Inflammatory infiltration into placentas of Neospora caninum challenged cattle correlates with clinical outcome of pregnancy

Autores
Canton, German Jose; Katzer, Frank; Maley, Stephen W.; Bartley, Paul M.; Benavides-Silván, Julio; Palarea-Albaladejo, Javier; Pang, Yvonne; Smith, Sionagh; Rocchi, Mara; Buxton, David; Innes, Elisabeth A.; Chianini, Francesca
Año de publicación
2014
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Infection with Neospora caninum stimulates host cell-mediated immune responses, which may be responsible for placental damage leading to bovine abortion. The aim of this study was to compare immune responses in the bovine placenta, following experimental infection in different stages of pregnancy. Placentomes were examined by immunohistochemistry and inflammation in early gestation was generally moderate to severe, particularly in the placentas carrying non-viable foetuses, whereas it was milder in later stages, mainly characterised by the presence of CD3+, CD4+ and γδ T-cells. This distinctive cellular immune response may explain the milder clinical outcome observed when animals are infected in later gestation.
EEA Balcarce
Fil: Canton, German Jose. Moredun Research Institute; Reino Unido. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Balcarce; Argentina
Fil: Katzer, Frank. Moredun Research Institute; Reino Unido
Fil: Maley, Stephen W. Moredun Research Institute; Reino Unido
Fil: Bartley, Paul M. Moredun Research Institute; Reino Unido
Fil: Benavides-Silván, Julio. Moredun Research Institute; Reino Unido. Consejo Superior de Investigaciones Científicas. Instituto de Ganadería de Montaña; España
Fil: Palarea-Albaladejo, Javier. Biomathematics & Statistics Scotland; Reino Unido
Fil: Pang, Yvonne. Moredun Research Institute; Reino Unido
Fil: Smith, Sionagh. University of Edinburgh. Royal (Dick) School of Veterinary Studies and Roslin Institute; Reino Unido
Fil: Rocchi, Mara. Moredun Research Institute; Reino Unido
Fil: Buxton, David. Moredun Research Institute; Reino Unido
Fil: Innes, Elisabeth A. Moredun Research Institute; Reino Unido
Fil: Chianini, Francesca. Moredun Research Institute; Reino Unido
Fuente
Veterinary Research 45 : 11 (2014)
Materia
Neospora caninum
Ganado Bovino
Enfermedades de los Animales
Placenta
Inflamación
Gestación
Cattle
Animal Diseases
Inflammation
Pregnancy
Nivel de accesibilidad
acceso abierto
Condiciones de uso
http://creativecommons.org/licenses/by-nc-sa/4.0/
Repositorio
INTA Digital (INTA)
Institución
Instituto Nacional de Tecnología Agropecuaria
OAI Identificador
oai:localhost:20.500.12123/4002
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spelling Inflammatory infiltration into placentas of Neospora caninum challenged cattle correlates with clinical outcome of pregnancyCanton, German JoseKatzer, FrankMaley, Stephen W.Bartley, Paul M.Benavides-Silván, JulioPalarea-Albaladejo, JavierPang, YvonneSmith, SionaghRocchi, MaraBuxton, DavidInnes, Elisabeth A.Chianini, FrancescaNeospora caninumGanado BovinoEnfermedades de los AnimalesPlacentaInflamaciónGestaciónCattleAnimal DiseasesInflammationPregnancyInfection with Neospora caninum stimulates host cell-mediated immune responses, which may be responsible for placental damage leading to bovine abortion. The aim of this study was to compare immune responses in the bovine placenta, following experimental infection in different stages of pregnancy. Placentomes were examined by immunohistochemistry and inflammation in early gestation was generally moderate to severe, particularly in the placentas carrying non-viable foetuses, whereas it was milder in later stages, mainly characterised by the presence of CD3+, CD4+ and γδ T-cells. This distinctive cellular immune response may explain the milder clinical outcome observed when animals are infected in later gestation.EEA BalcarceFil: Canton, German Jose. Moredun Research Institute; Reino Unido. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Balcarce; ArgentinaFil: Katzer, Frank. Moredun Research Institute; Reino UnidoFil: Maley, Stephen W. Moredun Research Institute; Reino UnidoFil: Bartley, Paul M. Moredun Research Institute; Reino UnidoFil: Benavides-Silván, Julio. Moredun Research Institute; Reino Unido. Consejo Superior de Investigaciones Científicas. Instituto de Ganadería de Montaña; EspañaFil: Palarea-Albaladejo, Javier. Biomathematics & Statistics Scotland; Reino UnidoFil: Pang, Yvonne. Moredun Research Institute; Reino UnidoFil: Smith, Sionagh. University of Edinburgh. Royal (Dick) School of Veterinary Studies and Roslin Institute; Reino UnidoFil: Rocchi, Mara. Moredun Research Institute; Reino UnidoFil: Buxton, David. Moredun Research Institute; Reino UnidoFil: Innes, Elisabeth A. Moredun Research Institute; Reino UnidoFil: Chianini, Francesca. Moredun Research Institute; Reino UnidoBMC2018-12-03T17:46:10Z2018-12-03T17:46:10Z2014-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfhttps://veterinaryresearch.biomedcentral.com/articles/10.1186/1297-9716-45-11http://hdl.handle.net/20.500.12123/40020928-42491297-9716https://doi.org/10.1186/1297-9716-45-11Veterinary Research 45 : 11 (2014)reponame:INTA Digital (INTA)instname:Instituto Nacional de Tecnología Agropecuariaenginfo:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by-nc-sa/4.0/Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)2025-09-29T13:44:30Zoai:localhost:20.500.12123/4002instacron:INTAInstitucionalhttp://repositorio.inta.gob.ar/Organismo científico-tecnológicoNo correspondehttp://repositorio.inta.gob.ar/oai/requesttripaldi.nicolas@inta.gob.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:l2025-09-29 13:44:31.046INTA Digital (INTA) - Instituto Nacional de Tecnología Agropecuariafalse
dc.title.none.fl_str_mv Inflammatory infiltration into placentas of Neospora caninum challenged cattle correlates with clinical outcome of pregnancy
title Inflammatory infiltration into placentas of Neospora caninum challenged cattle correlates with clinical outcome of pregnancy
spellingShingle Inflammatory infiltration into placentas of Neospora caninum challenged cattle correlates with clinical outcome of pregnancy
Canton, German Jose
Neospora caninum
Ganado Bovino
Enfermedades de los Animales
Placenta
Inflamación
Gestación
Cattle
Animal Diseases
Inflammation
Pregnancy
title_short Inflammatory infiltration into placentas of Neospora caninum challenged cattle correlates with clinical outcome of pregnancy
title_full Inflammatory infiltration into placentas of Neospora caninum challenged cattle correlates with clinical outcome of pregnancy
title_fullStr Inflammatory infiltration into placentas of Neospora caninum challenged cattle correlates with clinical outcome of pregnancy
title_full_unstemmed Inflammatory infiltration into placentas of Neospora caninum challenged cattle correlates with clinical outcome of pregnancy
title_sort Inflammatory infiltration into placentas of Neospora caninum challenged cattle correlates with clinical outcome of pregnancy
dc.creator.none.fl_str_mv Canton, German Jose
Katzer, Frank
Maley, Stephen W.
Bartley, Paul M.
Benavides-Silván, Julio
Palarea-Albaladejo, Javier
Pang, Yvonne
Smith, Sionagh
Rocchi, Mara
Buxton, David
Innes, Elisabeth A.
Chianini, Francesca
author Canton, German Jose
author_facet Canton, German Jose
Katzer, Frank
Maley, Stephen W.
Bartley, Paul M.
Benavides-Silván, Julio
Palarea-Albaladejo, Javier
Pang, Yvonne
Smith, Sionagh
Rocchi, Mara
Buxton, David
Innes, Elisabeth A.
Chianini, Francesca
author_role author
author2 Katzer, Frank
Maley, Stephen W.
Bartley, Paul M.
Benavides-Silván, Julio
Palarea-Albaladejo, Javier
Pang, Yvonne
Smith, Sionagh
Rocchi, Mara
Buxton, David
Innes, Elisabeth A.
Chianini, Francesca
author2_role author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Neospora caninum
Ganado Bovino
Enfermedades de los Animales
Placenta
Inflamación
Gestación
Cattle
Animal Diseases
Inflammation
Pregnancy
topic Neospora caninum
Ganado Bovino
Enfermedades de los Animales
Placenta
Inflamación
Gestación
Cattle
Animal Diseases
Inflammation
Pregnancy
dc.description.none.fl_txt_mv Infection with Neospora caninum stimulates host cell-mediated immune responses, which may be responsible for placental damage leading to bovine abortion. The aim of this study was to compare immune responses in the bovine placenta, following experimental infection in different stages of pregnancy. Placentomes were examined by immunohistochemistry and inflammation in early gestation was generally moderate to severe, particularly in the placentas carrying non-viable foetuses, whereas it was milder in later stages, mainly characterised by the presence of CD3+, CD4+ and γδ T-cells. This distinctive cellular immune response may explain the milder clinical outcome observed when animals are infected in later gestation.
EEA Balcarce
Fil: Canton, German Jose. Moredun Research Institute; Reino Unido. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Balcarce; Argentina
Fil: Katzer, Frank. Moredun Research Institute; Reino Unido
Fil: Maley, Stephen W. Moredun Research Institute; Reino Unido
Fil: Bartley, Paul M. Moredun Research Institute; Reino Unido
Fil: Benavides-Silván, Julio. Moredun Research Institute; Reino Unido. Consejo Superior de Investigaciones Científicas. Instituto de Ganadería de Montaña; España
Fil: Palarea-Albaladejo, Javier. Biomathematics & Statistics Scotland; Reino Unido
Fil: Pang, Yvonne. Moredun Research Institute; Reino Unido
Fil: Smith, Sionagh. University of Edinburgh. Royal (Dick) School of Veterinary Studies and Roslin Institute; Reino Unido
Fil: Rocchi, Mara. Moredun Research Institute; Reino Unido
Fil: Buxton, David. Moredun Research Institute; Reino Unido
Fil: Innes, Elisabeth A. Moredun Research Institute; Reino Unido
Fil: Chianini, Francesca. Moredun Research Institute; Reino Unido
description Infection with Neospora caninum stimulates host cell-mediated immune responses, which may be responsible for placental damage leading to bovine abortion. The aim of this study was to compare immune responses in the bovine placenta, following experimental infection in different stages of pregnancy. Placentomes were examined by immunohistochemistry and inflammation in early gestation was generally moderate to severe, particularly in the placentas carrying non-viable foetuses, whereas it was milder in later stages, mainly characterised by the presence of CD3+, CD4+ and γδ T-cells. This distinctive cellular immune response may explain the milder clinical outcome observed when animals are infected in later gestation.
publishDate 2014
dc.date.none.fl_str_mv 2014-01
2018-12-03T17:46:10Z
2018-12-03T17:46:10Z
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://veterinaryresearch.biomedcentral.com/articles/10.1186/1297-9716-45-11
http://hdl.handle.net/20.500.12123/4002
0928-4249
1297-9716
https://doi.org/10.1186/1297-9716-45-11
url https://veterinaryresearch.biomedcentral.com/articles/10.1186/1297-9716-45-11
http://hdl.handle.net/20.500.12123/4002
https://doi.org/10.1186/1297-9716-45-11
identifier_str_mv 0928-4249
1297-9716
dc.language.none.fl_str_mv eng
language eng
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by-nc-sa/4.0/
Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by-nc-sa/4.0/
Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv BMC
publisher.none.fl_str_mv BMC
dc.source.none.fl_str_mv Veterinary Research 45 : 11 (2014)
reponame:INTA Digital (INTA)
instname:Instituto Nacional de Tecnología Agropecuaria
reponame_str INTA Digital (INTA)
collection INTA Digital (INTA)
instname_str Instituto Nacional de Tecnología Agropecuaria
repository.name.fl_str_mv INTA Digital (INTA) - Instituto Nacional de Tecnología Agropecuaria
repository.mail.fl_str_mv tripaldi.nicolas@inta.gob.ar
_version_ 1844619128672878592
score 12.559606

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