Brain-derived neurotrophic factor interacts with adult-born immature cells in the dentate gyrus during consolidation of overlapping memories
- Autores
- Bekinschtein, Pedro Alejandro; Kent, Brianne A.; Oomen, Charlotte; Gregory D. Clemenson; Fred H. Gage; Lisa M. Saksida; Timothy J. Bussey
- Año de publicación
- 2014
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Successful memory involves not only remembering information over time but also keeping memories distinct and less confusable. The computational process for making representations of similar input patterns more distinct from each other has been referred to as “pattern separation.” Although adult-born immature neurons have been implicated in this memory feature, the precise role of these neurons and associated molecules in the processing of overlapping memories is unknown. Recently, we found that brain-derived neurotrophic factor (BDNF) in the dentate gyrus is required for the encoding/consolidation of overlapping memories. In this study, we provide evidence that consolidation of these “pattern-separated” memories requires the action of BDNF on immature neurons specifically.
Fil: Bekinschtein, Pedro Alejandro. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Biología Celular y Neurociencias; Argentina. University of Cambridge; Reino Unido. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Kent, Brianne A.. University of Cambridge; Reino Unido
Fil: Oomen, Charlotte. University of Cambridge; Reino Unido
Fil: Gregory D. Clemenson. Salk Institute For Biological Studies; Estados Unidos
Fil: Fred H. Gage. Salk Institute For Biological Studies; Estados Unidos
Fil: Lisa M. Saksida. University of Cambridge; Reino Unido
Fil: Timothy J. Bussey. University of Cambridge; Reino Unido - Materia
-
BDNF
DENTATE GYRUS
MEMORY CONSOLIDATION
NEUROGENESIS - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/15763
Ver los metadatos del registro completo
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Brain-derived neurotrophic factor interacts with adult-born immature cells in the dentate gyrus during consolidation of overlapping memoriesBekinschtein, Pedro AlejandroKent, Brianne A.Oomen, CharlotteGregory D. ClemensonFred H. GageLisa M. SaksidaTimothy J. BusseyBDNFDENTATE GYRUSMEMORY CONSOLIDATIONNEUROGENESIShttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Successful memory involves not only remembering information over time but also keeping memories distinct and less confusable. The computational process for making representations of similar input patterns more distinct from each other has been referred to as “pattern separation.” Although adult-born immature neurons have been implicated in this memory feature, the precise role of these neurons and associated molecules in the processing of overlapping memories is unknown. Recently, we found that brain-derived neurotrophic factor (BDNF) in the dentate gyrus is required for the encoding/consolidation of overlapping memories. In this study, we provide evidence that consolidation of these “pattern-separated” memories requires the action of BDNF on immature neurons specifically.Fil: Bekinschtein, Pedro Alejandro. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Biología Celular y Neurociencias; Argentina. University of Cambridge; Reino Unido. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Kent, Brianne A.. University of Cambridge; Reino UnidoFil: Oomen, Charlotte. University of Cambridge; Reino UnidoFil: Gregory D. Clemenson. Salk Institute For Biological Studies; Estados UnidosFil: Fred H. Gage. Salk Institute For Biological Studies; Estados UnidosFil: Lisa M. Saksida. University of Cambridge; Reino UnidoFil: Timothy J. Bussey. University of Cambridge; Reino UnidoWiley2014-08info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/15763Bekinschtein, Pedro Alejandro; Kent, Brianne A.; Oomen, Charlotte; Gregory D. Clemenson; Fred H. Gage; et al.; Brain-derived neurotrophic factor interacts with adult-born immature cells in the dentate gyrus during consolidation of overlapping memories; Wiley; Hippocampus; 24; 8; 8-2014; 905-9111050-9631enginfo:eu-repo/semantics/altIdentifier/url/http://onlinelibrary.wiley.com/doi/10.1002/hipo.22304/abstractinfo:eu-repo/semantics/altIdentifier/doi/10.1002/hipo.22304info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:47:48Zoai:ri.conicet.gov.ar:11336/15763instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:47:48.71CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
Brain-derived neurotrophic factor interacts with adult-born immature cells in the dentate gyrus during consolidation of overlapping memories |
title |
Brain-derived neurotrophic factor interacts with adult-born immature cells in the dentate gyrus during consolidation of overlapping memories |
spellingShingle |
Brain-derived neurotrophic factor interacts with adult-born immature cells in the dentate gyrus during consolidation of overlapping memories Bekinschtein, Pedro Alejandro BDNF DENTATE GYRUS MEMORY CONSOLIDATION NEUROGENESIS |
title_short |
Brain-derived neurotrophic factor interacts with adult-born immature cells in the dentate gyrus during consolidation of overlapping memories |
title_full |
Brain-derived neurotrophic factor interacts with adult-born immature cells in the dentate gyrus during consolidation of overlapping memories |
title_fullStr |
Brain-derived neurotrophic factor interacts with adult-born immature cells in the dentate gyrus during consolidation of overlapping memories |
title_full_unstemmed |
Brain-derived neurotrophic factor interacts with adult-born immature cells in the dentate gyrus during consolidation of overlapping memories |
title_sort |
Brain-derived neurotrophic factor interacts with adult-born immature cells in the dentate gyrus during consolidation of overlapping memories |
dc.creator.none.fl_str_mv |
Bekinschtein, Pedro Alejandro Kent, Brianne A. Oomen, Charlotte Gregory D. Clemenson Fred H. Gage Lisa M. Saksida Timothy J. Bussey |
author |
Bekinschtein, Pedro Alejandro |
author_facet |
Bekinschtein, Pedro Alejandro Kent, Brianne A. Oomen, Charlotte Gregory D. Clemenson Fred H. Gage Lisa M. Saksida Timothy J. Bussey |
author_role |
author |
author2 |
Kent, Brianne A. Oomen, Charlotte Gregory D. Clemenson Fred H. Gage Lisa M. Saksida Timothy J. Bussey |
author2_role |
author author author author author author |
dc.subject.none.fl_str_mv |
BDNF DENTATE GYRUS MEMORY CONSOLIDATION NEUROGENESIS |
topic |
BDNF DENTATE GYRUS MEMORY CONSOLIDATION NEUROGENESIS |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/1.6 https://purl.org/becyt/ford/1 |
dc.description.none.fl_txt_mv |
Successful memory involves not only remembering information over time but also keeping memories distinct and less confusable. The computational process for making representations of similar input patterns more distinct from each other has been referred to as “pattern separation.” Although adult-born immature neurons have been implicated in this memory feature, the precise role of these neurons and associated molecules in the processing of overlapping memories is unknown. Recently, we found that brain-derived neurotrophic factor (BDNF) in the dentate gyrus is required for the encoding/consolidation of overlapping memories. In this study, we provide evidence that consolidation of these “pattern-separated” memories requires the action of BDNF on immature neurons specifically. Fil: Bekinschtein, Pedro Alejandro. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Biología Celular y Neurociencias; Argentina. University of Cambridge; Reino Unido. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Kent, Brianne A.. University of Cambridge; Reino Unido Fil: Oomen, Charlotte. University of Cambridge; Reino Unido Fil: Gregory D. Clemenson. Salk Institute For Biological Studies; Estados Unidos Fil: Fred H. Gage. Salk Institute For Biological Studies; Estados Unidos Fil: Lisa M. Saksida. University of Cambridge; Reino Unido Fil: Timothy J. Bussey. University of Cambridge; Reino Unido |
description |
Successful memory involves not only remembering information over time but also keeping memories distinct and less confusable. The computational process for making representations of similar input patterns more distinct from each other has been referred to as “pattern separation.” Although adult-born immature neurons have been implicated in this memory feature, the precise role of these neurons and associated molecules in the processing of overlapping memories is unknown. Recently, we found that brain-derived neurotrophic factor (BDNF) in the dentate gyrus is required for the encoding/consolidation of overlapping memories. In this study, we provide evidence that consolidation of these “pattern-separated” memories requires the action of BDNF on immature neurons specifically. |
publishDate |
2014 |
dc.date.none.fl_str_mv |
2014-08 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/15763 Bekinschtein, Pedro Alejandro; Kent, Brianne A.; Oomen, Charlotte; Gregory D. Clemenson; Fred H. Gage; et al.; Brain-derived neurotrophic factor interacts with adult-born immature cells in the dentate gyrus during consolidation of overlapping memories; Wiley; Hippocampus; 24; 8; 8-2014; 905-911 1050-9631 |
url |
http://hdl.handle.net/11336/15763 |
identifier_str_mv |
Bekinschtein, Pedro Alejandro; Kent, Brianne A.; Oomen, Charlotte; Gregory D. Clemenson; Fred H. Gage; et al.; Brain-derived neurotrophic factor interacts with adult-born immature cells in the dentate gyrus during consolidation of overlapping memories; Wiley; Hippocampus; 24; 8; 8-2014; 905-911 1050-9631 |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/url/http://onlinelibrary.wiley.com/doi/10.1002/hipo.22304/abstract info:eu-repo/semantics/altIdentifier/doi/10.1002/hipo.22304 |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by/2.5/ar/ |
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openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by/2.5/ar/ |
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application/pdf application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
Wiley |
publisher.none.fl_str_mv |
Wiley |
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reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
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CONICET Digital (CONICET) |
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Consejo Nacional de Investigaciones Científicas y Técnicas |
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CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
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13.13397 |