Preliminary studies of elemental spatial redistribution in breast tumors

Autores
Sosa, Carlos Manuel; Sbarato, Viviana María; Pérez, Carlos Alberto; Bongiovanni, Guillermina Azucena; Sánchez, Héctor Jorge; Pérez, Roberto Daniel
Año de publicación
2013
Idioma
inglés
Tipo de recurso
documento de conferencia
Estado
versión publicada
Descripción
Ponencia presentada en la XXIII Reunião Anual de Usuários do LNLS/CNPEM. Campinas, Brasil, 26 al 27 de febrero de 2013.
Fil: Sosa, Carlos Manuel. Universidad Nacional de Córdoba; Argentina.
Fil: Sbarato, Viviana María. Universidad Nacional de Córdoba. Facultad de Ciencias Agropecuarias; Argentina.
Fil: Pérez, Carlos Alberto. Laboratório Nacional de Luz Síncrotron; Brasil.
Fil: Bongiovanni, Guillermina Azucena.Consejo Nacional de Investigaciones Cientificas y Técnicas; Argentina.
Fil: Sánchez, Héctor Jorge. Universidad Nacional de Córdoba; Argentina.
Fil: Pérez, Roberto Daniel. Universidad Nacional de Córdoba; Argentina.
Synchrotron radiation combined with capillary optics has been used as an optimal x-ray source for microanalysis. It can be used to excite x-ray fluorescence and this approach leads to very low detection limits on micrometric areas on very small samples. Synchrotron microscopic XRF (μ-SRXRF) allows quantitative study of the nature and degree of heterogeneity of inorganic constituents in biological samples. This microbeam method, due to intrinsic characteristics of SR, is able to implement multielemental spectrochemical analysis with spatial resolution on the micrometer scale. It shows high efficiency for element determination and short time of analysis requirements. In the present work, we applied μ-SRXRF to study spatial distribution of elements on normal and cancerous human breast tissue in order to identify possible correlations induced by the desease. Several authors have shown that there is a significant increase of Ca, Cr, Mn, Fe, Cu, Zn and Br in breast tumors compared to normal tissues. Since until now the research were mainly going to macroscopic level, it is interesting to study the spatial distribution of these elements to extend the knowledge to the microscopic scale. In these studies spatial redistribution of trace elements due to biochemical changes in tumors may be observed.
Fil: Sosa, Carlos Manuel. Universidad Nacional de Córdoba; Argentina.
Fil: Sbarato, Viviana María. Universidad Nacional de Córdoba. Facultad de Ciencias Agropecuarias; Argentina.
Fil: Pérez, Carlos Alberto. Laboratório Nacional de Luz Síncrotron; Brasil.
Fil: Bongiovanni, Guillermina Azucena.Consejo Nacional de Investigaciones Cientificas y Técnicas; Argentina.
Fil: Sánchez, Héctor Jorge. Universidad Nacional de Córdoba; Argentina.
Fil: Pérez, Roberto Daniel. Universidad Nacional de Córdoba; Argentina.
Materia
Tumor
Mama
FRX
Nivel de accesibilidad
acceso abierto
Condiciones de uso
Repositorio
Repositorio Digital Universitario (UNC)
Institución
Universidad Nacional de Córdoba
OAI Identificador
oai:rdu.unc.edu.ar:11086/16249
Acceder
id RDUUNC_e8dafeac454908b4f6af828f888f9687
oai_identifier_str oai:rdu.unc.edu.ar:11086/16249
network_acronym_str RDUUNC
repository_id_str 2572
network_name_str Repositorio Digital Universitario (UNC)
spelling Preliminary studies of elemental spatial redistribution in breast tumorsSosa, Carlos ManuelSbarato, Viviana MaríaPérez, Carlos AlbertoBongiovanni, Guillermina AzucenaSánchez, Héctor JorgePérez, Roberto DanielTumorMamaFRXPonencia presentada en la XXIII Reunião Anual de Usuários do LNLS/CNPEM. Campinas, Brasil, 26 al 27 de febrero de 2013.Fil: Sosa, Carlos Manuel. Universidad Nacional de Córdoba; Argentina.Fil: Sbarato, Viviana María. Universidad Nacional de Córdoba. Facultad de Ciencias Agropecuarias; Argentina.Fil: Pérez, Carlos Alberto. Laboratório Nacional de Luz Síncrotron; Brasil.Fil: Bongiovanni, Guillermina Azucena.Consejo Nacional de Investigaciones Cientificas y Técnicas; Argentina.Fil: Sánchez, Héctor Jorge. Universidad Nacional de Córdoba; Argentina.Fil: Pérez, Roberto Daniel. Universidad Nacional de Córdoba; Argentina.Synchrotron radiation combined with capillary optics has been used as an optimal x-ray source for microanalysis. It can be used to excite x-ray fluorescence and this approach leads to very low detection limits on micrometric areas on very small samples. Synchrotron microscopic XRF (μ-SRXRF) allows quantitative study of the nature and degree of heterogeneity of inorganic constituents in biological samples. This microbeam method, due to intrinsic characteristics of SR, is able to implement multielemental spectrochemical analysis with spatial resolution on the micrometer scale. It shows high efficiency for element determination and short time of analysis requirements. In the present work, we applied μ-SRXRF to study spatial distribution of elements on normal and cancerous human breast tissue in order to identify possible correlations induced by the desease. Several authors have shown that there is a significant increase of Ca, Cr, Mn, Fe, Cu, Zn and Br in breast tumors compared to normal tissues. Since until now the research were mainly going to macroscopic level, it is interesting to study the spatial distribution of these elements to extend the knowledge to the microscopic scale. In these studies spatial redistribution of trace elements due to biochemical changes in tumors may be observed.Fil: Sosa, Carlos Manuel. Universidad Nacional de Córdoba; Argentina.Fil: Sbarato, Viviana María. Universidad Nacional de Córdoba. Facultad de Ciencias Agropecuarias; Argentina.Fil: Pérez, Carlos Alberto. Laboratório Nacional de Luz Síncrotron; Brasil.Fil: Bongiovanni, Guillermina Azucena.Consejo Nacional de Investigaciones Cientificas y Técnicas; Argentina.Fil: Sánchez, Héctor Jorge. Universidad Nacional de Córdoba; Argentina.Fil: Pérez, Roberto Daniel. Universidad Nacional de Córdoba; Argentina.2013info:eu-repo/semantics/conferenceObjectinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_5794info:ar-repo/semantics/documentoDeConferenciaapplication/pdfhttp://hdl.handle.net/11086/16249enginfo:eu-repo/semantics/openAccessreponame:Repositorio Digital Universitario (UNC)instname:Universidad Nacional de Córdobainstacron:UNC2025-10-23T11:17:22Zoai:rdu.unc.edu.ar:11086/16249Institucionalhttps://rdu.unc.edu.ar/Universidad públicaNo correspondehttp://rdu.unc.edu.ar/oai/snrdoca.unc@gmail.comArgentinaNo correspondeNo correspondeNo correspondeopendoar:25722025-10-23 11:17:23.235Repositorio Digital Universitario (UNC) - Universidad Nacional de Córdobafalse
dc.title.none.fl_str_mv Preliminary studies of elemental spatial redistribution in breast tumors
title Preliminary studies of elemental spatial redistribution in breast tumors
spellingShingle Preliminary studies of elemental spatial redistribution in breast tumors
Sosa, Carlos Manuel
Tumor
Mama
FRX
title_short Preliminary studies of elemental spatial redistribution in breast tumors
title_full Preliminary studies of elemental spatial redistribution in breast tumors
title_fullStr Preliminary studies of elemental spatial redistribution in breast tumors
title_full_unstemmed Preliminary studies of elemental spatial redistribution in breast tumors
title_sort Preliminary studies of elemental spatial redistribution in breast tumors
dc.creator.none.fl_str_mv Sosa, Carlos Manuel
Sbarato, Viviana María
Pérez, Carlos Alberto
Bongiovanni, Guillermina Azucena
Sánchez, Héctor Jorge
Pérez, Roberto Daniel
author Sosa, Carlos Manuel
author_facet Sosa, Carlos Manuel
Sbarato, Viviana María
Pérez, Carlos Alberto
Bongiovanni, Guillermina Azucena
Sánchez, Héctor Jorge
Pérez, Roberto Daniel
author_role author
author2 Sbarato, Viviana María
Pérez, Carlos Alberto
Bongiovanni, Guillermina Azucena
Sánchez, Héctor Jorge
Pérez, Roberto Daniel
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv Tumor
Mama
FRX
topic Tumor
Mama
FRX
dc.description.none.fl_txt_mv Ponencia presentada en la XXIII Reunião Anual de Usuários do LNLS/CNPEM. Campinas, Brasil, 26 al 27 de febrero de 2013.
Fil: Sosa, Carlos Manuel. Universidad Nacional de Córdoba; Argentina.
Fil: Sbarato, Viviana María. Universidad Nacional de Córdoba. Facultad de Ciencias Agropecuarias; Argentina.
Fil: Pérez, Carlos Alberto. Laboratório Nacional de Luz Síncrotron; Brasil.
Fil: Bongiovanni, Guillermina Azucena.Consejo Nacional de Investigaciones Cientificas y Técnicas; Argentina.
Fil: Sánchez, Héctor Jorge. Universidad Nacional de Córdoba; Argentina.
Fil: Pérez, Roberto Daniel. Universidad Nacional de Córdoba; Argentina.
Synchrotron radiation combined with capillary optics has been used as an optimal x-ray source for microanalysis. It can be used to excite x-ray fluorescence and this approach leads to very low detection limits on micrometric areas on very small samples. Synchrotron microscopic XRF (μ-SRXRF) allows quantitative study of the nature and degree of heterogeneity of inorganic constituents in biological samples. This microbeam method, due to intrinsic characteristics of SR, is able to implement multielemental spectrochemical analysis with spatial resolution on the micrometer scale. It shows high efficiency for element determination and short time of analysis requirements. In the present work, we applied μ-SRXRF to study spatial distribution of elements on normal and cancerous human breast tissue in order to identify possible correlations induced by the desease. Several authors have shown that there is a significant increase of Ca, Cr, Mn, Fe, Cu, Zn and Br in breast tumors compared to normal tissues. Since until now the research were mainly going to macroscopic level, it is interesting to study the spatial distribution of these elements to extend the knowledge to the microscopic scale. In these studies spatial redistribution of trace elements due to biochemical changes in tumors may be observed.
Fil: Sosa, Carlos Manuel. Universidad Nacional de Córdoba; Argentina.
Fil: Sbarato, Viviana María. Universidad Nacional de Córdoba. Facultad de Ciencias Agropecuarias; Argentina.
Fil: Pérez, Carlos Alberto. Laboratório Nacional de Luz Síncrotron; Brasil.
Fil: Bongiovanni, Guillermina Azucena.Consejo Nacional de Investigaciones Cientificas y Técnicas; Argentina.
Fil: Sánchez, Héctor Jorge. Universidad Nacional de Córdoba; Argentina.
Fil: Pérez, Roberto Daniel. Universidad Nacional de Córdoba; Argentina.
description Ponencia presentada en la XXIII Reunião Anual de Usuários do LNLS/CNPEM. Campinas, Brasil, 26 al 27 de febrero de 2013.
publishDate 2013
dc.date.none.fl_str_mv 2013
dc.type.none.fl_str_mv info:eu-repo/semantics/conferenceObject
info:eu-repo/semantics/publishedVersion
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info:ar-repo/semantics/documentoDeConferencia
format conferenceObject
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11086/16249
url http://hdl.handle.net/11086/16249
dc.language.none.fl_str_mv eng
language eng
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Repositorio Digital Universitario (UNC)
instname:Universidad Nacional de Córdoba
instacron:UNC
reponame_str Repositorio Digital Universitario (UNC)
collection Repositorio Digital Universitario (UNC)
instname_str Universidad Nacional de Córdoba
instacron_str UNC
institution UNC
repository.name.fl_str_mv Repositorio Digital Universitario (UNC) - Universidad Nacional de Córdoba
repository.mail.fl_str_mv oca.unc@gmail.com
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score 12.982451

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