BDNF in the Dentate Gyrus Is Required for Consolidation of “Pattern-Separated” Memories

Autores
Bekinschtein, Pedro Alejandro; Kent, Brianne A.; Oomen, Charlotte A.; Clemenson, Gregory D.; Gage, Fred H.; Saksida, Lisa M.; Bussey, Timothy J.
Año de publicación
2013
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Successful memory involves not only remembering information over time, but also keeping memories distinct and less confusable. The computational process for making representations for similar input patterns more distinct from each other has been referred to as “pattern separation.” In this work, we developed a set of behavioral conditions that allowed us to manipulate the load for pattern separation at different stages of memory. Thus, we provide experimental evidence that a brain-derived neurotrophic factor (BDNF)-dependent pattern separation process occurs during the encoding/storage/consolidation, but not the retrieval stage of memory processing. We also found that a spontaneous increase in BDNF in the dentate gyrus of the hippocampus is associated with exposure to landmarks delineating similar, but not dissimilar, spatial locations, suggesting that BDNF is expressed on an “as-needed” basis for pattern separation.
Fil: Bekinschtein, Pedro Alejandro. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. University of Cambridge; Reino Unido. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Biología Celular y Neurociencias; Argentina
Fil: Kent, Brianne A.. University of Cambridge; Reino Unido
Fil: Oomen, Charlotte A.. University of Cambridge; Reino Unido
Fil: Clemenson, Gregory D.. Salk Institute for Biological Studies; Estados Unidos
Fil: Gage, Fred H.. Salk Institute for Biological Studies; Estados Unidos
Fil: Saksida, Lisa M.. University of Cambridge; Reino Unido
Fil: Bussey, Timothy J.. University of Cambridge; Reino Unido
Materia
PATTERN SEPARATION
BDNF
MEMORY CONSOLIDATION
DENTATE GYRUS
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/96233
Acceder
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network_name_str CONICET Digital (CONICET)
spelling BDNF in the Dentate Gyrus Is Required for Consolidation of “Pattern-Separated” MemoriesBekinschtein, Pedro AlejandroKent, Brianne A.Oomen, Charlotte A.Clemenson, Gregory D.Gage, Fred H.Saksida, Lisa M.Bussey, Timothy J.PATTERN SEPARATIONBDNFMEMORY CONSOLIDATIONDENTATE GYRUShttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Successful memory involves not only remembering information over time, but also keeping memories distinct and less confusable. The computational process for making representations for similar input patterns more distinct from each other has been referred to as “pattern separation.” In this work, we developed a set of behavioral conditions that allowed us to manipulate the load for pattern separation at different stages of memory. Thus, we provide experimental evidence that a brain-derived neurotrophic factor (BDNF)-dependent pattern separation process occurs during the encoding/storage/consolidation, but not the retrieval stage of memory processing. We also found that a spontaneous increase in BDNF in the dentate gyrus of the hippocampus is associated with exposure to landmarks delineating similar, but not dissimilar, spatial locations, suggesting that BDNF is expressed on an “as-needed” basis for pattern separation.Fil: Bekinschtein, Pedro Alejandro. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. University of Cambridge; Reino Unido. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Biología Celular y Neurociencias; ArgentinaFil: Kent, Brianne A.. University of Cambridge; Reino UnidoFil: Oomen, Charlotte A.. University of Cambridge; Reino UnidoFil: Clemenson, Gregory D.. Salk Institute for Biological Studies; Estados UnidosFil: Gage, Fred H.. Salk Institute for Biological Studies; Estados UnidosFil: Saksida, Lisa M.. University of Cambridge; Reino UnidoFil: Bussey, Timothy J.. University of Cambridge; Reino UnidoCell Press2013-11info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/96233Bekinschtein, Pedro Alejandro; Kent, Brianne A.; Oomen, Charlotte A.; Clemenson, Gregory D.; Gage, Fred H.; et al.; BDNF in the Dentate Gyrus Is Required for Consolidation of “Pattern-Separated” Memories; Cell Press; Cell Reports; 5; 3; 11-2013; 759-7682211-1247CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://www.cell.com/cell-reports/fulltext/S2211-1247%2813%2900550-0info:eu-repo/semantics/altIdentifier/doi/10.1016/j.celrep.2013.09.027info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:46:06Zoai:ri.conicet.gov.ar:11336/96233instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:46:06.415CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv BDNF in the Dentate Gyrus Is Required for Consolidation of “Pattern-Separated” Memories
title BDNF in the Dentate Gyrus Is Required for Consolidation of “Pattern-Separated” Memories
spellingShingle BDNF in the Dentate Gyrus Is Required for Consolidation of “Pattern-Separated” Memories
Bekinschtein, Pedro Alejandro
PATTERN SEPARATION
BDNF
MEMORY CONSOLIDATION
DENTATE GYRUS
title_short BDNF in the Dentate Gyrus Is Required for Consolidation of “Pattern-Separated” Memories
title_full BDNF in the Dentate Gyrus Is Required for Consolidation of “Pattern-Separated” Memories
title_fullStr BDNF in the Dentate Gyrus Is Required for Consolidation of “Pattern-Separated” Memories
title_full_unstemmed BDNF in the Dentate Gyrus Is Required for Consolidation of “Pattern-Separated” Memories
title_sort BDNF in the Dentate Gyrus Is Required for Consolidation of “Pattern-Separated” Memories
dc.creator.none.fl_str_mv Bekinschtein, Pedro Alejandro
Kent, Brianne A.
Oomen, Charlotte A.
Clemenson, Gregory D.
Gage, Fred H.
Saksida, Lisa M.
Bussey, Timothy J.
author Bekinschtein, Pedro Alejandro
author_facet Bekinschtein, Pedro Alejandro
Kent, Brianne A.
Oomen, Charlotte A.
Clemenson, Gregory D.
Gage, Fred H.
Saksida, Lisa M.
Bussey, Timothy J.
author_role author
author2 Kent, Brianne A.
Oomen, Charlotte A.
Clemenson, Gregory D.
Gage, Fred H.
Saksida, Lisa M.
Bussey, Timothy J.
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv PATTERN SEPARATION
BDNF
MEMORY CONSOLIDATION
DENTATE GYRUS
topic PATTERN SEPARATION
BDNF
MEMORY CONSOLIDATION
DENTATE GYRUS
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Successful memory involves not only remembering information over time, but also keeping memories distinct and less confusable. The computational process for making representations for similar input patterns more distinct from each other has been referred to as “pattern separation.” In this work, we developed a set of behavioral conditions that allowed us to manipulate the load for pattern separation at different stages of memory. Thus, we provide experimental evidence that a brain-derived neurotrophic factor (BDNF)-dependent pattern separation process occurs during the encoding/storage/consolidation, but not the retrieval stage of memory processing. We also found that a spontaneous increase in BDNF in the dentate gyrus of the hippocampus is associated with exposure to landmarks delineating similar, but not dissimilar, spatial locations, suggesting that BDNF is expressed on an “as-needed” basis for pattern separation.
Fil: Bekinschtein, Pedro Alejandro. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. University of Cambridge; Reino Unido. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Biología Celular y Neurociencias; Argentina
Fil: Kent, Brianne A.. University of Cambridge; Reino Unido
Fil: Oomen, Charlotte A.. University of Cambridge; Reino Unido
Fil: Clemenson, Gregory D.. Salk Institute for Biological Studies; Estados Unidos
Fil: Gage, Fred H.. Salk Institute for Biological Studies; Estados Unidos
Fil: Saksida, Lisa M.. University of Cambridge; Reino Unido
Fil: Bussey, Timothy J.. University of Cambridge; Reino Unido
description Successful memory involves not only remembering information over time, but also keeping memories distinct and less confusable. The computational process for making representations for similar input patterns more distinct from each other has been referred to as “pattern separation.” In this work, we developed a set of behavioral conditions that allowed us to manipulate the load for pattern separation at different stages of memory. Thus, we provide experimental evidence that a brain-derived neurotrophic factor (BDNF)-dependent pattern separation process occurs during the encoding/storage/consolidation, but not the retrieval stage of memory processing. We also found that a spontaneous increase in BDNF in the dentate gyrus of the hippocampus is associated with exposure to landmarks delineating similar, but not dissimilar, spatial locations, suggesting that BDNF is expressed on an “as-needed” basis for pattern separation.
publishDate 2013
dc.date.none.fl_str_mv 2013-11
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/96233
Bekinschtein, Pedro Alejandro; Kent, Brianne A.; Oomen, Charlotte A.; Clemenson, Gregory D.; Gage, Fred H.; et al.; BDNF in the Dentate Gyrus Is Required for Consolidation of “Pattern-Separated” Memories; Cell Press; Cell Reports; 5; 3; 11-2013; 759-768
2211-1247
CONICET Digital
CONICET
url http://hdl.handle.net/11336/96233
identifier_str_mv Bekinschtein, Pedro Alejandro; Kent, Brianne A.; Oomen, Charlotte A.; Clemenson, Gregory D.; Gage, Fred H.; et al.; BDNF in the Dentate Gyrus Is Required for Consolidation of “Pattern-Separated” Memories; Cell Press; Cell Reports; 5; 3; 11-2013; 759-768
2211-1247
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://www.cell.com/cell-reports/fulltext/S2211-1247%2813%2900550-0
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.celrep.2013.09.027
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Cell Press
publisher.none.fl_str_mv Cell Press
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1842268774309298176
score 13.13397

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