Antioxidant and anti-inflammatory activity characterization and genotoxicity evaluation of Ziziphus mistol ripe berries, exotic Argentinean fruit

Autores
Cardozo, María Luz; Ordóñez, Roxana Mabel; Alberto, Maria Rosa; Zampini, Iris Catiana; Isla, Maria Ines
Año de publicación
2011
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Ziziphus mistol Griseb. (Rhamnaceae), popularly known as 'mistol' is widely distributed throughout Perú, Bolivia, Paraguay and Argentina. Its fruit is consumed in different forms in several Argentinean communities. The aim of this work is to quantify Z. mistol fruit macronutrients and phytochemicals as well as to determine its functional antioxidant and anti-inflammatory properties and toxicity after two different processes: boiling and hydroalcoholic extraction. Phytochemical recovery was variable depending on the extraction method used. All preparations showed antioxidant activity, but the ethanolic one (EME) was significantly more active than the aqueous one (AME) as hydrogen or electron donors with SC50 values between 1.45 to 6.31 μg GAE/mL and 7.38 to 64.77 μg GAE/mL, respectively. The aqueous extraction was significantly more active than EME on superoxide and hydroxyl radical scavenging. Polyphenols showed a dose?response relationship (R2 > 0.90) with antioxidant capacity in the decoction and the alcoholic beverage. The maceration showed an inhibitory effect on lipoxygenase (LOX) activity with an inhibitory concentration (IC50) value of 183.80 μg gallic acid equivalents (GAE)/mL but the decoction did not. On the other hand, extracts did not show any mutagenic effect. Therefore, mistol fruits consumption could be encouraged not only for its functional properties, but also because of the positive ecological impact of preserving biological diversity through the exploitation of native natural resources in a regional economy.
Fil: Cardozo, María Luz. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto de Química del Noroeste. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia. Instituto de Química del Noroeste; Argentina. Universidad Nacional de Tucumán. Facultad de Ciencias Naturales e Instituto Miguel Lillo; Argentina
Fil: Ordóñez, Roxana Mabel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto de Química del Noroeste. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia. Instituto de Química del Noroeste; Argentina. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia; Argentina. Universidad Nacional de Tucumán. Facultad de Ciencias Naturales e Instituto Miguel Lillo; Argentina. Fundación Miguel Lillo; Argentina
Fil: Alberto, Maria Rosa. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto de Química del Noroeste. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia. Instituto de Química del Noroeste; Argentina. Fundación Miguel Lillo; Argentina
Fil: Zampini, Iris Catiana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto de Química del Noroeste. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia. Instituto de Química del Noroeste; Argentina. Universidad Nacional de Tucumán. Facultad de Ciencias Naturales e Instituto Miguel Lillo; Argentina. Fundación Miguel Lillo; Argentina
Fil: Isla, Maria Ines. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto de Química del Noroeste. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia. Instituto de Química del Noroeste; Argentina. Universidad Nacional de Tucumán. Facultad de Ciencias Naturales e Instituto Miguel Lillo; Argentina. Fundación Miguel Lillo; Argentina
Materia
Biological Activity
Genotoxicity
Ziziphus Mistol
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/51929
Acceder
id CONICETDig_4f70439e189acfca916b94b2587a7939
oai_identifier_str oai:ri.conicet.gov.ar:11336/51929
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Antioxidant and anti-inflammatory activity characterization and genotoxicity evaluation of Ziziphus mistol ripe berries, exotic Argentinean fruitCardozo, María LuzOrdóñez, Roxana MabelAlberto, Maria RosaZampini, Iris CatianaIsla, Maria InesBiological ActivityGenotoxicityZiziphus Mistolhttps://purl.org/becyt/ford/2.11https://purl.org/becyt/ford/2Ziziphus mistol Griseb. (Rhamnaceae), popularly known as 'mistol' is widely distributed throughout Perú, Bolivia, Paraguay and Argentina. Its fruit is consumed in different forms in several Argentinean communities. The aim of this work is to quantify Z. mistol fruit macronutrients and phytochemicals as well as to determine its functional antioxidant and anti-inflammatory properties and toxicity after two different processes: boiling and hydroalcoholic extraction. Phytochemical recovery was variable depending on the extraction method used. All preparations showed antioxidant activity, but the ethanolic one (EME) was significantly more active than the aqueous one (AME) as hydrogen or electron donors with SC50 values between 1.45 to 6.31 μg GAE/mL and 7.38 to 64.77 μg GAE/mL, respectively. The aqueous extraction was significantly more active than EME on superoxide and hydroxyl radical scavenging. Polyphenols showed a dose?response relationship (R2 > 0.90) with antioxidant capacity in the decoction and the alcoholic beverage. The maceration showed an inhibitory effect on lipoxygenase (LOX) activity with an inhibitory concentration (IC50) value of 183.80 μg gallic acid equivalents (GAE)/mL but the decoction did not. On the other hand, extracts did not show any mutagenic effect. Therefore, mistol fruits consumption could be encouraged not only for its functional properties, but also because of the positive ecological impact of preserving biological diversity through the exploitation of native natural resources in a regional economy.Fil: Cardozo, María Luz. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto de Química del Noroeste. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia. Instituto de Química del Noroeste; Argentina. Universidad Nacional de Tucumán. Facultad de Ciencias Naturales e Instituto Miguel Lillo; ArgentinaFil: Ordóñez, Roxana Mabel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto de Química del Noroeste. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia. Instituto de Química del Noroeste; Argentina. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia; Argentina. Universidad Nacional de Tucumán. Facultad de Ciencias Naturales e Instituto Miguel Lillo; Argentina. Fundación Miguel Lillo; ArgentinaFil: Alberto, Maria Rosa. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto de Química del Noroeste. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia. Instituto de Química del Noroeste; Argentina. Fundación Miguel Lillo; ArgentinaFil: Zampini, Iris Catiana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto de Química del Noroeste. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia. Instituto de Química del Noroeste; Argentina. Universidad Nacional de Tucumán. Facultad de Ciencias Naturales e Instituto Miguel Lillo; Argentina. Fundación Miguel Lillo; ArgentinaFil: Isla, Maria Ines. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto de Química del Noroeste. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia. Instituto de Química del Noroeste; Argentina. Universidad Nacional de Tucumán. Facultad de Ciencias Naturales e Instituto Miguel Lillo; Argentina. Fundación Miguel Lillo; ArgentinaElsevier Science2011-08info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/mswordapplication/pdfhttp://hdl.handle.net/11336/51929Cardozo, María Luz; Ordóñez, Roxana Mabel; Alberto, Maria Rosa; Zampini, Iris Catiana; Isla, Maria Ines; Antioxidant and anti-inflammatory activity characterization and genotoxicity evaluation of Ziziphus mistol ripe berries, exotic Argentinean fruit; Elsevier Science; Food Research International; 44; 7; 8-2011; 2063-20710963-9969CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.foodres.2011.02.040info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0963996911001426info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:29:42Zoai:ri.conicet.gov.ar:11336/51929instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:29:43.159CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Antioxidant and anti-inflammatory activity characterization and genotoxicity evaluation of Ziziphus mistol ripe berries, exotic Argentinean fruit
title Antioxidant and anti-inflammatory activity characterization and genotoxicity evaluation of Ziziphus mistol ripe berries, exotic Argentinean fruit
spellingShingle Antioxidant and anti-inflammatory activity characterization and genotoxicity evaluation of Ziziphus mistol ripe berries, exotic Argentinean fruit
Cardozo, María Luz
Biological Activity
Genotoxicity
Ziziphus Mistol
title_short Antioxidant and anti-inflammatory activity characterization and genotoxicity evaluation of Ziziphus mistol ripe berries, exotic Argentinean fruit
title_full Antioxidant and anti-inflammatory activity characterization and genotoxicity evaluation of Ziziphus mistol ripe berries, exotic Argentinean fruit
title_fullStr Antioxidant and anti-inflammatory activity characterization and genotoxicity evaluation of Ziziphus mistol ripe berries, exotic Argentinean fruit
title_full_unstemmed Antioxidant and anti-inflammatory activity characterization and genotoxicity evaluation of Ziziphus mistol ripe berries, exotic Argentinean fruit
title_sort Antioxidant and anti-inflammatory activity characterization and genotoxicity evaluation of Ziziphus mistol ripe berries, exotic Argentinean fruit
dc.creator.none.fl_str_mv Cardozo, María Luz
Ordóñez, Roxana Mabel
Alberto, Maria Rosa
Zampini, Iris Catiana
Isla, Maria Ines
author Cardozo, María Luz
author_facet Cardozo, María Luz
Ordóñez, Roxana Mabel
Alberto, Maria Rosa
Zampini, Iris Catiana
Isla, Maria Ines
author_role author
author2 Ordóñez, Roxana Mabel
Alberto, Maria Rosa
Zampini, Iris Catiana
Isla, Maria Ines
author2_role author
author
author
author
dc.subject.none.fl_str_mv Biological Activity
Genotoxicity
Ziziphus Mistol
topic Biological Activity
Genotoxicity
Ziziphus Mistol
purl_subject.fl_str_mv https://purl.org/becyt/ford/2.11
https://purl.org/becyt/ford/2
dc.description.none.fl_txt_mv Ziziphus mistol Griseb. (Rhamnaceae), popularly known as 'mistol' is widely distributed throughout Perú, Bolivia, Paraguay and Argentina. Its fruit is consumed in different forms in several Argentinean communities. The aim of this work is to quantify Z. mistol fruit macronutrients and phytochemicals as well as to determine its functional antioxidant and anti-inflammatory properties and toxicity after two different processes: boiling and hydroalcoholic extraction. Phytochemical recovery was variable depending on the extraction method used. All preparations showed antioxidant activity, but the ethanolic one (EME) was significantly more active than the aqueous one (AME) as hydrogen or electron donors with SC50 values between 1.45 to 6.31 μg GAE/mL and 7.38 to 64.77 μg GAE/mL, respectively. The aqueous extraction was significantly more active than EME on superoxide and hydroxyl radical scavenging. Polyphenols showed a dose?response relationship (R2 > 0.90) with antioxidant capacity in the decoction and the alcoholic beverage. The maceration showed an inhibitory effect on lipoxygenase (LOX) activity with an inhibitory concentration (IC50) value of 183.80 μg gallic acid equivalents (GAE)/mL but the decoction did not. On the other hand, extracts did not show any mutagenic effect. Therefore, mistol fruits consumption could be encouraged not only for its functional properties, but also because of the positive ecological impact of preserving biological diversity through the exploitation of native natural resources in a regional economy.
Fil: Cardozo, María Luz. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto de Química del Noroeste. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia. Instituto de Química del Noroeste; Argentina. Universidad Nacional de Tucumán. Facultad de Ciencias Naturales e Instituto Miguel Lillo; Argentina
Fil: Ordóñez, Roxana Mabel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto de Química del Noroeste. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia. Instituto de Química del Noroeste; Argentina. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia; Argentina. Universidad Nacional de Tucumán. Facultad de Ciencias Naturales e Instituto Miguel Lillo; Argentina. Fundación Miguel Lillo; Argentina
Fil: Alberto, Maria Rosa. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto de Química del Noroeste. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia. Instituto de Química del Noroeste; Argentina. Fundación Miguel Lillo; Argentina
Fil: Zampini, Iris Catiana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto de Química del Noroeste. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia. Instituto de Química del Noroeste; Argentina. Universidad Nacional de Tucumán. Facultad de Ciencias Naturales e Instituto Miguel Lillo; Argentina. Fundación Miguel Lillo; Argentina
Fil: Isla, Maria Ines. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto de Química del Noroeste. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia. Instituto de Química del Noroeste; Argentina. Universidad Nacional de Tucumán. Facultad de Ciencias Naturales e Instituto Miguel Lillo; Argentina. Fundación Miguel Lillo; Argentina
description Ziziphus mistol Griseb. (Rhamnaceae), popularly known as 'mistol' is widely distributed throughout Perú, Bolivia, Paraguay and Argentina. Its fruit is consumed in different forms in several Argentinean communities. The aim of this work is to quantify Z. mistol fruit macronutrients and phytochemicals as well as to determine its functional antioxidant and anti-inflammatory properties and toxicity after two different processes: boiling and hydroalcoholic extraction. Phytochemical recovery was variable depending on the extraction method used. All preparations showed antioxidant activity, but the ethanolic one (EME) was significantly more active than the aqueous one (AME) as hydrogen or electron donors with SC50 values between 1.45 to 6.31 μg GAE/mL and 7.38 to 64.77 μg GAE/mL, respectively. The aqueous extraction was significantly more active than EME on superoxide and hydroxyl radical scavenging. Polyphenols showed a dose?response relationship (R2 > 0.90) with antioxidant capacity in the decoction and the alcoholic beverage. The maceration showed an inhibitory effect on lipoxygenase (LOX) activity with an inhibitory concentration (IC50) value of 183.80 μg gallic acid equivalents (GAE)/mL but the decoction did not. On the other hand, extracts did not show any mutagenic effect. Therefore, mistol fruits consumption could be encouraged not only for its functional properties, but also because of the positive ecological impact of preserving biological diversity through the exploitation of native natural resources in a regional economy.
publishDate 2011
dc.date.none.fl_str_mv 2011-08
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/51929
Cardozo, María Luz; Ordóñez, Roxana Mabel; Alberto, Maria Rosa; Zampini, Iris Catiana; Isla, Maria Ines; Antioxidant and anti-inflammatory activity characterization and genotoxicity evaluation of Ziziphus mistol ripe berries, exotic Argentinean fruit; Elsevier Science; Food Research International; 44; 7; 8-2011; 2063-2071
0963-9969
CONICET Digital
CONICET
url http://hdl.handle.net/11336/51929
identifier_str_mv Cardozo, María Luz; Ordóñez, Roxana Mabel; Alberto, Maria Rosa; Zampini, Iris Catiana; Isla, Maria Ines; Antioxidant and anti-inflammatory activity characterization and genotoxicity evaluation of Ziziphus mistol ripe berries, exotic Argentinean fruit; Elsevier Science; Food Research International; 44; 7; 8-2011; 2063-2071
0963-9969
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1016/j.foodres.2011.02.040
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0963996911001426
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/msword
application/pdf
dc.publisher.none.fl_str_mv Elsevier Science
publisher.none.fl_str_mv Elsevier Science
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1844614303998541824
score 13.069144

Publicaciones similares