BDNF in the Dentate Gyrus Is Required for Consolidation of ‘‘Pattern-Separated’’ Memories

• Autores: Bekinschtein, Pedro Alejandro; Kent, Brianne A.; Oomen, Charlotte; Clemenson, Gregory D.; Gage, Fred H.; Saksida, Lisa M.; Bussey, Timothy J.
• Año de publicación: 2013
• Idioma: inglés
• Tipo de recurso: artículo
• Materia: PATTERN SEPARATION; BDNF; MEMORY CONSOLIDATION; DENTATE GYRUS
• Institución: Consejo Nacional de Investigaciones Científicas y Técnicas

Successful memory involves not only remembering information over time, but also keeping memories distinct and less confusable. The computational process for making representations for similar input patterns more distinct from each other has been referred to as ‘‘pattern separation.’’ In this work, we developed a set of behavioral conditions that allowed us to manipulate the load for pattern separation at different stages of memory. Thus, we provide experimental evidence that a brain-derived neurotrophic factor (BDNF)-dependent pattern separation process occurs during the encoding/storage/ consolidation, but not the retrieval stage of memory processing. We also found that a spontaneous increase in BDNF in the dentate gyrus of the hippocampus is associated with exposure to landmarks delineating similar, but not dissimilar, spatial locations, suggesting that BDNF is expressed on an ‘‘as-needed’’ basis for pattern separation.
Fil: Bekinschtein, Pedro Alejandro. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Biología Celular y Neurociencias; Argentina; University of Cambridge; Inglaterra; Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina;
Fil: Kent, Brianne A.. University of Cambridge; Inglaterra;
Fil: Oomen, Charlotte. University of Cambridge; Inglaterra;
Fil: Clemenson, Gregory D.. Salk Institute for Biological Studies; Estados Unidos de América;
Fil: Gage, Fred H.. Salk Institute for Biological Studies; Estados Unidos de América;
Fil: Saksida, Lisa M.. University of Cambridge; Inglaterra;
Fil: Bussey, Timothy J.. University of Cambridge; Inglaterra;