Antagonistic Monoaminergic Control of State Dependent Foraging in C. elegans

Autores
Blanco, Maria Gabriela; Lacour, Ailin; Florman, Jeremy; de Rosa, Maria Jose; Alkema, Mark; Rayes, Diego Hernán
Año de publicación
2025
Idioma
inglés
Tipo de recurso
documento de conferencia
Estado
versión publicada
Descripción
The perception of food as more rewarding after deprivation is an evolutionarily conserved phenomenon, yet its underlying neural mechanisms remain poorly understood. We dissect this process using the nematode C. elegans, a model organism with a well-defined nervous system and conserved neurochemistry that provides universal insights into state-dependent behaviors. In C. elegans, fasting triggers an enhanced slowing response upon food re-encounter, ensuring efficient exploitation of the source. We demonstrate that this behavior is governed by an antagonistic relationship between serotonin (5-HT) and tyramine (TA, the invertebrate analog of noradrenaline). The fasting-induced decline in TA disinhibits serotonergic signaling, which primes serotonergic neurons for a heightened response. Consequently, upon encountering food, these neurons release a surge of 5-HT that dramatically slows locomotion to ensure efficient feeding. This mechanism is confirmed in TA-deficient mutants, which exhibit hyperactive serotonergic neurons and an exaggerated slowing response. We further establish that TA directly inhibits the NSM neuron through the activation of two adrenergic-like GPCRs. This defines a neural switch where fasting reduces inhibitory monoamines, disinhibiting 5-HT to ensure feeding. Conservation of these neurotransmitters suggests similar principles govern state- dependent decisions across species, providing insight into foraging and appetite.
Fil: Blanco, Maria Gabriela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; Argentina
Fil: Lacour, Ailin. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; Argentina
Fil: Florman, Jeremy. University of Massachussets; Estados Unidos
Fil: de Rosa, Maria Jose. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; Argentina
Fil: Alkema, Mark. University of Massachussets; Estados Unidos
Fil: Rayes, Diego Hernán. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; Argentina
XL Meeting de la Sociedad Argentina de Investigación en Neurociencias
Buenos Aires
Argentina
Sociedad Argentina de Investigación en Neurociencias
Materia
C. ELEGANS
MONOAMINES
FORANGING
TIRAMINE
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/279787
Acceder
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network_name_str CONICET Digital (CONICET)
spelling Antagonistic Monoaminergic Control of State Dependent Foraging in C. elegansBlanco, Maria GabrielaLacour, AilinFlorman, Jeremyde Rosa, Maria JoseAlkema, MarkRayes, Diego HernánC. ELEGANSMONOAMINESFORANGINGTIRAMINEhttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1The perception of food as more rewarding after deprivation is an evolutionarily conserved phenomenon, yet its underlying neural mechanisms remain poorly understood. We dissect this process using the nematode C. elegans, a model organism with a well-defined nervous system and conserved neurochemistry that provides universal insights into state-dependent behaviors. In C. elegans, fasting triggers an enhanced slowing response upon food re-encounter, ensuring efficient exploitation of the source. We demonstrate that this behavior is governed by an antagonistic relationship between serotonin (5-HT) and tyramine (TA, the invertebrate analog of noradrenaline). The fasting-induced decline in TA disinhibits serotonergic signaling, which primes serotonergic neurons for a heightened response. Consequently, upon encountering food, these neurons release a surge of 5-HT that dramatically slows locomotion to ensure efficient feeding. This mechanism is confirmed in TA-deficient mutants, which exhibit hyperactive serotonergic neurons and an exaggerated slowing response. We further establish that TA directly inhibits the NSM neuron through the activation of two adrenergic-like GPCRs. This defines a neural switch where fasting reduces inhibitory monoamines, disinhibiting 5-HT to ensure feeding. Conservation of these neurotransmitters suggests similar principles govern state- dependent decisions across species, providing insight into foraging and appetite.Fil: Blanco, Maria Gabriela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; ArgentinaFil: Lacour, Ailin. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; ArgentinaFil: Florman, Jeremy. University of Massachussets; Estados UnidosFil: de Rosa, Maria Jose. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; ArgentinaFil: Alkema, Mark. University of Massachussets; Estados UnidosFil: Rayes, Diego Hernán. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; ArgentinaXL Meeting de la Sociedad Argentina de Investigación en NeurocienciasBuenos AiresArgentinaSociedad Argentina de Investigación en NeurocienciasSociedad Argentina de Investigación en Neurociencias2025info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/conferenceObjectReuniónBookhttp://purl.org/coar/resource_type/c_5794info:ar-repo/semantics/documentoDeConferenciaapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/279787Antagonistic Monoaminergic Control of State Dependent Foraging in C. elegans; XL Meeting de la Sociedad Argentina de Investigación en Neurociencias; Buenos Aires; Argentina; 2025; 169-169CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://csan2025.saneurociencias.org.ar/Internacionalinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2026-02-06T12:15:46Zoai:ri.conicet.gov.ar:11336/279787instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982026-02-06 12:15:46.728CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Antagonistic Monoaminergic Control of State Dependent Foraging in C. elegans
title Antagonistic Monoaminergic Control of State Dependent Foraging in C. elegans
spellingShingle Antagonistic Monoaminergic Control of State Dependent Foraging in C. elegans
Blanco, Maria Gabriela
C. ELEGANS
MONOAMINES
FORANGING
TIRAMINE
title_short Antagonistic Monoaminergic Control of State Dependent Foraging in C. elegans
title_full Antagonistic Monoaminergic Control of State Dependent Foraging in C. elegans
title_fullStr Antagonistic Monoaminergic Control of State Dependent Foraging in C. elegans
title_full_unstemmed Antagonistic Monoaminergic Control of State Dependent Foraging in C. elegans
title_sort Antagonistic Monoaminergic Control of State Dependent Foraging in C. elegans
dc.creator.none.fl_str_mv Blanco, Maria Gabriela
Lacour, Ailin
Florman, Jeremy
de Rosa, Maria Jose
Alkema, Mark
Rayes, Diego Hernán
author Blanco, Maria Gabriela
author_facet Blanco, Maria Gabriela
Lacour, Ailin
Florman, Jeremy
de Rosa, Maria Jose
Alkema, Mark
Rayes, Diego Hernán
author_role author
author2 Lacour, Ailin
Florman, Jeremy
de Rosa, Maria Jose
Alkema, Mark
Rayes, Diego Hernán
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv C. ELEGANS
MONOAMINES
FORANGING
TIRAMINE
topic C. ELEGANS
MONOAMINES
FORANGING
TIRAMINE
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv The perception of food as more rewarding after deprivation is an evolutionarily conserved phenomenon, yet its underlying neural mechanisms remain poorly understood. We dissect this process using the nematode C. elegans, a model organism with a well-defined nervous system and conserved neurochemistry that provides universal insights into state-dependent behaviors. In C. elegans, fasting triggers an enhanced slowing response upon food re-encounter, ensuring efficient exploitation of the source. We demonstrate that this behavior is governed by an antagonistic relationship between serotonin (5-HT) and tyramine (TA, the invertebrate analog of noradrenaline). The fasting-induced decline in TA disinhibits serotonergic signaling, which primes serotonergic neurons for a heightened response. Consequently, upon encountering food, these neurons release a surge of 5-HT that dramatically slows locomotion to ensure efficient feeding. This mechanism is confirmed in TA-deficient mutants, which exhibit hyperactive serotonergic neurons and an exaggerated slowing response. We further establish that TA directly inhibits the NSM neuron through the activation of two adrenergic-like GPCRs. This defines a neural switch where fasting reduces inhibitory monoamines, disinhibiting 5-HT to ensure feeding. Conservation of these neurotransmitters suggests similar principles govern state- dependent decisions across species, providing insight into foraging and appetite.
Fil: Blanco, Maria Gabriela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; Argentina
Fil: Lacour, Ailin. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; Argentina
Fil: Florman, Jeremy. University of Massachussets; Estados Unidos
Fil: de Rosa, Maria Jose. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; Argentina
Fil: Alkema, Mark. University of Massachussets; Estados Unidos
Fil: Rayes, Diego Hernán. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; Argentina
XL Meeting de la Sociedad Argentina de Investigación en Neurociencias
Buenos Aires
Argentina
Sociedad Argentina de Investigación en Neurociencias
description The perception of food as more rewarding after deprivation is an evolutionarily conserved phenomenon, yet its underlying neural mechanisms remain poorly understood. We dissect this process using the nematode C. elegans, a model organism with a well-defined nervous system and conserved neurochemistry that provides universal insights into state-dependent behaviors. In C. elegans, fasting triggers an enhanced slowing response upon food re-encounter, ensuring efficient exploitation of the source. We demonstrate that this behavior is governed by an antagonistic relationship between serotonin (5-HT) and tyramine (TA, the invertebrate analog of noradrenaline). The fasting-induced decline in TA disinhibits serotonergic signaling, which primes serotonergic neurons for a heightened response. Consequently, upon encountering food, these neurons release a surge of 5-HT that dramatically slows locomotion to ensure efficient feeding. This mechanism is confirmed in TA-deficient mutants, which exhibit hyperactive serotonergic neurons and an exaggerated slowing response. We further establish that TA directly inhibits the NSM neuron through the activation of two adrenergic-like GPCRs. This defines a neural switch where fasting reduces inhibitory monoamines, disinhibiting 5-HT to ensure feeding. Conservation of these neurotransmitters suggests similar principles govern state- dependent decisions across species, providing insight into foraging and appetite.
publishDate 2025
dc.date.none.fl_str_mv 2025
dc.type.none.fl_str_mv info:eu-repo/semantics/publishedVersion
info:eu-repo/semantics/conferenceObject
Reunión
Book
http://purl.org/coar/resource_type/c_5794
info:ar-repo/semantics/documentoDeConferencia
status_str publishedVersion
format conferenceObject
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/279787
Antagonistic Monoaminergic Control of State Dependent Foraging in C. elegans; XL Meeting de la Sociedad Argentina de Investigación en Neurociencias; Buenos Aires; Argentina; 2025; 169-169
CONICET Digital
CONICET
url http://hdl.handle.net/11336/279787
identifier_str_mv Antagonistic Monoaminergic Control of State Dependent Foraging in C. elegans; XL Meeting de la Sociedad Argentina de Investigación en Neurociencias; Buenos Aires; Argentina; 2025; 169-169
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://csan2025.saneurociencias.org.ar/
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.coverage.none.fl_str_mv Internacional
dc.publisher.none.fl_str_mv Sociedad Argentina de Investigación en Neurociencias
publisher.none.fl_str_mv Sociedad Argentina de Investigación en Neurociencias
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
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repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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