Positive effect of combined exercise training in a model of metabolic syndrome and menopause: Autonomic, inflammatory, and oxidative stress evaluations

Autores
Conti, Filipe Fernandes; Brito, Janaina de Oliveira; Bernardes, Nathalia; Dias, Danielle da Silva; Malfitano, Christiane; Morris, Mariana; Llesuy, Susana Francisca; Irigoyen, Maria-Cláudia; de Angelis, Kátia
Año de publicación
2015
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
It is now well established that after menopause cardiometabolic disorders become more common. Recently, resistance exercise has been recommended as a complement to aerobic (combined training, CT) for the treatment of cardiometabolic diseases. The aim of this study was to evaluate the effects of CT in hypertensive ovariectomized rats undergoing fructose overload in blood pressure variability (BPV), inflammation, and oxidative stress parameters. Female rats were divided into the following groups (n = 8/group): sedentary normotensive Wistarrats (C), and sedentary (FHO) or trained (FHOT) ovariectomized spontaneously hypertensive rats undergoing and fructose overload. CT was performed on a treadmill and ladder adapted to rats in alternate days (8 wk; 40-60% maximal capacity). Arterial pressure (AP) was directly measured. Oxidative stress and inflammation were measured on cardiac and renal tissues. The association of risk factors (hypertension + ovariectomy + fructose) promoted increase in insulin resistance, mean AP (FHO: 174 ± 4 vs. C: 108 ± 1 mmHg), heart rate (FHO: 403 ± 12 vs. C: 352 ± 11 beats/min), BPV, cardiac inflammation (tumor necrosis factor-a-FHO: 65.8 ± 9.9 vs. C: 23.3 ± 4.3 pg/mg protein), and oxidative stress cardiac and renal tissues. However, CT was able to reduce mean AP (FHOT: 158 ± 4 mmHg), heart rate (FHOT: 303 ± 5 beats/min), insulin resistance, and sympathetic modulation. Moreover, the trained rats presented increased nitric oxide bioavailability, reduced tumor necrosis factor-a (FHOT: 33.1 ± 4.9 pg/mg protein), increased IL-10 in cardiac tissue and reduced lipoperoxidation, and increased antioxidant defenses in cardiac and renal tissues. In conclusion, the association of risk factors promoted an additional impairment in metabolic, cardiovascular, autonomic, inflammatory, and oxidative stress parameters and combined exercise training was able to attenuate these dysfunctions..
Fil: Conti, Filipe Fernandes. Universidad Nove de Julho; Brasil
Fil: Brito, Janaina de Oliveira. Universidad Nove de Julho; Brasil
Fil: Bernardes, Nathalia. Universidade de Sao Paulo; Brasil. Universidad Nove de Julho; Brasil
Fil: Dias, Danielle da Silva. Universidad Nove de Julho; Brasil
Fil: Malfitano, Christiane. Universidad Nove de Julho; Brasil
Fil: Morris, Mariana. Universidad de Nova Southeastern; Estados Unidos
Fil: Llesuy, Susana Francisca. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires; Argentina
Fil: Irigoyen, Maria-Cláudia. Universidade de Sao Paulo; Brasil
Fil: de Angelis, Kátia. Universidad Nove de Julho; Brasil
Materia
BLOOD PRESSURE VARIABILITY
EXERCISE TRAINING
INFLAMMATION
MENOPAUSE
METABOLIC SYNDROME
OXIDATIVE STRESS
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/99260

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oai_identifier_str oai:ri.conicet.gov.ar:11336/99260
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Positive effect of combined exercise training in a model of metabolic syndrome and menopause: Autonomic, inflammatory, and oxidative stress evaluationsConti, Filipe FernandesBrito, Janaina de OliveiraBernardes, NathaliaDias, Danielle da SilvaMalfitano, ChristianeMorris, MarianaLlesuy, Susana FranciscaIrigoyen, Maria-Cláudiade Angelis, KátiaBLOOD PRESSURE VARIABILITYEXERCISE TRAININGINFLAMMATIONMENOPAUSEMETABOLIC SYNDROMEOXIDATIVE STRESShttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1It is now well established that after menopause cardiometabolic disorders become more common. Recently, resistance exercise has been recommended as a complement to aerobic (combined training, CT) for the treatment of cardiometabolic diseases. The aim of this study was to evaluate the effects of CT in hypertensive ovariectomized rats undergoing fructose overload in blood pressure variability (BPV), inflammation, and oxidative stress parameters. Female rats were divided into the following groups (n = 8/group): sedentary normotensive Wistarrats (C), and sedentary (FHO) or trained (FHOT) ovariectomized spontaneously hypertensive rats undergoing and fructose overload. CT was performed on a treadmill and ladder adapted to rats in alternate days (8 wk; 40-60% maximal capacity). Arterial pressure (AP) was directly measured. Oxidative stress and inflammation were measured on cardiac and renal tissues. The association of risk factors (hypertension + ovariectomy + fructose) promoted increase in insulin resistance, mean AP (FHO: 174 ± 4 vs. C: 108 ± 1 mmHg), heart rate (FHO: 403 ± 12 vs. C: 352 ± 11 beats/min), BPV, cardiac inflammation (tumor necrosis factor-a-FHO: 65.8 ± 9.9 vs. C: 23.3 ± 4.3 pg/mg protein), and oxidative stress cardiac and renal tissues. However, CT was able to reduce mean AP (FHOT: 158 ± 4 mmHg), heart rate (FHOT: 303 ± 5 beats/min), insulin resistance, and sympathetic modulation. Moreover, the trained rats presented increased nitric oxide bioavailability, reduced tumor necrosis factor-a (FHOT: 33.1 ± 4.9 pg/mg protein), increased IL-10 in cardiac tissue and reduced lipoperoxidation, and increased antioxidant defenses in cardiac and renal tissues. In conclusion, the association of risk factors promoted an additional impairment in metabolic, cardiovascular, autonomic, inflammatory, and oxidative stress parameters and combined exercise training was able to attenuate these dysfunctions..Fil: Conti, Filipe Fernandes. Universidad Nove de Julho; BrasilFil: Brito, Janaina de Oliveira. Universidad Nove de Julho; BrasilFil: Bernardes, Nathalia. Universidade de Sao Paulo; Brasil. Universidad Nove de Julho; BrasilFil: Dias, Danielle da Silva. Universidad Nove de Julho; BrasilFil: Malfitano, Christiane. Universidad Nove de Julho; BrasilFil: Morris, Mariana. Universidad de Nova Southeastern; Estados UnidosFil: Llesuy, Susana Francisca. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires; ArgentinaFil: Irigoyen, Maria-Cláudia. Universidade de Sao Paulo; BrasilFil: de Angelis, Kátia. Universidad Nove de Julho; BrasilAmerican Physiological Society2015-09info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/99260Conti, Filipe Fernandes; Brito, Janaina de Oliveira; Bernardes, Nathalia; Dias, Danielle da Silva; Malfitano, Christiane; et al.; Positive effect of combined exercise training in a model of metabolic syndrome and menopause: Autonomic, inflammatory, and oxidative stress evaluations; American Physiological Society; American Journal Of Physiology-regulatory, Integrative And Comparative Physiology; 309; 12; 9-2015; R1532-R15390002-95130363-6119CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://journals.physiology.org/doi/full/10.1152/ajpregu.00076.2015info:eu-repo/semantics/altIdentifier/doi/10.1152/ajpregu.00076.2015info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:38:21Zoai:ri.conicet.gov.ar:11336/99260instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:38:21.587CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Positive effect of combined exercise training in a model of metabolic syndrome and menopause: Autonomic, inflammatory, and oxidative stress evaluations
title Positive effect of combined exercise training in a model of metabolic syndrome and menopause: Autonomic, inflammatory, and oxidative stress evaluations
spellingShingle Positive effect of combined exercise training in a model of metabolic syndrome and menopause: Autonomic, inflammatory, and oxidative stress evaluations
Conti, Filipe Fernandes
BLOOD PRESSURE VARIABILITY
EXERCISE TRAINING
INFLAMMATION
MENOPAUSE
METABOLIC SYNDROME
OXIDATIVE STRESS
title_short Positive effect of combined exercise training in a model of metabolic syndrome and menopause: Autonomic, inflammatory, and oxidative stress evaluations
title_full Positive effect of combined exercise training in a model of metabolic syndrome and menopause: Autonomic, inflammatory, and oxidative stress evaluations
title_fullStr Positive effect of combined exercise training in a model of metabolic syndrome and menopause: Autonomic, inflammatory, and oxidative stress evaluations
title_full_unstemmed Positive effect of combined exercise training in a model of metabolic syndrome and menopause: Autonomic, inflammatory, and oxidative stress evaluations
title_sort Positive effect of combined exercise training in a model of metabolic syndrome and menopause: Autonomic, inflammatory, and oxidative stress evaluations
dc.creator.none.fl_str_mv Conti, Filipe Fernandes
Brito, Janaina de Oliveira
Bernardes, Nathalia
Dias, Danielle da Silva
Malfitano, Christiane
Morris, Mariana
Llesuy, Susana Francisca
Irigoyen, Maria-Cláudia
de Angelis, Kátia
author Conti, Filipe Fernandes
author_facet Conti, Filipe Fernandes
Brito, Janaina de Oliveira
Bernardes, Nathalia
Dias, Danielle da Silva
Malfitano, Christiane
Morris, Mariana
Llesuy, Susana Francisca
Irigoyen, Maria-Cláudia
de Angelis, Kátia
author_role author
author2 Brito, Janaina de Oliveira
Bernardes, Nathalia
Dias, Danielle da Silva
Malfitano, Christiane
Morris, Mariana
Llesuy, Susana Francisca
Irigoyen, Maria-Cláudia
de Angelis, Kátia
author2_role author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv BLOOD PRESSURE VARIABILITY
EXERCISE TRAINING
INFLAMMATION
MENOPAUSE
METABOLIC SYNDROME
OXIDATIVE STRESS
topic BLOOD PRESSURE VARIABILITY
EXERCISE TRAINING
INFLAMMATION
MENOPAUSE
METABOLIC SYNDROME
OXIDATIVE STRESS
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv It is now well established that after menopause cardiometabolic disorders become more common. Recently, resistance exercise has been recommended as a complement to aerobic (combined training, CT) for the treatment of cardiometabolic diseases. The aim of this study was to evaluate the effects of CT in hypertensive ovariectomized rats undergoing fructose overload in blood pressure variability (BPV), inflammation, and oxidative stress parameters. Female rats were divided into the following groups (n = 8/group): sedentary normotensive Wistarrats (C), and sedentary (FHO) or trained (FHOT) ovariectomized spontaneously hypertensive rats undergoing and fructose overload. CT was performed on a treadmill and ladder adapted to rats in alternate days (8 wk; 40-60% maximal capacity). Arterial pressure (AP) was directly measured. Oxidative stress and inflammation were measured on cardiac and renal tissues. The association of risk factors (hypertension + ovariectomy + fructose) promoted increase in insulin resistance, mean AP (FHO: 174 ± 4 vs. C: 108 ± 1 mmHg), heart rate (FHO: 403 ± 12 vs. C: 352 ± 11 beats/min), BPV, cardiac inflammation (tumor necrosis factor-a-FHO: 65.8 ± 9.9 vs. C: 23.3 ± 4.3 pg/mg protein), and oxidative stress cardiac and renal tissues. However, CT was able to reduce mean AP (FHOT: 158 ± 4 mmHg), heart rate (FHOT: 303 ± 5 beats/min), insulin resistance, and sympathetic modulation. Moreover, the trained rats presented increased nitric oxide bioavailability, reduced tumor necrosis factor-a (FHOT: 33.1 ± 4.9 pg/mg protein), increased IL-10 in cardiac tissue and reduced lipoperoxidation, and increased antioxidant defenses in cardiac and renal tissues. In conclusion, the association of risk factors promoted an additional impairment in metabolic, cardiovascular, autonomic, inflammatory, and oxidative stress parameters and combined exercise training was able to attenuate these dysfunctions..
Fil: Conti, Filipe Fernandes. Universidad Nove de Julho; Brasil
Fil: Brito, Janaina de Oliveira. Universidad Nove de Julho; Brasil
Fil: Bernardes, Nathalia. Universidade de Sao Paulo; Brasil. Universidad Nove de Julho; Brasil
Fil: Dias, Danielle da Silva. Universidad Nove de Julho; Brasil
Fil: Malfitano, Christiane. Universidad Nove de Julho; Brasil
Fil: Morris, Mariana. Universidad de Nova Southeastern; Estados Unidos
Fil: Llesuy, Susana Francisca. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires; Argentina
Fil: Irigoyen, Maria-Cláudia. Universidade de Sao Paulo; Brasil
Fil: de Angelis, Kátia. Universidad Nove de Julho; Brasil
description It is now well established that after menopause cardiometabolic disorders become more common. Recently, resistance exercise has been recommended as a complement to aerobic (combined training, CT) for the treatment of cardiometabolic diseases. The aim of this study was to evaluate the effects of CT in hypertensive ovariectomized rats undergoing fructose overload in blood pressure variability (BPV), inflammation, and oxidative stress parameters. Female rats were divided into the following groups (n = 8/group): sedentary normotensive Wistarrats (C), and sedentary (FHO) or trained (FHOT) ovariectomized spontaneously hypertensive rats undergoing and fructose overload. CT was performed on a treadmill and ladder adapted to rats in alternate days (8 wk; 40-60% maximal capacity). Arterial pressure (AP) was directly measured. Oxidative stress and inflammation were measured on cardiac and renal tissues. The association of risk factors (hypertension + ovariectomy + fructose) promoted increase in insulin resistance, mean AP (FHO: 174 ± 4 vs. C: 108 ± 1 mmHg), heart rate (FHO: 403 ± 12 vs. C: 352 ± 11 beats/min), BPV, cardiac inflammation (tumor necrosis factor-a-FHO: 65.8 ± 9.9 vs. C: 23.3 ± 4.3 pg/mg protein), and oxidative stress cardiac and renal tissues. However, CT was able to reduce mean AP (FHOT: 158 ± 4 mmHg), heart rate (FHOT: 303 ± 5 beats/min), insulin resistance, and sympathetic modulation. Moreover, the trained rats presented increased nitric oxide bioavailability, reduced tumor necrosis factor-a (FHOT: 33.1 ± 4.9 pg/mg protein), increased IL-10 in cardiac tissue and reduced lipoperoxidation, and increased antioxidant defenses in cardiac and renal tissues. In conclusion, the association of risk factors promoted an additional impairment in metabolic, cardiovascular, autonomic, inflammatory, and oxidative stress parameters and combined exercise training was able to attenuate these dysfunctions..
publishDate 2015
dc.date.none.fl_str_mv 2015-09
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/99260
Conti, Filipe Fernandes; Brito, Janaina de Oliveira; Bernardes, Nathalia; Dias, Danielle da Silva; Malfitano, Christiane; et al.; Positive effect of combined exercise training in a model of metabolic syndrome and menopause: Autonomic, inflammatory, and oxidative stress evaluations; American Physiological Society; American Journal Of Physiology-regulatory, Integrative And Comparative Physiology; 309; 12; 9-2015; R1532-R1539
0002-9513
0363-6119
CONICET Digital
CONICET
url http://hdl.handle.net/11336/99260
identifier_str_mv Conti, Filipe Fernandes; Brito, Janaina de Oliveira; Bernardes, Nathalia; Dias, Danielle da Silva; Malfitano, Christiane; et al.; Positive effect of combined exercise training in a model of metabolic syndrome and menopause: Autonomic, inflammatory, and oxidative stress evaluations; American Physiological Society; American Journal Of Physiology-regulatory, Integrative And Comparative Physiology; 309; 12; 9-2015; R1532-R1539
0002-9513
0363-6119
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://journals.physiology.org/doi/full/10.1152/ajpregu.00076.2015
info:eu-repo/semantics/altIdentifier/doi/10.1152/ajpregu.00076.2015
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv American Physiological Society
publisher.none.fl_str_mv American Physiological Society
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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