Combined aerobic and resistance exercise training attenuates cardiac dysfunctions in a model of diabetes and menopause

Autores
Callado Sanches, Iris; Buzin, Morgana; Fernandes Conti, Filipe; Da Silva Dias, Danielle; Paixão dos Santos, Camila; Sirvente, Raquel; Salemi, Vera Maria Cury; Llesuy, Susana Francisca; Irigoyen, Maria Cláudia; De Angelis, Kátia
Año de publicación
2018
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The study aimed at evaluating the effects of combined aerobic and resistance exercise training on cardiac morphometry and function, oxidative stress and inflammatory parameters in diabetic ovariectomized rats. For this, female Wistar rats (10 weeks-old) were divided into 4 groups (n = 8): euglycemic (E), diabetic (streptozotocin, 50 mg/kg, iv) (D), diabetic ovariectomized (DO) and trained diabetic ovariectomized (TDO). The combined exercise training was performed on a treadmill and in a ladder adapted to rats (8 weeks, at 40-60% of maximal capacity). The left ventricle (LV) morphometry and function were evaluated by echocardiography. Oxidative stress and inflammatory markers were measured on ventricles tissue. The sedentary diabetic animals (D and DO) showed impaired systolic and diastolic functions, as well as increased cardiac overload, evaluated by myocardial performance index (MPI- D: 0.32 ± 0.05; DO: 0.39 ± 0.13 vs. E: 0.25 ± 0.07), in relation to E group. Systolic and MPI dysfunctions were exacerbated in DO when compared to D group. The DO group presented higher protein oxidation and TNF-α/IL-10 ratio than D groups. Glutathione redox ratio (GSH/GSSG) and IL-10 were decreased in both D and DO groups when compared to E group. Exercise training improved exercise capacity, systolic and diastolic functions and MPI (0.18±0.11). The TDO group showed reduced protein oxidation and TNF-α/IL-10 ratio and increased GSH/GSSG and IL-10 in relation to the DO group. These results showed that combined exercise training was able to attenuate the cardiac dysfunctions, probably by reducing inflammation and oxidative stress in an experimental model of diabetes and menopause.
Fil: Callado Sanches, Iris. Universidade de Sao Paulo; Brasil
Fil: Buzin, Morgana. Universidade Nove de Julho; Brasil
Fil: Fernandes Conti, Filipe. Universidade Nove de Julho; Brasil
Fil: Da Silva Dias, Danielle. Universidade Nove de Julho; Brasil
Fil: Paixão dos Santos, Camila. Universidade Nove de Julho; Brasil
Fil: Sirvente, Raquel. Universidade de Sao Paulo; Brasil
Fil: Salemi, Vera Maria Cury. Universidade de Sao Paulo; Brasil
Fil: Llesuy, Susana Francisca. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Bioquímica y Medicina Molecular. Universidad de Buenos Aires. Facultad Medicina. Instituto de Bioquímica y Medicina Molecular; Argentina
Fil: Irigoyen, Maria Cláudia. Universidade de Sao Paulo; Brasil
Fil: De Angelis, Kátia. Universidade de Sao Paulo; Brasil
Materia
Combined aerobic and resistance exercise training
cardiac disfuntion
oxidative stress
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/220711
Acceder
id CONICETDig_99d8a3f159cd3fd74f643df13cad798b
oai_identifier_str oai:ri.conicet.gov.ar:11336/220711
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Combined aerobic and resistance exercise training attenuates cardiac dysfunctions in a model of diabetes and menopauseCallado Sanches, IrisBuzin, MorganaFernandes Conti, FilipeDa Silva Dias, DaniellePaixão dos Santos, CamilaSirvente, RaquelSalemi, Vera Maria CuryLlesuy, Susana FranciscaIrigoyen, Maria CláudiaDe Angelis, KátiaCombined aerobic and resistance exercise trainingcardiac disfuntionoxidative stresshttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1The study aimed at evaluating the effects of combined aerobic and resistance exercise training on cardiac morphometry and function, oxidative stress and inflammatory parameters in diabetic ovariectomized rats. For this, female Wistar rats (10 weeks-old) were divided into 4 groups (n = 8): euglycemic (E), diabetic (streptozotocin, 50 mg/kg, iv) (D), diabetic ovariectomized (DO) and trained diabetic ovariectomized (TDO). The combined exercise training was performed on a treadmill and in a ladder adapted to rats (8 weeks, at 40-60% of maximal capacity). The left ventricle (LV) morphometry and function were evaluated by echocardiography. Oxidative stress and inflammatory markers were measured on ventricles tissue. The sedentary diabetic animals (D and DO) showed impaired systolic and diastolic functions, as well as increased cardiac overload, evaluated by myocardial performance index (MPI- D: 0.32 ± 0.05; DO: 0.39 ± 0.13 vs. E: 0.25 ± 0.07), in relation to E group. Systolic and MPI dysfunctions were exacerbated in DO when compared to D group. The DO group presented higher protein oxidation and TNF-α/IL-10 ratio than D groups. Glutathione redox ratio (GSH/GSSG) and IL-10 were decreased in both D and DO groups when compared to E group. Exercise training improved exercise capacity, systolic and diastolic functions and MPI (0.18±0.11). The TDO group showed reduced protein oxidation and TNF-α/IL-10 ratio and increased GSH/GSSG and IL-10 in relation to the DO group. These results showed that combined exercise training was able to attenuate the cardiac dysfunctions, probably by reducing inflammation and oxidative stress in an experimental model of diabetes and menopause.Fil: Callado Sanches, Iris. Universidade de Sao Paulo; BrasilFil: Buzin, Morgana. Universidade Nove de Julho; BrasilFil: Fernandes Conti, Filipe. Universidade Nove de Julho; BrasilFil: Da Silva Dias, Danielle. Universidade Nove de Julho; BrasilFil: Paixão dos Santos, Camila. Universidade Nove de Julho; BrasilFil: Sirvente, Raquel. Universidade de Sao Paulo; BrasilFil: Salemi, Vera Maria Cury. Universidade de Sao Paulo; BrasilFil: Llesuy, Susana Francisca. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Bioquímica y Medicina Molecular. Universidad de Buenos Aires. Facultad Medicina. Instituto de Bioquímica y Medicina Molecular; ArgentinaFil: Irigoyen, Maria Cláudia. Universidade de Sao Paulo; BrasilFil: De Angelis, Kátia. Universidade de Sao Paulo; BrasilPublic Library of Science2018-09info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/220711Callado Sanches, Iris; Buzin, Morgana; Fernandes Conti, Filipe; Da Silva Dias, Danielle; Paixão dos Santos, Camila; et al.; Combined aerobic and resistance exercise training attenuates cardiac dysfunctions in a model of diabetes and menopause; Public Library of Science; Plos One; 13; 9; 9-2018; 1-151932-6203CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1371/journal.pone.0202731info:eu-repo/semantics/altIdentifier/url/https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0202731info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:05:54Zoai:ri.conicet.gov.ar:11336/220711instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:05:55.247CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Combined aerobic and resistance exercise training attenuates cardiac dysfunctions in a model of diabetes and menopause
title Combined aerobic and resistance exercise training attenuates cardiac dysfunctions in a model of diabetes and menopause
spellingShingle Combined aerobic and resistance exercise training attenuates cardiac dysfunctions in a model of diabetes and menopause
Callado Sanches, Iris
Combined aerobic and resistance exercise training
cardiac disfuntion
oxidative stress
title_short Combined aerobic and resistance exercise training attenuates cardiac dysfunctions in a model of diabetes and menopause
title_full Combined aerobic and resistance exercise training attenuates cardiac dysfunctions in a model of diabetes and menopause
title_fullStr Combined aerobic and resistance exercise training attenuates cardiac dysfunctions in a model of diabetes and menopause
title_full_unstemmed Combined aerobic and resistance exercise training attenuates cardiac dysfunctions in a model of diabetes and menopause
title_sort Combined aerobic and resistance exercise training attenuates cardiac dysfunctions in a model of diabetes and menopause
dc.creator.none.fl_str_mv Callado Sanches, Iris
Buzin, Morgana
Fernandes Conti, Filipe
Da Silva Dias, Danielle
Paixão dos Santos, Camila
Sirvente, Raquel
Salemi, Vera Maria Cury
Llesuy, Susana Francisca
Irigoyen, Maria Cláudia
De Angelis, Kátia
author Callado Sanches, Iris
author_facet Callado Sanches, Iris
Buzin, Morgana
Fernandes Conti, Filipe
Da Silva Dias, Danielle
Paixão dos Santos, Camila
Sirvente, Raquel
Salemi, Vera Maria Cury
Llesuy, Susana Francisca
Irigoyen, Maria Cláudia
De Angelis, Kátia
author_role author
author2 Buzin, Morgana
Fernandes Conti, Filipe
Da Silva Dias, Danielle
Paixão dos Santos, Camila
Sirvente, Raquel
Salemi, Vera Maria Cury
Llesuy, Susana Francisca
Irigoyen, Maria Cláudia
De Angelis, Kátia
author2_role author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Combined aerobic and resistance exercise training
cardiac disfuntion
oxidative stress
topic Combined aerobic and resistance exercise training
cardiac disfuntion
oxidative stress
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv The study aimed at evaluating the effects of combined aerobic and resistance exercise training on cardiac morphometry and function, oxidative stress and inflammatory parameters in diabetic ovariectomized rats. For this, female Wistar rats (10 weeks-old) were divided into 4 groups (n = 8): euglycemic (E), diabetic (streptozotocin, 50 mg/kg, iv) (D), diabetic ovariectomized (DO) and trained diabetic ovariectomized (TDO). The combined exercise training was performed on a treadmill and in a ladder adapted to rats (8 weeks, at 40-60% of maximal capacity). The left ventricle (LV) morphometry and function were evaluated by echocardiography. Oxidative stress and inflammatory markers were measured on ventricles tissue. The sedentary diabetic animals (D and DO) showed impaired systolic and diastolic functions, as well as increased cardiac overload, evaluated by myocardial performance index (MPI- D: 0.32 ± 0.05; DO: 0.39 ± 0.13 vs. E: 0.25 ± 0.07), in relation to E group. Systolic and MPI dysfunctions were exacerbated in DO when compared to D group. The DO group presented higher protein oxidation and TNF-α/IL-10 ratio than D groups. Glutathione redox ratio (GSH/GSSG) and IL-10 were decreased in both D and DO groups when compared to E group. Exercise training improved exercise capacity, systolic and diastolic functions and MPI (0.18±0.11). The TDO group showed reduced protein oxidation and TNF-α/IL-10 ratio and increased GSH/GSSG and IL-10 in relation to the DO group. These results showed that combined exercise training was able to attenuate the cardiac dysfunctions, probably by reducing inflammation and oxidative stress in an experimental model of diabetes and menopause.
Fil: Callado Sanches, Iris. Universidade de Sao Paulo; Brasil
Fil: Buzin, Morgana. Universidade Nove de Julho; Brasil
Fil: Fernandes Conti, Filipe. Universidade Nove de Julho; Brasil
Fil: Da Silva Dias, Danielle. Universidade Nove de Julho; Brasil
Fil: Paixão dos Santos, Camila. Universidade Nove de Julho; Brasil
Fil: Sirvente, Raquel. Universidade de Sao Paulo; Brasil
Fil: Salemi, Vera Maria Cury. Universidade de Sao Paulo; Brasil
Fil: Llesuy, Susana Francisca. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Bioquímica y Medicina Molecular. Universidad de Buenos Aires. Facultad Medicina. Instituto de Bioquímica y Medicina Molecular; Argentina
Fil: Irigoyen, Maria Cláudia. Universidade de Sao Paulo; Brasil
Fil: De Angelis, Kátia. Universidade de Sao Paulo; Brasil
description The study aimed at evaluating the effects of combined aerobic and resistance exercise training on cardiac morphometry and function, oxidative stress and inflammatory parameters in diabetic ovariectomized rats. For this, female Wistar rats (10 weeks-old) were divided into 4 groups (n = 8): euglycemic (E), diabetic (streptozotocin, 50 mg/kg, iv) (D), diabetic ovariectomized (DO) and trained diabetic ovariectomized (TDO). The combined exercise training was performed on a treadmill and in a ladder adapted to rats (8 weeks, at 40-60% of maximal capacity). The left ventricle (LV) morphometry and function were evaluated by echocardiography. Oxidative stress and inflammatory markers were measured on ventricles tissue. The sedentary diabetic animals (D and DO) showed impaired systolic and diastolic functions, as well as increased cardiac overload, evaluated by myocardial performance index (MPI- D: 0.32 ± 0.05; DO: 0.39 ± 0.13 vs. E: 0.25 ± 0.07), in relation to E group. Systolic and MPI dysfunctions were exacerbated in DO when compared to D group. The DO group presented higher protein oxidation and TNF-α/IL-10 ratio than D groups. Glutathione redox ratio (GSH/GSSG) and IL-10 were decreased in both D and DO groups when compared to E group. Exercise training improved exercise capacity, systolic and diastolic functions and MPI (0.18±0.11). The TDO group showed reduced protein oxidation and TNF-α/IL-10 ratio and increased GSH/GSSG and IL-10 in relation to the DO group. These results showed that combined exercise training was able to attenuate the cardiac dysfunctions, probably by reducing inflammation and oxidative stress in an experimental model of diabetes and menopause.
publishDate 2018
dc.date.none.fl_str_mv 2018-09
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/220711
Callado Sanches, Iris; Buzin, Morgana; Fernandes Conti, Filipe; Da Silva Dias, Danielle; Paixão dos Santos, Camila; et al.; Combined aerobic and resistance exercise training attenuates cardiac dysfunctions in a model of diabetes and menopause; Public Library of Science; Plos One; 13; 9; 9-2018; 1-15
1932-6203
CONICET Digital
CONICET
url http://hdl.handle.net/11336/220711
identifier_str_mv Callado Sanches, Iris; Buzin, Morgana; Fernandes Conti, Filipe; Da Silva Dias, Danielle; Paixão dos Santos, Camila; et al.; Combined aerobic and resistance exercise training attenuates cardiac dysfunctions in a model of diabetes and menopause; Public Library of Science; Plos One; 13; 9; 9-2018; 1-15
1932-6203
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1371/journal.pone.0202731
info:eu-repo/semantics/altIdentifier/url/https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0202731
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Public Library of Science
publisher.none.fl_str_mv Public Library of Science
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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