Positive effect of combined exercise training in a model of metabolic syndrome and menopause: Autonomic, inflammatory, and oxidative stress evaluations
- Autores
- Conti, Filipe Fernandes; Brito, Janaina de Oliveira; Bernardes, Nathalia; Dias, Danielle da Silva; Malfitano, Christiane; Morris, Mariana; Llesuy, Susana Francisca; Irigoyen, Maria-Cláudia; de Angelis, Kátia
- Año de publicación
- 2015
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- It is now well established that after menopause cardiometabolic disorders become more common. Recently, resistance exercise has been recommended as a complement to aerobic (combined training, CT) for the treatment of cardiometabolic diseases. The aim of this study was to evaluate the effects of CT in hypertensive ovariectomized rats undergoing fructose overload in blood pressure variability (BPV), inflammation, and oxidative stress parameters. Female rats were divided into the following groups (n = 8/group): sedentary normotensive Wistarrats (C), and sedentary (FHO) or trained (FHOT) ovariectomized spontaneously hypertensive rats undergoing and fructose overload. CT was performed on a treadmill and ladder adapted to rats in alternate days (8 wk; 40-60% maximal capacity). Arterial pressure (AP) was directly measured. Oxidative stress and inflammation were measured on cardiac and renal tissues. The association of risk factors (hypertension + ovariectomy + fructose) promoted increase in insulin resistance, mean AP (FHO: 174 ± 4 vs. C: 108 ± 1 mmHg), heart rate (FHO: 403 ± 12 vs. C: 352 ± 11 beats/min), BPV, cardiac inflammation (tumor necrosis factor-a-FHO: 65.8 ± 9.9 vs. C: 23.3 ± 4.3 pg/mg protein), and oxidative stress cardiac and renal tissues. However, CT was able to reduce mean AP (FHOT: 158 ± 4 mmHg), heart rate (FHOT: 303 ± 5 beats/min), insulin resistance, and sympathetic modulation. Moreover, the trained rats presented increased nitric oxide bioavailability, reduced tumor necrosis factor-a (FHOT: 33.1 ± 4.9 pg/mg protein), increased IL-10 in cardiac tissue and reduced lipoperoxidation, and increased antioxidant defenses in cardiac and renal tissues. In conclusion, the association of risk factors promoted an additional impairment in metabolic, cardiovascular, autonomic, inflammatory, and oxidative stress parameters and combined exercise training was able to attenuate these dysfunctions..
Fil: Conti, Filipe Fernandes. Universidad Nove de Julho; Brasil
Fil: Brito, Janaina de Oliveira. Universidad Nove de Julho; Brasil
Fil: Bernardes, Nathalia. Universidade de Sao Paulo; Brasil. Universidad Nove de Julho; Brasil
Fil: Dias, Danielle da Silva. Universidad Nove de Julho; Brasil
Fil: Malfitano, Christiane. Universidad Nove de Julho; Brasil
Fil: Morris, Mariana. Universidad de Nova Southeastern; Estados Unidos
Fil: Llesuy, Susana Francisca. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires; Argentina
Fil: Irigoyen, Maria-Cláudia. Universidade de Sao Paulo; Brasil
Fil: de Angelis, Kátia. Universidad Nove de Julho; Brasil - Materia
-
BLOOD PRESSURE VARIABILITY
EXERCISE TRAINING
INFLAMMATION
MENOPAUSE
METABOLIC SYNDROME
OXIDATIVE STRESS - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/99260
Ver los metadatos del registro completo
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oai:ri.conicet.gov.ar:11336/99260 |
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spelling |
Positive effect of combined exercise training in a model of metabolic syndrome and menopause: Autonomic, inflammatory, and oxidative stress evaluationsConti, Filipe FernandesBrito, Janaina de OliveiraBernardes, NathaliaDias, Danielle da SilvaMalfitano, ChristianeMorris, MarianaLlesuy, Susana FranciscaIrigoyen, Maria-Cláudiade Angelis, KátiaBLOOD PRESSURE VARIABILITYEXERCISE TRAININGINFLAMMATIONMENOPAUSEMETABOLIC SYNDROMEOXIDATIVE STRESShttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1It is now well established that after menopause cardiometabolic disorders become more common. Recently, resistance exercise has been recommended as a complement to aerobic (combined training, CT) for the treatment of cardiometabolic diseases. The aim of this study was to evaluate the effects of CT in hypertensive ovariectomized rats undergoing fructose overload in blood pressure variability (BPV), inflammation, and oxidative stress parameters. Female rats were divided into the following groups (n = 8/group): sedentary normotensive Wistarrats (C), and sedentary (FHO) or trained (FHOT) ovariectomized spontaneously hypertensive rats undergoing and fructose overload. CT was performed on a treadmill and ladder adapted to rats in alternate days (8 wk; 40-60% maximal capacity). Arterial pressure (AP) was directly measured. Oxidative stress and inflammation were measured on cardiac and renal tissues. The association of risk factors (hypertension + ovariectomy + fructose) promoted increase in insulin resistance, mean AP (FHO: 174 ± 4 vs. C: 108 ± 1 mmHg), heart rate (FHO: 403 ± 12 vs. C: 352 ± 11 beats/min), BPV, cardiac inflammation (tumor necrosis factor-a-FHO: 65.8 ± 9.9 vs. C: 23.3 ± 4.3 pg/mg protein), and oxidative stress cardiac and renal tissues. However, CT was able to reduce mean AP (FHOT: 158 ± 4 mmHg), heart rate (FHOT: 303 ± 5 beats/min), insulin resistance, and sympathetic modulation. Moreover, the trained rats presented increased nitric oxide bioavailability, reduced tumor necrosis factor-a (FHOT: 33.1 ± 4.9 pg/mg protein), increased IL-10 in cardiac tissue and reduced lipoperoxidation, and increased antioxidant defenses in cardiac and renal tissues. In conclusion, the association of risk factors promoted an additional impairment in metabolic, cardiovascular, autonomic, inflammatory, and oxidative stress parameters and combined exercise training was able to attenuate these dysfunctions..Fil: Conti, Filipe Fernandes. Universidad Nove de Julho; BrasilFil: Brito, Janaina de Oliveira. Universidad Nove de Julho; BrasilFil: Bernardes, Nathalia. Universidade de Sao Paulo; Brasil. Universidad Nove de Julho; BrasilFil: Dias, Danielle da Silva. Universidad Nove de Julho; BrasilFil: Malfitano, Christiane. Universidad Nove de Julho; BrasilFil: Morris, Mariana. Universidad de Nova Southeastern; Estados UnidosFil: Llesuy, Susana Francisca. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires; ArgentinaFil: Irigoyen, Maria-Cláudia. Universidade de Sao Paulo; BrasilFil: de Angelis, Kátia. Universidad Nove de Julho; BrasilAmerican Physiological Society2015-09info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/99260Conti, Filipe Fernandes; Brito, Janaina de Oliveira; Bernardes, Nathalia; Dias, Danielle da Silva; Malfitano, Christiane; et al.; Positive effect of combined exercise training in a model of metabolic syndrome and menopause: Autonomic, inflammatory, and oxidative stress evaluations; American Physiological Society; American Journal Of Physiology-regulatory, Integrative And Comparative Physiology; 309; 12; 9-2015; R1532-R15390002-95130363-6119CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://journals.physiology.org/doi/full/10.1152/ajpregu.00076.2015info:eu-repo/semantics/altIdentifier/doi/10.1152/ajpregu.00076.2015info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:38:21Zoai:ri.conicet.gov.ar:11336/99260instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:38:21.587CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
Positive effect of combined exercise training in a model of metabolic syndrome and menopause: Autonomic, inflammatory, and oxidative stress evaluations |
title |
Positive effect of combined exercise training in a model of metabolic syndrome and menopause: Autonomic, inflammatory, and oxidative stress evaluations |
spellingShingle |
Positive effect of combined exercise training in a model of metabolic syndrome and menopause: Autonomic, inflammatory, and oxidative stress evaluations Conti, Filipe Fernandes BLOOD PRESSURE VARIABILITY EXERCISE TRAINING INFLAMMATION MENOPAUSE METABOLIC SYNDROME OXIDATIVE STRESS |
title_short |
Positive effect of combined exercise training in a model of metabolic syndrome and menopause: Autonomic, inflammatory, and oxidative stress evaluations |
title_full |
Positive effect of combined exercise training in a model of metabolic syndrome and menopause: Autonomic, inflammatory, and oxidative stress evaluations |
title_fullStr |
Positive effect of combined exercise training in a model of metabolic syndrome and menopause: Autonomic, inflammatory, and oxidative stress evaluations |
title_full_unstemmed |
Positive effect of combined exercise training in a model of metabolic syndrome and menopause: Autonomic, inflammatory, and oxidative stress evaluations |
title_sort |
Positive effect of combined exercise training in a model of metabolic syndrome and menopause: Autonomic, inflammatory, and oxidative stress evaluations |
dc.creator.none.fl_str_mv |
Conti, Filipe Fernandes Brito, Janaina de Oliveira Bernardes, Nathalia Dias, Danielle da Silva Malfitano, Christiane Morris, Mariana Llesuy, Susana Francisca Irigoyen, Maria-Cláudia de Angelis, Kátia |
author |
Conti, Filipe Fernandes |
author_facet |
Conti, Filipe Fernandes Brito, Janaina de Oliveira Bernardes, Nathalia Dias, Danielle da Silva Malfitano, Christiane Morris, Mariana Llesuy, Susana Francisca Irigoyen, Maria-Cláudia de Angelis, Kátia |
author_role |
author |
author2 |
Brito, Janaina de Oliveira Bernardes, Nathalia Dias, Danielle da Silva Malfitano, Christiane Morris, Mariana Llesuy, Susana Francisca Irigoyen, Maria-Cláudia de Angelis, Kátia |
author2_role |
author author author author author author author author |
dc.subject.none.fl_str_mv |
BLOOD PRESSURE VARIABILITY EXERCISE TRAINING INFLAMMATION MENOPAUSE METABOLIC SYNDROME OXIDATIVE STRESS |
topic |
BLOOD PRESSURE VARIABILITY EXERCISE TRAINING INFLAMMATION MENOPAUSE METABOLIC SYNDROME OXIDATIVE STRESS |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/1.6 https://purl.org/becyt/ford/1 |
dc.description.none.fl_txt_mv |
It is now well established that after menopause cardiometabolic disorders become more common. Recently, resistance exercise has been recommended as a complement to aerobic (combined training, CT) for the treatment of cardiometabolic diseases. The aim of this study was to evaluate the effects of CT in hypertensive ovariectomized rats undergoing fructose overload in blood pressure variability (BPV), inflammation, and oxidative stress parameters. Female rats were divided into the following groups (n = 8/group): sedentary normotensive Wistarrats (C), and sedentary (FHO) or trained (FHOT) ovariectomized spontaneously hypertensive rats undergoing and fructose overload. CT was performed on a treadmill and ladder adapted to rats in alternate days (8 wk; 40-60% maximal capacity). Arterial pressure (AP) was directly measured. Oxidative stress and inflammation were measured on cardiac and renal tissues. The association of risk factors (hypertension + ovariectomy + fructose) promoted increase in insulin resistance, mean AP (FHO: 174 ± 4 vs. C: 108 ± 1 mmHg), heart rate (FHO: 403 ± 12 vs. C: 352 ± 11 beats/min), BPV, cardiac inflammation (tumor necrosis factor-a-FHO: 65.8 ± 9.9 vs. C: 23.3 ± 4.3 pg/mg protein), and oxidative stress cardiac and renal tissues. However, CT was able to reduce mean AP (FHOT: 158 ± 4 mmHg), heart rate (FHOT: 303 ± 5 beats/min), insulin resistance, and sympathetic modulation. Moreover, the trained rats presented increased nitric oxide bioavailability, reduced tumor necrosis factor-a (FHOT: 33.1 ± 4.9 pg/mg protein), increased IL-10 in cardiac tissue and reduced lipoperoxidation, and increased antioxidant defenses in cardiac and renal tissues. In conclusion, the association of risk factors promoted an additional impairment in metabolic, cardiovascular, autonomic, inflammatory, and oxidative stress parameters and combined exercise training was able to attenuate these dysfunctions.. Fil: Conti, Filipe Fernandes. Universidad Nove de Julho; Brasil Fil: Brito, Janaina de Oliveira. Universidad Nove de Julho; Brasil Fil: Bernardes, Nathalia. Universidade de Sao Paulo; Brasil. Universidad Nove de Julho; Brasil Fil: Dias, Danielle da Silva. Universidad Nove de Julho; Brasil Fil: Malfitano, Christiane. Universidad Nove de Julho; Brasil Fil: Morris, Mariana. Universidad de Nova Southeastern; Estados Unidos Fil: Llesuy, Susana Francisca. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires; Argentina Fil: Irigoyen, Maria-Cláudia. Universidade de Sao Paulo; Brasil Fil: de Angelis, Kátia. Universidad Nove de Julho; Brasil |
description |
It is now well established that after menopause cardiometabolic disorders become more common. Recently, resistance exercise has been recommended as a complement to aerobic (combined training, CT) for the treatment of cardiometabolic diseases. The aim of this study was to evaluate the effects of CT in hypertensive ovariectomized rats undergoing fructose overload in blood pressure variability (BPV), inflammation, and oxidative stress parameters. Female rats were divided into the following groups (n = 8/group): sedentary normotensive Wistarrats (C), and sedentary (FHO) or trained (FHOT) ovariectomized spontaneously hypertensive rats undergoing and fructose overload. CT was performed on a treadmill and ladder adapted to rats in alternate days (8 wk; 40-60% maximal capacity). Arterial pressure (AP) was directly measured. Oxidative stress and inflammation were measured on cardiac and renal tissues. The association of risk factors (hypertension + ovariectomy + fructose) promoted increase in insulin resistance, mean AP (FHO: 174 ± 4 vs. C: 108 ± 1 mmHg), heart rate (FHO: 403 ± 12 vs. C: 352 ± 11 beats/min), BPV, cardiac inflammation (tumor necrosis factor-a-FHO: 65.8 ± 9.9 vs. C: 23.3 ± 4.3 pg/mg protein), and oxidative stress cardiac and renal tissues. However, CT was able to reduce mean AP (FHOT: 158 ± 4 mmHg), heart rate (FHOT: 303 ± 5 beats/min), insulin resistance, and sympathetic modulation. Moreover, the trained rats presented increased nitric oxide bioavailability, reduced tumor necrosis factor-a (FHOT: 33.1 ± 4.9 pg/mg protein), increased IL-10 in cardiac tissue and reduced lipoperoxidation, and increased antioxidant defenses in cardiac and renal tissues. In conclusion, the association of risk factors promoted an additional impairment in metabolic, cardiovascular, autonomic, inflammatory, and oxidative stress parameters and combined exercise training was able to attenuate these dysfunctions.. |
publishDate |
2015 |
dc.date.none.fl_str_mv |
2015-09 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/99260 Conti, Filipe Fernandes; Brito, Janaina de Oliveira; Bernardes, Nathalia; Dias, Danielle da Silva; Malfitano, Christiane; et al.; Positive effect of combined exercise training in a model of metabolic syndrome and menopause: Autonomic, inflammatory, and oxidative stress evaluations; American Physiological Society; American Journal Of Physiology-regulatory, Integrative And Comparative Physiology; 309; 12; 9-2015; R1532-R1539 0002-9513 0363-6119 CONICET Digital CONICET |
url |
http://hdl.handle.net/11336/99260 |
identifier_str_mv |
Conti, Filipe Fernandes; Brito, Janaina de Oliveira; Bernardes, Nathalia; Dias, Danielle da Silva; Malfitano, Christiane; et al.; Positive effect of combined exercise training in a model of metabolic syndrome and menopause: Autonomic, inflammatory, and oxidative stress evaluations; American Physiological Society; American Journal Of Physiology-regulatory, Integrative And Comparative Physiology; 309; 12; 9-2015; R1532-R1539 0002-9513 0363-6119 CONICET Digital CONICET |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/url/https://journals.physiology.org/doi/full/10.1152/ajpregu.00076.2015 info:eu-repo/semantics/altIdentifier/doi/10.1152/ajpregu.00076.2015 |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
American Physiological Society |
publisher.none.fl_str_mv |
American Physiological Society |
dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
reponame_str |
CONICET Digital (CONICET) |
collection |
CONICET Digital (CONICET) |
instname_str |
Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.name.fl_str_mv |
CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
_version_ |
1844614405867700224 |
score |
13.070432 |