Dynamic Role of Adult-Born Dentate Granule Cells in Memory Processing
- Autores
- Kropff, Emilio; Yang, Sung Min; Schinder, Alejandro Fabián
- Año de publicación
- 2015
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Throughout the adult life of all mammals including humans, new neurons are incorporated to the dentate gyrus of the hippocampus. During a critical window that lasts about two weeks, adult-born immature neurons are more excitable and plastic than mature ones, and they respond to a wider range of inputs. In apparent contradiction, new neurons have been shown to be crucial to solve behavioral tasks that involve the discrimination of very similar situations, which would instead require high input specificity. We propose that immature neurons are initially unspecific because their task is to identify novel elements inside a high dimensional input space. With maturation, they would specialize to represent details of these novel inputs, favoring discrimination.
Fil: Kropff, Emilio. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; Argentina
Fil: Yang, Sung Min. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; Argentina
Fil: Schinder, Alejandro Fabián. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; Argentina - Materia
-
NEUROGENESIS
DENTATE GYRUS
PATTERN SEPARATION
HIPPOCAMPUS - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/138103
Ver los metadatos del registro completo
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Dynamic Role of Adult-Born Dentate Granule Cells in Memory ProcessingKropff, EmilioYang, Sung MinSchinder, Alejandro FabiánNEUROGENESISDENTATE GYRUSPATTERN SEPARATIONHIPPOCAMPUShttps://purl.org/becyt/ford/3.5https://purl.org/becyt/ford/3Throughout the adult life of all mammals including humans, new neurons are incorporated to the dentate gyrus of the hippocampus. During a critical window that lasts about two weeks, adult-born immature neurons are more excitable and plastic than mature ones, and they respond to a wider range of inputs. In apparent contradiction, new neurons have been shown to be crucial to solve behavioral tasks that involve the discrimination of very similar situations, which would instead require high input specificity. We propose that immature neurons are initially unspecific because their task is to identify novel elements inside a high dimensional input space. With maturation, they would specialize to represent details of these novel inputs, favoring discrimination.Fil: Kropff, Emilio. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; ArgentinaFil: Yang, Sung Min. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; ArgentinaFil: Schinder, Alejandro Fabián. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; ArgentinaCurrent Biology2015-06info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/138103Kropff, Emilio; Yang, Sung Min; Schinder, Alejandro Fabián; Dynamic Role of Adult-Born Dentate Granule Cells in Memory Processing; Current Biology; Current Opinion In Neurobiology; 35; 6-2015; 21-260959-43881873-6882CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/abs/pii/S0959438815000963info:eu-repo/semantics/altIdentifier/doi/10.1016/j.conb.2015.06.002info:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4641801/info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:54:34Zoai:ri.conicet.gov.ar:11336/138103instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:54:34.483CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
Dynamic Role of Adult-Born Dentate Granule Cells in Memory Processing |
title |
Dynamic Role of Adult-Born Dentate Granule Cells in Memory Processing |
spellingShingle |
Dynamic Role of Adult-Born Dentate Granule Cells in Memory Processing Kropff, Emilio NEUROGENESIS DENTATE GYRUS PATTERN SEPARATION HIPPOCAMPUS |
title_short |
Dynamic Role of Adult-Born Dentate Granule Cells in Memory Processing |
title_full |
Dynamic Role of Adult-Born Dentate Granule Cells in Memory Processing |
title_fullStr |
Dynamic Role of Adult-Born Dentate Granule Cells in Memory Processing |
title_full_unstemmed |
Dynamic Role of Adult-Born Dentate Granule Cells in Memory Processing |
title_sort |
Dynamic Role of Adult-Born Dentate Granule Cells in Memory Processing |
dc.creator.none.fl_str_mv |
Kropff, Emilio Yang, Sung Min Schinder, Alejandro Fabián |
author |
Kropff, Emilio |
author_facet |
Kropff, Emilio Yang, Sung Min Schinder, Alejandro Fabián |
author_role |
author |
author2 |
Yang, Sung Min Schinder, Alejandro Fabián |
author2_role |
author author |
dc.subject.none.fl_str_mv |
NEUROGENESIS DENTATE GYRUS PATTERN SEPARATION HIPPOCAMPUS |
topic |
NEUROGENESIS DENTATE GYRUS PATTERN SEPARATION HIPPOCAMPUS |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/3.5 https://purl.org/becyt/ford/3 |
dc.description.none.fl_txt_mv |
Throughout the adult life of all mammals including humans, new neurons are incorporated to the dentate gyrus of the hippocampus. During a critical window that lasts about two weeks, adult-born immature neurons are more excitable and plastic than mature ones, and they respond to a wider range of inputs. In apparent contradiction, new neurons have been shown to be crucial to solve behavioral tasks that involve the discrimination of very similar situations, which would instead require high input specificity. We propose that immature neurons are initially unspecific because their task is to identify novel elements inside a high dimensional input space. With maturation, they would specialize to represent details of these novel inputs, favoring discrimination. Fil: Kropff, Emilio. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; Argentina Fil: Yang, Sung Min. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; Argentina Fil: Schinder, Alejandro Fabián. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; Argentina |
description |
Throughout the adult life of all mammals including humans, new neurons are incorporated to the dentate gyrus of the hippocampus. During a critical window that lasts about two weeks, adult-born immature neurons are more excitable and plastic than mature ones, and they respond to a wider range of inputs. In apparent contradiction, new neurons have been shown to be crucial to solve behavioral tasks that involve the discrimination of very similar situations, which would instead require high input specificity. We propose that immature neurons are initially unspecific because their task is to identify novel elements inside a high dimensional input space. With maturation, they would specialize to represent details of these novel inputs, favoring discrimination. |
publishDate |
2015 |
dc.date.none.fl_str_mv |
2015-06 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/138103 Kropff, Emilio; Yang, Sung Min; Schinder, Alejandro Fabián; Dynamic Role of Adult-Born Dentate Granule Cells in Memory Processing; Current Biology; Current Opinion In Neurobiology; 35; 6-2015; 21-26 0959-4388 1873-6882 CONICET Digital CONICET |
url |
http://hdl.handle.net/11336/138103 |
identifier_str_mv |
Kropff, Emilio; Yang, Sung Min; Schinder, Alejandro Fabián; Dynamic Role of Adult-Born Dentate Granule Cells in Memory Processing; Current Biology; Current Opinion In Neurobiology; 35; 6-2015; 21-26 0959-4388 1873-6882 CONICET Digital CONICET |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/abs/pii/S0959438815000963 info:eu-repo/semantics/altIdentifier/doi/10.1016/j.conb.2015.06.002 info:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4641801/ |
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openAccess |
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https://creativecommons.org/licenses/by-nc-nd/2.5/ar/ |
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Current Biology |
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Current Biology |
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CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
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