Nitrosylation: An adverse factor in Uremic Haemolytic Syndrome. Antitoxin effect of Ziziphus mistol Griseb

Autores
Aiassa, Virginia; Albrecht, Claudia; Bustos, Pamela Soledad; Ortega, María Gabriela; Eraso, Alberto Jorge; Albesa, Ines
Año de publicación
2013
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Toxins of Escherichia coli (STEC) causing Uremic Hemolytic Syndrome (UHS) generate oxidative stress in human blood with more production of nitric oxide (NO) than reactive oxygen species (ROS). Shiga toxin (Stx) together with the hemolysin (Hly) increased lipid oxidation, as evaluated by malondialdehyde MDA and oxidation of proteins. The addition of Ziziphus mistol Griseb extracts decreased NO, ROS, MDA and simultaneously caused an increase in the degradation of oxidized proteins to advanced oxidation protein products (AOPPs) in controls and samples with toxins. Furthermore, the nitrosylated proteins/AOPP ratio was reduced, due to the increase of AOPP. Z. mistol Griseb extracts exhibited a high proportion of polyphenols and flavonoids, with evident correlation with ferrous reduction antioxidant potential (FRAP). The plasma of eight children with UHS showed oxidative stress and NO stimulus, comparable to the effect of toxins during the assays in vitro. UHS children presented high levels of nitrosylated proteins respect to control children of similar age. Although the degradation of oxidized proteins to AOPP rose in UHS children,the nitrosylated proteins/AOPP rate increased as a consequence of the elevated nitrosative stress observed in these patients.
Fil: Aiassa, Virginia. Universidad Nacional de Cordoba. Facultad de Ciencias Quimicas. Departamento de Farmacia; Argentina
Fil: Albrecht, Claudia. Universidad Nacional de Cordoba. Facultad de Ciencias Medicas. Escuela de Nutricion; Argentina
Fil: Bustos, Pamela Soledad. Universidad Nacional de Cordoba. Facultad de Ciencias Quimicas. Departamento de Farmacia; Argentina
Fil: Ortega, María Gabriela. Universidad Nacional de Cordoba. Facultad de Ciencias Quimicas. Departamento de Farmacia; Argentina
Fil: Eraso, Alberto Jorge. Universidad Nacional de Cordoba. Facultad de Ciencias Medicas. Escuela de Nutricion; Argentina
Fil: Albesa, Ines. Universidad Nacional de Cordoba. Facultad de Ciencias Quimicas. Departamento de Farmacia; Argentina
Materia
Uremic Hemolytic Syndrome
Escherichia Coli
Ziziphus Mistol Griseb
Nitrosylation
Oxidative Stress
Advanced Oxidation Protein Products
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/11161
Acceder
id CONICETDig_f1b028ceb66ce9ee078f35e34f193296
oai_identifier_str oai:ri.conicet.gov.ar:11336/11161
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Nitrosylation: An adverse factor in Uremic Haemolytic Syndrome. Antitoxin effect of Ziziphus mistol GrisebAiassa, VirginiaAlbrecht, ClaudiaBustos, Pamela SoledadOrtega, María GabrielaEraso, Alberto JorgeAlbesa, InesUremic Hemolytic SyndromeEscherichia ColiZiziphus Mistol GrisebNitrosylationOxidative StressAdvanced Oxidation Protein Productshttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3Toxins of Escherichia coli (STEC) causing Uremic Hemolytic Syndrome (UHS) generate oxidative stress in human blood with more production of nitric oxide (NO) than reactive oxygen species (ROS). Shiga toxin (Stx) together with the hemolysin (Hly) increased lipid oxidation, as evaluated by malondialdehyde MDA and oxidation of proteins. The addition of Ziziphus mistol Griseb extracts decreased NO, ROS, MDA and simultaneously caused an increase in the degradation of oxidized proteins to advanced oxidation protein products (AOPPs) in controls and samples with toxins. Furthermore, the nitrosylated proteins/AOPP ratio was reduced, due to the increase of AOPP. Z. mistol Griseb extracts exhibited a high proportion of polyphenols and flavonoids, with evident correlation with ferrous reduction antioxidant potential (FRAP). The plasma of eight children with UHS showed oxidative stress and NO stimulus, comparable to the effect of toxins during the assays in vitro. UHS children presented high levels of nitrosylated proteins respect to control children of similar age. Although the degradation of oxidized proteins to AOPP rose in UHS children,the nitrosylated proteins/AOPP rate increased as a consequence of the elevated nitrosative stress observed in these patients.Fil: Aiassa, Virginia. Universidad Nacional de Cordoba. Facultad de Ciencias Quimicas. Departamento de Farmacia; ArgentinaFil: Albrecht, Claudia. Universidad Nacional de Cordoba. Facultad de Ciencias Medicas. Escuela de Nutricion; ArgentinaFil: Bustos, Pamela Soledad. Universidad Nacional de Cordoba. Facultad de Ciencias Quimicas. Departamento de Farmacia; ArgentinaFil: Ortega, María Gabriela. Universidad Nacional de Cordoba. Facultad de Ciencias Quimicas. Departamento de Farmacia; ArgentinaFil: Eraso, Alberto Jorge. Universidad Nacional de Cordoba. Facultad de Ciencias Medicas. Escuela de Nutricion; ArgentinaFil: Albesa, Ines. Universidad Nacional de Cordoba. Facultad de Ciencias Quimicas. Departamento de Farmacia; ArgentinaElsevier2013-02info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/11161Aiassa, Virginia; Albrecht, Claudia; Bustos, Pamela Soledad; Ortega, María Gabriela; Eraso, Alberto Jorge; et al.; Nitrosylation: An adverse factor in Uremic Haemolytic Syndrome. Antitoxin effect of Ziziphus mistol Griseb; Elsevier; Food And Chemical Toxicology; 56; 2-2013; 381-3860278-6915enginfo:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0278691513001452info:eu-repo/semantics/altIdentifier/doi/10.1016/j.fct.2013.02.036info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:52:39Zoai:ri.conicet.gov.ar:11336/11161instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:52:39.297CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Nitrosylation: An adverse factor in Uremic Haemolytic Syndrome. Antitoxin effect of Ziziphus mistol Griseb
title Nitrosylation: An adverse factor in Uremic Haemolytic Syndrome. Antitoxin effect of Ziziphus mistol Griseb
spellingShingle Nitrosylation: An adverse factor in Uremic Haemolytic Syndrome. Antitoxin effect of Ziziphus mistol Griseb
Aiassa, Virginia
Uremic Hemolytic Syndrome
Escherichia Coli
Ziziphus Mistol Griseb
Nitrosylation
Oxidative Stress
Advanced Oxidation Protein Products
title_short Nitrosylation: An adverse factor in Uremic Haemolytic Syndrome. Antitoxin effect of Ziziphus mistol Griseb
title_full Nitrosylation: An adverse factor in Uremic Haemolytic Syndrome. Antitoxin effect of Ziziphus mistol Griseb
title_fullStr Nitrosylation: An adverse factor in Uremic Haemolytic Syndrome. Antitoxin effect of Ziziphus mistol Griseb
title_full_unstemmed Nitrosylation: An adverse factor in Uremic Haemolytic Syndrome. Antitoxin effect of Ziziphus mistol Griseb
title_sort Nitrosylation: An adverse factor in Uremic Haemolytic Syndrome. Antitoxin effect of Ziziphus mistol Griseb
dc.creator.none.fl_str_mv Aiassa, Virginia
Albrecht, Claudia
Bustos, Pamela Soledad
Ortega, María Gabriela
Eraso, Alberto Jorge
Albesa, Ines
author Aiassa, Virginia
author_facet Aiassa, Virginia
Albrecht, Claudia
Bustos, Pamela Soledad
Ortega, María Gabriela
Eraso, Alberto Jorge
Albesa, Ines
author_role author
author2 Albrecht, Claudia
Bustos, Pamela Soledad
Ortega, María Gabriela
Eraso, Alberto Jorge
Albesa, Ines
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv Uremic Hemolytic Syndrome
Escherichia Coli
Ziziphus Mistol Griseb
Nitrosylation
Oxidative Stress
Advanced Oxidation Protein Products
topic Uremic Hemolytic Syndrome
Escherichia Coli
Ziziphus Mistol Griseb
Nitrosylation
Oxidative Stress
Advanced Oxidation Protein Products
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Toxins of Escherichia coli (STEC) causing Uremic Hemolytic Syndrome (UHS) generate oxidative stress in human blood with more production of nitric oxide (NO) than reactive oxygen species (ROS). Shiga toxin (Stx) together with the hemolysin (Hly) increased lipid oxidation, as evaluated by malondialdehyde MDA and oxidation of proteins. The addition of Ziziphus mistol Griseb extracts decreased NO, ROS, MDA and simultaneously caused an increase in the degradation of oxidized proteins to advanced oxidation protein products (AOPPs) in controls and samples with toxins. Furthermore, the nitrosylated proteins/AOPP ratio was reduced, due to the increase of AOPP. Z. mistol Griseb extracts exhibited a high proportion of polyphenols and flavonoids, with evident correlation with ferrous reduction antioxidant potential (FRAP). The plasma of eight children with UHS showed oxidative stress and NO stimulus, comparable to the effect of toxins during the assays in vitro. UHS children presented high levels of nitrosylated proteins respect to control children of similar age. Although the degradation of oxidized proteins to AOPP rose in UHS children,the nitrosylated proteins/AOPP rate increased as a consequence of the elevated nitrosative stress observed in these patients.
Fil: Aiassa, Virginia. Universidad Nacional de Cordoba. Facultad de Ciencias Quimicas. Departamento de Farmacia; Argentina
Fil: Albrecht, Claudia. Universidad Nacional de Cordoba. Facultad de Ciencias Medicas. Escuela de Nutricion; Argentina
Fil: Bustos, Pamela Soledad. Universidad Nacional de Cordoba. Facultad de Ciencias Quimicas. Departamento de Farmacia; Argentina
Fil: Ortega, María Gabriela. Universidad Nacional de Cordoba. Facultad de Ciencias Quimicas. Departamento de Farmacia; Argentina
Fil: Eraso, Alberto Jorge. Universidad Nacional de Cordoba. Facultad de Ciencias Medicas. Escuela de Nutricion; Argentina
Fil: Albesa, Ines. Universidad Nacional de Cordoba. Facultad de Ciencias Quimicas. Departamento de Farmacia; Argentina
description Toxins of Escherichia coli (STEC) causing Uremic Hemolytic Syndrome (UHS) generate oxidative stress in human blood with more production of nitric oxide (NO) than reactive oxygen species (ROS). Shiga toxin (Stx) together with the hemolysin (Hly) increased lipid oxidation, as evaluated by malondialdehyde MDA and oxidation of proteins. The addition of Ziziphus mistol Griseb extracts decreased NO, ROS, MDA and simultaneously caused an increase in the degradation of oxidized proteins to advanced oxidation protein products (AOPPs) in controls and samples with toxins. Furthermore, the nitrosylated proteins/AOPP ratio was reduced, due to the increase of AOPP. Z. mistol Griseb extracts exhibited a high proportion of polyphenols and flavonoids, with evident correlation with ferrous reduction antioxidant potential (FRAP). The plasma of eight children with UHS showed oxidative stress and NO stimulus, comparable to the effect of toxins during the assays in vitro. UHS children presented high levels of nitrosylated proteins respect to control children of similar age. Although the degradation of oxidized proteins to AOPP rose in UHS children,the nitrosylated proteins/AOPP rate increased as a consequence of the elevated nitrosative stress observed in these patients.
publishDate 2013
dc.date.none.fl_str_mv 2013-02
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/11161
Aiassa, Virginia; Albrecht, Claudia; Bustos, Pamela Soledad; Ortega, María Gabriela; Eraso, Alberto Jorge; et al.; Nitrosylation: An adverse factor in Uremic Haemolytic Syndrome. Antitoxin effect of Ziziphus mistol Griseb; Elsevier; Food And Chemical Toxicology; 56; 2-2013; 381-386
0278-6915
url http://hdl.handle.net/11336/11161
identifier_str_mv Aiassa, Virginia; Albrecht, Claudia; Bustos, Pamela Soledad; Ortega, María Gabriela; Eraso, Alberto Jorge; et al.; Nitrosylation: An adverse factor in Uremic Haemolytic Syndrome. Antitoxin effect of Ziziphus mistol Griseb; Elsevier; Food And Chemical Toxicology; 56; 2-2013; 381-386
0278-6915
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0278691513001452
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.fct.2013.02.036
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.13397

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