Antinociceptive, anti-inflammatory effects and safety of Ziziphus mistol fruits
- Autores
- Reynoso, Marcos Adrian; Daud, Adriana del Valle; Belizán, María Melina Eleonora; Sánchez Riera, Alvaro; Vera, Nancy Roxana
- Año de publicación
- 2016
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Ziziphus mistol Griseb. (Rhamnaceae), popularly known as ?mistol,? is widely distributed throughout Perú, Bolivia, Paraguay and Argentina. Its fruit is consumed in different forms in several argentinean communities. The present study was carried out to investigate the medicinal properties and safety of Ziziphus mistol (mistol) fruits ethanol and aqueous extracts and arrope. Antinociceptive activity was assessed using the formalin, acetic acid-induced writhing and tail-flick tests in rats. Anti-inflammatory effects were determinated through carrageenan induced edema test and cotton pellet-induced granuloma formation, in rats. The safety was evaluated with test of acute toxicity (48 hs) and sub-chronic toxicity (91 days).All extracts (1,000 mg / kg body weight) showed significant inhibition (P <0.05) in the pain and inflammation experimentally induced. In the acute toxicity study, a single dose of 4000 and 8000 mg/kg b.w., produced no mortality and no clinical signs of disease were observed after 48 h. In the sub-chronic toxicity study the extracts no caused significant visible signs of toxicity, nor mortality for 91 consecutive days of treatment. No significant differences were found in relative organ weights and hematological and biochemical parameters between the treated groups and the control groups. Aqueous extract and arrope of Z. mistol fruits could be good source of antinociceptive and anti-inflamatory agents because of its good activity and safety.
Fil: Reynoso, Marcos Adrian. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia. Instituto de Biología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán; Argentina
Fil: Daud, Adriana del Valle. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia. Instituto de Biología; Argentina
Fil: Belizán, María Melina Eleonora. Universidad Nacional de Tucuman. Facultad de Bioquímica, Química y Farmacia. Instituto de Farmacia. Cátedra de Farmacoquímica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán; Argentina
Fil: Sánchez Riera, Alvaro. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia. Instituto de Biología; Argentina
Fil: Vera, Nancy Roxana. Universidad Nacional de Tucuman. Facultad de Bioquímica, Química y Farmacia. Instituto de Farmacia. Cátedra de Farmacoquímica; Argentina - Materia
-
ANTINOCICEPTIVE
ANTIINFLAMMATORY
ZIZIPHUS MISTOL
SAFETY - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/108176
Ver los metadatos del registro completo
id |
CONICETDig_3cf50adae17b0b8abdf6f4abf2a8bec8 |
---|---|
oai_identifier_str |
oai:ri.conicet.gov.ar:11336/108176 |
network_acronym_str |
CONICETDig |
repository_id_str |
3498 |
network_name_str |
CONICET Digital (CONICET) |
spelling |
Antinociceptive, anti-inflammatory effects and safety of Ziziphus mistol fruitsReynoso, Marcos AdrianDaud, Adriana del ValleBelizán, María Melina EleonoraSánchez Riera, AlvaroVera, Nancy RoxanaANTINOCICEPTIVEANTIINFLAMMATORYZIZIPHUS MISTOLSAFETYhttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Ziziphus mistol Griseb. (Rhamnaceae), popularly known as ?mistol,? is widely distributed throughout Perú, Bolivia, Paraguay and Argentina. Its fruit is consumed in different forms in several argentinean communities. The present study was carried out to investigate the medicinal properties and safety of Ziziphus mistol (mistol) fruits ethanol and aqueous extracts and arrope. Antinociceptive activity was assessed using the formalin, acetic acid-induced writhing and tail-flick tests in rats. Anti-inflammatory effects were determinated through carrageenan induced edema test and cotton pellet-induced granuloma formation, in rats. The safety was evaluated with test of acute toxicity (48 hs) and sub-chronic toxicity (91 days).All extracts (1,000 mg / kg body weight) showed significant inhibition (P <0.05) in the pain and inflammation experimentally induced. In the acute toxicity study, a single dose of 4000 and 8000 mg/kg b.w., produced no mortality and no clinical signs of disease were observed after 48 h. In the sub-chronic toxicity study the extracts no caused significant visible signs of toxicity, nor mortality for 91 consecutive days of treatment. No significant differences were found in relative organ weights and hematological and biochemical parameters between the treated groups and the control groups. Aqueous extract and arrope of Z. mistol fruits could be good source of antinociceptive and anti-inflamatory agents because of its good activity and safety.Fil: Reynoso, Marcos Adrian. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia. Instituto de Biología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán; ArgentinaFil: Daud, Adriana del Valle. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia. Instituto de Biología; ArgentinaFil: Belizán, María Melina Eleonora. Universidad Nacional de Tucuman. Facultad de Bioquímica, Química y Farmacia. Instituto de Farmacia. Cátedra de Farmacoquímica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán; ArgentinaFil: Sánchez Riera, Alvaro. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia. Instituto de Biología; ArgentinaFil: Vera, Nancy Roxana. Universidad Nacional de Tucuman. Facultad de Bioquímica, Química y Farmacia. Instituto de Farmacia. Cátedra de Farmacoquímica; ArgentinaInternational Journal of Pharmaceutical Sciences and Drug Research2016-03info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/108176Reynoso, Marcos Adrian; Daud, Adriana del Valle; Belizán, María Melina Eleonora; Sánchez Riera, Alvaro; Vera, Nancy Roxana; Antinociceptive, anti-inflammatory effects and safety of Ziziphus mistol fruits; International Journal of Pharmaceutical Sciences and Drug Research ; International Journal of Pharmaceutical Sciences and Drug Research ; 8; 2; 3-2016; 103-1100975-248XCONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://ijpsdr.com/index.php/ijpsdr/article/download/499/457info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:40:37Zoai:ri.conicet.gov.ar:11336/108176instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:40:37.403CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
Antinociceptive, anti-inflammatory effects and safety of Ziziphus mistol fruits |
title |
Antinociceptive, anti-inflammatory effects and safety of Ziziphus mistol fruits |
spellingShingle |
Antinociceptive, anti-inflammatory effects and safety of Ziziphus mistol fruits Reynoso, Marcos Adrian ANTINOCICEPTIVE ANTIINFLAMMATORY ZIZIPHUS MISTOL SAFETY |
title_short |
Antinociceptive, anti-inflammatory effects and safety of Ziziphus mistol fruits |
title_full |
Antinociceptive, anti-inflammatory effects and safety of Ziziphus mistol fruits |
title_fullStr |
Antinociceptive, anti-inflammatory effects and safety of Ziziphus mistol fruits |
title_full_unstemmed |
Antinociceptive, anti-inflammatory effects and safety of Ziziphus mistol fruits |
title_sort |
Antinociceptive, anti-inflammatory effects and safety of Ziziphus mistol fruits |
dc.creator.none.fl_str_mv |
Reynoso, Marcos Adrian Daud, Adriana del Valle Belizán, María Melina Eleonora Sánchez Riera, Alvaro Vera, Nancy Roxana |
author |
Reynoso, Marcos Adrian |
author_facet |
Reynoso, Marcos Adrian Daud, Adriana del Valle Belizán, María Melina Eleonora Sánchez Riera, Alvaro Vera, Nancy Roxana |
author_role |
author |
author2 |
Daud, Adriana del Valle Belizán, María Melina Eleonora Sánchez Riera, Alvaro Vera, Nancy Roxana |
author2_role |
author author author author |
dc.subject.none.fl_str_mv |
ANTINOCICEPTIVE ANTIINFLAMMATORY ZIZIPHUS MISTOL SAFETY |
topic |
ANTINOCICEPTIVE ANTIINFLAMMATORY ZIZIPHUS MISTOL SAFETY |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/1.6 https://purl.org/becyt/ford/1 |
dc.description.none.fl_txt_mv |
Ziziphus mistol Griseb. (Rhamnaceae), popularly known as ?mistol,? is widely distributed throughout Perú, Bolivia, Paraguay and Argentina. Its fruit is consumed in different forms in several argentinean communities. The present study was carried out to investigate the medicinal properties and safety of Ziziphus mistol (mistol) fruits ethanol and aqueous extracts and arrope. Antinociceptive activity was assessed using the formalin, acetic acid-induced writhing and tail-flick tests in rats. Anti-inflammatory effects were determinated through carrageenan induced edema test and cotton pellet-induced granuloma formation, in rats. The safety was evaluated with test of acute toxicity (48 hs) and sub-chronic toxicity (91 days).All extracts (1,000 mg / kg body weight) showed significant inhibition (P <0.05) in the pain and inflammation experimentally induced. In the acute toxicity study, a single dose of 4000 and 8000 mg/kg b.w., produced no mortality and no clinical signs of disease were observed after 48 h. In the sub-chronic toxicity study the extracts no caused significant visible signs of toxicity, nor mortality for 91 consecutive days of treatment. No significant differences were found in relative organ weights and hematological and biochemical parameters between the treated groups and the control groups. Aqueous extract and arrope of Z. mistol fruits could be good source of antinociceptive and anti-inflamatory agents because of its good activity and safety. Fil: Reynoso, Marcos Adrian. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia. Instituto de Biología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán; Argentina Fil: Daud, Adriana del Valle. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia. Instituto de Biología; Argentina Fil: Belizán, María Melina Eleonora. Universidad Nacional de Tucuman. Facultad de Bioquímica, Química y Farmacia. Instituto de Farmacia. Cátedra de Farmacoquímica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán; Argentina Fil: Sánchez Riera, Alvaro. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia. Instituto de Biología; Argentina Fil: Vera, Nancy Roxana. Universidad Nacional de Tucuman. Facultad de Bioquímica, Química y Farmacia. Instituto de Farmacia. Cátedra de Farmacoquímica; Argentina |
description |
Ziziphus mistol Griseb. (Rhamnaceae), popularly known as ?mistol,? is widely distributed throughout Perú, Bolivia, Paraguay and Argentina. Its fruit is consumed in different forms in several argentinean communities. The present study was carried out to investigate the medicinal properties and safety of Ziziphus mistol (mistol) fruits ethanol and aqueous extracts and arrope. Antinociceptive activity was assessed using the formalin, acetic acid-induced writhing and tail-flick tests in rats. Anti-inflammatory effects were determinated through carrageenan induced edema test and cotton pellet-induced granuloma formation, in rats. The safety was evaluated with test of acute toxicity (48 hs) and sub-chronic toxicity (91 days).All extracts (1,000 mg / kg body weight) showed significant inhibition (P <0.05) in the pain and inflammation experimentally induced. In the acute toxicity study, a single dose of 4000 and 8000 mg/kg b.w., produced no mortality and no clinical signs of disease were observed after 48 h. In the sub-chronic toxicity study the extracts no caused significant visible signs of toxicity, nor mortality for 91 consecutive days of treatment. No significant differences were found in relative organ weights and hematological and biochemical parameters between the treated groups and the control groups. Aqueous extract and arrope of Z. mistol fruits could be good source of antinociceptive and anti-inflamatory agents because of its good activity and safety. |
publishDate |
2016 |
dc.date.none.fl_str_mv |
2016-03 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/108176 Reynoso, Marcos Adrian; Daud, Adriana del Valle; Belizán, María Melina Eleonora; Sánchez Riera, Alvaro; Vera, Nancy Roxana; Antinociceptive, anti-inflammatory effects and safety of Ziziphus mistol fruits; International Journal of Pharmaceutical Sciences and Drug Research ; International Journal of Pharmaceutical Sciences and Drug Research ; 8; 2; 3-2016; 103-110 0975-248X CONICET Digital CONICET |
url |
http://hdl.handle.net/11336/108176 |
identifier_str_mv |
Reynoso, Marcos Adrian; Daud, Adriana del Valle; Belizán, María Melina Eleonora; Sánchez Riera, Alvaro; Vera, Nancy Roxana; Antinociceptive, anti-inflammatory effects and safety of Ziziphus mistol fruits; International Journal of Pharmaceutical Sciences and Drug Research ; International Journal of Pharmaceutical Sciences and Drug Research ; 8; 2; 3-2016; 103-110 0975-248X CONICET Digital CONICET |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/url/http://ijpsdr.com/index.php/ijpsdr/article/download/499/457 |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
International Journal of Pharmaceutical Sciences and Drug Research |
publisher.none.fl_str_mv |
International Journal of Pharmaceutical Sciences and Drug Research |
dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
reponame_str |
CONICET Digital (CONICET) |
collection |
CONICET Digital (CONICET) |
instname_str |
Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.name.fl_str_mv |
CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
_version_ |
1844614434788474880 |
score |
13.070432 |