Behavioral state transitions in C. elegans

Autores
Blanco, Maria Gabriela; Florman, Jeremy; Alkema, Mark; de Rosa, Maria Jose; Rayes, Diego Hernán
Año de publicación
2023
Idioma
inglés
Tipo de recurso
documento de conferencia
Estado
versión publicada
Descripción
Changes in food seeking behaviors are influenced by physiological internal states. During foraging, animals can switch from one state to another, for example, from satiety while feeding to hunger and stress when there is food shortage. Referred to as the “happiness hormone”, serotonin has been related in many animals to modulate feeding in favorable environmental conditions. On the other hand, noradrenaline is the major conserved neurotransmitter implicated in triggering a stress response. In this work, we are interested in how these neurotransmitters interact to modulate the animal`s internal state in behavioral transitions. The complexity of the mammalian brain complicates the study of neuronal processes. The nematode Caenorhabditis elegans is suitable for understanding neuronal signaling because of its simple and well-described nervous system. During a prolonged fasting period, animals decrease their locomotion. We demonstrate that locomotion can be resumed by adding tyramine, the analog of noradrenaline in invertebrates. Interestingly, serotonin produces the opposite effect by reducing locomotion. These results suggest that serotonin acts antagonistically to tyramine. Also, when the environment improves and fasted animals encounter food, they release serotonin to slow their locomotion and promote feeding. We found that this slowing response and the activity of the serotonergic neurons upon food encounter are enhanced in tyramine-deficient mutants. Given that tyramine levels decrease during fasting, we hypothesize that the lack of tyramine upon fasting disinhibits the serotonergic neurons and favors their activity upon refeeding. Considering the conservation of neuronal components, we believe that our results may contribute to the understanding of the nervous control of state dependent foraging strategies
Fil: Blanco, Maria Gabriela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina
Fil: Florman, Jeremy. University Of Massachussets. Medical School. Department Of Neurobiology; Estados Unidos
Fil: Alkema, Mark. University Of Massachussets. Medical School. Department Of Neurobiology; Estados Unidos
Fil: de Rosa, Maria Jose. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina
Fil: Rayes, Diego Hernán. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina
III Latin American Worm Meeting
Valaparaíso
Chile
Universidad de Valparaíso
Centro Interdisciplinario De Neurociencia De Valparaíso
Materia
Modulación Neuronal
C. elegans
serotonina
tiramina
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/229146
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/229146
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repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Behavioral state transitions in C. elegansBlanco, Maria GabrielaFlorman, JeremyAlkema, Markde Rosa, Maria JoseRayes, Diego HernánModulación NeuronalC. elegansserotoninatiraminahttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Changes in food seeking behaviors are influenced by physiological internal states. During foraging, animals can switch from one state to another, for example, from satiety while feeding to hunger and stress when there is food shortage. Referred to as the “happiness hormone”, serotonin has been related in many animals to modulate feeding in favorable environmental conditions. On the other hand, noradrenaline is the major conserved neurotransmitter implicated in triggering a stress response. In this work, we are interested in how these neurotransmitters interact to modulate the animal`s internal state in behavioral transitions. The complexity of the mammalian brain complicates the study of neuronal processes. The nematode Caenorhabditis elegans is suitable for understanding neuronal signaling because of its simple and well-described nervous system. During a prolonged fasting period, animals decrease their locomotion. We demonstrate that locomotion can be resumed by adding tyramine, the analog of noradrenaline in invertebrates. Interestingly, serotonin produces the opposite effect by reducing locomotion. These results suggest that serotonin acts antagonistically to tyramine. Also, when the environment improves and fasted animals encounter food, they release serotonin to slow their locomotion and promote feeding. We found that this slowing response and the activity of the serotonergic neurons upon food encounter are enhanced in tyramine-deficient mutants. Given that tyramine levels decrease during fasting, we hypothesize that the lack of tyramine upon fasting disinhibits the serotonergic neurons and favors their activity upon refeeding. Considering the conservation of neuronal components, we believe that our results may contribute to the understanding of the nervous control of state dependent foraging strategiesFil: Blanco, Maria Gabriela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; ArgentinaFil: Florman, Jeremy. University Of Massachussets. Medical School. Department Of Neurobiology; Estados UnidosFil: Alkema, Mark. University Of Massachussets. Medical School. Department Of Neurobiology; Estados UnidosFil: de Rosa, Maria Jose. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; ArgentinaFil: Rayes, Diego Hernán. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; ArgentinaIII Latin American Worm MeetingValaparaísoChileUniversidad de ValparaísoCentro Interdisciplinario De Neurociencia De ValparaísoUniversidad de Valparaíso2023info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/conferenceObjectReuniónBookhttp://purl.org/coar/resource_type/c_5794info:ar-repo/semantics/documentoDeConferenciaapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/229146Behavioral state transitions in C. elegans; III Latin American Worm Meeting; Valaparaíso; Chile; 2023; 26-26CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://cinv.uv.cl/en/3rd-la-worm-meeting/Internacionalinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:06:01Zoai:ri.conicet.gov.ar:11336/229146instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:06:01.914CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Behavioral state transitions in C. elegans
title Behavioral state transitions in C. elegans
spellingShingle Behavioral state transitions in C. elegans
Blanco, Maria Gabriela
Modulación Neuronal
C. elegans
serotonina
tiramina
title_short Behavioral state transitions in C. elegans
title_full Behavioral state transitions in C. elegans
title_fullStr Behavioral state transitions in C. elegans
title_full_unstemmed Behavioral state transitions in C. elegans
title_sort Behavioral state transitions in C. elegans
dc.creator.none.fl_str_mv Blanco, Maria Gabriela
Florman, Jeremy
Alkema, Mark
de Rosa, Maria Jose
Rayes, Diego Hernán
author Blanco, Maria Gabriela
author_facet Blanco, Maria Gabriela
Florman, Jeremy
Alkema, Mark
de Rosa, Maria Jose
Rayes, Diego Hernán
author_role author
author2 Florman, Jeremy
Alkema, Mark
de Rosa, Maria Jose
Rayes, Diego Hernán
author2_role author
author
author
author
dc.subject.none.fl_str_mv Modulación Neuronal
C. elegans
serotonina
tiramina
topic Modulación Neuronal
C. elegans
serotonina
tiramina
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Changes in food seeking behaviors are influenced by physiological internal states. During foraging, animals can switch from one state to another, for example, from satiety while feeding to hunger and stress when there is food shortage. Referred to as the “happiness hormone”, serotonin has been related in many animals to modulate feeding in favorable environmental conditions. On the other hand, noradrenaline is the major conserved neurotransmitter implicated in triggering a stress response. In this work, we are interested in how these neurotransmitters interact to modulate the animal`s internal state in behavioral transitions. The complexity of the mammalian brain complicates the study of neuronal processes. The nematode Caenorhabditis elegans is suitable for understanding neuronal signaling because of its simple and well-described nervous system. During a prolonged fasting period, animals decrease their locomotion. We demonstrate that locomotion can be resumed by adding tyramine, the analog of noradrenaline in invertebrates. Interestingly, serotonin produces the opposite effect by reducing locomotion. These results suggest that serotonin acts antagonistically to tyramine. Also, when the environment improves and fasted animals encounter food, they release serotonin to slow their locomotion and promote feeding. We found that this slowing response and the activity of the serotonergic neurons upon food encounter are enhanced in tyramine-deficient mutants. Given that tyramine levels decrease during fasting, we hypothesize that the lack of tyramine upon fasting disinhibits the serotonergic neurons and favors their activity upon refeeding. Considering the conservation of neuronal components, we believe that our results may contribute to the understanding of the nervous control of state dependent foraging strategies
Fil: Blanco, Maria Gabriela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina
Fil: Florman, Jeremy. University Of Massachussets. Medical School. Department Of Neurobiology; Estados Unidos
Fil: Alkema, Mark. University Of Massachussets. Medical School. Department Of Neurobiology; Estados Unidos
Fil: de Rosa, Maria Jose. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina
Fil: Rayes, Diego Hernán. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina
III Latin American Worm Meeting
Valaparaíso
Chile
Universidad de Valparaíso
Centro Interdisciplinario De Neurociencia De Valparaíso
description Changes in food seeking behaviors are influenced by physiological internal states. During foraging, animals can switch from one state to another, for example, from satiety while feeding to hunger and stress when there is food shortage. Referred to as the “happiness hormone”, serotonin has been related in many animals to modulate feeding in favorable environmental conditions. On the other hand, noradrenaline is the major conserved neurotransmitter implicated in triggering a stress response. In this work, we are interested in how these neurotransmitters interact to modulate the animal`s internal state in behavioral transitions. The complexity of the mammalian brain complicates the study of neuronal processes. The nematode Caenorhabditis elegans is suitable for understanding neuronal signaling because of its simple and well-described nervous system. During a prolonged fasting period, animals decrease their locomotion. We demonstrate that locomotion can be resumed by adding tyramine, the analog of noradrenaline in invertebrates. Interestingly, serotonin produces the opposite effect by reducing locomotion. These results suggest that serotonin acts antagonistically to tyramine. Also, when the environment improves and fasted animals encounter food, they release serotonin to slow their locomotion and promote feeding. We found that this slowing response and the activity of the serotonergic neurons upon food encounter are enhanced in tyramine-deficient mutants. Given that tyramine levels decrease during fasting, we hypothesize that the lack of tyramine upon fasting disinhibits the serotonergic neurons and favors their activity upon refeeding. Considering the conservation of neuronal components, we believe that our results may contribute to the understanding of the nervous control of state dependent foraging strategies
publishDate 2023
dc.date.none.fl_str_mv 2023
dc.type.none.fl_str_mv info:eu-repo/semantics/publishedVersion
info:eu-repo/semantics/conferenceObject
Reunión
Book
http://purl.org/coar/resource_type/c_5794
info:ar-repo/semantics/documentoDeConferencia
status_str publishedVersion
format conferenceObject
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/229146
Behavioral state transitions in C. elegans; III Latin American Worm Meeting; Valaparaíso; Chile; 2023; 26-26
CONICET Digital
CONICET
url http://hdl.handle.net/11336/229146
identifier_str_mv Behavioral state transitions in C. elegans; III Latin American Worm Meeting; Valaparaíso; Chile; 2023; 26-26
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://cinv.uv.cl/en/3rd-la-worm-meeting/
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.coverage.none.fl_str_mv Internacional
dc.publisher.none.fl_str_mv Universidad de Valparaíso
publisher.none.fl_str_mv Universidad de Valparaíso
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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