NMDA receptors and BDNF are necessary for discrimination of overlapping spatial and non-spatial memories in perirhinal cortex and hippocampus

Autores
Miranda, Magdalena; Kent, Brianne A.; Morici, Juan Facundo; Gallo, Francisco Tomás; Saksida, Lisa M.; Bussey, Timothy J.; Weisstaub, Noelia V.; Bekinschtein, Pedro Alejandro
Año de publicación
2018
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Successful memory involves not only remembering information over time but also keeping memories distinct and less confusable. Discrimination of overlapping representations has been investigated in the dentate gyrus (DG) of the hippocampus and largely in the perirhinal cortex (Prh). In particular, the DG was shown to be important for discrimination of overlapping spatial memories and Prh was shown to be important for discrimination of overlapping object memories. In the present study, we used both a DG-dependent and a Prh-dependent task and manipulated the load of similarity between either spatial or object stimuli during information encoding. We showed that N-methyl-D-aspartate-type glutamate receptors (NMDAr) and BDNF participate of the same cellular network during consolidation of both overlapping object and spatial memories in the Prh and DG, respectively. This argues in favor of conserved cellular mechanisms across regions despite anatomical differences.
Fil: Miranda, Magdalena. Instituto de Neurología Cognitiva; Argentina. Universidad Favaloro; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Kent, Brianne A.. University of British Columbia; Canadá
Fil: Morici, Juan Facundo. Instituto de Neurología Cognitiva; Argentina. Universidad Favaloro; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Gallo, Francisco Tomás. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Instituto de Neurología Cognitiva; Argentina. Universidad Favaloro; Argentina
Fil: Saksida, Lisa M.. University of Cambridge; Reino Unido. Western University; Canadá
Fil: Bussey, Timothy J.. University of Cambridge; Reino Unido. Western University; Canadá
Fil: Weisstaub, Noelia V.. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Favaloro; Argentina. Instituto de Neurología Cognitiva; Argentina
Fil: Bekinschtein, Pedro Alejandro. Instituto de Neurología Cognitiva; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Favaloro; Argentina
Materia
BDNF
DENTATE GYRUS
NMDA RECEPTORS
OBJECT RECOGNITION
PATTERN SEPARATION
PERIRHINAL CORTEX
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/99364

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spelling NMDA receptors and BDNF are necessary for discrimination of overlapping spatial and non-spatial memories in perirhinal cortex and hippocampusMiranda, MagdalenaKent, Brianne A.Morici, Juan FacundoGallo, Francisco TomásSaksida, Lisa M.Bussey, Timothy J.Weisstaub, Noelia V.Bekinschtein, Pedro AlejandroBDNFDENTATE GYRUSNMDA RECEPTORSOBJECT RECOGNITIONPATTERN SEPARATIONPERIRHINAL CORTEXhttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Successful memory involves not only remembering information over time but also keeping memories distinct and less confusable. Discrimination of overlapping representations has been investigated in the dentate gyrus (DG) of the hippocampus and largely in the perirhinal cortex (Prh). In particular, the DG was shown to be important for discrimination of overlapping spatial memories and Prh was shown to be important for discrimination of overlapping object memories. In the present study, we used both a DG-dependent and a Prh-dependent task and manipulated the load of similarity between either spatial or object stimuli during information encoding. We showed that N-methyl-D-aspartate-type glutamate receptors (NMDAr) and BDNF participate of the same cellular network during consolidation of both overlapping object and spatial memories in the Prh and DG, respectively. This argues in favor of conserved cellular mechanisms across regions despite anatomical differences.Fil: Miranda, Magdalena. Instituto de Neurología Cognitiva; Argentina. Universidad Favaloro; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Kent, Brianne A.. University of British Columbia; CanadáFil: Morici, Juan Facundo. Instituto de Neurología Cognitiva; Argentina. Universidad Favaloro; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Gallo, Francisco Tomás. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Instituto de Neurología Cognitiva; Argentina. Universidad Favaloro; ArgentinaFil: Saksida, Lisa M.. University of Cambridge; Reino Unido. Western University; CanadáFil: Bussey, Timothy J.. University of Cambridge; Reino Unido. Western University; CanadáFil: Weisstaub, Noelia V.. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Favaloro; Argentina. Instituto de Neurología Cognitiva; ArgentinaFil: Bekinschtein, Pedro Alejandro. Instituto de Neurología Cognitiva; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Favaloro; ArgentinaAcademic Press Inc Elsevier Science2018-11info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/99364Miranda, Magdalena; Kent, Brianne A.; Morici, Juan Facundo; Gallo, Francisco Tomás; Saksida, Lisa M.; et al.; NMDA receptors and BDNF are necessary for discrimination of overlapping spatial and non-spatial memories in perirhinal cortex and hippocampus; Academic Press Inc Elsevier Science; Neurobiology of Learning and Memory; 155; 11-2018; 337-3431074-7427CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S1074742718302132info:eu-repo/semantics/altIdentifier/doi/10.1016/j.nlm.2018.08.019info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T10:09:33Zoai:ri.conicet.gov.ar:11336/99364instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 10:09:33.974CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv NMDA receptors and BDNF are necessary for discrimination of overlapping spatial and non-spatial memories in perirhinal cortex and hippocampus
title NMDA receptors and BDNF are necessary for discrimination of overlapping spatial and non-spatial memories in perirhinal cortex and hippocampus
spellingShingle NMDA receptors and BDNF are necessary for discrimination of overlapping spatial and non-spatial memories in perirhinal cortex and hippocampus
Miranda, Magdalena
BDNF
DENTATE GYRUS
NMDA RECEPTORS
OBJECT RECOGNITION
PATTERN SEPARATION
PERIRHINAL CORTEX
title_short NMDA receptors and BDNF are necessary for discrimination of overlapping spatial and non-spatial memories in perirhinal cortex and hippocampus
title_full NMDA receptors and BDNF are necessary for discrimination of overlapping spatial and non-spatial memories in perirhinal cortex and hippocampus
title_fullStr NMDA receptors and BDNF are necessary for discrimination of overlapping spatial and non-spatial memories in perirhinal cortex and hippocampus
title_full_unstemmed NMDA receptors and BDNF are necessary for discrimination of overlapping spatial and non-spatial memories in perirhinal cortex and hippocampus
title_sort NMDA receptors and BDNF are necessary for discrimination of overlapping spatial and non-spatial memories in perirhinal cortex and hippocampus
dc.creator.none.fl_str_mv Miranda, Magdalena
Kent, Brianne A.
Morici, Juan Facundo
Gallo, Francisco Tomás
Saksida, Lisa M.
Bussey, Timothy J.
Weisstaub, Noelia V.
Bekinschtein, Pedro Alejandro
author Miranda, Magdalena
author_facet Miranda, Magdalena
Kent, Brianne A.
Morici, Juan Facundo
Gallo, Francisco Tomás
Saksida, Lisa M.
Bussey, Timothy J.
Weisstaub, Noelia V.
Bekinschtein, Pedro Alejandro
author_role author
author2 Kent, Brianne A.
Morici, Juan Facundo
Gallo, Francisco Tomás
Saksida, Lisa M.
Bussey, Timothy J.
Weisstaub, Noelia V.
Bekinschtein, Pedro Alejandro
author2_role author
author
author
author
author
author
author
dc.subject.none.fl_str_mv BDNF
DENTATE GYRUS
NMDA RECEPTORS
OBJECT RECOGNITION
PATTERN SEPARATION
PERIRHINAL CORTEX
topic BDNF
DENTATE GYRUS
NMDA RECEPTORS
OBJECT RECOGNITION
PATTERN SEPARATION
PERIRHINAL CORTEX
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Successful memory involves not only remembering information over time but also keeping memories distinct and less confusable. Discrimination of overlapping representations has been investigated in the dentate gyrus (DG) of the hippocampus and largely in the perirhinal cortex (Prh). In particular, the DG was shown to be important for discrimination of overlapping spatial memories and Prh was shown to be important for discrimination of overlapping object memories. In the present study, we used both a DG-dependent and a Prh-dependent task and manipulated the load of similarity between either spatial or object stimuli during information encoding. We showed that N-methyl-D-aspartate-type glutamate receptors (NMDAr) and BDNF participate of the same cellular network during consolidation of both overlapping object and spatial memories in the Prh and DG, respectively. This argues in favor of conserved cellular mechanisms across regions despite anatomical differences.
Fil: Miranda, Magdalena. Instituto de Neurología Cognitiva; Argentina. Universidad Favaloro; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Kent, Brianne A.. University of British Columbia; Canadá
Fil: Morici, Juan Facundo. Instituto de Neurología Cognitiva; Argentina. Universidad Favaloro; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Gallo, Francisco Tomás. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Instituto de Neurología Cognitiva; Argentina. Universidad Favaloro; Argentina
Fil: Saksida, Lisa M.. University of Cambridge; Reino Unido. Western University; Canadá
Fil: Bussey, Timothy J.. University of Cambridge; Reino Unido. Western University; Canadá
Fil: Weisstaub, Noelia V.. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Favaloro; Argentina. Instituto de Neurología Cognitiva; Argentina
Fil: Bekinschtein, Pedro Alejandro. Instituto de Neurología Cognitiva; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Favaloro; Argentina
description Successful memory involves not only remembering information over time but also keeping memories distinct and less confusable. Discrimination of overlapping representations has been investigated in the dentate gyrus (DG) of the hippocampus and largely in the perirhinal cortex (Prh). In particular, the DG was shown to be important for discrimination of overlapping spatial memories and Prh was shown to be important for discrimination of overlapping object memories. In the present study, we used both a DG-dependent and a Prh-dependent task and manipulated the load of similarity between either spatial or object stimuli during information encoding. We showed that N-methyl-D-aspartate-type glutamate receptors (NMDAr) and BDNF participate of the same cellular network during consolidation of both overlapping object and spatial memories in the Prh and DG, respectively. This argues in favor of conserved cellular mechanisms across regions despite anatomical differences.
publishDate 2018
dc.date.none.fl_str_mv 2018-11
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/99364
Miranda, Magdalena; Kent, Brianne A.; Morici, Juan Facundo; Gallo, Francisco Tomás; Saksida, Lisa M.; et al.; NMDA receptors and BDNF are necessary for discrimination of overlapping spatial and non-spatial memories in perirhinal cortex and hippocampus; Academic Press Inc Elsevier Science; Neurobiology of Learning and Memory; 155; 11-2018; 337-343
1074-7427
CONICET Digital
CONICET
url http://hdl.handle.net/11336/99364
identifier_str_mv Miranda, Magdalena; Kent, Brianne A.; Morici, Juan Facundo; Gallo, Francisco Tomás; Saksida, Lisa M.; et al.; NMDA receptors and BDNF are necessary for discrimination of overlapping spatial and non-spatial memories in perirhinal cortex and hippocampus; Academic Press Inc Elsevier Science; Neurobiology of Learning and Memory; 155; 11-2018; 337-343
1074-7427
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S1074742718302132
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.nlm.2018.08.019
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Academic Press Inc Elsevier Science
publisher.none.fl_str_mv Academic Press Inc Elsevier Science
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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