A distinctive layering pattern of mouse dentate granule cells is generated by developmental and adult neurogenesis

Autores
Mathews, Emily A.; Morgenstern, Nicolás Andrés; Piatti, Veronica del Carmen; Zhao, Chunmei; Jessberger, Sebastian; Schinder, Alejandro Fabian; Gage, Fred H.
Año de publicación
2010
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
New neurons are continuously added throughout life to the dentate gyrus of the mammalian hippocampus. During embryonic and early postnatal development, the dentate gyrus is formed in an outside-in layering pattern that may extend through adulthood. In this work, we sought to quantify systematically the relative position of dentate granule cells generated at different ages. We used 5'-bromo-2'-deoxyuridine (BrdU) and retroviral methodologies to birth date cells born in the embryonic, early postnatal, and adult hippocampus and assessed their final position in the adult mouse granule cell layer. We also quantified both developmental and adult-born cohorts of neural progenitor cells that contribute to the pool of adult progenitor cells. Our data confirm that the outside-in layering of the dentate gyrus continues through adulthood and that early-born cells constitute most of the adult dentate gyrus. We also found that substantial numbers of the dividing cells in the adult dentate gyrus were derived from early-dividing cells and retained BrdU, suggesting that a subpopulation of hippocampal progenitors divides infrequently from early development onward.
Fil: Mathews, Emily A.. Salk Institute For Biological Studies; Estados Unidos. University Of California At San Diego; Estados Unidos
Fil: Morgenstern, Nicolás Andrés. Fundación Instituto Leloir; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquimicas de Buenos Aires; Argentina
Fil: Piatti, Veronica del Carmen. Fundación Instituto Leloir; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquimicas de Buenos Aires; Argentina
Fil: Zhao, Chunmei. Salk Institute for Biological Studies; Estados Unidos
Fil: Jessberger, Sebastian. Salk Institute for Biological Studies; Estados Unidos
Fil: Schinder, Alejandro Fabian. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquimicas de Buenos Aires; Argentina. Fundación Instituto Leloir; Argentina
Fil: Gage, Fred H.. Salk Institute For Biological Studies; Estados Unidos
Materia
Developmental Neurogenesis
Adult Neurogenesis
Dentate Gyrus
Neural Stem Cell
Retrovirus
Brdu
Cell Layering
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/15209
Acceder
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network_name_str CONICET Digital (CONICET)
spelling A distinctive layering pattern of mouse dentate granule cells is generated by developmental and adult neurogenesisMathews, Emily A.Morgenstern, Nicolás AndrésPiatti, Veronica del CarmenZhao, ChunmeiJessberger, SebastianSchinder, Alejandro FabianGage, Fred H.Developmental NeurogenesisAdult NeurogenesisDentate GyrusNeural Stem CellRetrovirusBrduCell Layeringhttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3New neurons are continuously added throughout life to the dentate gyrus of the mammalian hippocampus. During embryonic and early postnatal development, the dentate gyrus is formed in an outside-in layering pattern that may extend through adulthood. In this work, we sought to quantify systematically the relative position of dentate granule cells generated at different ages. We used 5'-bromo-2'-deoxyuridine (BrdU) and retroviral methodologies to birth date cells born in the embryonic, early postnatal, and adult hippocampus and assessed their final position in the adult mouse granule cell layer. We also quantified both developmental and adult-born cohorts of neural progenitor cells that contribute to the pool of adult progenitor cells. Our data confirm that the outside-in layering of the dentate gyrus continues through adulthood and that early-born cells constitute most of the adult dentate gyrus. We also found that substantial numbers of the dividing cells in the adult dentate gyrus were derived from early-dividing cells and retained BrdU, suggesting that a subpopulation of hippocampal progenitors divides infrequently from early development onward.Fil: Mathews, Emily A.. Salk Institute For Biological Studies; Estados Unidos. University Of California At San Diego; Estados UnidosFil: Morgenstern, Nicolás Andrés. Fundación Instituto Leloir; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquimicas de Buenos Aires; ArgentinaFil: Piatti, Veronica del Carmen. Fundación Instituto Leloir; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquimicas de Buenos Aires; ArgentinaFil: Zhao, Chunmei. Salk Institute for Biological Studies; Estados UnidosFil: Jessberger, Sebastian. Salk Institute for Biological Studies; Estados UnidosFil: Schinder, Alejandro Fabian. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquimicas de Buenos Aires; Argentina. Fundación Instituto Leloir; ArgentinaFil: Gage, Fred H.. Salk Institute For Biological Studies; Estados UnidosWiley2010info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/15209Mathews, Emily A.; Morgenstern, Nicolás Andrés; Piatti, Veronica del Carmen; Zhao, Chunmei; Jessberger, Sebastian; et al.; A distinctive layering pattern of mouse dentate granule cells is generated by developmental and adult neurogenesis; Wiley; Journal Of Comparative Neurology; 518; 22; 2010; 4479-44901096-9861enginfo:eu-repo/semantics/altIdentifier/url/http://onlinelibrary.wiley.com/doi/10.1002/cne.22489/fullinfo:eu-repo/semantics/altIdentifier/doi/10.1002/cne.22489info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:58:37Zoai:ri.conicet.gov.ar:11336/15209instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:58:37.659CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv A distinctive layering pattern of mouse dentate granule cells is generated by developmental and adult neurogenesis
title A distinctive layering pattern of mouse dentate granule cells is generated by developmental and adult neurogenesis
spellingShingle A distinctive layering pattern of mouse dentate granule cells is generated by developmental and adult neurogenesis
Mathews, Emily A.
Developmental Neurogenesis
Adult Neurogenesis
Dentate Gyrus
Neural Stem Cell
Retrovirus
Brdu
Cell Layering
title_short A distinctive layering pattern of mouse dentate granule cells is generated by developmental and adult neurogenesis
title_full A distinctive layering pattern of mouse dentate granule cells is generated by developmental and adult neurogenesis
title_fullStr A distinctive layering pattern of mouse dentate granule cells is generated by developmental and adult neurogenesis
title_full_unstemmed A distinctive layering pattern of mouse dentate granule cells is generated by developmental and adult neurogenesis
title_sort A distinctive layering pattern of mouse dentate granule cells is generated by developmental and adult neurogenesis
dc.creator.none.fl_str_mv Mathews, Emily A.
Morgenstern, Nicolás Andrés
Piatti, Veronica del Carmen
Zhao, Chunmei
Jessberger, Sebastian
Schinder, Alejandro Fabian
Gage, Fred H.
author Mathews, Emily A.
author_facet Mathews, Emily A.
Morgenstern, Nicolás Andrés
Piatti, Veronica del Carmen
Zhao, Chunmei
Jessberger, Sebastian
Schinder, Alejandro Fabian
Gage, Fred H.
author_role author
author2 Morgenstern, Nicolás Andrés
Piatti, Veronica del Carmen
Zhao, Chunmei
Jessberger, Sebastian
Schinder, Alejandro Fabian
Gage, Fred H.
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv Developmental Neurogenesis
Adult Neurogenesis
Dentate Gyrus
Neural Stem Cell
Retrovirus
Brdu
Cell Layering
topic Developmental Neurogenesis
Adult Neurogenesis
Dentate Gyrus
Neural Stem Cell
Retrovirus
Brdu
Cell Layering
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv New neurons are continuously added throughout life to the dentate gyrus of the mammalian hippocampus. During embryonic and early postnatal development, the dentate gyrus is formed in an outside-in layering pattern that may extend through adulthood. In this work, we sought to quantify systematically the relative position of dentate granule cells generated at different ages. We used 5'-bromo-2'-deoxyuridine (BrdU) and retroviral methodologies to birth date cells born in the embryonic, early postnatal, and adult hippocampus and assessed their final position in the adult mouse granule cell layer. We also quantified both developmental and adult-born cohorts of neural progenitor cells that contribute to the pool of adult progenitor cells. Our data confirm that the outside-in layering of the dentate gyrus continues through adulthood and that early-born cells constitute most of the adult dentate gyrus. We also found that substantial numbers of the dividing cells in the adult dentate gyrus were derived from early-dividing cells and retained BrdU, suggesting that a subpopulation of hippocampal progenitors divides infrequently from early development onward.
Fil: Mathews, Emily A.. Salk Institute For Biological Studies; Estados Unidos. University Of California At San Diego; Estados Unidos
Fil: Morgenstern, Nicolás Andrés. Fundación Instituto Leloir; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquimicas de Buenos Aires; Argentina
Fil: Piatti, Veronica del Carmen. Fundación Instituto Leloir; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquimicas de Buenos Aires; Argentina
Fil: Zhao, Chunmei. Salk Institute for Biological Studies; Estados Unidos
Fil: Jessberger, Sebastian. Salk Institute for Biological Studies; Estados Unidos
Fil: Schinder, Alejandro Fabian. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquimicas de Buenos Aires; Argentina. Fundación Instituto Leloir; Argentina
Fil: Gage, Fred H.. Salk Institute For Biological Studies; Estados Unidos
description New neurons are continuously added throughout life to the dentate gyrus of the mammalian hippocampus. During embryonic and early postnatal development, the dentate gyrus is formed in an outside-in layering pattern that may extend through adulthood. In this work, we sought to quantify systematically the relative position of dentate granule cells generated at different ages. We used 5'-bromo-2'-deoxyuridine (BrdU) and retroviral methodologies to birth date cells born in the embryonic, early postnatal, and adult hippocampus and assessed their final position in the adult mouse granule cell layer. We also quantified both developmental and adult-born cohorts of neural progenitor cells that contribute to the pool of adult progenitor cells. Our data confirm that the outside-in layering of the dentate gyrus continues through adulthood and that early-born cells constitute most of the adult dentate gyrus. We also found that substantial numbers of the dividing cells in the adult dentate gyrus were derived from early-dividing cells and retained BrdU, suggesting that a subpopulation of hippocampal progenitors divides infrequently from early development onward.
publishDate 2010
dc.date.none.fl_str_mv 2010
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/15209
Mathews, Emily A.; Morgenstern, Nicolás Andrés; Piatti, Veronica del Carmen; Zhao, Chunmei; Jessberger, Sebastian; et al.; A distinctive layering pattern of mouse dentate granule cells is generated by developmental and adult neurogenesis; Wiley; Journal Of Comparative Neurology; 518; 22; 2010; 4479-4490
1096-9861
url http://hdl.handle.net/11336/15209
identifier_str_mv Mathews, Emily A.; Morgenstern, Nicolás Andrés; Piatti, Veronica del Carmen; Zhao, Chunmei; Jessberger, Sebastian; et al.; A distinctive layering pattern of mouse dentate granule cells is generated by developmental and adult neurogenesis; Wiley; Journal Of Comparative Neurology; 518; 22; 2010; 4479-4490
1096-9861
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://onlinelibrary.wiley.com/doi/10.1002/cne.22489/full
info:eu-repo/semantics/altIdentifier/doi/10.1002/cne.22489
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Wiley
publisher.none.fl_str_mv Wiley
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.13397

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