Combined aerobic and resistance exercise training improve hypertension associated with menopause
- Autores
- Shimojo, Guilherme Lemos; Da Silva Dias, Danielle; Malfitano, Christiane; Sanches, Iris Callado; Llesuy, Susana Francisca; Ulloa, Luis; Irigoyen, Maria Cläudia; De Angelis, Kätia
- Año de publicación
- 2018
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- The prevalence of hypertension sharply increases in menopausal women. Recent studies have demonstrated that aerobic or resistance training may help control hypertension. In this study, we report that combining aerobic and resistance training may provide an effective therapeutic approach for hypertension control, attenuating inflammation and oxidative stress in ovariectomized rats. Female Wistar and spontaneous hypertensive rats (SHR) were distributed into four groups: sedentary control (C), sedentary hypertensive (HR), sedentary hypertensive ovariectomized (HR-O), and combined trained hypertensive ovariectomized (T-HR-O). Combined exercise training was performed on a motor treadmill (aerobic training) and on a ladder adapted to rats (resistance training), in alternate days for 8 weeks. Direct arterial pressure was recorded and oxidative stress and inflammation were evaluated in cardiac and renal tissue. Ovariectomy increases increased mean arterial blood pressure, sympathetic modulation, and oxidative stress in SHR. Combining aerobic and resistance training reduced mean arterial blood pressure (12% vs. HR-O), heart rate (8% vs. HR-O), vascular sympathetic modulation (40% vs. HR-O), and improved baroreflex sensitivity. Combined training reduced cardiac inflammation (TNF and IL-6) and cardiac and renal lipoperoxidation (59% and 57%, respectively vs. HR-O). It also enhanced cardiac (71%) and renal (76%) total antioxidant capacity when compared to HR-O group. In conclusion, combining aerobic and resistance training improves mean arterial blood pressure, cardiovascular autonomic control, preventing cardiac and renal oxidative stress and inflammation in an experimental hypertension model with surgical menopause induced with ovariectomy.
Fil: Shimojo, Guilherme Lemos. Universidade Nove de Julho; Brasil
Fil: Da Silva Dias, Danielle. Universidade Nove de Julho; Brasil
Fil: Malfitano, Christiane. Universidade Nove de Julho; Brasil
Fil: Sanches, Iris Callado. Universidade Sao Judas Tadeu; Brasil
Fil: Llesuy, Susana Francisca. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Bioquímica y Medicina Molecular. Universidad de Buenos Aires. Facultad Medicina. Instituto de Bioquímica y Medicina Molecular; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Química Analítica y Fisicoquímica. Cátedra de Química General e Inorgánica; Argentina
Fil: Ulloa, Luis. Rutgers University; Estados Unidos. Universidade Nove de Julho; Brasil
Fil: Irigoyen, Maria Cläudia. Universidade de Sao Paulo; Brasil
Fil: De Angelis, Kätia. Universidade Federal de Sao Paulo; Brasil. Universidade Nove de Julho; Brasil - Materia
-
CARDIOVASCULAR AUTONOMIC DYSFUNCTION
COMBINED EXERCISE TRAINING
HYPERTENSION
INFLAMMATION
KIDNEY
OVARIECTOMY
OXIDATIVE STRESS - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/227941
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CONICET Digital (CONICET) |
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Combined aerobic and resistance exercise training improve hypertension associated with menopauseShimojo, Guilherme LemosDa Silva Dias, DanielleMalfitano, ChristianeSanches, Iris CalladoLlesuy, Susana FranciscaUlloa, LuisIrigoyen, Maria CläudiaDe Angelis, KätiaCARDIOVASCULAR AUTONOMIC DYSFUNCTIONCOMBINED EXERCISE TRAININGHYPERTENSIONINFLAMMATIONKIDNEYOVARIECTOMYOXIDATIVE STRESShttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1The prevalence of hypertension sharply increases in menopausal women. Recent studies have demonstrated that aerobic or resistance training may help control hypertension. In this study, we report that combining aerobic and resistance training may provide an effective therapeutic approach for hypertension control, attenuating inflammation and oxidative stress in ovariectomized rats. Female Wistar and spontaneous hypertensive rats (SHR) were distributed into four groups: sedentary control (C), sedentary hypertensive (HR), sedentary hypertensive ovariectomized (HR-O), and combined trained hypertensive ovariectomized (T-HR-O). Combined exercise training was performed on a motor treadmill (aerobic training) and on a ladder adapted to rats (resistance training), in alternate days for 8 weeks. Direct arterial pressure was recorded and oxidative stress and inflammation were evaluated in cardiac and renal tissue. Ovariectomy increases increased mean arterial blood pressure, sympathetic modulation, and oxidative stress in SHR. Combining aerobic and resistance training reduced mean arterial blood pressure (12% vs. HR-O), heart rate (8% vs. HR-O), vascular sympathetic modulation (40% vs. HR-O), and improved baroreflex sensitivity. Combined training reduced cardiac inflammation (TNF and IL-6) and cardiac and renal lipoperoxidation (59% and 57%, respectively vs. HR-O). It also enhanced cardiac (71%) and renal (76%) total antioxidant capacity when compared to HR-O group. In conclusion, combining aerobic and resistance training improves mean arterial blood pressure, cardiovascular autonomic control, preventing cardiac and renal oxidative stress and inflammation in an experimental hypertension model with surgical menopause induced with ovariectomy.Fil: Shimojo, Guilherme Lemos. Universidade Nove de Julho; BrasilFil: Da Silva Dias, Danielle. Universidade Nove de Julho; BrasilFil: Malfitano, Christiane. Universidade Nove de Julho; BrasilFil: Sanches, Iris Callado. Universidade Sao Judas Tadeu; BrasilFil: Llesuy, Susana Francisca. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Bioquímica y Medicina Molecular. Universidad de Buenos Aires. Facultad Medicina. Instituto de Bioquímica y Medicina Molecular; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Química Analítica y Fisicoquímica. Cátedra de Química General e Inorgánica; ArgentinaFil: Ulloa, Luis. Rutgers University; Estados Unidos. Universidade Nove de Julho; BrasilFil: Irigoyen, Maria Cläudia. Universidade de Sao Paulo; BrasilFil: De Angelis, Kätia. Universidade Federal de Sao Paulo; Brasil. Universidade Nove de Julho; BrasilFrontiers Media2018-10info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/227941Shimojo, Guilherme Lemos; Da Silva Dias, Danielle; Malfitano, Christiane; Sanches, Iris Callado; Llesuy, Susana Francisca; et al.; Combined aerobic and resistance exercise training improve hypertension associated with menopause; Frontiers Media; Frontiers in Physiology; 9; 10-2018; 1-111664-042XCONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.frontiersin.org/journals/physiology/articles/10.3389/fphys.2018.01471/fullinfo:eu-repo/semantics/altIdentifier/doi/10.3389/fphys.2018.01471info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:17:36Zoai:ri.conicet.gov.ar:11336/227941instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:17:37.113CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
Combined aerobic and resistance exercise training improve hypertension associated with menopause |
title |
Combined aerobic and resistance exercise training improve hypertension associated with menopause |
spellingShingle |
Combined aerobic and resistance exercise training improve hypertension associated with menopause Shimojo, Guilherme Lemos CARDIOVASCULAR AUTONOMIC DYSFUNCTION COMBINED EXERCISE TRAINING HYPERTENSION INFLAMMATION KIDNEY OVARIECTOMY OXIDATIVE STRESS |
title_short |
Combined aerobic and resistance exercise training improve hypertension associated with menopause |
title_full |
Combined aerobic and resistance exercise training improve hypertension associated with menopause |
title_fullStr |
Combined aerobic and resistance exercise training improve hypertension associated with menopause |
title_full_unstemmed |
Combined aerobic and resistance exercise training improve hypertension associated with menopause |
title_sort |
Combined aerobic and resistance exercise training improve hypertension associated with menopause |
dc.creator.none.fl_str_mv |
Shimojo, Guilherme Lemos Da Silva Dias, Danielle Malfitano, Christiane Sanches, Iris Callado Llesuy, Susana Francisca Ulloa, Luis Irigoyen, Maria Cläudia De Angelis, Kätia |
author |
Shimojo, Guilherme Lemos |
author_facet |
Shimojo, Guilherme Lemos Da Silva Dias, Danielle Malfitano, Christiane Sanches, Iris Callado Llesuy, Susana Francisca Ulloa, Luis Irigoyen, Maria Cläudia De Angelis, Kätia |
author_role |
author |
author2 |
Da Silva Dias, Danielle Malfitano, Christiane Sanches, Iris Callado Llesuy, Susana Francisca Ulloa, Luis Irigoyen, Maria Cläudia De Angelis, Kätia |
author2_role |
author author author author author author author |
dc.subject.none.fl_str_mv |
CARDIOVASCULAR AUTONOMIC DYSFUNCTION COMBINED EXERCISE TRAINING HYPERTENSION INFLAMMATION KIDNEY OVARIECTOMY OXIDATIVE STRESS |
topic |
CARDIOVASCULAR AUTONOMIC DYSFUNCTION COMBINED EXERCISE TRAINING HYPERTENSION INFLAMMATION KIDNEY OVARIECTOMY OXIDATIVE STRESS |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/1.6 https://purl.org/becyt/ford/1 |
dc.description.none.fl_txt_mv |
The prevalence of hypertension sharply increases in menopausal women. Recent studies have demonstrated that aerobic or resistance training may help control hypertension. In this study, we report that combining aerobic and resistance training may provide an effective therapeutic approach for hypertension control, attenuating inflammation and oxidative stress in ovariectomized rats. Female Wistar and spontaneous hypertensive rats (SHR) were distributed into four groups: sedentary control (C), sedentary hypertensive (HR), sedentary hypertensive ovariectomized (HR-O), and combined trained hypertensive ovariectomized (T-HR-O). Combined exercise training was performed on a motor treadmill (aerobic training) and on a ladder adapted to rats (resistance training), in alternate days for 8 weeks. Direct arterial pressure was recorded and oxidative stress and inflammation were evaluated in cardiac and renal tissue. Ovariectomy increases increased mean arterial blood pressure, sympathetic modulation, and oxidative stress in SHR. Combining aerobic and resistance training reduced mean arterial blood pressure (12% vs. HR-O), heart rate (8% vs. HR-O), vascular sympathetic modulation (40% vs. HR-O), and improved baroreflex sensitivity. Combined training reduced cardiac inflammation (TNF and IL-6) and cardiac and renal lipoperoxidation (59% and 57%, respectively vs. HR-O). It also enhanced cardiac (71%) and renal (76%) total antioxidant capacity when compared to HR-O group. In conclusion, combining aerobic and resistance training improves mean arterial blood pressure, cardiovascular autonomic control, preventing cardiac and renal oxidative stress and inflammation in an experimental hypertension model with surgical menopause induced with ovariectomy. Fil: Shimojo, Guilherme Lemos. Universidade Nove de Julho; Brasil Fil: Da Silva Dias, Danielle. Universidade Nove de Julho; Brasil Fil: Malfitano, Christiane. Universidade Nove de Julho; Brasil Fil: Sanches, Iris Callado. Universidade Sao Judas Tadeu; Brasil Fil: Llesuy, Susana Francisca. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Bioquímica y Medicina Molecular. Universidad de Buenos Aires. Facultad Medicina. Instituto de Bioquímica y Medicina Molecular; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Química Analítica y Fisicoquímica. Cátedra de Química General e Inorgánica; Argentina Fil: Ulloa, Luis. Rutgers University; Estados Unidos. Universidade Nove de Julho; Brasil Fil: Irigoyen, Maria Cläudia. Universidade de Sao Paulo; Brasil Fil: De Angelis, Kätia. Universidade Federal de Sao Paulo; Brasil. Universidade Nove de Julho; Brasil |
description |
The prevalence of hypertension sharply increases in menopausal women. Recent studies have demonstrated that aerobic or resistance training may help control hypertension. In this study, we report that combining aerobic and resistance training may provide an effective therapeutic approach for hypertension control, attenuating inflammation and oxidative stress in ovariectomized rats. Female Wistar and spontaneous hypertensive rats (SHR) were distributed into four groups: sedentary control (C), sedentary hypertensive (HR), sedentary hypertensive ovariectomized (HR-O), and combined trained hypertensive ovariectomized (T-HR-O). Combined exercise training was performed on a motor treadmill (aerobic training) and on a ladder adapted to rats (resistance training), in alternate days for 8 weeks. Direct arterial pressure was recorded and oxidative stress and inflammation were evaluated in cardiac and renal tissue. Ovariectomy increases increased mean arterial blood pressure, sympathetic modulation, and oxidative stress in SHR. Combining aerobic and resistance training reduced mean arterial blood pressure (12% vs. HR-O), heart rate (8% vs. HR-O), vascular sympathetic modulation (40% vs. HR-O), and improved baroreflex sensitivity. Combined training reduced cardiac inflammation (TNF and IL-6) and cardiac and renal lipoperoxidation (59% and 57%, respectively vs. HR-O). It also enhanced cardiac (71%) and renal (76%) total antioxidant capacity when compared to HR-O group. In conclusion, combining aerobic and resistance training improves mean arterial blood pressure, cardiovascular autonomic control, preventing cardiac and renal oxidative stress and inflammation in an experimental hypertension model with surgical menopause induced with ovariectomy. |
publishDate |
2018 |
dc.date.none.fl_str_mv |
2018-10 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/227941 Shimojo, Guilherme Lemos; Da Silva Dias, Danielle; Malfitano, Christiane; Sanches, Iris Callado; Llesuy, Susana Francisca; et al.; Combined aerobic and resistance exercise training improve hypertension associated with menopause; Frontiers Media; Frontiers in Physiology; 9; 10-2018; 1-11 1664-042X CONICET Digital CONICET |
url |
http://hdl.handle.net/11336/227941 |
identifier_str_mv |
Shimojo, Guilherme Lemos; Da Silva Dias, Danielle; Malfitano, Christiane; Sanches, Iris Callado; Llesuy, Susana Francisca; et al.; Combined aerobic and resistance exercise training improve hypertension associated with menopause; Frontiers Media; Frontiers in Physiology; 9; 10-2018; 1-11 1664-042X CONICET Digital CONICET |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/url/https://www.frontiersin.org/journals/physiology/articles/10.3389/fphys.2018.01471/full info:eu-repo/semantics/altIdentifier/doi/10.3389/fphys.2018.01471 |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
Frontiers Media |
publisher.none.fl_str_mv |
Frontiers Media |
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reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
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CONICET Digital (CONICET) |
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CONICET Digital (CONICET) |
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Consejo Nacional de Investigaciones Científicas y Técnicas |
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CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
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13.070432 |