Prevalence and characterization of methicillin-resistant Staphylococcus aureus among healthy children in a city of Argentina
- Autores
- Gardella, N.; Murzicato, S.; Di Gregorio, Sabrina Noelia; Cuirolo, Arabela Ximena; Desse, J.; Crudo, F.; Gutkind, Gabriel Osvaldo; Mollerach, Marta Eugenia
- Año de publicación
- 2011
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Community acquired methicillin-resistant Staphylococcus aureus (CA-MRSA) is a major global problem. Healthy carriers of S. aureus strains have an important role in the dissemination of this bacterium. The aim of this study was to estimate the prevalence of S. aureus and methicillin-resistant S. aureus (MRSA) carriage among healthy children in a city of Buenos Aires province, Argentina, and to determine the potential risk factors for its acquisition. We also described the molecular features of MRSA strains circulating in this population. S. aureus carriage was investigated in all children attending the last year of kindergarten during the 2008 school- year period. Household contacts of MRSA carriers were also screened. Of 316 healthy children, 98 (31.0%) carried S. aureus, including 14 MRSA carriers (4.4%) and 84 methicillin susceptible S. aureus (MSSA) carriers (26.6%). All MRSA isolates carried the SCCmec type IV cassette. Eight of the fourteen isolates were closely related to the clone responsible for most severe community- acquired MRSA infections caused in our country (CAA: PFGE A, SCCmec IV, spa t311, ST5). Two subtypes (A1 and A2) were distinguished in this group by PFGE. Both had agr type II and presented the same virulence determinants, except for PVL coding genes and sea that were only harbored by subtype A1. Our results, based on the analysis of MRSA isolates recovered in the screening of healthy children, provide evidence of a community reservoir of the major CA-MRSA clone described in Argentina.
Fil: Gardella, N.. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina
Fil: Murzicato, S.. Hospital Municipal de San Antonio de Areco; Argentina
Fil: Di Gregorio, Sabrina Noelia. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina
Fil: Cuirolo, Arabela Ximena. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina
Fil: Desse, J.. Hospital Paroissien; Argentina
Fil: Crudo, F.. Hospital Municipal de San Antonio de Areco; Argentina
Fil: Gutkind, Gabriel Osvaldo. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina
Fil: Mollerach, Marta Eugenia. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina - Materia
-
Staphylococcus Aureus
Mrsa - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/13309
Ver los metadatos del registro completo
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Prevalence and characterization of methicillin-resistant Staphylococcus aureus among healthy children in a city of ArgentinaGardella, N.Murzicato, S.Di Gregorio, Sabrina NoeliaCuirolo, Arabela XimenaDesse, J.Crudo, F.Gutkind, Gabriel OsvaldoMollerach, Marta EugeniaStaphylococcus AureusMrsahttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3Community acquired methicillin-resistant Staphylococcus aureus (CA-MRSA) is a major global problem. Healthy carriers of S. aureus strains have an important role in the dissemination of this bacterium. The aim of this study was to estimate the prevalence of S. aureus and methicillin-resistant S. aureus (MRSA) carriage among healthy children in a city of Buenos Aires province, Argentina, and to determine the potential risk factors for its acquisition. We also described the molecular features of MRSA strains circulating in this population. S. aureus carriage was investigated in all children attending the last year of kindergarten during the 2008 school- year period. Household contacts of MRSA carriers were also screened. Of 316 healthy children, 98 (31.0%) carried S. aureus, including 14 MRSA carriers (4.4%) and 84 methicillin susceptible S. aureus (MSSA) carriers (26.6%). All MRSA isolates carried the SCCmec type IV cassette. Eight of the fourteen isolates were closely related to the clone responsible for most severe community- acquired MRSA infections caused in our country (CAA: PFGE A, SCCmec IV, spa t311, ST5). Two subtypes (A1 and A2) were distinguished in this group by PFGE. Both had agr type II and presented the same virulence determinants, except for PVL coding genes and sea that were only harbored by subtype A1. Our results, based on the analysis of MRSA isolates recovered in the screening of healthy children, provide evidence of a community reservoir of the major CA-MRSA clone described in Argentina.Fil: Gardella, N.. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; ArgentinaFil: Murzicato, S.. Hospital Municipal de San Antonio de Areco; ArgentinaFil: Di Gregorio, Sabrina Noelia. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; ArgentinaFil: Cuirolo, Arabela Ximena. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; ArgentinaFil: Desse, J.. Hospital Paroissien; ArgentinaFil: Crudo, F.. Hospital Municipal de San Antonio de Areco; ArgentinaFil: Gutkind, Gabriel Osvaldo. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; ArgentinaFil: Mollerach, Marta Eugenia. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; ArgentinaElsevier Science2011-05info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/13309Gardella, N.; Murzicato, S.; Di Gregorio, Sabrina Noelia; Cuirolo, Arabela Ximena; Desse, J.; et al.; Prevalence and characterization of methicillin-resistant Staphylococcus aureus among healthy children in a city of Argentina; Elsevier Science; Infection, Genetics And Evolution; 11; 5; 5-2011; 1066-10711567-1348enginfo:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S1567134811001006info:eu-repo/semantics/altIdentifier/doi/10.1016/j.meegid.2011.03.019info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:43:34Zoai:ri.conicet.gov.ar:11336/13309instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:43:34.924CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
Prevalence and characterization of methicillin-resistant Staphylococcus aureus among healthy children in a city of Argentina |
title |
Prevalence and characterization of methicillin-resistant Staphylococcus aureus among healthy children in a city of Argentina |
spellingShingle |
Prevalence and characterization of methicillin-resistant Staphylococcus aureus among healthy children in a city of Argentina Gardella, N. Staphylococcus Aureus Mrsa |
title_short |
Prevalence and characterization of methicillin-resistant Staphylococcus aureus among healthy children in a city of Argentina |
title_full |
Prevalence and characterization of methicillin-resistant Staphylococcus aureus among healthy children in a city of Argentina |
title_fullStr |
Prevalence and characterization of methicillin-resistant Staphylococcus aureus among healthy children in a city of Argentina |
title_full_unstemmed |
Prevalence and characterization of methicillin-resistant Staphylococcus aureus among healthy children in a city of Argentina |
title_sort |
Prevalence and characterization of methicillin-resistant Staphylococcus aureus among healthy children in a city of Argentina |
dc.creator.none.fl_str_mv |
Gardella, N. Murzicato, S. Di Gregorio, Sabrina Noelia Cuirolo, Arabela Ximena Desse, J. Crudo, F. Gutkind, Gabriel Osvaldo Mollerach, Marta Eugenia |
author |
Gardella, N. |
author_facet |
Gardella, N. Murzicato, S. Di Gregorio, Sabrina Noelia Cuirolo, Arabela Ximena Desse, J. Crudo, F. Gutkind, Gabriel Osvaldo Mollerach, Marta Eugenia |
author_role |
author |
author2 |
Murzicato, S. Di Gregorio, Sabrina Noelia Cuirolo, Arabela Ximena Desse, J. Crudo, F. Gutkind, Gabriel Osvaldo Mollerach, Marta Eugenia |
author2_role |
author author author author author author author |
dc.subject.none.fl_str_mv |
Staphylococcus Aureus Mrsa |
topic |
Staphylococcus Aureus Mrsa |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/3.3 https://purl.org/becyt/ford/3 |
dc.description.none.fl_txt_mv |
Community acquired methicillin-resistant Staphylococcus aureus (CA-MRSA) is a major global problem. Healthy carriers of S. aureus strains have an important role in the dissemination of this bacterium. The aim of this study was to estimate the prevalence of S. aureus and methicillin-resistant S. aureus (MRSA) carriage among healthy children in a city of Buenos Aires province, Argentina, and to determine the potential risk factors for its acquisition. We also described the molecular features of MRSA strains circulating in this population. S. aureus carriage was investigated in all children attending the last year of kindergarten during the 2008 school- year period. Household contacts of MRSA carriers were also screened. Of 316 healthy children, 98 (31.0%) carried S. aureus, including 14 MRSA carriers (4.4%) and 84 methicillin susceptible S. aureus (MSSA) carriers (26.6%). All MRSA isolates carried the SCCmec type IV cassette. Eight of the fourteen isolates were closely related to the clone responsible for most severe community- acquired MRSA infections caused in our country (CAA: PFGE A, SCCmec IV, spa t311, ST5). Two subtypes (A1 and A2) were distinguished in this group by PFGE. Both had agr type II and presented the same virulence determinants, except for PVL coding genes and sea that were only harbored by subtype A1. Our results, based on the analysis of MRSA isolates recovered in the screening of healthy children, provide evidence of a community reservoir of the major CA-MRSA clone described in Argentina. Fil: Gardella, N.. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina Fil: Murzicato, S.. Hospital Municipal de San Antonio de Areco; Argentina Fil: Di Gregorio, Sabrina Noelia. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina Fil: Cuirolo, Arabela Ximena. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina Fil: Desse, J.. Hospital Paroissien; Argentina Fil: Crudo, F.. Hospital Municipal de San Antonio de Areco; Argentina Fil: Gutkind, Gabriel Osvaldo. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina Fil: Mollerach, Marta Eugenia. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina |
description |
Community acquired methicillin-resistant Staphylococcus aureus (CA-MRSA) is a major global problem. Healthy carriers of S. aureus strains have an important role in the dissemination of this bacterium. The aim of this study was to estimate the prevalence of S. aureus and methicillin-resistant S. aureus (MRSA) carriage among healthy children in a city of Buenos Aires province, Argentina, and to determine the potential risk factors for its acquisition. We also described the molecular features of MRSA strains circulating in this population. S. aureus carriage was investigated in all children attending the last year of kindergarten during the 2008 school- year period. Household contacts of MRSA carriers were also screened. Of 316 healthy children, 98 (31.0%) carried S. aureus, including 14 MRSA carriers (4.4%) and 84 methicillin susceptible S. aureus (MSSA) carriers (26.6%). All MRSA isolates carried the SCCmec type IV cassette. Eight of the fourteen isolates were closely related to the clone responsible for most severe community- acquired MRSA infections caused in our country (CAA: PFGE A, SCCmec IV, spa t311, ST5). Two subtypes (A1 and A2) were distinguished in this group by PFGE. Both had agr type II and presented the same virulence determinants, except for PVL coding genes and sea that were only harbored by subtype A1. Our results, based on the analysis of MRSA isolates recovered in the screening of healthy children, provide evidence of a community reservoir of the major CA-MRSA clone described in Argentina. |
publishDate |
2011 |
dc.date.none.fl_str_mv |
2011-05 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/13309 Gardella, N.; Murzicato, S.; Di Gregorio, Sabrina Noelia; Cuirolo, Arabela Ximena; Desse, J.; et al.; Prevalence and characterization of methicillin-resistant Staphylococcus aureus among healthy children in a city of Argentina; Elsevier Science; Infection, Genetics And Evolution; 11; 5; 5-2011; 1066-1071 1567-1348 |
url |
http://hdl.handle.net/11336/13309 |
identifier_str_mv |
Gardella, N.; Murzicato, S.; Di Gregorio, Sabrina Noelia; Cuirolo, Arabela Ximena; Desse, J.; et al.; Prevalence and characterization of methicillin-resistant Staphylococcus aureus among healthy children in a city of Argentina; Elsevier Science; Infection, Genetics And Evolution; 11; 5; 5-2011; 1066-1071 1567-1348 |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S1567134811001006 info:eu-repo/semantics/altIdentifier/doi/10.1016/j.meegid.2011.03.019 |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-nd/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf application/pdf application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
Elsevier Science |
publisher.none.fl_str_mv |
Elsevier Science |
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reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
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CONICET Digital (CONICET) |
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Consejo Nacional de Investigaciones Científicas y Técnicas |
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CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
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dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
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1842268611113123840 |
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13.13397 |