Aerobic exercise training promotes additional cardiac benefits better than resistance exercise training in postmenopausal rats with diabetes

Autores
Quinteiro, Hugo; Buzin, Morgana; Fernandes Conti, Filipe; Silva Dias, Danielle da; Figueroa, Diego; Llesuy, Susana Francisca; Irigoyen, Maria Claudia; Callado Sanches, Iris; De Angelis, Kátia
Año de publicación
2014
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
OBJECTIVE: The aim of this study was to evaluate the effects of aerobic exercise training or resistance exercise training on cardiac morphometric, functional, and oxidative stress parameters in rats with ovarian hormone deprivation and diabetes. METHODS: Female Wistar rats (200-220 g) were divided into a sham-operated group (euglycemic sham-operated sedentary [ES]; n = 8) and three ovariectomized (bilateral removal of ovaries) and diabetic (streptozotocin 50 mg/kg IV) groups as follows: diabetic ovariectomized sedentary (DOS; n = 8), diabetic ovariectomized undergoing aerobic exercise training (DOTA; n = 8), and diabetic ovariectomized undergoing resistance exercise training (DOTR; n = 8). After 8 weeks of resistance (ladder) or aerobic (treadmill) exercise training, left ventricle function and morphometry were evaluated by echocardiography, whereas oxidative stress was evaluated at the left ventricle. RESULTS: The DOS group presented with increased left ventricle cavity in diastole and relative wall thickness (RWT), and these changes were attenuated in both DOTA and DOTR groups. Systolic and diastolic function was impaired in the DOS group compared with the ES group, and only the DOTA group was able to reverse this dysfunction. Lipoperoxidation and glutathione redox balance were improved in both trained groups compared with the DOS group. Glutathione peroxidase and superoxide dismutase were higher in the DOTA group than in the other studied groups. Correlations were observed between lipoperoxidation and left ventricle cavity in diastole (r = 0.55), between redox balance and RWT (r = 0.62), and between lipoperoxidation and RWT (r = -0.60). CONCLUSIONS: Aerobic exercise training and resistance exercise training promote attenuation of cardiac morphometric dysfunction associated with a reduction in oxidative stress in an experimental model of diabetes and menopause. However, only dynamic aerobic exercise training is able to attenuate systolic and diastolic dysfunction under this condition.
Fil: Quinteiro, Hugo. Universidade Nove de Julho. Laboratory of Translational Physiology; Brasil
Fil: Buzin, Morgana. Universidade Nove de Julho. Laboratory of Translational Physiology; Brasil
Fil: Fernandes Conti, Filipe. Universidade Nove de Julho. Laboratory of Translational Physiology; Brasil
Fil: Silva Dias, Danielle da. Universidade Nove de Julho. Laboratory of Translational Physiology; Brasil
Fil: Figueroa, Diego. Universidade de Sao Paulo; Brasil
Fil: Llesuy, Susana Francisca. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Bioquímica y Medicina Molecular. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Bioquímica y Medicina Molecular; Argentina
Fil: Irigoyen, Maria Claudia. Universidade de Sao Paulo; Brasil
Fil: Callado Sanches, Iris. Universidade Nove de Julho. Laboratory of Translational Physiology; Brasil
Fil: De Angelis, Kátia. Universidade Nove de Julho. Laboratory of Translational Physiology; Brasil
Materia
Resistance Exercise
Aerobic Exercise
Menopause
Diabetes
Cardiac Function
Oxidative Stress
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/30728
Acceder
id CONICETDig_689623344c3e6b8e8e0a510edceb7ebb
oai_identifier_str oai:ri.conicet.gov.ar:11336/30728
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Aerobic exercise training promotes additional cardiac benefits better than resistance exercise training in postmenopausal rats with diabetesQuinteiro, HugoBuzin, MorganaFernandes Conti, FilipeSilva Dias, Danielle daFigueroa, DiegoLlesuy, Susana FranciscaIrigoyen, Maria ClaudiaCallado Sanches, IrisDe Angelis, KátiaResistance ExerciseAerobic ExerciseMenopauseDiabetesCardiac FunctionOxidative Stresshttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3OBJECTIVE: The aim of this study was to evaluate the effects of aerobic exercise training or resistance exercise training on cardiac morphometric, functional, and oxidative stress parameters in rats with ovarian hormone deprivation and diabetes. METHODS: Female Wistar rats (200-220 g) were divided into a sham-operated group (euglycemic sham-operated sedentary [ES]; n = 8) and three ovariectomized (bilateral removal of ovaries) and diabetic (streptozotocin 50 mg/kg IV) groups as follows: diabetic ovariectomized sedentary (DOS; n = 8), diabetic ovariectomized undergoing aerobic exercise training (DOTA; n = 8), and diabetic ovariectomized undergoing resistance exercise training (DOTR; n = 8). After 8 weeks of resistance (ladder) or aerobic (treadmill) exercise training, left ventricle function and morphometry were evaluated by echocardiography, whereas oxidative stress was evaluated at the left ventricle. RESULTS: The DOS group presented with increased left ventricle cavity in diastole and relative wall thickness (RWT), and these changes were attenuated in both DOTA and DOTR groups. Systolic and diastolic function was impaired in the DOS group compared with the ES group, and only the DOTA group was able to reverse this dysfunction. Lipoperoxidation and glutathione redox balance were improved in both trained groups compared with the DOS group. Glutathione peroxidase and superoxide dismutase were higher in the DOTA group than in the other studied groups. Correlations were observed between lipoperoxidation and left ventricle cavity in diastole (r = 0.55), between redox balance and RWT (r = 0.62), and between lipoperoxidation and RWT (r = -0.60). CONCLUSIONS: Aerobic exercise training and resistance exercise training promote attenuation of cardiac morphometric dysfunction associated with a reduction in oxidative stress in an experimental model of diabetes and menopause. However, only dynamic aerobic exercise training is able to attenuate systolic and diastolic dysfunction under this condition.Fil: Quinteiro, Hugo. Universidade Nove de Julho. Laboratory of Translational Physiology; BrasilFil: Buzin, Morgana. Universidade Nove de Julho. Laboratory of Translational Physiology; BrasilFil: Fernandes Conti, Filipe. Universidade Nove de Julho. Laboratory of Translational Physiology; BrasilFil: Silva Dias, Danielle da. Universidade Nove de Julho. Laboratory of Translational Physiology; BrasilFil: Figueroa, Diego. Universidade de Sao Paulo; BrasilFil: Llesuy, Susana Francisca. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Bioquímica y Medicina Molecular. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Bioquímica y Medicina Molecular; ArgentinaFil: Irigoyen, Maria Claudia. Universidade de Sao Paulo; BrasilFil: Callado Sanches, Iris. Universidade Nove de Julho. Laboratory of Translational Physiology; BrasilFil: De Angelis, Kátia. Universidade Nove de Julho. Laboratory of Translational Physiology; BrasilLippincott Williams2014-05info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/30728De Angelis, Kátia; Callado Sanches, Iris; Irigoyen, Maria Claudia; Llesuy, Susana Francisca; Figueroa, Diego; Silva Dias, Danielle da; et al.; Aerobic exercise training promotes additional cardiac benefits better than resistance exercise training in postmenopausal rats with diabetes; Lippincott Williams; Menopause; 22; 5; 5-2014; 534-5411072-3714CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1097/gme.0000000000000344info:eu-repo/semantics/altIdentifier/url/http://journals.lww.com/menopausejournal/pages/articleviewer.aspx?year=2015&issue=05000&article=00010&type=abstractinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:32:19Zoai:ri.conicet.gov.ar:11336/30728instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:32:19.721CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Aerobic exercise training promotes additional cardiac benefits better than resistance exercise training in postmenopausal rats with diabetes
title Aerobic exercise training promotes additional cardiac benefits better than resistance exercise training in postmenopausal rats with diabetes
spellingShingle Aerobic exercise training promotes additional cardiac benefits better than resistance exercise training in postmenopausal rats with diabetes
Quinteiro, Hugo
Resistance Exercise
Aerobic Exercise
Menopause
Diabetes
Cardiac Function
Oxidative Stress
title_short Aerobic exercise training promotes additional cardiac benefits better than resistance exercise training in postmenopausal rats with diabetes
title_full Aerobic exercise training promotes additional cardiac benefits better than resistance exercise training in postmenopausal rats with diabetes
title_fullStr Aerobic exercise training promotes additional cardiac benefits better than resistance exercise training in postmenopausal rats with diabetes
title_full_unstemmed Aerobic exercise training promotes additional cardiac benefits better than resistance exercise training in postmenopausal rats with diabetes
title_sort Aerobic exercise training promotes additional cardiac benefits better than resistance exercise training in postmenopausal rats with diabetes
dc.creator.none.fl_str_mv Quinteiro, Hugo
Buzin, Morgana
Fernandes Conti, Filipe
Silva Dias, Danielle da
Figueroa, Diego
Llesuy, Susana Francisca
Irigoyen, Maria Claudia
Callado Sanches, Iris
De Angelis, Kátia
author Quinteiro, Hugo
author_facet Quinteiro, Hugo
Buzin, Morgana
Fernandes Conti, Filipe
Silva Dias, Danielle da
Figueroa, Diego
Llesuy, Susana Francisca
Irigoyen, Maria Claudia
Callado Sanches, Iris
De Angelis, Kátia
author_role author
author2 Buzin, Morgana
Fernandes Conti, Filipe
Silva Dias, Danielle da
Figueroa, Diego
Llesuy, Susana Francisca
Irigoyen, Maria Claudia
Callado Sanches, Iris
De Angelis, Kátia
author2_role author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Resistance Exercise
Aerobic Exercise
Menopause
Diabetes
Cardiac Function
Oxidative Stress
topic Resistance Exercise
Aerobic Exercise
Menopause
Diabetes
Cardiac Function
Oxidative Stress
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv OBJECTIVE: The aim of this study was to evaluate the effects of aerobic exercise training or resistance exercise training on cardiac morphometric, functional, and oxidative stress parameters in rats with ovarian hormone deprivation and diabetes. METHODS: Female Wistar rats (200-220 g) were divided into a sham-operated group (euglycemic sham-operated sedentary [ES]; n = 8) and three ovariectomized (bilateral removal of ovaries) and diabetic (streptozotocin 50 mg/kg IV) groups as follows: diabetic ovariectomized sedentary (DOS; n = 8), diabetic ovariectomized undergoing aerobic exercise training (DOTA; n = 8), and diabetic ovariectomized undergoing resistance exercise training (DOTR; n = 8). After 8 weeks of resistance (ladder) or aerobic (treadmill) exercise training, left ventricle function and morphometry were evaluated by echocardiography, whereas oxidative stress was evaluated at the left ventricle. RESULTS: The DOS group presented with increased left ventricle cavity in diastole and relative wall thickness (RWT), and these changes were attenuated in both DOTA and DOTR groups. Systolic and diastolic function was impaired in the DOS group compared with the ES group, and only the DOTA group was able to reverse this dysfunction. Lipoperoxidation and glutathione redox balance were improved in both trained groups compared with the DOS group. Glutathione peroxidase and superoxide dismutase were higher in the DOTA group than in the other studied groups. Correlations were observed between lipoperoxidation and left ventricle cavity in diastole (r = 0.55), between redox balance and RWT (r = 0.62), and between lipoperoxidation and RWT (r = -0.60). CONCLUSIONS: Aerobic exercise training and resistance exercise training promote attenuation of cardiac morphometric dysfunction associated with a reduction in oxidative stress in an experimental model of diabetes and menopause. However, only dynamic aerobic exercise training is able to attenuate systolic and diastolic dysfunction under this condition.
Fil: Quinteiro, Hugo. Universidade Nove de Julho. Laboratory of Translational Physiology; Brasil
Fil: Buzin, Morgana. Universidade Nove de Julho. Laboratory of Translational Physiology; Brasil
Fil: Fernandes Conti, Filipe. Universidade Nove de Julho. Laboratory of Translational Physiology; Brasil
Fil: Silva Dias, Danielle da. Universidade Nove de Julho. Laboratory of Translational Physiology; Brasil
Fil: Figueroa, Diego. Universidade de Sao Paulo; Brasil
Fil: Llesuy, Susana Francisca. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Bioquímica y Medicina Molecular. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Bioquímica y Medicina Molecular; Argentina
Fil: Irigoyen, Maria Claudia. Universidade de Sao Paulo; Brasil
Fil: Callado Sanches, Iris. Universidade Nove de Julho. Laboratory of Translational Physiology; Brasil
Fil: De Angelis, Kátia. Universidade Nove de Julho. Laboratory of Translational Physiology; Brasil
description OBJECTIVE: The aim of this study was to evaluate the effects of aerobic exercise training or resistance exercise training on cardiac morphometric, functional, and oxidative stress parameters in rats with ovarian hormone deprivation and diabetes. METHODS: Female Wistar rats (200-220 g) were divided into a sham-operated group (euglycemic sham-operated sedentary [ES]; n = 8) and three ovariectomized (bilateral removal of ovaries) and diabetic (streptozotocin 50 mg/kg IV) groups as follows: diabetic ovariectomized sedentary (DOS; n = 8), diabetic ovariectomized undergoing aerobic exercise training (DOTA; n = 8), and diabetic ovariectomized undergoing resistance exercise training (DOTR; n = 8). After 8 weeks of resistance (ladder) or aerobic (treadmill) exercise training, left ventricle function and morphometry were evaluated by echocardiography, whereas oxidative stress was evaluated at the left ventricle. RESULTS: The DOS group presented with increased left ventricle cavity in diastole and relative wall thickness (RWT), and these changes were attenuated in both DOTA and DOTR groups. Systolic and diastolic function was impaired in the DOS group compared with the ES group, and only the DOTA group was able to reverse this dysfunction. Lipoperoxidation and glutathione redox balance were improved in both trained groups compared with the DOS group. Glutathione peroxidase and superoxide dismutase were higher in the DOTA group than in the other studied groups. Correlations were observed between lipoperoxidation and left ventricle cavity in diastole (r = 0.55), between redox balance and RWT (r = 0.62), and between lipoperoxidation and RWT (r = -0.60). CONCLUSIONS: Aerobic exercise training and resistance exercise training promote attenuation of cardiac morphometric dysfunction associated with a reduction in oxidative stress in an experimental model of diabetes and menopause. However, only dynamic aerobic exercise training is able to attenuate systolic and diastolic dysfunction under this condition.
publishDate 2014
dc.date.none.fl_str_mv 2014-05
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/30728
De Angelis, Kátia; Callado Sanches, Iris; Irigoyen, Maria Claudia; Llesuy, Susana Francisca; Figueroa, Diego; Silva Dias, Danielle da; et al.; Aerobic exercise training promotes additional cardiac benefits better than resistance exercise training in postmenopausal rats with diabetes; Lippincott Williams; Menopause; 22; 5; 5-2014; 534-541
1072-3714
CONICET Digital
CONICET
url http://hdl.handle.net/11336/30728
identifier_str_mv De Angelis, Kátia; Callado Sanches, Iris; Irigoyen, Maria Claudia; Llesuy, Susana Francisca; Figueroa, Diego; Silva Dias, Danielle da; et al.; Aerobic exercise training promotes additional cardiac benefits better than resistance exercise training in postmenopausal rats with diabetes; Lippincott Williams; Menopause; 22; 5; 5-2014; 534-541
1072-3714
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1097/gme.0000000000000344
info:eu-repo/semantics/altIdentifier/url/http://journals.lww.com/menopausejournal/pages/articleviewer.aspx?year=2015&issue=05000&article=00010&type=abstract
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Lippincott Williams
publisher.none.fl_str_mv Lippincott Williams
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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