NMDA receptors and BDNF are necessary for discrimination of overlapping spatial and non-spatial memories in perirhinal cortex and hippocampus
- Autores
- Miranda, Magdalena; Kent, Brianne A.; Morici, Juan Facundo; Gallo, Francisco Tomás; Saksida, Lisa M.; Bussey, Timothy J.; Weisstaub, Noelia V.; Bekinschtein, Pedro Alejandro
- Año de publicación
- 2018
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Successful memory involves not only remembering information over time but also keeping memories distinct and less confusable. Discrimination of overlapping representations has been investigated in the dentate gyrus (DG) of the hippocampus and largely in the perirhinal cortex (Prh). In particular, the DG was shown to be important for discrimination of overlapping spatial memories and Prh was shown to be important for discrimination of overlapping object memories. In the present study, we used both a DG-dependent and a Prh-dependent task and manipulated the load of similarity between either spatial or object stimuli during information encoding. We showed that N-methyl-D-aspartate-type glutamate receptors (NMDAr) and BDNF participate of the same cellular network during consolidation of both overlapping object and spatial memories in the Prh and DG, respectively. This argues in favor of conserved cellular mechanisms across regions despite anatomical differences.
Fil: Miranda, Magdalena. Instituto de Neurología Cognitiva; Argentina. Universidad Favaloro; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Kent, Brianne A.. University of British Columbia; Canadá
Fil: Morici, Juan Facundo. Instituto de Neurología Cognitiva; Argentina. Universidad Favaloro; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Gallo, Francisco Tomás. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Instituto de Neurología Cognitiva; Argentina. Universidad Favaloro; Argentina
Fil: Saksida, Lisa M.. University of Cambridge; Reino Unido. Western University; Canadá
Fil: Bussey, Timothy J.. University of Cambridge; Reino Unido. Western University; Canadá
Fil: Weisstaub, Noelia V.. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Favaloro; Argentina. Instituto de Neurología Cognitiva; Argentina
Fil: Bekinschtein, Pedro Alejandro. Instituto de Neurología Cognitiva; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Favaloro; Argentina - Materia
-
BDNF
DENTATE GYRUS
NMDA RECEPTORS
OBJECT RECOGNITION
PATTERN SEPARATION
PERIRHINAL CORTEX - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/99364
Ver los metadatos del registro completo
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CONICET Digital (CONICET) |
spelling |
NMDA receptors and BDNF are necessary for discrimination of overlapping spatial and non-spatial memories in perirhinal cortex and hippocampusMiranda, MagdalenaKent, Brianne A.Morici, Juan FacundoGallo, Francisco TomásSaksida, Lisa M.Bussey, Timothy J.Weisstaub, Noelia V.Bekinschtein, Pedro AlejandroBDNFDENTATE GYRUSNMDA RECEPTORSOBJECT RECOGNITIONPATTERN SEPARATIONPERIRHINAL CORTEXhttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Successful memory involves not only remembering information over time but also keeping memories distinct and less confusable. Discrimination of overlapping representations has been investigated in the dentate gyrus (DG) of the hippocampus and largely in the perirhinal cortex (Prh). In particular, the DG was shown to be important for discrimination of overlapping spatial memories and Prh was shown to be important for discrimination of overlapping object memories. In the present study, we used both a DG-dependent and a Prh-dependent task and manipulated the load of similarity between either spatial or object stimuli during information encoding. We showed that N-methyl-D-aspartate-type glutamate receptors (NMDAr) and BDNF participate of the same cellular network during consolidation of both overlapping object and spatial memories in the Prh and DG, respectively. This argues in favor of conserved cellular mechanisms across regions despite anatomical differences.Fil: Miranda, Magdalena. Instituto de Neurología Cognitiva; Argentina. Universidad Favaloro; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Kent, Brianne A.. University of British Columbia; CanadáFil: Morici, Juan Facundo. Instituto de Neurología Cognitiva; Argentina. Universidad Favaloro; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Gallo, Francisco Tomás. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Instituto de Neurología Cognitiva; Argentina. Universidad Favaloro; ArgentinaFil: Saksida, Lisa M.. University of Cambridge; Reino Unido. Western University; CanadáFil: Bussey, Timothy J.. University of Cambridge; Reino Unido. Western University; CanadáFil: Weisstaub, Noelia V.. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Favaloro; Argentina. Instituto de Neurología Cognitiva; ArgentinaFil: Bekinschtein, Pedro Alejandro. Instituto de Neurología Cognitiva; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Favaloro; ArgentinaAcademic Press Inc Elsevier Science2018-11info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/99364Miranda, Magdalena; Kent, Brianne A.; Morici, Juan Facundo; Gallo, Francisco Tomás; Saksida, Lisa M.; et al.; NMDA receptors and BDNF are necessary for discrimination of overlapping spatial and non-spatial memories in perirhinal cortex and hippocampus; Academic Press Inc Elsevier Science; Neurobiology of Learning and Memory; 155; 11-2018; 337-3431074-7427CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S1074742718302132info:eu-repo/semantics/altIdentifier/doi/10.1016/j.nlm.2018.08.019info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T10:09:33Zoai:ri.conicet.gov.ar:11336/99364instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 10:09:33.974CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
NMDA receptors and BDNF are necessary for discrimination of overlapping spatial and non-spatial memories in perirhinal cortex and hippocampus |
title |
NMDA receptors and BDNF are necessary for discrimination of overlapping spatial and non-spatial memories in perirhinal cortex and hippocampus |
spellingShingle |
NMDA receptors and BDNF are necessary for discrimination of overlapping spatial and non-spatial memories in perirhinal cortex and hippocampus Miranda, Magdalena BDNF DENTATE GYRUS NMDA RECEPTORS OBJECT RECOGNITION PATTERN SEPARATION PERIRHINAL CORTEX |
title_short |
NMDA receptors and BDNF are necessary for discrimination of overlapping spatial and non-spatial memories in perirhinal cortex and hippocampus |
title_full |
NMDA receptors and BDNF are necessary for discrimination of overlapping spatial and non-spatial memories in perirhinal cortex and hippocampus |
title_fullStr |
NMDA receptors and BDNF are necessary for discrimination of overlapping spatial and non-spatial memories in perirhinal cortex and hippocampus |
title_full_unstemmed |
NMDA receptors and BDNF are necessary for discrimination of overlapping spatial and non-spatial memories in perirhinal cortex and hippocampus |
title_sort |
NMDA receptors and BDNF are necessary for discrimination of overlapping spatial and non-spatial memories in perirhinal cortex and hippocampus |
dc.creator.none.fl_str_mv |
Miranda, Magdalena Kent, Brianne A. Morici, Juan Facundo Gallo, Francisco Tomás Saksida, Lisa M. Bussey, Timothy J. Weisstaub, Noelia V. Bekinschtein, Pedro Alejandro |
author |
Miranda, Magdalena |
author_facet |
Miranda, Magdalena Kent, Brianne A. Morici, Juan Facundo Gallo, Francisco Tomás Saksida, Lisa M. Bussey, Timothy J. Weisstaub, Noelia V. Bekinschtein, Pedro Alejandro |
author_role |
author |
author2 |
Kent, Brianne A. Morici, Juan Facundo Gallo, Francisco Tomás Saksida, Lisa M. Bussey, Timothy J. Weisstaub, Noelia V. Bekinschtein, Pedro Alejandro |
author2_role |
author author author author author author author |
dc.subject.none.fl_str_mv |
BDNF DENTATE GYRUS NMDA RECEPTORS OBJECT RECOGNITION PATTERN SEPARATION PERIRHINAL CORTEX |
topic |
BDNF DENTATE GYRUS NMDA RECEPTORS OBJECT RECOGNITION PATTERN SEPARATION PERIRHINAL CORTEX |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/3.1 https://purl.org/becyt/ford/3 |
dc.description.none.fl_txt_mv |
Successful memory involves not only remembering information over time but also keeping memories distinct and less confusable. Discrimination of overlapping representations has been investigated in the dentate gyrus (DG) of the hippocampus and largely in the perirhinal cortex (Prh). In particular, the DG was shown to be important for discrimination of overlapping spatial memories and Prh was shown to be important for discrimination of overlapping object memories. In the present study, we used both a DG-dependent and a Prh-dependent task and manipulated the load of similarity between either spatial or object stimuli during information encoding. We showed that N-methyl-D-aspartate-type glutamate receptors (NMDAr) and BDNF participate of the same cellular network during consolidation of both overlapping object and spatial memories in the Prh and DG, respectively. This argues in favor of conserved cellular mechanisms across regions despite anatomical differences. Fil: Miranda, Magdalena. Instituto de Neurología Cognitiva; Argentina. Universidad Favaloro; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Kent, Brianne A.. University of British Columbia; Canadá Fil: Morici, Juan Facundo. Instituto de Neurología Cognitiva; Argentina. Universidad Favaloro; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Gallo, Francisco Tomás. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Instituto de Neurología Cognitiva; Argentina. Universidad Favaloro; Argentina Fil: Saksida, Lisa M.. University of Cambridge; Reino Unido. Western University; Canadá Fil: Bussey, Timothy J.. University of Cambridge; Reino Unido. Western University; Canadá Fil: Weisstaub, Noelia V.. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Favaloro; Argentina. Instituto de Neurología Cognitiva; Argentina Fil: Bekinschtein, Pedro Alejandro. Instituto de Neurología Cognitiva; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Favaloro; Argentina |
description |
Successful memory involves not only remembering information over time but also keeping memories distinct and less confusable. Discrimination of overlapping representations has been investigated in the dentate gyrus (DG) of the hippocampus and largely in the perirhinal cortex (Prh). In particular, the DG was shown to be important for discrimination of overlapping spatial memories and Prh was shown to be important for discrimination of overlapping object memories. In the present study, we used both a DG-dependent and a Prh-dependent task and manipulated the load of similarity between either spatial or object stimuli during information encoding. We showed that N-methyl-D-aspartate-type glutamate receptors (NMDAr) and BDNF participate of the same cellular network during consolidation of both overlapping object and spatial memories in the Prh and DG, respectively. This argues in favor of conserved cellular mechanisms across regions despite anatomical differences. |
publishDate |
2018 |
dc.date.none.fl_str_mv |
2018-11 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/99364 Miranda, Magdalena; Kent, Brianne A.; Morici, Juan Facundo; Gallo, Francisco Tomás; Saksida, Lisa M.; et al.; NMDA receptors and BDNF are necessary for discrimination of overlapping spatial and non-spatial memories in perirhinal cortex and hippocampus; Academic Press Inc Elsevier Science; Neurobiology of Learning and Memory; 155; 11-2018; 337-343 1074-7427 CONICET Digital CONICET |
url |
http://hdl.handle.net/11336/99364 |
identifier_str_mv |
Miranda, Magdalena; Kent, Brianne A.; Morici, Juan Facundo; Gallo, Francisco Tomás; Saksida, Lisa M.; et al.; NMDA receptors and BDNF are necessary for discrimination of overlapping spatial and non-spatial memories in perirhinal cortex and hippocampus; Academic Press Inc Elsevier Science; Neurobiology of Learning and Memory; 155; 11-2018; 337-343 1074-7427 CONICET Digital CONICET |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S1074742718302132 info:eu-repo/semantics/altIdentifier/doi/10.1016/j.nlm.2018.08.019 |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-nd/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf application/pdf application/pdf application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
Academic Press Inc Elsevier Science |
publisher.none.fl_str_mv |
Academic Press Inc Elsevier Science |
dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
reponame_str |
CONICET Digital (CONICET) |
collection |
CONICET Digital (CONICET) |
instname_str |
Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.name.fl_str_mv |
CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
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1842270086189023232 |
score |
13.13397 |