Study of the Potential Value of Ilex affinis (Aquifoliaceae) as a Novel Source for the Food and Pharmaceutical Industries

Autores
Cogoi, Laura Carolina; Martino, Renzo Fabricio; Giberti, Gustavo Carlos; Anesini, Claudia Alejandra; Filip, Rosana
Año de publicación
2014
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Ilex paraguariensis St. Hilaire (Aquifoliaceae) is processed industrially to produce the commercial product “yerba mate” which is used as a tea-like beverage. It is one of the most commercialized plants of South America. It is exported to the US, Europe and Asia as vegetal drug or extracts used in complementary and alternative medicine and in formulations for functional foods due to its properties as a CNS stimulant, diuretic, weight reducing, antioxidant and antihypercholesterolemic, among others. Ilex affinis grows in the same habitat and is used as substitute or adulterant of I. paraguariensis. This species was never investigated before. The objective of this work was to assess the phytochemical composition and to determine the pharmacological activity, according with the major compounds present in it. The results showed small quantities of caffeine and theobromine, but a considerable amount of polyphenols, especially chlorogenic acid and isochlorogenic acid. I. affinis extracts presented scavenging activity on free radical DPPH in a concentration-dependent manner. Antiproliferative action on lymphoma cell line exerting both cytostatic and cytotoxic activities was also demonstrated.
Fil: Cogoi, Laura Carolina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Metabolismo del Fármaco. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Metabolismo del Fármaco; Argentina
Fil: Martino, Renzo Fabricio. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Metabolismo del Fármaco. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Metabolismo del Fármaco; Argentina
Fil: Giberti, Gustavo Carlos. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Metabolismo del Fármaco. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Metabolismo del Fármaco; Argentina
Fil: Anesini, Claudia Alejandra. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Metabolismo del Fármaco. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Metabolismo del Fármaco; Argentina
Fil: Filip, Rosana. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Metabolismo del Fármaco. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Metabolismo del Fármaco; Argentina
Materia
ILEX AFFINIS
ILEX PARAGUARIENSIS
POLYPHENOLS
CHLOROGENIC ACID
ANTIPROLIFERATIVE ACTIVITY
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/18556
Acceder
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repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Study of the Potential Value of Ilex affinis (Aquifoliaceae) as a Novel Source for the Food and Pharmaceutical IndustriesCogoi, Laura CarolinaMartino, Renzo FabricioGiberti, Gustavo CarlosAnesini, Claudia AlejandraFilip, RosanaILEX AFFINISILEX PARAGUARIENSISPOLYPHENOLSCHLOROGENIC ACIDANTIPROLIFERATIVE ACTIVITYhttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3Ilex paraguariensis St. Hilaire (Aquifoliaceae) is processed industrially to produce the commercial product “yerba mate” which is used as a tea-like beverage. It is one of the most commercialized plants of South America. It is exported to the US, Europe and Asia as vegetal drug or extracts used in complementary and alternative medicine and in formulations for functional foods due to its properties as a CNS stimulant, diuretic, weight reducing, antioxidant and antihypercholesterolemic, among others. Ilex affinis grows in the same habitat and is used as substitute or adulterant of I. paraguariensis. This species was never investigated before. The objective of this work was to assess the phytochemical composition and to determine the pharmacological activity, according with the major compounds present in it. The results showed small quantities of caffeine and theobromine, but a considerable amount of polyphenols, especially chlorogenic acid and isochlorogenic acid. I. affinis extracts presented scavenging activity on free radical DPPH in a concentration-dependent manner. Antiproliferative action on lymphoma cell line exerting both cytostatic and cytotoxic activities was also demonstrated.Fil: Cogoi, Laura Carolina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Metabolismo del Fármaco. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Metabolismo del Fármaco; ArgentinaFil: Martino, Renzo Fabricio. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Metabolismo del Fármaco. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Metabolismo del Fármaco; ArgentinaFil: Giberti, Gustavo Carlos. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Metabolismo del Fármaco. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Metabolismo del Fármaco; ArgentinaFil: Anesini, Claudia Alejandra. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Metabolismo del Fármaco. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Metabolismo del Fármaco; ArgentinaFil: Filip, Rosana. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Metabolismo del Fármaco. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Metabolismo del Fármaco; ArgentinaDavid Publishing2014-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/18556Cogoi, Laura Carolina; Martino, Renzo Fabricio; Giberti, Gustavo Carlos; Anesini, Claudia Alejandra; Filip, Rosana; Study of the Potential Value of Ilex affinis (Aquifoliaceae) as a Novel Source for the Food and Pharmaceutical Industries; David Publishing; Journal of Life Sciences; 8; 1; 1-2014; 10-141934-7391CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://www.davidpublishing.org/DownLoad/?id=16399info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-22T11:45:57Zoai:ri.conicet.gov.ar:11336/18556instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-22 11:45:57.555CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Study of the Potential Value of Ilex affinis (Aquifoliaceae) as a Novel Source for the Food and Pharmaceutical Industries
title Study of the Potential Value of Ilex affinis (Aquifoliaceae) as a Novel Source for the Food and Pharmaceutical Industries
spellingShingle Study of the Potential Value of Ilex affinis (Aquifoliaceae) as a Novel Source for the Food and Pharmaceutical Industries
Cogoi, Laura Carolina
ILEX AFFINIS
ILEX PARAGUARIENSIS
POLYPHENOLS
CHLOROGENIC ACID
ANTIPROLIFERATIVE ACTIVITY
title_short Study of the Potential Value of Ilex affinis (Aquifoliaceae) as a Novel Source for the Food and Pharmaceutical Industries
title_full Study of the Potential Value of Ilex affinis (Aquifoliaceae) as a Novel Source for the Food and Pharmaceutical Industries
title_fullStr Study of the Potential Value of Ilex affinis (Aquifoliaceae) as a Novel Source for the Food and Pharmaceutical Industries
title_full_unstemmed Study of the Potential Value of Ilex affinis (Aquifoliaceae) as a Novel Source for the Food and Pharmaceutical Industries
title_sort Study of the Potential Value of Ilex affinis (Aquifoliaceae) as a Novel Source for the Food and Pharmaceutical Industries
dc.creator.none.fl_str_mv Cogoi, Laura Carolina
Martino, Renzo Fabricio
Giberti, Gustavo Carlos
Anesini, Claudia Alejandra
Filip, Rosana
author Cogoi, Laura Carolina
author_facet Cogoi, Laura Carolina
Martino, Renzo Fabricio
Giberti, Gustavo Carlos
Anesini, Claudia Alejandra
Filip, Rosana
author_role author
author2 Martino, Renzo Fabricio
Giberti, Gustavo Carlos
Anesini, Claudia Alejandra
Filip, Rosana
author2_role author
author
author
author
dc.subject.none.fl_str_mv ILEX AFFINIS
ILEX PARAGUARIENSIS
POLYPHENOLS
CHLOROGENIC ACID
ANTIPROLIFERATIVE ACTIVITY
topic ILEX AFFINIS
ILEX PARAGUARIENSIS
POLYPHENOLS
CHLOROGENIC ACID
ANTIPROLIFERATIVE ACTIVITY
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Ilex paraguariensis St. Hilaire (Aquifoliaceae) is processed industrially to produce the commercial product “yerba mate” which is used as a tea-like beverage. It is one of the most commercialized plants of South America. It is exported to the US, Europe and Asia as vegetal drug or extracts used in complementary and alternative medicine and in formulations for functional foods due to its properties as a CNS stimulant, diuretic, weight reducing, antioxidant and antihypercholesterolemic, among others. Ilex affinis grows in the same habitat and is used as substitute or adulterant of I. paraguariensis. This species was never investigated before. The objective of this work was to assess the phytochemical composition and to determine the pharmacological activity, according with the major compounds present in it. The results showed small quantities of caffeine and theobromine, but a considerable amount of polyphenols, especially chlorogenic acid and isochlorogenic acid. I. affinis extracts presented scavenging activity on free radical DPPH in a concentration-dependent manner. Antiproliferative action on lymphoma cell line exerting both cytostatic and cytotoxic activities was also demonstrated.
Fil: Cogoi, Laura Carolina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Metabolismo del Fármaco. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Metabolismo del Fármaco; Argentina
Fil: Martino, Renzo Fabricio. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Metabolismo del Fármaco. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Metabolismo del Fármaco; Argentina
Fil: Giberti, Gustavo Carlos. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Metabolismo del Fármaco. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Metabolismo del Fármaco; Argentina
Fil: Anesini, Claudia Alejandra. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Metabolismo del Fármaco. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Metabolismo del Fármaco; Argentina
Fil: Filip, Rosana. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Metabolismo del Fármaco. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Metabolismo del Fármaco; Argentina
description Ilex paraguariensis St. Hilaire (Aquifoliaceae) is processed industrially to produce the commercial product “yerba mate” which is used as a tea-like beverage. It is one of the most commercialized plants of South America. It is exported to the US, Europe and Asia as vegetal drug or extracts used in complementary and alternative medicine and in formulations for functional foods due to its properties as a CNS stimulant, diuretic, weight reducing, antioxidant and antihypercholesterolemic, among others. Ilex affinis grows in the same habitat and is used as substitute or adulterant of I. paraguariensis. This species was never investigated before. The objective of this work was to assess the phytochemical composition and to determine the pharmacological activity, according with the major compounds present in it. The results showed small quantities of caffeine and theobromine, but a considerable amount of polyphenols, especially chlorogenic acid and isochlorogenic acid. I. affinis extracts presented scavenging activity on free radical DPPH in a concentration-dependent manner. Antiproliferative action on lymphoma cell line exerting both cytostatic and cytotoxic activities was also demonstrated.
publishDate 2014
dc.date.none.fl_str_mv 2014-01
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/18556
Cogoi, Laura Carolina; Martino, Renzo Fabricio; Giberti, Gustavo Carlos; Anesini, Claudia Alejandra; Filip, Rosana; Study of the Potential Value of Ilex affinis (Aquifoliaceae) as a Novel Source for the Food and Pharmaceutical Industries; David Publishing; Journal of Life Sciences; 8; 1; 1-2014; 10-14
1934-7391
CONICET Digital
CONICET
url http://hdl.handle.net/11336/18556
identifier_str_mv Cogoi, Laura Carolina; Martino, Renzo Fabricio; Giberti, Gustavo Carlos; Anesini, Claudia Alejandra; Filip, Rosana; Study of the Potential Value of Ilex affinis (Aquifoliaceae) as a Novel Source for the Food and Pharmaceutical Industries; David Publishing; Journal of Life Sciences; 8; 1; 1-2014; 10-14
1934-7391
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://www.davidpublishing.org/DownLoad/?id=16399
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv David Publishing
publisher.none.fl_str_mv David Publishing
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 12.982451

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