Brain-derived neurotrophic factor interacts with adult-born immature cells in the dentate gyrus during consolidation of overlapping memories

Autores
Bekinschtein, Pedro Alejandro; Kent, Brianne A.; Oomen, Charlotte; Gregory D. Clemenson; Fred H. Gage; Lisa M. Saksida; Timothy J. Bussey
Año de publicación
2014
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Successful memory involves not only remembering information over time but also keeping memories distinct and less confusable. The computational process for making representations of similar input patterns more distinct from each other has been referred to as “pattern separation.” Although adult-born immature neurons have been implicated in this memory feature, the precise role of these neurons and associated molecules in the processing of overlapping memories is unknown. Recently, we found that brain-derived neurotrophic factor (BDNF) in the dentate gyrus is required for the encoding/consolidation of overlapping memories. In this study, we provide evidence that consolidation of these “pattern-separated” memories requires the action of BDNF on immature neurons specifically.
Fil: Bekinschtein, Pedro Alejandro. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Biología Celular y Neurociencias; Argentina. University of Cambridge; Reino Unido. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Kent, Brianne A.. University of Cambridge; Reino Unido
Fil: Oomen, Charlotte. University of Cambridge; Reino Unido
Fil: Gregory D. Clemenson. Salk Institute For Biological Studies; Estados Unidos
Fil: Fred H. Gage. Salk Institute For Biological Studies; Estados Unidos
Fil: Lisa M. Saksida. University of Cambridge; Reino Unido
Fil: Timothy J. Bussey. University of Cambridge; Reino Unido
Materia
BDNF
DENTATE GYRUS
MEMORY CONSOLIDATION
NEUROGENESIS
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/15763
Acceder
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network_acronym_str CONICETDig
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network_name_str CONICET Digital (CONICET)
spelling Brain-derived neurotrophic factor interacts with adult-born immature cells in the dentate gyrus during consolidation of overlapping memoriesBekinschtein, Pedro AlejandroKent, Brianne A.Oomen, CharlotteGregory D. ClemensonFred H. GageLisa M. SaksidaTimothy J. BusseyBDNFDENTATE GYRUSMEMORY CONSOLIDATIONNEUROGENESIShttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Successful memory involves not only remembering information over time but also keeping memories distinct and less confusable. The computational process for making representations of similar input patterns more distinct from each other has been referred to as “pattern separation.” Although adult-born immature neurons have been implicated in this memory feature, the precise role of these neurons and associated molecules in the processing of overlapping memories is unknown. Recently, we found that brain-derived neurotrophic factor (BDNF) in the dentate gyrus is required for the encoding/consolidation of overlapping memories. In this study, we provide evidence that consolidation of these “pattern-separated” memories requires the action of BDNF on immature neurons specifically.Fil: Bekinschtein, Pedro Alejandro. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Biología Celular y Neurociencias; Argentina. University of Cambridge; Reino Unido. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Kent, Brianne A.. University of Cambridge; Reino UnidoFil: Oomen, Charlotte. University of Cambridge; Reino UnidoFil: Gregory D. Clemenson. Salk Institute For Biological Studies; Estados UnidosFil: Fred H. Gage. Salk Institute For Biological Studies; Estados UnidosFil: Lisa M. Saksida. University of Cambridge; Reino UnidoFil: Timothy J. Bussey. University of Cambridge; Reino UnidoWiley2014-08info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/15763Bekinschtein, Pedro Alejandro; Kent, Brianne A.; Oomen, Charlotte; Gregory D. Clemenson; Fred H. Gage; et al.; Brain-derived neurotrophic factor interacts with adult-born immature cells in the dentate gyrus during consolidation of overlapping memories; Wiley; Hippocampus; 24; 8; 8-2014; 905-9111050-9631enginfo:eu-repo/semantics/altIdentifier/url/http://onlinelibrary.wiley.com/doi/10.1002/hipo.22304/abstractinfo:eu-repo/semantics/altIdentifier/doi/10.1002/hipo.22304info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:40:15Zoai:ri.conicet.gov.ar:11336/15763instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:40:15.9CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Brain-derived neurotrophic factor interacts with adult-born immature cells in the dentate gyrus during consolidation of overlapping memories
title Brain-derived neurotrophic factor interacts with adult-born immature cells in the dentate gyrus during consolidation of overlapping memories
spellingShingle Brain-derived neurotrophic factor interacts with adult-born immature cells in the dentate gyrus during consolidation of overlapping memories
Bekinschtein, Pedro Alejandro
BDNF
DENTATE GYRUS
MEMORY CONSOLIDATION
NEUROGENESIS
title_short Brain-derived neurotrophic factor interacts with adult-born immature cells in the dentate gyrus during consolidation of overlapping memories
title_full Brain-derived neurotrophic factor interacts with adult-born immature cells in the dentate gyrus during consolidation of overlapping memories
title_fullStr Brain-derived neurotrophic factor interacts with adult-born immature cells in the dentate gyrus during consolidation of overlapping memories
title_full_unstemmed Brain-derived neurotrophic factor interacts with adult-born immature cells in the dentate gyrus during consolidation of overlapping memories
title_sort Brain-derived neurotrophic factor interacts with adult-born immature cells in the dentate gyrus during consolidation of overlapping memories
dc.creator.none.fl_str_mv Bekinschtein, Pedro Alejandro
Kent, Brianne A.
Oomen, Charlotte
Gregory D. Clemenson
Fred H. Gage
Lisa M. Saksida
Timothy J. Bussey
author Bekinschtein, Pedro Alejandro
author_facet Bekinschtein, Pedro Alejandro
Kent, Brianne A.
Oomen, Charlotte
Gregory D. Clemenson
Fred H. Gage
Lisa M. Saksida
Timothy J. Bussey
author_role author
author2 Kent, Brianne A.
Oomen, Charlotte
Gregory D. Clemenson
Fred H. Gage
Lisa M. Saksida
Timothy J. Bussey
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv BDNF
DENTATE GYRUS
MEMORY CONSOLIDATION
NEUROGENESIS
topic BDNF
DENTATE GYRUS
MEMORY CONSOLIDATION
NEUROGENESIS
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Successful memory involves not only remembering information over time but also keeping memories distinct and less confusable. The computational process for making representations of similar input patterns more distinct from each other has been referred to as “pattern separation.” Although adult-born immature neurons have been implicated in this memory feature, the precise role of these neurons and associated molecules in the processing of overlapping memories is unknown. Recently, we found that brain-derived neurotrophic factor (BDNF) in the dentate gyrus is required for the encoding/consolidation of overlapping memories. In this study, we provide evidence that consolidation of these “pattern-separated” memories requires the action of BDNF on immature neurons specifically.
Fil: Bekinschtein, Pedro Alejandro. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Biología Celular y Neurociencias; Argentina. University of Cambridge; Reino Unido. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Kent, Brianne A.. University of Cambridge; Reino Unido
Fil: Oomen, Charlotte. University of Cambridge; Reino Unido
Fil: Gregory D. Clemenson. Salk Institute For Biological Studies; Estados Unidos
Fil: Fred H. Gage. Salk Institute For Biological Studies; Estados Unidos
Fil: Lisa M. Saksida. University of Cambridge; Reino Unido
Fil: Timothy J. Bussey. University of Cambridge; Reino Unido
description Successful memory involves not only remembering information over time but also keeping memories distinct and less confusable. The computational process for making representations of similar input patterns more distinct from each other has been referred to as “pattern separation.” Although adult-born immature neurons have been implicated in this memory feature, the precise role of these neurons and associated molecules in the processing of overlapping memories is unknown. Recently, we found that brain-derived neurotrophic factor (BDNF) in the dentate gyrus is required for the encoding/consolidation of overlapping memories. In this study, we provide evidence that consolidation of these “pattern-separated” memories requires the action of BDNF on immature neurons specifically.
publishDate 2014
dc.date.none.fl_str_mv 2014-08
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/15763
Bekinschtein, Pedro Alejandro; Kent, Brianne A.; Oomen, Charlotte; Gregory D. Clemenson; Fred H. Gage; et al.; Brain-derived neurotrophic factor interacts with adult-born immature cells in the dentate gyrus during consolidation of overlapping memories; Wiley; Hippocampus; 24; 8; 8-2014; 905-911
1050-9631
url http://hdl.handle.net/11336/15763
identifier_str_mv Bekinschtein, Pedro Alejandro; Kent, Brianne A.; Oomen, Charlotte; Gregory D. Clemenson; Fred H. Gage; et al.; Brain-derived neurotrophic factor interacts with adult-born immature cells in the dentate gyrus during consolidation of overlapping memories; Wiley; Hippocampus; 24; 8; 8-2014; 905-911
1050-9631
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://onlinelibrary.wiley.com/doi/10.1002/hipo.22304/abstract
info:eu-repo/semantics/altIdentifier/doi/10.1002/hipo.22304
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Wiley
publisher.none.fl_str_mv Wiley
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.069144

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