Combined aerobic and resistance exercise training improve hypertension associated with menopause

Autores
Shimojo, Guilherme Lemos; Da Silva Dias, Danielle; Malfitano, Christiane; Sanches, Iris Callado; Llesuy, Susana Francisca; Ulloa, Luis; Irigoyen, Maria Cläudia; De Angelis, Kätia
Año de publicación
2018
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The prevalence of hypertension sharply increases in menopausal women. Recent studies have demonstrated that aerobic or resistance training may help control hypertension. In this study, we report that combining aerobic and resistance training may provide an effective therapeutic approach for hypertension control, attenuating inflammation and oxidative stress in ovariectomized rats. Female Wistar and spontaneous hypertensive rats (SHR) were distributed into four groups: sedentary control (C), sedentary hypertensive (HR), sedentary hypertensive ovariectomized (HR-O), and combined trained hypertensive ovariectomized (T-HR-O). Combined exercise training was performed on a motor treadmill (aerobic training) and on a ladder adapted to rats (resistance training), in alternate days for 8 weeks. Direct arterial pressure was recorded and oxidative stress and inflammation were evaluated in cardiac and renal tissue. Ovariectomy increases increased mean arterial blood pressure, sympathetic modulation, and oxidative stress in SHR. Combining aerobic and resistance training reduced mean arterial blood pressure (12% vs. HR-O), heart rate (8% vs. HR-O), vascular sympathetic modulation (40% vs. HR-O), and improved baroreflex sensitivity. Combined training reduced cardiac inflammation (TNF and IL-6) and cardiac and renal lipoperoxidation (59% and 57%, respectively vs. HR-O). It also enhanced cardiac (71%) and renal (76%) total antioxidant capacity when compared to HR-O group. In conclusion, combining aerobic and resistance training improves mean arterial blood pressure, cardiovascular autonomic control, preventing cardiac and renal oxidative stress and inflammation in an experimental hypertension model with surgical menopause induced with ovariectomy.
Fil: Shimojo, Guilherme Lemos. Universidade Nove de Julho; Brasil
Fil: Da Silva Dias, Danielle. Universidade Nove de Julho; Brasil
Fil: Malfitano, Christiane. Universidade Nove de Julho; Brasil
Fil: Sanches, Iris Callado. Universidade Sao Judas Tadeu; Brasil
Fil: Llesuy, Susana Francisca. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Bioquímica y Medicina Molecular. Universidad de Buenos Aires. Facultad Medicina. Instituto de Bioquímica y Medicina Molecular; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Química Analítica y Fisicoquímica. Cátedra de Química General e Inorgánica; Argentina
Fil: Ulloa, Luis. Rutgers University; Estados Unidos. Universidade Nove de Julho; Brasil
Fil: Irigoyen, Maria Cläudia. Universidade de Sao Paulo; Brasil
Fil: De Angelis, Kätia. Universidade Federal de Sao Paulo; Brasil. Universidade Nove de Julho; Brasil
Materia
CARDIOVASCULAR AUTONOMIC DYSFUNCTION
COMBINED EXERCISE TRAINING
HYPERTENSION
INFLAMMATION
KIDNEY
OVARIECTOMY
OXIDATIVE STRESS
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/227941

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repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Combined aerobic and resistance exercise training improve hypertension associated with menopauseShimojo, Guilherme LemosDa Silva Dias, DanielleMalfitano, ChristianeSanches, Iris CalladoLlesuy, Susana FranciscaUlloa, LuisIrigoyen, Maria CläudiaDe Angelis, KätiaCARDIOVASCULAR AUTONOMIC DYSFUNCTIONCOMBINED EXERCISE TRAININGHYPERTENSIONINFLAMMATIONKIDNEYOVARIECTOMYOXIDATIVE STRESShttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1The prevalence of hypertension sharply increases in menopausal women. Recent studies have demonstrated that aerobic or resistance training may help control hypertension. In this study, we report that combining aerobic and resistance training may provide an effective therapeutic approach for hypertension control, attenuating inflammation and oxidative stress in ovariectomized rats. Female Wistar and spontaneous hypertensive rats (SHR) were distributed into four groups: sedentary control (C), sedentary hypertensive (HR), sedentary hypertensive ovariectomized (HR-O), and combined trained hypertensive ovariectomized (T-HR-O). Combined exercise training was performed on a motor treadmill (aerobic training) and on a ladder adapted to rats (resistance training), in alternate days for 8 weeks. Direct arterial pressure was recorded and oxidative stress and inflammation were evaluated in cardiac and renal tissue. Ovariectomy increases increased mean arterial blood pressure, sympathetic modulation, and oxidative stress in SHR. Combining aerobic and resistance training reduced mean arterial blood pressure (12% vs. HR-O), heart rate (8% vs. HR-O), vascular sympathetic modulation (40% vs. HR-O), and improved baroreflex sensitivity. Combined training reduced cardiac inflammation (TNF and IL-6) and cardiac and renal lipoperoxidation (59% and 57%, respectively vs. HR-O). It also enhanced cardiac (71%) and renal (76%) total antioxidant capacity when compared to HR-O group. In conclusion, combining aerobic and resistance training improves mean arterial blood pressure, cardiovascular autonomic control, preventing cardiac and renal oxidative stress and inflammation in an experimental hypertension model with surgical menopause induced with ovariectomy.Fil: Shimojo, Guilherme Lemos. Universidade Nove de Julho; BrasilFil: Da Silva Dias, Danielle. Universidade Nove de Julho; BrasilFil: Malfitano, Christiane. Universidade Nove de Julho; BrasilFil: Sanches, Iris Callado. Universidade Sao Judas Tadeu; BrasilFil: Llesuy, Susana Francisca. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Bioquímica y Medicina Molecular. Universidad de Buenos Aires. Facultad Medicina. Instituto de Bioquímica y Medicina Molecular; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Química Analítica y Fisicoquímica. Cátedra de Química General e Inorgánica; ArgentinaFil: Ulloa, Luis. Rutgers University; Estados Unidos. Universidade Nove de Julho; BrasilFil: Irigoyen, Maria Cläudia. Universidade de Sao Paulo; BrasilFil: De Angelis, Kätia. Universidade Federal de Sao Paulo; Brasil. Universidade Nove de Julho; BrasilFrontiers Media2018-10info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/227941Shimojo, Guilherme Lemos; Da Silva Dias, Danielle; Malfitano, Christiane; Sanches, Iris Callado; Llesuy, Susana Francisca; et al.; Combined aerobic and resistance exercise training improve hypertension associated with menopause; Frontiers Media; Frontiers in Physiology; 9; 10-2018; 1-111664-042XCONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.frontiersin.org/journals/physiology/articles/10.3389/fphys.2018.01471/fullinfo:eu-repo/semantics/altIdentifier/doi/10.3389/fphys.2018.01471info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:17:36Zoai:ri.conicet.gov.ar:11336/227941instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:17:37.113CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Combined aerobic and resistance exercise training improve hypertension associated with menopause
title Combined aerobic and resistance exercise training improve hypertension associated with menopause
spellingShingle Combined aerobic and resistance exercise training improve hypertension associated with menopause
Shimojo, Guilherme Lemos
CARDIOVASCULAR AUTONOMIC DYSFUNCTION
COMBINED EXERCISE TRAINING
HYPERTENSION
INFLAMMATION
KIDNEY
OVARIECTOMY
OXIDATIVE STRESS
title_short Combined aerobic and resistance exercise training improve hypertension associated with menopause
title_full Combined aerobic and resistance exercise training improve hypertension associated with menopause
title_fullStr Combined aerobic and resistance exercise training improve hypertension associated with menopause
title_full_unstemmed Combined aerobic and resistance exercise training improve hypertension associated with menopause
title_sort Combined aerobic and resistance exercise training improve hypertension associated with menopause
dc.creator.none.fl_str_mv Shimojo, Guilherme Lemos
Da Silva Dias, Danielle
Malfitano, Christiane
Sanches, Iris Callado
Llesuy, Susana Francisca
Ulloa, Luis
Irigoyen, Maria Cläudia
De Angelis, Kätia
author Shimojo, Guilherme Lemos
author_facet Shimojo, Guilherme Lemos
Da Silva Dias, Danielle
Malfitano, Christiane
Sanches, Iris Callado
Llesuy, Susana Francisca
Ulloa, Luis
Irigoyen, Maria Cläudia
De Angelis, Kätia
author_role author
author2 Da Silva Dias, Danielle
Malfitano, Christiane
Sanches, Iris Callado
Llesuy, Susana Francisca
Ulloa, Luis
Irigoyen, Maria Cläudia
De Angelis, Kätia
author2_role author
author
author
author
author
author
author
dc.subject.none.fl_str_mv CARDIOVASCULAR AUTONOMIC DYSFUNCTION
COMBINED EXERCISE TRAINING
HYPERTENSION
INFLAMMATION
KIDNEY
OVARIECTOMY
OXIDATIVE STRESS
topic CARDIOVASCULAR AUTONOMIC DYSFUNCTION
COMBINED EXERCISE TRAINING
HYPERTENSION
INFLAMMATION
KIDNEY
OVARIECTOMY
OXIDATIVE STRESS
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv The prevalence of hypertension sharply increases in menopausal women. Recent studies have demonstrated that aerobic or resistance training may help control hypertension. In this study, we report that combining aerobic and resistance training may provide an effective therapeutic approach for hypertension control, attenuating inflammation and oxidative stress in ovariectomized rats. Female Wistar and spontaneous hypertensive rats (SHR) were distributed into four groups: sedentary control (C), sedentary hypertensive (HR), sedentary hypertensive ovariectomized (HR-O), and combined trained hypertensive ovariectomized (T-HR-O). Combined exercise training was performed on a motor treadmill (aerobic training) and on a ladder adapted to rats (resistance training), in alternate days for 8 weeks. Direct arterial pressure was recorded and oxidative stress and inflammation were evaluated in cardiac and renal tissue. Ovariectomy increases increased mean arterial blood pressure, sympathetic modulation, and oxidative stress in SHR. Combining aerobic and resistance training reduced mean arterial blood pressure (12% vs. HR-O), heart rate (8% vs. HR-O), vascular sympathetic modulation (40% vs. HR-O), and improved baroreflex sensitivity. Combined training reduced cardiac inflammation (TNF and IL-6) and cardiac and renal lipoperoxidation (59% and 57%, respectively vs. HR-O). It also enhanced cardiac (71%) and renal (76%) total antioxidant capacity when compared to HR-O group. In conclusion, combining aerobic and resistance training improves mean arterial blood pressure, cardiovascular autonomic control, preventing cardiac and renal oxidative stress and inflammation in an experimental hypertension model with surgical menopause induced with ovariectomy.
Fil: Shimojo, Guilherme Lemos. Universidade Nove de Julho; Brasil
Fil: Da Silva Dias, Danielle. Universidade Nove de Julho; Brasil
Fil: Malfitano, Christiane. Universidade Nove de Julho; Brasil
Fil: Sanches, Iris Callado. Universidade Sao Judas Tadeu; Brasil
Fil: Llesuy, Susana Francisca. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Bioquímica y Medicina Molecular. Universidad de Buenos Aires. Facultad Medicina. Instituto de Bioquímica y Medicina Molecular; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Química Analítica y Fisicoquímica. Cátedra de Química General e Inorgánica; Argentina
Fil: Ulloa, Luis. Rutgers University; Estados Unidos. Universidade Nove de Julho; Brasil
Fil: Irigoyen, Maria Cläudia. Universidade de Sao Paulo; Brasil
Fil: De Angelis, Kätia. Universidade Federal de Sao Paulo; Brasil. Universidade Nove de Julho; Brasil
description The prevalence of hypertension sharply increases in menopausal women. Recent studies have demonstrated that aerobic or resistance training may help control hypertension. In this study, we report that combining aerobic and resistance training may provide an effective therapeutic approach for hypertension control, attenuating inflammation and oxidative stress in ovariectomized rats. Female Wistar and spontaneous hypertensive rats (SHR) were distributed into four groups: sedentary control (C), sedentary hypertensive (HR), sedentary hypertensive ovariectomized (HR-O), and combined trained hypertensive ovariectomized (T-HR-O). Combined exercise training was performed on a motor treadmill (aerobic training) and on a ladder adapted to rats (resistance training), in alternate days for 8 weeks. Direct arterial pressure was recorded and oxidative stress and inflammation were evaluated in cardiac and renal tissue. Ovariectomy increases increased mean arterial blood pressure, sympathetic modulation, and oxidative stress in SHR. Combining aerobic and resistance training reduced mean arterial blood pressure (12% vs. HR-O), heart rate (8% vs. HR-O), vascular sympathetic modulation (40% vs. HR-O), and improved baroreflex sensitivity. Combined training reduced cardiac inflammation (TNF and IL-6) and cardiac and renal lipoperoxidation (59% and 57%, respectively vs. HR-O). It also enhanced cardiac (71%) and renal (76%) total antioxidant capacity when compared to HR-O group. In conclusion, combining aerobic and resistance training improves mean arterial blood pressure, cardiovascular autonomic control, preventing cardiac and renal oxidative stress and inflammation in an experimental hypertension model with surgical menopause induced with ovariectomy.
publishDate 2018
dc.date.none.fl_str_mv 2018-10
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/227941
Shimojo, Guilherme Lemos; Da Silva Dias, Danielle; Malfitano, Christiane; Sanches, Iris Callado; Llesuy, Susana Francisca; et al.; Combined aerobic and resistance exercise training improve hypertension associated with menopause; Frontiers Media; Frontiers in Physiology; 9; 10-2018; 1-11
1664-042X
CONICET Digital
CONICET
url http://hdl.handle.net/11336/227941
identifier_str_mv Shimojo, Guilherme Lemos; Da Silva Dias, Danielle; Malfitano, Christiane; Sanches, Iris Callado; Llesuy, Susana Francisca; et al.; Combined aerobic and resistance exercise training improve hypertension associated with menopause; Frontiers Media; Frontiers in Physiology; 9; 10-2018; 1-11
1664-042X
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.frontiersin.org/journals/physiology/articles/10.3389/fphys.2018.01471/full
info:eu-repo/semantics/altIdentifier/doi/10.3389/fphys.2018.01471
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Frontiers Media
publisher.none.fl_str_mv Frontiers Media
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
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instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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