Characterization of Immune Cell Infiltration in the Placentome of Water Buffaloes (Bubalus bubalis) Infected with Neospora caninum During Pregnancy

Autores
Cantón, G. J.; Konrad, José Luis; Moore, Dadin Prando; Caspe, S. G.; Palarea Albaladejo, J.; Campero, C. M.; Chianini, F.
Año de publicación
2014
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Neospora caninum infection in cattle stimulates host immune responses, which may be responsible for placental damage leading to abortion. Susceptibility of water buffaloes (Bubalus bubalis) to neosporosis is not well understood, although vertical transmission and fetal death have been documented. The aim of this study was to characterize the immune response in the placentome of water buffalo following experimental infection in early gestation with the Nc-1 strain of N. caninum. Placentomes were examined by immunohistochemistry using antibodies specific for T-cell subsets, natural killer cells and CD79acy cells. Placental inflammation was characterized by the infiltration of CD3+ and CD4+ T cells and T cells expressing the gd T-cell receptor. The distribution of these cellular subsets in buffalo placentomes was similar to that previously described in cattle infected with N. caninum in early gestation, but the lesions were milder, which may explain the lower number of abortions observed in this species after infection.
Fil: Cantón, G. J.. Moderun Research Institute; Reino Unido. Instituto Nacional de Tecnología Agropecuaria; Argentina
Fil: Konrad, José Luis. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional del Nordeste; Argentina
Fil: Moore, Dadin Prando. Biomathematics and Statistics Scotland (BioSS); Reino Unido. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Caspe, S. G.. Instituto Nacional de Tecnología Agropecuaria; Argentina
Fil: Palarea Albaladejo, J.. Biomathematics and Statistics Scotland (BioSS); Reino Unido
Fil: Campero, C. M.. Instituto Nacional de Tecnología Agropecuaria; Argentina
Fil: Chianini, F.. Moderun Research Institute; Reino Unido
Materia
Immunity
Placentome
Neospora Caninum
Buffalo
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/10403
Acceder
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network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Characterization of Immune Cell Infiltration in the Placentome of Water Buffaloes (Bubalus bubalis) Infected with Neospora caninum During PregnancyCantón, G. J.Konrad, José LuisMoore, Dadin PrandoCaspe, S. G.Palarea Albaladejo, J.Campero, C. M.Chianini, F.ImmunityPlacentomeNeospora CaninumBuffalohttps://purl.org/becyt/ford/4.3https://purl.org/becyt/ford/4Neospora caninum infection in cattle stimulates host immune responses, which may be responsible for placental damage leading to abortion. Susceptibility of water buffaloes (Bubalus bubalis) to neosporosis is not well understood, although vertical transmission and fetal death have been documented. The aim of this study was to characterize the immune response in the placentome of water buffalo following experimental infection in early gestation with the Nc-1 strain of N. caninum. Placentomes were examined by immunohistochemistry using antibodies specific for T-cell subsets, natural killer cells and CD79acy cells. Placental inflammation was characterized by the infiltration of CD3+ and CD4+ T cells and T cells expressing the gd T-cell receptor. The distribution of these cellular subsets in buffalo placentomes was similar to that previously described in cattle infected with N. caninum in early gestation, but the lesions were milder, which may explain the lower number of abortions observed in this species after infection.Fil: Cantón, G. J.. Moderun Research Institute; Reino Unido. Instituto Nacional de Tecnología Agropecuaria; ArgentinaFil: Konrad, José Luis. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional del Nordeste; ArgentinaFil: Moore, Dadin Prando. Biomathematics and Statistics Scotland (BioSS); Reino Unido. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Caspe, S. G.. Instituto Nacional de Tecnología Agropecuaria; ArgentinaFil: Palarea Albaladejo, J.. Biomathematics and Statistics Scotland (BioSS); Reino UnidoFil: Campero, C. M.. Instituto Nacional de Tecnología Agropecuaria; ArgentinaFil: Chianini, F.. Moderun Research Institute; Reino UnidoElsevier2014-05info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/10403Cantón, G. J.; Konrad, José Luis; Moore, Dadin Prando; Caspe, S. G.; Palarea Albaladejo, J.; et al.; Characterization of Immune Cell Infiltration in the Placentome of Water Buffaloes (Bubalus bubalis) Infected with Neospora caninum During Pregnancy; Elsevier; Journal Of Comparative Pathology; 150; 4; 5-2014; 463-4680021-9975enginfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.jcpa.2013.12.003info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0021997513003836info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:41:17Zoai:ri.conicet.gov.ar:11336/10403instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:41:17.442CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Characterization of Immune Cell Infiltration in the Placentome of Water Buffaloes (Bubalus bubalis) Infected with Neospora caninum During Pregnancy
title Characterization of Immune Cell Infiltration in the Placentome of Water Buffaloes (Bubalus bubalis) Infected with Neospora caninum During Pregnancy
spellingShingle Characterization of Immune Cell Infiltration in the Placentome of Water Buffaloes (Bubalus bubalis) Infected with Neospora caninum During Pregnancy
Cantón, G. J.
Immunity
Placentome
Neospora Caninum
Buffalo
title_short Characterization of Immune Cell Infiltration in the Placentome of Water Buffaloes (Bubalus bubalis) Infected with Neospora caninum During Pregnancy
title_full Characterization of Immune Cell Infiltration in the Placentome of Water Buffaloes (Bubalus bubalis) Infected with Neospora caninum During Pregnancy
title_fullStr Characterization of Immune Cell Infiltration in the Placentome of Water Buffaloes (Bubalus bubalis) Infected with Neospora caninum During Pregnancy
title_full_unstemmed Characterization of Immune Cell Infiltration in the Placentome of Water Buffaloes (Bubalus bubalis) Infected with Neospora caninum During Pregnancy
title_sort Characterization of Immune Cell Infiltration in the Placentome of Water Buffaloes (Bubalus bubalis) Infected with Neospora caninum During Pregnancy
dc.creator.none.fl_str_mv Cantón, G. J.
Konrad, José Luis
Moore, Dadin Prando
Caspe, S. G.
Palarea Albaladejo, J.
Campero, C. M.
Chianini, F.
author Cantón, G. J.
author_facet Cantón, G. J.
Konrad, José Luis
Moore, Dadin Prando
Caspe, S. G.
Palarea Albaladejo, J.
Campero, C. M.
Chianini, F.
author_role author
author2 Konrad, José Luis
Moore, Dadin Prando
Caspe, S. G.
Palarea Albaladejo, J.
Campero, C. M.
Chianini, F.
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv Immunity
Placentome
Neospora Caninum
Buffalo
topic Immunity
Placentome
Neospora Caninum
Buffalo
purl_subject.fl_str_mv https://purl.org/becyt/ford/4.3
https://purl.org/becyt/ford/4
dc.description.none.fl_txt_mv Neospora caninum infection in cattle stimulates host immune responses, which may be responsible for placental damage leading to abortion. Susceptibility of water buffaloes (Bubalus bubalis) to neosporosis is not well understood, although vertical transmission and fetal death have been documented. The aim of this study was to characterize the immune response in the placentome of water buffalo following experimental infection in early gestation with the Nc-1 strain of N. caninum. Placentomes were examined by immunohistochemistry using antibodies specific for T-cell subsets, natural killer cells and CD79acy cells. Placental inflammation was characterized by the infiltration of CD3+ and CD4+ T cells and T cells expressing the gd T-cell receptor. The distribution of these cellular subsets in buffalo placentomes was similar to that previously described in cattle infected with N. caninum in early gestation, but the lesions were milder, which may explain the lower number of abortions observed in this species after infection.
Fil: Cantón, G. J.. Moderun Research Institute; Reino Unido. Instituto Nacional de Tecnología Agropecuaria; Argentina
Fil: Konrad, José Luis. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional del Nordeste; Argentina
Fil: Moore, Dadin Prando. Biomathematics and Statistics Scotland (BioSS); Reino Unido. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Caspe, S. G.. Instituto Nacional de Tecnología Agropecuaria; Argentina
Fil: Palarea Albaladejo, J.. Biomathematics and Statistics Scotland (BioSS); Reino Unido
Fil: Campero, C. M.. Instituto Nacional de Tecnología Agropecuaria; Argentina
Fil: Chianini, F.. Moderun Research Institute; Reino Unido
description Neospora caninum infection in cattle stimulates host immune responses, which may be responsible for placental damage leading to abortion. Susceptibility of water buffaloes (Bubalus bubalis) to neosporosis is not well understood, although vertical transmission and fetal death have been documented. The aim of this study was to characterize the immune response in the placentome of water buffalo following experimental infection in early gestation with the Nc-1 strain of N. caninum. Placentomes were examined by immunohistochemistry using antibodies specific for T-cell subsets, natural killer cells and CD79acy cells. Placental inflammation was characterized by the infiltration of CD3+ and CD4+ T cells and T cells expressing the gd T-cell receptor. The distribution of these cellular subsets in buffalo placentomes was similar to that previously described in cattle infected with N. caninum in early gestation, but the lesions were milder, which may explain the lower number of abortions observed in this species after infection.
publishDate 2014
dc.date.none.fl_str_mv 2014-05
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/10403
Cantón, G. J.; Konrad, José Luis; Moore, Dadin Prando; Caspe, S. G.; Palarea Albaladejo, J.; et al.; Characterization of Immune Cell Infiltration in the Placentome of Water Buffaloes (Bubalus bubalis) Infected with Neospora caninum During Pregnancy; Elsevier; Journal Of Comparative Pathology; 150; 4; 5-2014; 463-468
0021-9975
url http://hdl.handle.net/11336/10403
identifier_str_mv Cantón, G. J.; Konrad, José Luis; Moore, Dadin Prando; Caspe, S. G.; Palarea Albaladejo, J.; et al.; Characterization of Immune Cell Infiltration in the Placentome of Water Buffaloes (Bubalus bubalis) Infected with Neospora caninum During Pregnancy; Elsevier; Journal Of Comparative Pathology; 150; 4; 5-2014; 463-468
0021-9975
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1016/j.jcpa.2013.12.003
info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0021997513003836
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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