Cardiovascular autonomic dysfunction and oxidative stress induced by fructose overload in an experimental model of hypertension and menopause

Autores
Conti, Filipe Fernandes; Brito, Janaina de Oliveira; Bernardes, Nathalia; Dias, Danielle da Silva; Sanches, Iris Callado; Malfitano, Christiane; Llesuy, Susana Francisca; Irigoyen, Maria-Claudia; De Angelis, Kátia
Año de publicación
2014
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Background: Metabolic syndrome is characterized by the association of 3 or more risk factors, including: abdominal obesity associated with an excess of abdominal fat, insulin resistance, type 2 diabetes, dyslipidemia and hypertension. Moreover, the prevalence of hypertension and metabolic dysfunctions sharply increases after the menopause. However, the mechanisms involved in these changes are not well understood. Thus, the aim of this study was to assess the effects of fructose overload on cardiovascular autonomic modulation, inflammation and cardiac oxidative stress in an experimental model of hypertension and menopause. Methods: Female SHR rats were divided into (n = 8/group): hypertensive (H), hypertensive ovariectomized (HO) and hypertensive ovariectomized undergoing fructose overload (100 g/L in drinking water) (FHO). Arterial pressure (AP) signals were directly recorded. Cardiac autonomic modulation was evaluated by spectral analysis. Oxidative stress was evaluated in cardiac tissue. Results: AP was higher in the FHO group when compared to the other groups. Fructose overload promoted an increase in body and fat weight, triglyceride concentration and a reduction in insulin sensitivity. IL-10 was reduced in the FHO group when compared to the H group. TNF-α was higher in the FHO when compared to all other groups. Lipoperoxidation was higher and glutathione redox balance was reduced in the FHO group when compared to other groups, an indication of increased oxidative stress. A negative correlation was found between IL-10 and adipose tissue. Conclusion: Fructose overload promoted an impairment in cardiac autonomic modulation associated with inflammation and oxidative stress in hypertensive rats undergoing ovarian hormone deprivation.
Fil: Conti, Filipe Fernandes. Universidad Nove de Julho; Brasil
Fil: Brito, Janaina de Oliveira. Universidad Nove de Julho; Brasil
Fil: Bernardes, Nathalia. Universidade de Sao Paulo; Brasil
Fil: Dias, Danielle da Silva. Universidad Nove de Julho; Brasil
Fil: Sanches, Iris Callado. Universidad Nove de Julho; Brasil
Fil: Malfitano, Christiane. Universidad Nove de Julho; Brasil
Fil: Llesuy, Susana Francisca. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Química Analítica y Fisicoquímica; Argentina
Fil: Irigoyen, Maria-Claudia. Universidade de Sao Paulo; Brasil
Fil: De Angelis, Kátia. Universidad Nove de Julho; Brasil
Materia
BLOOD PRESSURE VARIABILITY
HEART RATE VARIABILITY
INFLAMMATION
MENOPAUSE
METABOLIC SYNDROME
OXIDATIVE STRESS
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/99459
Acceder
id CONICETDig_b5fa59539e53d96dcc7e7142a4553eff
oai_identifier_str oai:ri.conicet.gov.ar:11336/99459
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Cardiovascular autonomic dysfunction and oxidative stress induced by fructose overload in an experimental model of hypertension and menopauseConti, Filipe FernandesBrito, Janaina de OliveiraBernardes, NathaliaDias, Danielle da SilvaSanches, Iris CalladoMalfitano, ChristianeLlesuy, Susana FranciscaIrigoyen, Maria-ClaudiaDe Angelis, KátiaBLOOD PRESSURE VARIABILITYHEART RATE VARIABILITYINFLAMMATIONMENOPAUSEMETABOLIC SYNDROMEOXIDATIVE STRESShttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Background: Metabolic syndrome is characterized by the association of 3 or more risk factors, including: abdominal obesity associated with an excess of abdominal fat, insulin resistance, type 2 diabetes, dyslipidemia and hypertension. Moreover, the prevalence of hypertension and metabolic dysfunctions sharply increases after the menopause. However, the mechanisms involved in these changes are not well understood. Thus, the aim of this study was to assess the effects of fructose overload on cardiovascular autonomic modulation, inflammation and cardiac oxidative stress in an experimental model of hypertension and menopause. Methods: Female SHR rats were divided into (n = 8/group): hypertensive (H), hypertensive ovariectomized (HO) and hypertensive ovariectomized undergoing fructose overload (100 g/L in drinking water) (FHO). Arterial pressure (AP) signals were directly recorded. Cardiac autonomic modulation was evaluated by spectral analysis. Oxidative stress was evaluated in cardiac tissue. Results: AP was higher in the FHO group when compared to the other groups. Fructose overload promoted an increase in body and fat weight, triglyceride concentration and a reduction in insulin sensitivity. IL-10 was reduced in the FHO group when compared to the H group. TNF-α was higher in the FHO when compared to all other groups. Lipoperoxidation was higher and glutathione redox balance was reduced in the FHO group when compared to other groups, an indication of increased oxidative stress. A negative correlation was found between IL-10 and adipose tissue. Conclusion: Fructose overload promoted an impairment in cardiac autonomic modulation associated with inflammation and oxidative stress in hypertensive rats undergoing ovarian hormone deprivation.Fil: Conti, Filipe Fernandes. Universidad Nove de Julho; BrasilFil: Brito, Janaina de Oliveira. Universidad Nove de Julho; BrasilFil: Bernardes, Nathalia. Universidade de Sao Paulo; BrasilFil: Dias, Danielle da Silva. Universidad Nove de Julho; BrasilFil: Sanches, Iris Callado. Universidad Nove de Julho; BrasilFil: Malfitano, Christiane. Universidad Nove de Julho; BrasilFil: Llesuy, Susana Francisca. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Química Analítica y Fisicoquímica; ArgentinaFil: Irigoyen, Maria-Claudia. Universidade de Sao Paulo; BrasilFil: De Angelis, Kátia. Universidad Nove de Julho; BrasilBioMed Central2014-12info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/99459Conti, Filipe Fernandes; Brito, Janaina de Oliveira; Bernardes, Nathalia; Dias, Danielle da Silva; Sanches, Iris Callado; et al.; Cardiovascular autonomic dysfunction and oxidative stress induced by fructose overload in an experimental model of hypertension and menopause; BioMed Central; Bmc Cardiovascular Disorders; 14; 1; 12-2014; 1-71471-2261CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://bmccardiovascdisord.biomedcentral.com/articles/10.1186/1471-2261-14-185info:eu-repo/semantics/altIdentifier/doi/10.1186/1471-2261-14-185info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:34:20Zoai:ri.conicet.gov.ar:11336/99459instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:34:21.026CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Cardiovascular autonomic dysfunction and oxidative stress induced by fructose overload in an experimental model of hypertension and menopause
title Cardiovascular autonomic dysfunction and oxidative stress induced by fructose overload in an experimental model of hypertension and menopause
spellingShingle Cardiovascular autonomic dysfunction and oxidative stress induced by fructose overload in an experimental model of hypertension and menopause
Conti, Filipe Fernandes
BLOOD PRESSURE VARIABILITY
HEART RATE VARIABILITY
INFLAMMATION
MENOPAUSE
METABOLIC SYNDROME
OXIDATIVE STRESS
title_short Cardiovascular autonomic dysfunction and oxidative stress induced by fructose overload in an experimental model of hypertension and menopause
title_full Cardiovascular autonomic dysfunction and oxidative stress induced by fructose overload in an experimental model of hypertension and menopause
title_fullStr Cardiovascular autonomic dysfunction and oxidative stress induced by fructose overload in an experimental model of hypertension and menopause
title_full_unstemmed Cardiovascular autonomic dysfunction and oxidative stress induced by fructose overload in an experimental model of hypertension and menopause
title_sort Cardiovascular autonomic dysfunction and oxidative stress induced by fructose overload in an experimental model of hypertension and menopause
dc.creator.none.fl_str_mv Conti, Filipe Fernandes
Brito, Janaina de Oliveira
Bernardes, Nathalia
Dias, Danielle da Silva
Sanches, Iris Callado
Malfitano, Christiane
Llesuy, Susana Francisca
Irigoyen, Maria-Claudia
De Angelis, Kátia
author Conti, Filipe Fernandes
author_facet Conti, Filipe Fernandes
Brito, Janaina de Oliveira
Bernardes, Nathalia
Dias, Danielle da Silva
Sanches, Iris Callado
Malfitano, Christiane
Llesuy, Susana Francisca
Irigoyen, Maria-Claudia
De Angelis, Kátia
author_role author
author2 Brito, Janaina de Oliveira
Bernardes, Nathalia
Dias, Danielle da Silva
Sanches, Iris Callado
Malfitano, Christiane
Llesuy, Susana Francisca
Irigoyen, Maria-Claudia
De Angelis, Kátia
author2_role author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv BLOOD PRESSURE VARIABILITY
HEART RATE VARIABILITY
INFLAMMATION
MENOPAUSE
METABOLIC SYNDROME
OXIDATIVE STRESS
topic BLOOD PRESSURE VARIABILITY
HEART RATE VARIABILITY
INFLAMMATION
MENOPAUSE
METABOLIC SYNDROME
OXIDATIVE STRESS
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Background: Metabolic syndrome is characterized by the association of 3 or more risk factors, including: abdominal obesity associated with an excess of abdominal fat, insulin resistance, type 2 diabetes, dyslipidemia and hypertension. Moreover, the prevalence of hypertension and metabolic dysfunctions sharply increases after the menopause. However, the mechanisms involved in these changes are not well understood. Thus, the aim of this study was to assess the effects of fructose overload on cardiovascular autonomic modulation, inflammation and cardiac oxidative stress in an experimental model of hypertension and menopause. Methods: Female SHR rats were divided into (n = 8/group): hypertensive (H), hypertensive ovariectomized (HO) and hypertensive ovariectomized undergoing fructose overload (100 g/L in drinking water) (FHO). Arterial pressure (AP) signals were directly recorded. Cardiac autonomic modulation was evaluated by spectral analysis. Oxidative stress was evaluated in cardiac tissue. Results: AP was higher in the FHO group when compared to the other groups. Fructose overload promoted an increase in body and fat weight, triglyceride concentration and a reduction in insulin sensitivity. IL-10 was reduced in the FHO group when compared to the H group. TNF-α was higher in the FHO when compared to all other groups. Lipoperoxidation was higher and glutathione redox balance was reduced in the FHO group when compared to other groups, an indication of increased oxidative stress. A negative correlation was found between IL-10 and adipose tissue. Conclusion: Fructose overload promoted an impairment in cardiac autonomic modulation associated with inflammation and oxidative stress in hypertensive rats undergoing ovarian hormone deprivation.
Fil: Conti, Filipe Fernandes. Universidad Nove de Julho; Brasil
Fil: Brito, Janaina de Oliveira. Universidad Nove de Julho; Brasil
Fil: Bernardes, Nathalia. Universidade de Sao Paulo; Brasil
Fil: Dias, Danielle da Silva. Universidad Nove de Julho; Brasil
Fil: Sanches, Iris Callado. Universidad Nove de Julho; Brasil
Fil: Malfitano, Christiane. Universidad Nove de Julho; Brasil
Fil: Llesuy, Susana Francisca. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Química Analítica y Fisicoquímica; Argentina
Fil: Irigoyen, Maria-Claudia. Universidade de Sao Paulo; Brasil
Fil: De Angelis, Kátia. Universidad Nove de Julho; Brasil
description Background: Metabolic syndrome is characterized by the association of 3 or more risk factors, including: abdominal obesity associated with an excess of abdominal fat, insulin resistance, type 2 diabetes, dyslipidemia and hypertension. Moreover, the prevalence of hypertension and metabolic dysfunctions sharply increases after the menopause. However, the mechanisms involved in these changes are not well understood. Thus, the aim of this study was to assess the effects of fructose overload on cardiovascular autonomic modulation, inflammation and cardiac oxidative stress in an experimental model of hypertension and menopause. Methods: Female SHR rats were divided into (n = 8/group): hypertensive (H), hypertensive ovariectomized (HO) and hypertensive ovariectomized undergoing fructose overload (100 g/L in drinking water) (FHO). Arterial pressure (AP) signals were directly recorded. Cardiac autonomic modulation was evaluated by spectral analysis. Oxidative stress was evaluated in cardiac tissue. Results: AP was higher in the FHO group when compared to the other groups. Fructose overload promoted an increase in body and fat weight, triglyceride concentration and a reduction in insulin sensitivity. IL-10 was reduced in the FHO group when compared to the H group. TNF-α was higher in the FHO when compared to all other groups. Lipoperoxidation was higher and glutathione redox balance was reduced in the FHO group when compared to other groups, an indication of increased oxidative stress. A negative correlation was found between IL-10 and adipose tissue. Conclusion: Fructose overload promoted an impairment in cardiac autonomic modulation associated with inflammation and oxidative stress in hypertensive rats undergoing ovarian hormone deprivation.
publishDate 2014
dc.date.none.fl_str_mv 2014-12
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/99459
Conti, Filipe Fernandes; Brito, Janaina de Oliveira; Bernardes, Nathalia; Dias, Danielle da Silva; Sanches, Iris Callado; et al.; Cardiovascular autonomic dysfunction and oxidative stress induced by fructose overload in an experimental model of hypertension and menopause; BioMed Central; Bmc Cardiovascular Disorders; 14; 1; 12-2014; 1-7
1471-2261
CONICET Digital
CONICET
url http://hdl.handle.net/11336/99459
identifier_str_mv Conti, Filipe Fernandes; Brito, Janaina de Oliveira; Bernardes, Nathalia; Dias, Danielle da Silva; Sanches, Iris Callado; et al.; Cardiovascular autonomic dysfunction and oxidative stress induced by fructose overload in an experimental model of hypertension and menopause; BioMed Central; Bmc Cardiovascular Disorders; 14; 1; 12-2014; 1-7
1471-2261
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://bmccardiovascdisord.biomedcentral.com/articles/10.1186/1471-2261-14-185
info:eu-repo/semantics/altIdentifier/doi/10.1186/1471-2261-14-185
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv BioMed Central
publisher.none.fl_str_mv BioMed Central
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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