Different evolution of S. aureus methicillin-resistant and methicillin-susceptible infections, Argentina

Autores
Barcudi, Danilo Andres; Blasko, Enrique Gabriel; Gonzalez, María José; Gagetti, Paula Silvana; Lamberghini, Ricardo; Garnero, Analía; Sarkis, Claudia; Faccone, Diego Francisco; Lucero, Celeste; Tosoroni, Dario; Bocco, Jose Luis; Corso, Alejandra; Sola, Claudia del Valle
Año de publicación
2023
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Staphylococcus aureus-(SA) is widespread among healthcare-associated-(HA) and the community-associated-(CA) infections. However, the contributions of MRSA and MSSA to the SA overall burden remain unclear. In a nationally-representative-survey conducted in Argentina, 668 SA clinical isolates from 60 hospitals were examined in a prospective, cross-sectional, multicenter study in April 2015. The study aimed to analyze MRSA molecular epidemiology, estimate overall SA infection incidence (MSSA, MRSA, and genotypes) in community-onset (CO: HACO, Healthcare Associated-CO and CACO, Community-Associated-CO) and healthcare-onset (HO: HAHO, Healthcare-associated-HO) infections, stratified by age groups. Additionally temporal evolution was estimated by comparing this study´s (2015) incidence values with a previous study (2009) in the same region. Erythromycin-resistant-MSSA and all MRSA strains were genetically typed. The SA total-infections (TI) overall-incidence was 49.1/100,000 monthly-visits, 25.1 and 24.0 for MRSA and MSSA respectively (P=0.5889), in April 2015. In adults with invasive infections (INVI), MSSA was 15.7 and MRSA was 11.8 (P=0.0288), 1.3-fold higher. HA SA infections, both MSSA and MRSA, surpassed CA infections by over threefold. During 2009-2015, there was a significant 23.4% increase in the SA infections overall incidence, mainly driven by MSSA, notably a 54.2% increase in INVI among adults, while MRSA infection rates remained stable. The MSSA rise was accompanied by increased antimicrobial resistance, particularly to erythromycin, linked to MSSA-CC398-t1451-ermT + - IEC+ -pvl- emergence. The SA-infections rise was primarily attributed to community-onset infections (37.3% and 62.4% increase for TI and INVI, respectively), particularly HACO MSSA and HACO-MRSA in adults, as well as CACO-MSSA. The main CA-MRSA-PFGEtypeN-ST30-SCCmecIVc-PVL+/- clone along with other clones (USA300-ST8-IV-LV-PVL+/- , Journal Pre-proof 5 PFGE-typeDD-ST97-IV- PVL- ) added to rather than replaced CA-MRSA-PFGE-typeI-ST5- SCCmecIVa-PVL+/- clone in HA invasive-infections. They also displaced clone HA-MRSA PFGE-typeA-ST5-SCCmecI, mainly in HAHO infections The overall-burden of SA infections is rising in Argentina, driven primarily by community onset MSSA, particularly in adults, linked to increased erythromycin-resistance and MSSACC398-t1451-ermT + -IEC+ -pvl- emergence. Novel knowledge and transmission-control strategies are required for MSSA
Fil: Barcudi, Danilo Andres. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; Argentina
Fil: Blasko, Enrique Gabriel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; Argentina
Fil: Gonzalez, María José. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; Argentina
Fil: Gagetti, Paula Silvana. Dirección Nacional de Institutos de Investigación. Administración Nacional de Laboratorios e Institutos de Salud. Instituto Nacional de Enfermedades Infecciosas. Área de Antimicrobianos; Argentina
Fil: Lamberghini, Ricardo. Universidad Nacional de Córdoba; Argentina
Fil: Garnero, Analía. Gobierno de la Provincia de Cordoba. Ministerio de Salud. Hospital de Niños de la Santísima Trinidad.; Argentina
Fil: Sarkis, Claudia. Gobierno de la Ciudad de Buenos Aires. Hospital de Pediatría "Juan P. Garrahan"; Argentina
Fil: Faccone, Diego Francisco. Dirección Nacional de Institutos de Investigación. Administración Nacional de Laboratorios e Institutos de Salud. Instituto Nacional de Enfermedades Infecciosas. Área de Antimicrobianos; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Lucero, Celeste. Dirección Nacional de Institutos de Investigación. Administración Nacional de Laboratorios e Institutos de Salud. Instituto Nacional de Enfermedades Infecciosas. Área de Antimicrobianos; Argentina
Fil: Tosoroni, Dario. Universidad Nacional de Córdoba; Argentina
Fil: Bocco, Jose Luis. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; Argentina
Fil: Corso, Alejandra. Dirección Nacional de Institutos de Investigación. Administración Nacional de Laboratorios e Institutos de Salud. Instituto Nacional de Enfermedades Infecciosas. Área de Antimicrobianos; Argentina
Fil: Sola, Claudia del Valle. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; Argentina
Materia
STAPHYLOCOCCUS AUREUS
MRSA
METHICILLIN-RESISTANCE
EVOLUTION
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/220401
Acceder
id CONICETDig_10bb3547b79db4e49ebf496ccb2ec709
oai_identifier_str oai:ri.conicet.gov.ar:11336/220401
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Different evolution of S. aureus methicillin-resistant and methicillin-susceptible infections, ArgentinaBarcudi, Danilo AndresBlasko, Enrique GabrielGonzalez, María JoséGagetti, Paula SilvanaLamberghini, RicardoGarnero, AnalíaSarkis, ClaudiaFaccone, Diego FranciscoLucero, CelesteTosoroni, DarioBocco, Jose LuisCorso, AlejandraSola, Claudia del ValleSTAPHYLOCOCCUS AUREUSMRSAMETHICILLIN-RESISTANCEEVOLUTIONhttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3Staphylococcus aureus-(SA) is widespread among healthcare-associated-(HA) and the community-associated-(CA) infections. However, the contributions of MRSA and MSSA to the SA overall burden remain unclear. In a nationally-representative-survey conducted in Argentina, 668 SA clinical isolates from 60 hospitals were examined in a prospective, cross-sectional, multicenter study in April 2015. The study aimed to analyze MRSA molecular epidemiology, estimate overall SA infection incidence (MSSA, MRSA, and genotypes) in community-onset (CO: HACO, Healthcare Associated-CO and CACO, Community-Associated-CO) and healthcare-onset (HO: HAHO, Healthcare-associated-HO) infections, stratified by age groups. Additionally temporal evolution was estimated by comparing this study´s (2015) incidence values with a previous study (2009) in the same region. Erythromycin-resistant-MSSA and all MRSA strains were genetically typed. The SA total-infections (TI) overall-incidence was 49.1/100,000 monthly-visits, 25.1 and 24.0 for MRSA and MSSA respectively (P=0.5889), in April 2015. In adults with invasive infections (INVI), MSSA was 15.7 and MRSA was 11.8 (P=0.0288), 1.3-fold higher. HA SA infections, both MSSA and MRSA, surpassed CA infections by over threefold. During 2009-2015, there was a significant 23.4% increase in the SA infections overall incidence, mainly driven by MSSA, notably a 54.2% increase in INVI among adults, while MRSA infection rates remained stable. The MSSA rise was accompanied by increased antimicrobial resistance, particularly to erythromycin, linked to MSSA-CC398-t1451-ermT + - IEC+ -pvl- emergence. The SA-infections rise was primarily attributed to community-onset infections (37.3% and 62.4% increase for TI and INVI, respectively), particularly HACO MSSA and HACO-MRSA in adults, as well as CACO-MSSA. The main CA-MRSA-PFGEtypeN-ST30-SCCmecIVc-PVL+/- clone along with other clones (USA300-ST8-IV-LV-PVL+/- , Journal Pre-proof 5 PFGE-typeDD-ST97-IV- PVL- ) added to rather than replaced CA-MRSA-PFGE-typeI-ST5- SCCmecIVa-PVL+/- clone in HA invasive-infections. They also displaced clone HA-MRSA PFGE-typeA-ST5-SCCmecI, mainly in HAHO infections The overall-burden of SA infections is rising in Argentina, driven primarily by community onset MSSA, particularly in adults, linked to increased erythromycin-resistance and MSSACC398-t1451-ermT + -IEC+ -pvl- emergence. Novel knowledge and transmission-control strategies are required for MSSAFil: Barcudi, Danilo Andres. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; ArgentinaFil: Blasko, Enrique Gabriel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; ArgentinaFil: Gonzalez, María José. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; ArgentinaFil: Gagetti, Paula Silvana. Dirección Nacional de Institutos de Investigación. Administración Nacional de Laboratorios e Institutos de Salud. Instituto Nacional de Enfermedades Infecciosas. Área de Antimicrobianos; ArgentinaFil: Lamberghini, Ricardo. Universidad Nacional de Córdoba; ArgentinaFil: Garnero, Analía. Gobierno de la Provincia de Cordoba. Ministerio de Salud. Hospital de Niños de la Santísima Trinidad.; ArgentinaFil: Sarkis, Claudia. Gobierno de la Ciudad de Buenos Aires. Hospital de Pediatría "Juan P. Garrahan"; ArgentinaFil: Faccone, Diego Francisco. Dirección Nacional de Institutos de Investigación. Administración Nacional de Laboratorios e Institutos de Salud. Instituto Nacional de Enfermedades Infecciosas. Área de Antimicrobianos; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Lucero, Celeste. Dirección Nacional de Institutos de Investigación. Administración Nacional de Laboratorios e Institutos de Salud. Instituto Nacional de Enfermedades Infecciosas. Área de Antimicrobianos; ArgentinaFil: Tosoroni, Dario. Universidad Nacional de Córdoba; ArgentinaFil: Bocco, Jose Luis. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; ArgentinaFil: Corso, Alejandra. Dirección Nacional de Institutos de Investigación. Administración Nacional de Laboratorios e Institutos de Salud. Instituto Nacional de Enfermedades Infecciosas. Área de Antimicrobianos; ArgentinaFil: Sola, Claudia del Valle. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; ArgentinaElsevier2023-11info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/220401Barcudi, Danilo Andres; Blasko, Enrique Gabriel; Gonzalez, María José; Gagetti, Paula Silvana; Lamberghini, Ricardo; et al.; Different evolution of S. aureus methicillin-resistant and methicillin-susceptible infections, Argentina; Elsevier; Heliyon; 11-2023; 1-532405-8440CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://linkinghub.elsevier.com/retrieve/pii/S2405844023098183info:eu-repo/semantics/altIdentifier/doi/10.1016/j.heliyon.2023.e22610info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T10:10:18Zoai:ri.conicet.gov.ar:11336/220401instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 10:10:18.646CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Different evolution of S. aureus methicillin-resistant and methicillin-susceptible infections, Argentina
title Different evolution of S. aureus methicillin-resistant and methicillin-susceptible infections, Argentina
spellingShingle Different evolution of S. aureus methicillin-resistant and methicillin-susceptible infections, Argentina
Barcudi, Danilo Andres
STAPHYLOCOCCUS AUREUS
MRSA
METHICILLIN-RESISTANCE
EVOLUTION
title_short Different evolution of S. aureus methicillin-resistant and methicillin-susceptible infections, Argentina
title_full Different evolution of S. aureus methicillin-resistant and methicillin-susceptible infections, Argentina
title_fullStr Different evolution of S. aureus methicillin-resistant and methicillin-susceptible infections, Argentina
title_full_unstemmed Different evolution of S. aureus methicillin-resistant and methicillin-susceptible infections, Argentina
title_sort Different evolution of S. aureus methicillin-resistant and methicillin-susceptible infections, Argentina
dc.creator.none.fl_str_mv Barcudi, Danilo Andres
Blasko, Enrique Gabriel
Gonzalez, María José
Gagetti, Paula Silvana
Lamberghini, Ricardo
Garnero, Analía
Sarkis, Claudia
Faccone, Diego Francisco
Lucero, Celeste
Tosoroni, Dario
Bocco, Jose Luis
Corso, Alejandra
Sola, Claudia del Valle
author Barcudi, Danilo Andres
author_facet Barcudi, Danilo Andres
Blasko, Enrique Gabriel
Gonzalez, María José
Gagetti, Paula Silvana
Lamberghini, Ricardo
Garnero, Analía
Sarkis, Claudia
Faccone, Diego Francisco
Lucero, Celeste
Tosoroni, Dario
Bocco, Jose Luis
Corso, Alejandra
Sola, Claudia del Valle
author_role author
author2 Blasko, Enrique Gabriel
Gonzalez, María José
Gagetti, Paula Silvana
Lamberghini, Ricardo
Garnero, Analía
Sarkis, Claudia
Faccone, Diego Francisco
Lucero, Celeste
Tosoroni, Dario
Bocco, Jose Luis
Corso, Alejandra
Sola, Claudia del Valle
author2_role author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv STAPHYLOCOCCUS AUREUS
MRSA
METHICILLIN-RESISTANCE
EVOLUTION
topic STAPHYLOCOCCUS AUREUS
MRSA
METHICILLIN-RESISTANCE
EVOLUTION
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Staphylococcus aureus-(SA) is widespread among healthcare-associated-(HA) and the community-associated-(CA) infections. However, the contributions of MRSA and MSSA to the SA overall burden remain unclear. In a nationally-representative-survey conducted in Argentina, 668 SA clinical isolates from 60 hospitals were examined in a prospective, cross-sectional, multicenter study in April 2015. The study aimed to analyze MRSA molecular epidemiology, estimate overall SA infection incidence (MSSA, MRSA, and genotypes) in community-onset (CO: HACO, Healthcare Associated-CO and CACO, Community-Associated-CO) and healthcare-onset (HO: HAHO, Healthcare-associated-HO) infections, stratified by age groups. Additionally temporal evolution was estimated by comparing this study´s (2015) incidence values with a previous study (2009) in the same region. Erythromycin-resistant-MSSA and all MRSA strains were genetically typed. The SA total-infections (TI) overall-incidence was 49.1/100,000 monthly-visits, 25.1 and 24.0 for MRSA and MSSA respectively (P=0.5889), in April 2015. In adults with invasive infections (INVI), MSSA was 15.7 and MRSA was 11.8 (P=0.0288), 1.3-fold higher. HA SA infections, both MSSA and MRSA, surpassed CA infections by over threefold. During 2009-2015, there was a significant 23.4% increase in the SA infections overall incidence, mainly driven by MSSA, notably a 54.2% increase in INVI among adults, while MRSA infection rates remained stable. The MSSA rise was accompanied by increased antimicrobial resistance, particularly to erythromycin, linked to MSSA-CC398-t1451-ermT + - IEC+ -pvl- emergence. The SA-infections rise was primarily attributed to community-onset infections (37.3% and 62.4% increase for TI and INVI, respectively), particularly HACO MSSA and HACO-MRSA in adults, as well as CACO-MSSA. The main CA-MRSA-PFGEtypeN-ST30-SCCmecIVc-PVL+/- clone along with other clones (USA300-ST8-IV-LV-PVL+/- , Journal Pre-proof 5 PFGE-typeDD-ST97-IV- PVL- ) added to rather than replaced CA-MRSA-PFGE-typeI-ST5- SCCmecIVa-PVL+/- clone in HA invasive-infections. They also displaced clone HA-MRSA PFGE-typeA-ST5-SCCmecI, mainly in HAHO infections The overall-burden of SA infections is rising in Argentina, driven primarily by community onset MSSA, particularly in adults, linked to increased erythromycin-resistance and MSSACC398-t1451-ermT + -IEC+ -pvl- emergence. Novel knowledge and transmission-control strategies are required for MSSA
Fil: Barcudi, Danilo Andres. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; Argentina
Fil: Blasko, Enrique Gabriel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; Argentina
Fil: Gonzalez, María José. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; Argentina
Fil: Gagetti, Paula Silvana. Dirección Nacional de Institutos de Investigación. Administración Nacional de Laboratorios e Institutos de Salud. Instituto Nacional de Enfermedades Infecciosas. Área de Antimicrobianos; Argentina
Fil: Lamberghini, Ricardo. Universidad Nacional de Córdoba; Argentina
Fil: Garnero, Analía. Gobierno de la Provincia de Cordoba. Ministerio de Salud. Hospital de Niños de la Santísima Trinidad.; Argentina
Fil: Sarkis, Claudia. Gobierno de la Ciudad de Buenos Aires. Hospital de Pediatría "Juan P. Garrahan"; Argentina
Fil: Faccone, Diego Francisco. Dirección Nacional de Institutos de Investigación. Administración Nacional de Laboratorios e Institutos de Salud. Instituto Nacional de Enfermedades Infecciosas. Área de Antimicrobianos; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Lucero, Celeste. Dirección Nacional de Institutos de Investigación. Administración Nacional de Laboratorios e Institutos de Salud. Instituto Nacional de Enfermedades Infecciosas. Área de Antimicrobianos; Argentina
Fil: Tosoroni, Dario. Universidad Nacional de Córdoba; Argentina
Fil: Bocco, Jose Luis. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; Argentina
Fil: Corso, Alejandra. Dirección Nacional de Institutos de Investigación. Administración Nacional de Laboratorios e Institutos de Salud. Instituto Nacional de Enfermedades Infecciosas. Área de Antimicrobianos; Argentina
Fil: Sola, Claudia del Valle. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; Argentina
description Staphylococcus aureus-(SA) is widespread among healthcare-associated-(HA) and the community-associated-(CA) infections. However, the contributions of MRSA and MSSA to the SA overall burden remain unclear. In a nationally-representative-survey conducted in Argentina, 668 SA clinical isolates from 60 hospitals were examined in a prospective, cross-sectional, multicenter study in April 2015. The study aimed to analyze MRSA molecular epidemiology, estimate overall SA infection incidence (MSSA, MRSA, and genotypes) in community-onset (CO: HACO, Healthcare Associated-CO and CACO, Community-Associated-CO) and healthcare-onset (HO: HAHO, Healthcare-associated-HO) infections, stratified by age groups. Additionally temporal evolution was estimated by comparing this study´s (2015) incidence values with a previous study (2009) in the same region. Erythromycin-resistant-MSSA and all MRSA strains were genetically typed. The SA total-infections (TI) overall-incidence was 49.1/100,000 monthly-visits, 25.1 and 24.0 for MRSA and MSSA respectively (P=0.5889), in April 2015. In adults with invasive infections (INVI), MSSA was 15.7 and MRSA was 11.8 (P=0.0288), 1.3-fold higher. HA SA infections, both MSSA and MRSA, surpassed CA infections by over threefold. During 2009-2015, there was a significant 23.4% increase in the SA infections overall incidence, mainly driven by MSSA, notably a 54.2% increase in INVI among adults, while MRSA infection rates remained stable. The MSSA rise was accompanied by increased antimicrobial resistance, particularly to erythromycin, linked to MSSA-CC398-t1451-ermT + - IEC+ -pvl- emergence. The SA-infections rise was primarily attributed to community-onset infections (37.3% and 62.4% increase for TI and INVI, respectively), particularly HACO MSSA and HACO-MRSA in adults, as well as CACO-MSSA. The main CA-MRSA-PFGEtypeN-ST30-SCCmecIVc-PVL+/- clone along with other clones (USA300-ST8-IV-LV-PVL+/- , Journal Pre-proof 5 PFGE-typeDD-ST97-IV- PVL- ) added to rather than replaced CA-MRSA-PFGE-typeI-ST5- SCCmecIVa-PVL+/- clone in HA invasive-infections. They also displaced clone HA-MRSA PFGE-typeA-ST5-SCCmecI, mainly in HAHO infections The overall-burden of SA infections is rising in Argentina, driven primarily by community onset MSSA, particularly in adults, linked to increased erythromycin-resistance and MSSACC398-t1451-ermT + -IEC+ -pvl- emergence. Novel knowledge and transmission-control strategies are required for MSSA
publishDate 2023
dc.date.none.fl_str_mv 2023-11
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/220401
Barcudi, Danilo Andres; Blasko, Enrique Gabriel; Gonzalez, María José; Gagetti, Paula Silvana; Lamberghini, Ricardo; et al.; Different evolution of S. aureus methicillin-resistant and methicillin-susceptible infections, Argentina; Elsevier; Heliyon; 11-2023; 1-53
2405-8440
CONICET Digital
CONICET
url http://hdl.handle.net/11336/220401
identifier_str_mv Barcudi, Danilo Andres; Blasko, Enrique Gabriel; Gonzalez, María José; Gagetti, Paula Silvana; Lamberghini, Ricardo; et al.; Different evolution of S. aureus methicillin-resistant and methicillin-susceptible infections, Argentina; Elsevier; Heliyon; 11-2023; 1-53
2405-8440
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://linkinghub.elsevier.com/retrieve/pii/S2405844023098183
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.heliyon.2023.e22610
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.13397

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