes seem to be dependent on the expression of the clock gene Bmal1 in the liver and in myeloid immune cells. The understanding of the role of the circadian system in sepsis pathology could be an important tool to improve patient therapies.
publishDate 2021
dc.date.none.fl_str_mv 2021-12-09
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/155167
Mul Fedele, Malena Lis; Senna, Camila Agustina; Aiello, Ignacio; Golombek, Diego Andrés; Paladino, Natalia; Circadian rhythms in bacterial sepsis pathology: What we know and what we should know; Bacteria and Host; Frontiers in Cellular and Infection Microbiology; 11; 773181; 9-12-2021; 1-8
2235-2988
CONICET Digital
CONICET
url http://hdl.handle.net/11336/155167
identifier_str_mv Mul Fedele, Malena Lis; Senna, Camila Agustina; Aiello, Ignacio; Golombek, Diego Andrés; Paladino, Natalia; Circadian rhythms in bacterial sepsis pathology: What we know and what we should know; Bacteria and Host; Frontiers in Cellular and Infection Microbiology; 11; 773181; 9-12-2021; 1-8
2235-2988
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.frontiersin.org/articles/10.3389/fcimb.2021.773181/full
info:eu-repo/semantics/altIdentifier/doi/10.3389/fcimb.2021.773181
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Bacteria and Host
publisher.none.fl_str_mv Bacteria and Host
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.13397

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