Astaxanthin obtained from freshwater crustaceans mitigates visceral adiposity by modulating adipose tissue lipogenesis and ameliorates dyslipidemia in high-sucrose diet fed rats
- Autores
- Vargas, Matias Rodrigo; Ferreira, María del Rosario; Collins, Pablo; D’Alessandro, Maria Eugenia
- Año de publicación
- 2025
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- The incidence of overweight and obesity continues to grow at alarming rates around the world. The search for foods with potential benefits in the prevention/treatment of overweight/obesity and related disorders has great relevance. The aim of this study was to evaluate the effect of astaxanthin (ASTX) from freshwater crustaceans (crabs) upon visceral adiposity, adipose tissue lipid metabolism disorders and dyslipidemia present in a Metabolic Syndrome rodent model. Male Wistar rats were fed for 90 days with 1 of 4 experimental diets: a-Reference group (RD) received a standard commercial rodent diet, b- High-sucrose diet (HSD) group received a HSD, c- RD+ASTX group received a standard commercial rodent diet plus ASTX, d- HSD+ASTX group received a HSD plus ASTX. The rats were given orally either ASTX (10 mg/kg body weight/day in sunflower oil) or only sunflower oil. Compared with HSD-fed rats, HSD+ASTX group had lower body weight gain (19%) and both reduced abdominal circumference (5%) and visceral adiposity index (5%). Energy intake was 24% lower at the middle of the experimental period. Epididymal adipocytes size and triglyceride (TG) content was reduced by 14%. Besides, fatty acid synthase, malic enzyme and glucose-6-phosphate dehydrogenase activities in epididymal adipose tissue were 43%, 28% and 38% lower respectively. These changes were accompanied by lower TG (25%) and cholesterol (27%) serum levels, atherogenic index (31%) and reduced Systolic (12%) and Diastolic (15%) blood pressure. The results show that ASTX could be a potential strategy to prevent/attenuate the incidence of metabolic risk factors such as overweight/adiposity and dyslipidemia.
EEA Rafaela
Fil: Vargas, Matias Rodrigo. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Laboratorio de Estudio de Enfermedades Metabólicas Relacionadas con la Nutrición; Argentina
Fil: Ferreira, María del Rosario. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Laboratorio de Estudio de Enfermedades Metabólicas Relacionadas con la Nutrición; Argentina
Fil: Ferreira, María del Rosario. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Collins, Pablo. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Rafaela. Centro Operativo Experimental A.G.; Argentina
Fil: Collins, Pablo. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: D’Alessandro, Maria Eugenia. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Laboratorio de Estudio de Enfermedades Metabólicas Relacionadas con la Nutrición; Argentina
Fil: D’Alessandro, Maria Eugenia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina - Fuente
- The Journal of Nutritional Biochemistry 142 : 109924. (August 2025)
- Materia
-
Astaxantina
Tejido Adiposo
Adiposidad
Rata
Sucrosa
Astaxanthin
Adipose Tissue
Adiposity
Rats
Sucrose
Freshwater Crustaceans
Marisco de Agua Dulce - Nivel de accesibilidad
- acceso restringido
- Condiciones de uso
- http://creativecommons.org/licenses/by-nc-sa/4.0/
- Repositorio
- Institución
- Instituto Nacional de Tecnología Agropecuaria
- OAI Identificador
- oai:localhost:20.500.12123/22235
Ver los metadatos del registro completo
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Astaxanthin obtained from freshwater crustaceans mitigates visceral adiposity by modulating adipose tissue lipogenesis and ameliorates dyslipidemia in high-sucrose diet fed ratsVargas, Matias RodrigoFerreira, María del RosarioCollins, PabloD’Alessandro, Maria EugeniaAstaxantinaTejido AdiposoAdiposidadRataSucrosaAstaxanthinAdipose TissueAdiposityRatsSucroseFreshwater CrustaceansMarisco de Agua DulceThe incidence of overweight and obesity continues to grow at alarming rates around the world. The search for foods with potential benefits in the prevention/treatment of overweight/obesity and related disorders has great relevance. The aim of this study was to evaluate the effect of astaxanthin (ASTX) from freshwater crustaceans (crabs) upon visceral adiposity, adipose tissue lipid metabolism disorders and dyslipidemia present in a Metabolic Syndrome rodent model. Male Wistar rats were fed for 90 days with 1 of 4 experimental diets: a-Reference group (RD) received a standard commercial rodent diet, b- High-sucrose diet (HSD) group received a HSD, c- RD+ASTX group received a standard commercial rodent diet plus ASTX, d- HSD+ASTX group received a HSD plus ASTX. The rats were given orally either ASTX (10 mg/kg body weight/day in sunflower oil) or only sunflower oil. Compared with HSD-fed rats, HSD+ASTX group had lower body weight gain (19%) and both reduced abdominal circumference (5%) and visceral adiposity index (5%). Energy intake was 24% lower at the middle of the experimental period. Epididymal adipocytes size and triglyceride (TG) content was reduced by 14%. Besides, fatty acid synthase, malic enzyme and glucose-6-phosphate dehydrogenase activities in epididymal adipose tissue were 43%, 28% and 38% lower respectively. These changes were accompanied by lower TG (25%) and cholesterol (27%) serum levels, atherogenic index (31%) and reduced Systolic (12%) and Diastolic (15%) blood pressure. The results show that ASTX could be a potential strategy to prevent/attenuate the incidence of metabolic risk factors such as overweight/adiposity and dyslipidemia.EEA RafaelaFil: Vargas, Matias Rodrigo. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Laboratorio de Estudio de Enfermedades Metabólicas Relacionadas con la Nutrición; ArgentinaFil: Ferreira, María del Rosario. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Laboratorio de Estudio de Enfermedades Metabólicas Relacionadas con la Nutrición; ArgentinaFil: Ferreira, María del Rosario. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Collins, Pablo. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Rafaela. Centro Operativo Experimental A.G.; ArgentinaFil: Collins, Pablo. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: D’Alessandro, Maria Eugenia. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Laboratorio de Estudio de Enfermedades Metabólicas Relacionadas con la Nutrición; ArgentinaFil: D’Alessandro, Maria Eugenia. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaElsevier2025-05-12T11:46:48Z2025-05-12T11:46:48Z2025-08info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfhttp://hdl.handle.net/20.500.12123/22235https://www.sciencedirect.com/science/article/abs/pii/S09552863250008770955-28631873-4847https://doi.org/10.1016/j.jnutbio.2025.109924The Journal of Nutritional Biochemistry 142 : 109924. (August 2025)reponame:INTA Digital (INTA)instname:Instituto Nacional de Tecnología Agropecuariaenginfo:eu-repo/semantics/restrictedAccesshttp://creativecommons.org/licenses/by-nc-sa/4.0/Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)2025-09-04T09:51:03Zoai:localhost:20.500.12123/22235instacron:INTAInstitucionalhttp://repositorio.inta.gob.ar/Organismo científico-tecnológicoNo correspondehttp://repositorio.inta.gob.ar/oai/requesttripaldi.nicolas@inta.gob.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:l2025-09-04 09:51:03.881INTA Digital (INTA) - Instituto Nacional de Tecnología Agropecuariafalse |
dc.title.none.fl_str_mv |
Astaxanthin obtained from freshwater crustaceans mitigates visceral adiposity by modulating adipose tissue lipogenesis and ameliorates dyslipidemia in high-sucrose diet fed rats |
title |
Astaxanthin obtained from freshwater crustaceans mitigates visceral adiposity by modulating adipose tissue lipogenesis and ameliorates dyslipidemia in high-sucrose diet fed rats |
spellingShingle |
Astaxanthin obtained from freshwater crustaceans mitigates visceral adiposity by modulating adipose tissue lipogenesis and ameliorates dyslipidemia in high-sucrose diet fed rats Vargas, Matias Rodrigo Astaxantina Tejido Adiposo Adiposidad Rata Sucrosa Astaxanthin Adipose Tissue Adiposity Rats Sucrose Freshwater Crustaceans Marisco de Agua Dulce |
title_short |
Astaxanthin obtained from freshwater crustaceans mitigates visceral adiposity by modulating adipose tissue lipogenesis and ameliorates dyslipidemia in high-sucrose diet fed rats |
title_full |
Astaxanthin obtained from freshwater crustaceans mitigates visceral adiposity by modulating adipose tissue lipogenesis and ameliorates dyslipidemia in high-sucrose diet fed rats |
title_fullStr |
Astaxanthin obtained from freshwater crustaceans mitigates visceral adiposity by modulating adipose tissue lipogenesis and ameliorates dyslipidemia in high-sucrose diet fed rats |
title_full_unstemmed |
Astaxanthin obtained from freshwater crustaceans mitigates visceral adiposity by modulating adipose tissue lipogenesis and ameliorates dyslipidemia in high-sucrose diet fed rats |
title_sort |
Astaxanthin obtained from freshwater crustaceans mitigates visceral adiposity by modulating adipose tissue lipogenesis and ameliorates dyslipidemia in high-sucrose diet fed rats |
dc.creator.none.fl_str_mv |
Vargas, Matias Rodrigo Ferreira, María del Rosario Collins, Pablo D’Alessandro, Maria Eugenia |
author |
Vargas, Matias Rodrigo |
author_facet |
Vargas, Matias Rodrigo Ferreira, María del Rosario Collins, Pablo D’Alessandro, Maria Eugenia |
author_role |
author |
author2 |
Ferreira, María del Rosario Collins, Pablo D’Alessandro, Maria Eugenia |
author2_role |
author author author |
dc.subject.none.fl_str_mv |
Astaxantina Tejido Adiposo Adiposidad Rata Sucrosa Astaxanthin Adipose Tissue Adiposity Rats Sucrose Freshwater Crustaceans Marisco de Agua Dulce |
topic |
Astaxantina Tejido Adiposo Adiposidad Rata Sucrosa Astaxanthin Adipose Tissue Adiposity Rats Sucrose Freshwater Crustaceans Marisco de Agua Dulce |
dc.description.none.fl_txt_mv |
The incidence of overweight and obesity continues to grow at alarming rates around the world. The search for foods with potential benefits in the prevention/treatment of overweight/obesity and related disorders has great relevance. The aim of this study was to evaluate the effect of astaxanthin (ASTX) from freshwater crustaceans (crabs) upon visceral adiposity, adipose tissue lipid metabolism disorders and dyslipidemia present in a Metabolic Syndrome rodent model. Male Wistar rats were fed for 90 days with 1 of 4 experimental diets: a-Reference group (RD) received a standard commercial rodent diet, b- High-sucrose diet (HSD) group received a HSD, c- RD+ASTX group received a standard commercial rodent diet plus ASTX, d- HSD+ASTX group received a HSD plus ASTX. The rats were given orally either ASTX (10 mg/kg body weight/day in sunflower oil) or only sunflower oil. Compared with HSD-fed rats, HSD+ASTX group had lower body weight gain (19%) and both reduced abdominal circumference (5%) and visceral adiposity index (5%). Energy intake was 24% lower at the middle of the experimental period. Epididymal adipocytes size and triglyceride (TG) content was reduced by 14%. Besides, fatty acid synthase, malic enzyme and glucose-6-phosphate dehydrogenase activities in epididymal adipose tissue were 43%, 28% and 38% lower respectively. These changes were accompanied by lower TG (25%) and cholesterol (27%) serum levels, atherogenic index (31%) and reduced Systolic (12%) and Diastolic (15%) blood pressure. The results show that ASTX could be a potential strategy to prevent/attenuate the incidence of metabolic risk factors such as overweight/adiposity and dyslipidemia. EEA Rafaela Fil: Vargas, Matias Rodrigo. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Laboratorio de Estudio de Enfermedades Metabólicas Relacionadas con la Nutrición; Argentina Fil: Ferreira, María del Rosario. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Laboratorio de Estudio de Enfermedades Metabólicas Relacionadas con la Nutrición; Argentina Fil: Ferreira, María del Rosario. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Collins, Pablo. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Rafaela. Centro Operativo Experimental A.G.; Argentina Fil: Collins, Pablo. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: D’Alessandro, Maria Eugenia. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Laboratorio de Estudio de Enfermedades Metabólicas Relacionadas con la Nutrición; Argentina Fil: D’Alessandro, Maria Eugenia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina |
description |
The incidence of overweight and obesity continues to grow at alarming rates around the world. The search for foods with potential benefits in the prevention/treatment of overweight/obesity and related disorders has great relevance. The aim of this study was to evaluate the effect of astaxanthin (ASTX) from freshwater crustaceans (crabs) upon visceral adiposity, adipose tissue lipid metabolism disorders and dyslipidemia present in a Metabolic Syndrome rodent model. Male Wistar rats were fed for 90 days with 1 of 4 experimental diets: a-Reference group (RD) received a standard commercial rodent diet, b- High-sucrose diet (HSD) group received a HSD, c- RD+ASTX group received a standard commercial rodent diet plus ASTX, d- HSD+ASTX group received a HSD plus ASTX. The rats were given orally either ASTX (10 mg/kg body weight/day in sunflower oil) or only sunflower oil. Compared with HSD-fed rats, HSD+ASTX group had lower body weight gain (19%) and both reduced abdominal circumference (5%) and visceral adiposity index (5%). Energy intake was 24% lower at the middle of the experimental period. Epididymal adipocytes size and triglyceride (TG) content was reduced by 14%. Besides, fatty acid synthase, malic enzyme and glucose-6-phosphate dehydrogenase activities in epididymal adipose tissue were 43%, 28% and 38% lower respectively. These changes were accompanied by lower TG (25%) and cholesterol (27%) serum levels, atherogenic index (31%) and reduced Systolic (12%) and Diastolic (15%) blood pressure. The results show that ASTX could be a potential strategy to prevent/attenuate the incidence of metabolic risk factors such as overweight/adiposity and dyslipidemia. |
publishDate |
2025 |
dc.date.none.fl_str_mv |
2025-05-12T11:46:48Z 2025-05-12T11:46:48Z 2025-08 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/20.500.12123/22235 https://www.sciencedirect.com/science/article/abs/pii/S0955286325000877 0955-2863 1873-4847 https://doi.org/10.1016/j.jnutbio.2025.109924 |
url |
http://hdl.handle.net/20.500.12123/22235 https://www.sciencedirect.com/science/article/abs/pii/S0955286325000877 https://doi.org/10.1016/j.jnutbio.2025.109924 |
identifier_str_mv |
0955-2863 1873-4847 |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/restrictedAccess http://creativecommons.org/licenses/by-nc-sa/4.0/ Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) |
eu_rights_str_mv |
restrictedAccess |
rights_invalid_str_mv |
http://creativecommons.org/licenses/by-nc-sa/4.0/ Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Elsevier |
publisher.none.fl_str_mv |
Elsevier |
dc.source.none.fl_str_mv |
The Journal of Nutritional Biochemistry 142 : 109924. (August 2025) reponame:INTA Digital (INTA) instname:Instituto Nacional de Tecnología Agropecuaria |
reponame_str |
INTA Digital (INTA) |
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INTA Digital (INTA) |
instname_str |
Instituto Nacional de Tecnología Agropecuaria |
repository.name.fl_str_mv |
INTA Digital (INTA) - Instituto Nacional de Tecnología Agropecuaria |
repository.mail.fl_str_mv |
tripaldi.nicolas@inta.gob.ar |
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