Astaxanthin obtained from freshwater crustaceans mitigates visceral adiposity by modulating adipose tissue lipogenesis and ameliorates dyslipidemia in high-sucrose diet fed rats

Autores
Vargas, Matias Rodrigo; Ferreira, María del Rosario; Collins, Pablo; D’Alessandro, Maria Eugenia
Año de publicación
2025
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The incidence of overweight and obesity continues to grow at alarming rates around the world. The search for foods with potential benefits in the prevention/treatment of overweight/obesity and related disorders has great relevance. The aim of this study was to evaluate the effect of astaxanthin (ASTX) from freshwater crustaceans (crabs) upon visceral adiposity, adipose tissue lipid metabolism disorders and dyslipidemia present in a Metabolic Syndrome rodent model. Male Wistar rats were fed for 90 days with 1 of 4 experimental diets: a-Reference group (RD) received a standard commercial rodent diet, b- High-sucrose diet (HSD) group received a HSD, c- RD+ASTX group received a standard commercial rodent diet plus ASTX, d- HSD+ASTX group received a HSD plus ASTX. The rats were given orally either ASTX (10 mg/kg body weight/day in sunflower oil) or only sunflower oil. Compared with HSD-fed rats, HSD+ASTX group had lower body weight gain (19%) and both reduced abdominal circumference (5%) and visceral adiposity index (5%). Energy intake was 24% lower at the middle of the experimental period. Epididymal adipocytes size and triglyceride (TG) content was reduced by 14%. Besides, fatty acid synthase, malic enzyme and glucose-6-phosphate dehydrogenase activities in epididymal adipose tissue were 43%, 28% and 38% lower respectively. These changes were accompanied by lower TG (25%) and cholesterol (27%) serum levels, atherogenic index (31%) and reduced Systolic (12%) and Diastolic (15%) blood pressure. The results show that ASTX could be a potential strategy to prevent/attenuate the incidence of metabolic risk factors such as overweight/adiposity and dyslipidemia.
EEA Rafaela
Fil: Vargas, Matias Rodrigo. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Laboratorio de Estudio de Enfermedades Metabólicas Relacionadas con la Nutrición; Argentina
Fil: Ferreira, María del Rosario. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Laboratorio de Estudio de Enfermedades Metabólicas Relacionadas con la Nutrición; Argentina
Fil: Ferreira, María del Rosario. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Collins, Pablo. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Rafaela. Centro Operativo Experimental A.G.; Argentina
Fil: Collins, Pablo. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: D’Alessandro, Maria Eugenia. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Laboratorio de Estudio de Enfermedades Metabólicas Relacionadas con la Nutrición; Argentina
Fil: D’Alessandro, Maria Eugenia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fuente
The Journal of Nutritional Biochemistry 142 : 109924. (August 2025)
Materia
Astaxantina
Tejido Adiposo
Adiposidad
Rata
Sucrosa
Astaxanthin
Adipose Tissue
Adiposity
Rats
Sucrose
Freshwater Crustaceans
Marisco de Agua Dulce
Nivel de accesibilidad
acceso restringido
Condiciones de uso
http://creativecommons.org/licenses/by-nc-sa/4.0/
Repositorio
INTA Digital (INTA)
Institución
Instituto Nacional de Tecnología Agropecuaria
OAI Identificador
oai:localhost:20.500.12123/22235

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oai_identifier_str oai:localhost:20.500.12123/22235
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network_name_str INTA Digital (INTA)
spelling Astaxanthin obtained from freshwater crustaceans mitigates visceral adiposity by modulating adipose tissue lipogenesis and ameliorates dyslipidemia in high-sucrose diet fed ratsVargas, Matias RodrigoFerreira, María del RosarioCollins, PabloD’Alessandro, Maria EugeniaAstaxantinaTejido AdiposoAdiposidadRataSucrosaAstaxanthinAdipose TissueAdiposityRatsSucroseFreshwater CrustaceansMarisco de Agua DulceThe incidence of overweight and obesity continues to grow at alarming rates around the world. The search for foods with potential benefits in the prevention/treatment of overweight/obesity and related disorders has great relevance. The aim of this study was to evaluate the effect of astaxanthin (ASTX) from freshwater crustaceans (crabs) upon visceral adiposity, adipose tissue lipid metabolism disorders and dyslipidemia present in a Metabolic Syndrome rodent model. Male Wistar rats were fed for 90 days with 1 of 4 experimental diets: a-Reference group (RD) received a standard commercial rodent diet, b- High-sucrose diet (HSD) group received a HSD, c- RD+ASTX group received a standard commercial rodent diet plus ASTX, d- HSD+ASTX group received a HSD plus ASTX. The rats were given orally either ASTX (10 mg/kg body weight/day in sunflower oil) or only sunflower oil. Compared with HSD-fed rats, HSD+ASTX group had lower body weight gain (19%) and both reduced abdominal circumference (5%) and visceral adiposity index (5%). Energy intake was 24% lower at the middle of the experimental period. Epididymal adipocytes size and triglyceride (TG) content was reduced by 14%. Besides, fatty acid synthase, malic enzyme and glucose-6-phosphate dehydrogenase activities in epididymal adipose tissue were 43%, 28% and 38% lower respectively. These changes were accompanied by lower TG (25%) and cholesterol (27%) serum levels, atherogenic index (31%) and reduced Systolic (12%) and Diastolic (15%) blood pressure. The results show that ASTX could be a potential strategy to prevent/attenuate the incidence of metabolic risk factors such as overweight/adiposity and dyslipidemia.EEA RafaelaFil: Vargas, Matias Rodrigo. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Laboratorio de Estudio de Enfermedades Metabólicas Relacionadas con la Nutrición; ArgentinaFil: Ferreira, María del Rosario. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Laboratorio de Estudio de Enfermedades Metabólicas Relacionadas con la Nutrición; ArgentinaFil: Ferreira, María del Rosario. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Collins, Pablo. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Rafaela. Centro Operativo Experimental A.G.; ArgentinaFil: Collins, Pablo. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: D’Alessandro, Maria Eugenia. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Laboratorio de Estudio de Enfermedades Metabólicas Relacionadas con la Nutrición; ArgentinaFil: D’Alessandro, Maria Eugenia. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaElsevier2025-05-12T11:46:48Z2025-05-12T11:46:48Z2025-08info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfhttp://hdl.handle.net/20.500.12123/22235https://www.sciencedirect.com/science/article/abs/pii/S09552863250008770955-28631873-4847https://doi.org/10.1016/j.jnutbio.2025.109924The Journal of Nutritional Biochemistry 142 : 109924. (August 2025)reponame:INTA Digital (INTA)instname:Instituto Nacional de Tecnología Agropecuariaenginfo:eu-repo/semantics/restrictedAccesshttp://creativecommons.org/licenses/by-nc-sa/4.0/Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)2025-09-04T09:51:03Zoai:localhost:20.500.12123/22235instacron:INTAInstitucionalhttp://repositorio.inta.gob.ar/Organismo científico-tecnológicoNo correspondehttp://repositorio.inta.gob.ar/oai/requesttripaldi.nicolas@inta.gob.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:l2025-09-04 09:51:03.881INTA Digital (INTA) - Instituto Nacional de Tecnología Agropecuariafalse
dc.title.none.fl_str_mv Astaxanthin obtained from freshwater crustaceans mitigates visceral adiposity by modulating adipose tissue lipogenesis and ameliorates dyslipidemia in high-sucrose diet fed rats
title Astaxanthin obtained from freshwater crustaceans mitigates visceral adiposity by modulating adipose tissue lipogenesis and ameliorates dyslipidemia in high-sucrose diet fed rats
spellingShingle Astaxanthin obtained from freshwater crustaceans mitigates visceral adiposity by modulating adipose tissue lipogenesis and ameliorates dyslipidemia in high-sucrose diet fed rats
Vargas, Matias Rodrigo
Astaxantina
Tejido Adiposo
Adiposidad
Rata
Sucrosa
Astaxanthin
Adipose Tissue
Adiposity
Rats
Sucrose
Freshwater Crustaceans
Marisco de Agua Dulce
title_short Astaxanthin obtained from freshwater crustaceans mitigates visceral adiposity by modulating adipose tissue lipogenesis and ameliorates dyslipidemia in high-sucrose diet fed rats
title_full Astaxanthin obtained from freshwater crustaceans mitigates visceral adiposity by modulating adipose tissue lipogenesis and ameliorates dyslipidemia in high-sucrose diet fed rats
title_fullStr Astaxanthin obtained from freshwater crustaceans mitigates visceral adiposity by modulating adipose tissue lipogenesis and ameliorates dyslipidemia in high-sucrose diet fed rats
title_full_unstemmed Astaxanthin obtained from freshwater crustaceans mitigates visceral adiposity by modulating adipose tissue lipogenesis and ameliorates dyslipidemia in high-sucrose diet fed rats
title_sort Astaxanthin obtained from freshwater crustaceans mitigates visceral adiposity by modulating adipose tissue lipogenesis and ameliorates dyslipidemia in high-sucrose diet fed rats
dc.creator.none.fl_str_mv Vargas, Matias Rodrigo
Ferreira, María del Rosario
Collins, Pablo
D’Alessandro, Maria Eugenia
author Vargas, Matias Rodrigo
author_facet Vargas, Matias Rodrigo
Ferreira, María del Rosario
Collins, Pablo
D’Alessandro, Maria Eugenia
author_role author
author2 Ferreira, María del Rosario
Collins, Pablo
D’Alessandro, Maria Eugenia
author2_role author
author
author
dc.subject.none.fl_str_mv Astaxantina
Tejido Adiposo
Adiposidad
Rata
Sucrosa
Astaxanthin
Adipose Tissue
Adiposity
Rats
Sucrose
Freshwater Crustaceans
Marisco de Agua Dulce
topic Astaxantina
Tejido Adiposo
Adiposidad
Rata
Sucrosa
Astaxanthin
Adipose Tissue
Adiposity
Rats
Sucrose
Freshwater Crustaceans
Marisco de Agua Dulce
dc.description.none.fl_txt_mv The incidence of overweight and obesity continues to grow at alarming rates around the world. The search for foods with potential benefits in the prevention/treatment of overweight/obesity and related disorders has great relevance. The aim of this study was to evaluate the effect of astaxanthin (ASTX) from freshwater crustaceans (crabs) upon visceral adiposity, adipose tissue lipid metabolism disorders and dyslipidemia present in a Metabolic Syndrome rodent model. Male Wistar rats were fed for 90 days with 1 of 4 experimental diets: a-Reference group (RD) received a standard commercial rodent diet, b- High-sucrose diet (HSD) group received a HSD, c- RD+ASTX group received a standard commercial rodent diet plus ASTX, d- HSD+ASTX group received a HSD plus ASTX. The rats were given orally either ASTX (10 mg/kg body weight/day in sunflower oil) or only sunflower oil. Compared with HSD-fed rats, HSD+ASTX group had lower body weight gain (19%) and both reduced abdominal circumference (5%) and visceral adiposity index (5%). Energy intake was 24% lower at the middle of the experimental period. Epididymal adipocytes size and triglyceride (TG) content was reduced by 14%. Besides, fatty acid synthase, malic enzyme and glucose-6-phosphate dehydrogenase activities in epididymal adipose tissue were 43%, 28% and 38% lower respectively. These changes were accompanied by lower TG (25%) and cholesterol (27%) serum levels, atherogenic index (31%) and reduced Systolic (12%) and Diastolic (15%) blood pressure. The results show that ASTX could be a potential strategy to prevent/attenuate the incidence of metabolic risk factors such as overweight/adiposity and dyslipidemia.
EEA Rafaela
Fil: Vargas, Matias Rodrigo. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Laboratorio de Estudio de Enfermedades Metabólicas Relacionadas con la Nutrición; Argentina
Fil: Ferreira, María del Rosario. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Laboratorio de Estudio de Enfermedades Metabólicas Relacionadas con la Nutrición; Argentina
Fil: Ferreira, María del Rosario. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Collins, Pablo. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Rafaela. Centro Operativo Experimental A.G.; Argentina
Fil: Collins, Pablo. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: D’Alessandro, Maria Eugenia. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Laboratorio de Estudio de Enfermedades Metabólicas Relacionadas con la Nutrición; Argentina
Fil: D’Alessandro, Maria Eugenia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
description The incidence of overweight and obesity continues to grow at alarming rates around the world. The search for foods with potential benefits in the prevention/treatment of overweight/obesity and related disorders has great relevance. The aim of this study was to evaluate the effect of astaxanthin (ASTX) from freshwater crustaceans (crabs) upon visceral adiposity, adipose tissue lipid metabolism disorders and dyslipidemia present in a Metabolic Syndrome rodent model. Male Wistar rats were fed for 90 days with 1 of 4 experimental diets: a-Reference group (RD) received a standard commercial rodent diet, b- High-sucrose diet (HSD) group received a HSD, c- RD+ASTX group received a standard commercial rodent diet plus ASTX, d- HSD+ASTX group received a HSD plus ASTX. The rats were given orally either ASTX (10 mg/kg body weight/day in sunflower oil) or only sunflower oil. Compared with HSD-fed rats, HSD+ASTX group had lower body weight gain (19%) and both reduced abdominal circumference (5%) and visceral adiposity index (5%). Energy intake was 24% lower at the middle of the experimental period. Epididymal adipocytes size and triglyceride (TG) content was reduced by 14%. Besides, fatty acid synthase, malic enzyme and glucose-6-phosphate dehydrogenase activities in epididymal adipose tissue were 43%, 28% and 38% lower respectively. These changes were accompanied by lower TG (25%) and cholesterol (27%) serum levels, atherogenic index (31%) and reduced Systolic (12%) and Diastolic (15%) blood pressure. The results show that ASTX could be a potential strategy to prevent/attenuate the incidence of metabolic risk factors such as overweight/adiposity and dyslipidemia.
publishDate 2025
dc.date.none.fl_str_mv 2025-05-12T11:46:48Z
2025-05-12T11:46:48Z
2025-08
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
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info:ar-repo/semantics/articulo
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status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/20.500.12123/22235
https://www.sciencedirect.com/science/article/abs/pii/S0955286325000877
0955-2863
1873-4847
https://doi.org/10.1016/j.jnutbio.2025.109924
url http://hdl.handle.net/20.500.12123/22235
https://www.sciencedirect.com/science/article/abs/pii/S0955286325000877
https://doi.org/10.1016/j.jnutbio.2025.109924
identifier_str_mv 0955-2863
1873-4847
dc.language.none.fl_str_mv eng
language eng
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Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
eu_rights_str_mv restrictedAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by-nc-sa/4.0/
Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv The Journal of Nutritional Biochemistry 142 : 109924. (August 2025)
reponame:INTA Digital (INTA)
instname:Instituto Nacional de Tecnología Agropecuaria
reponame_str INTA Digital (INTA)
collection INTA Digital (INTA)
instname_str Instituto Nacional de Tecnología Agropecuaria
repository.name.fl_str_mv INTA Digital (INTA) - Instituto Nacional de Tecnología Agropecuaria
repository.mail.fl_str_mv tripaldi.nicolas@inta.gob.ar
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