Characterization of Immune Cell Infiltration in the Placentome of Water Buffaloes (Bubalus bubalis) Infected with Neospora caninum During Pregnancy

Autores
Canton, German Jose; Konrad, Jose Luis; Moore, Prando Dadin; Caspe, Sergio Gaston; Palarea-Albaladejo, Javier; Campero, Carlos Manuel; Chianini, Francesca
Año de publicación
2014
Idioma
inglés
Tipo de recurso
artículo
Estado
versión aceptada
Descripción
Neospora caninum infection in cattle stimulates host immune responses, which may be responsible for placental damage leading to abortion. Susceptibility of water buffaloes (Bubalus bubalis) to neosporosis is not well understood, although vertical transmission and fetal death have been documented. The aim of this study was to characterize the immune response in the placentome of water buffalo following experimental infection in early gestation with the Nc-1 strain of N. caninum. Placentomes were examined by immunohistochemistry using antibodies specific for T-cell subsets, natural killer cells and CD79αcy cells. Placental inflammation was characterized by the infiltration of CD3+ and CD4+ T cells and T cells expressing the γδ T-cell receptor. The distribution of these cellular subsets in buffalo placentomes was similar to that previously described in cattle infected with N. caninum in early gestation, but the lesions were milder, which may explain the lower number of abortions observed in this species after infection.
EEA Balcarce
Fil: Canton, German Jose. Moredun Research Institute; Reino Unido. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Balcarce; Argentina
Fil: Konrad, Jose Luis. Universidad Nacional del Nordeste. Facultad de Veterinaria; Argentina
Fil: Moore, Prando Dadin. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Caspe, Sergio Gaston. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Mercedes; Argentina
Fil: Palarea-Albaladejo, Javier. Biomathematics & Statistics Scotland; Reino Unido
Fil: Campero, Carlos Manuel. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Balcarce; Argentina
Fil: Chianini, Francesca. Moredun Research Institute; Reino Unido
Fuente
Journal of Comparative Pathology 150 (4) : 463-468 (May 2014)
Materia
Neospora caninum
Respuesta Inmunológica
Búfalo de Agua
Gestación
Inmunidad
Immune Response
Water Buffaloes
Pregnancy
Immunity
Nivel de accesibilidad
acceso abierto
Condiciones de uso
http://creativecommons.org/licenses/by-nc-sa/4.0/
Repositorio
INTA Digital (INTA)
Institución
Instituto Nacional de Tecnología Agropecuaria
OAI Identificador
oai:localhost:20.500.12123/4559
Acceder
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oai_identifier_str oai:localhost:20.500.12123/4559
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network_name_str INTA Digital (INTA)
spelling Characterization of Immune Cell Infiltration in the Placentome of Water Buffaloes (Bubalus bubalis) Infected with Neospora caninum During PregnancyCanton, German JoseKonrad, Jose LuisMoore, Prando DadinCaspe, Sergio GastonPalarea-Albaladejo, JavierCampero, Carlos ManuelChianini, FrancescaNeospora caninumRespuesta InmunológicaBúfalo de AguaGestaciónInmunidadImmune ResponseWater BuffaloesPregnancyImmunityNeospora caninum infection in cattle stimulates host immune responses, which may be responsible for placental damage leading to abortion. Susceptibility of water buffaloes (Bubalus bubalis) to neosporosis is not well understood, although vertical transmission and fetal death have been documented. The aim of this study was to characterize the immune response in the placentome of water buffalo following experimental infection in early gestation with the Nc-1 strain of N. caninum. Placentomes were examined by immunohistochemistry using antibodies specific for T-cell subsets, natural killer cells and CD79αcy cells. Placental inflammation was characterized by the infiltration of CD3+ and CD4+ T cells and T cells expressing the γδ T-cell receptor. The distribution of these cellular subsets in buffalo placentomes was similar to that previously described in cattle infected with N. caninum in early gestation, but the lesions were milder, which may explain the lower number of abortions observed in this species after infection.EEA BalcarceFil: Canton, German Jose. Moredun Research Institute; Reino Unido. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Balcarce; ArgentinaFil: Konrad, Jose Luis. Universidad Nacional del Nordeste. Facultad de Veterinaria; ArgentinaFil: Moore, Prando Dadin. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Caspe, Sergio Gaston. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Mercedes; ArgentinaFil: Palarea-Albaladejo, Javier. Biomathematics & Statistics Scotland; Reino UnidoFil: Campero, Carlos Manuel. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Balcarce; ArgentinaFil: Chianini, Francesca. Moredun Research Institute; Reino UnidoElsevier2019-03-08T13:56:25Z2019-03-08T13:56:25Z2014-05info:eu-repo/semantics/articleinfo:eu-repo/semantics/acceptedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfhttp://hdl.handle.net/20.500.12123/4559https://www.sciencedirect.com/science/article/pii/S00219975130038360021-9975https://doi.org/10.1016/j.jcpa.2013.12.003Journal of Comparative Pathology 150 (4) : 463-468 (May 2014)reponame:INTA Digital (INTA)instname:Instituto Nacional de Tecnología Agropecuariaenginfo:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by-nc-sa/4.0/Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)2025-09-29T13:44:35Zoai:localhost:20.500.12123/4559instacron:INTAInstitucionalhttp://repositorio.inta.gob.ar/Organismo científico-tecnológicoNo correspondehttp://repositorio.inta.gob.ar/oai/requesttripaldi.nicolas@inta.gob.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:l2025-09-29 13:44:35.837INTA Digital (INTA) - Instituto Nacional de Tecnología Agropecuariafalse
dc.title.none.fl_str_mv Characterization of Immune Cell Infiltration in the Placentome of Water Buffaloes (Bubalus bubalis) Infected with Neospora caninum During Pregnancy
title Characterization of Immune Cell Infiltration in the Placentome of Water Buffaloes (Bubalus bubalis) Infected with Neospora caninum During Pregnancy
spellingShingle Characterization of Immune Cell Infiltration in the Placentome of Water Buffaloes (Bubalus bubalis) Infected with Neospora caninum During Pregnancy
Canton, German Jose
Neospora caninum
Respuesta Inmunológica
Búfalo de Agua
Gestación
Inmunidad
Immune Response
Water Buffaloes
Pregnancy
Immunity
title_short Characterization of Immune Cell Infiltration in the Placentome of Water Buffaloes (Bubalus bubalis) Infected with Neospora caninum During Pregnancy
title_full Characterization of Immune Cell Infiltration in the Placentome of Water Buffaloes (Bubalus bubalis) Infected with Neospora caninum During Pregnancy
title_fullStr Characterization of Immune Cell Infiltration in the Placentome of Water Buffaloes (Bubalus bubalis) Infected with Neospora caninum During Pregnancy
title_full_unstemmed Characterization of Immune Cell Infiltration in the Placentome of Water Buffaloes (Bubalus bubalis) Infected with Neospora caninum During Pregnancy
title_sort Characterization of Immune Cell Infiltration in the Placentome of Water Buffaloes (Bubalus bubalis) Infected with Neospora caninum During Pregnancy
dc.creator.none.fl_str_mv Canton, German Jose
Konrad, Jose Luis
Moore, Prando Dadin
Caspe, Sergio Gaston
Palarea-Albaladejo, Javier
Campero, Carlos Manuel
Chianini, Francesca
author Canton, German Jose
author_facet Canton, German Jose
Konrad, Jose Luis
Moore, Prando Dadin
Caspe, Sergio Gaston
Palarea-Albaladejo, Javier
Campero, Carlos Manuel
Chianini, Francesca
author_role author
author2 Konrad, Jose Luis
Moore, Prando Dadin
Caspe, Sergio Gaston
Palarea-Albaladejo, Javier
Campero, Carlos Manuel
Chianini, Francesca
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv Neospora caninum
Respuesta Inmunológica
Búfalo de Agua
Gestación
Inmunidad
Immune Response
Water Buffaloes
Pregnancy
Immunity
topic Neospora caninum
Respuesta Inmunológica
Búfalo de Agua
Gestación
Inmunidad
Immune Response
Water Buffaloes
Pregnancy
Immunity
dc.description.none.fl_txt_mv Neospora caninum infection in cattle stimulates host immune responses, which may be responsible for placental damage leading to abortion. Susceptibility of water buffaloes (Bubalus bubalis) to neosporosis is not well understood, although vertical transmission and fetal death have been documented. The aim of this study was to characterize the immune response in the placentome of water buffalo following experimental infection in early gestation with the Nc-1 strain of N. caninum. Placentomes were examined by immunohistochemistry using antibodies specific for T-cell subsets, natural killer cells and CD79αcy cells. Placental inflammation was characterized by the infiltration of CD3+ and CD4+ T cells and T cells expressing the γδ T-cell receptor. The distribution of these cellular subsets in buffalo placentomes was similar to that previously described in cattle infected with N. caninum in early gestation, but the lesions were milder, which may explain the lower number of abortions observed in this species after infection.
EEA Balcarce
Fil: Canton, German Jose. Moredun Research Institute; Reino Unido. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Balcarce; Argentina
Fil: Konrad, Jose Luis. Universidad Nacional del Nordeste. Facultad de Veterinaria; Argentina
Fil: Moore, Prando Dadin. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Caspe, Sergio Gaston. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Mercedes; Argentina
Fil: Palarea-Albaladejo, Javier. Biomathematics & Statistics Scotland; Reino Unido
Fil: Campero, Carlos Manuel. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Balcarce; Argentina
Fil: Chianini, Francesca. Moredun Research Institute; Reino Unido
description Neospora caninum infection in cattle stimulates host immune responses, which may be responsible for placental damage leading to abortion. Susceptibility of water buffaloes (Bubalus bubalis) to neosporosis is not well understood, although vertical transmission and fetal death have been documented. The aim of this study was to characterize the immune response in the placentome of water buffalo following experimental infection in early gestation with the Nc-1 strain of N. caninum. Placentomes were examined by immunohistochemistry using antibodies specific for T-cell subsets, natural killer cells and CD79αcy cells. Placental inflammation was characterized by the infiltration of CD3+ and CD4+ T cells and T cells expressing the γδ T-cell receptor. The distribution of these cellular subsets in buffalo placentomes was similar to that previously described in cattle infected with N. caninum in early gestation, but the lesions were milder, which may explain the lower number of abortions observed in this species after infection.
publishDate 2014
dc.date.none.fl_str_mv 2014-05
2019-03-08T13:56:25Z
2019-03-08T13:56:25Z
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/acceptedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str acceptedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/20.500.12123/4559
https://www.sciencedirect.com/science/article/pii/S0021997513003836
0021-9975
https://doi.org/10.1016/j.jcpa.2013.12.003
url http://hdl.handle.net/20.500.12123/4559
https://www.sciencedirect.com/science/article/pii/S0021997513003836
https://doi.org/10.1016/j.jcpa.2013.12.003
identifier_str_mv 0021-9975
dc.language.none.fl_str_mv eng
language eng
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by-nc-sa/4.0/
Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by-nc-sa/4.0/
Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv Journal of Comparative Pathology 150 (4) : 463-468 (May 2014)
reponame:INTA Digital (INTA)
instname:Instituto Nacional de Tecnología Agropecuaria
reponame_str INTA Digital (INTA)
collection INTA Digital (INTA)
instname_str Instituto Nacional de Tecnología Agropecuaria
repository.name.fl_str_mv INTA Digital (INTA) - Instituto Nacional de Tecnología Agropecuaria
repository.mail.fl_str_mv tripaldi.nicolas@inta.gob.ar
_version_ 1844619131392884736
score 12.559606

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