Community-associated methicillin-resistant Staphylococcus aureus in children treated in Uruguay
- Autores
- Pardo, Lorena; Vola, Magdalena; Macedo Viñas, Marina; Machado, Virginia; Cuello, Dianna; Mollerach, Marta Eugenia; Castro, Marta; Pirez, Catalina; Varela, Gustavo; Algorta, Gabriela
- Año de publicación
- 2013
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Introduction: Staphylococcus aureus produces a variety of diseases among children, ranging from skin and soft tissue infections to invasive life-threatening diseases. Since 1990, an increasing number of diseases produced by community-associated methicillin-resistant S. aureus (CA-MRSA) isolates have been reported. The aim of this study was to describe the importance and the microbiological characteristics of S. aureus isolates recovered from children treated at the Hospital Pediátrico del Centro Hospitalario ?Pereira Rossell? (HP-CHPR); focusing on invasive diseases caused by CA-MRSA isolates, as well as some clinical aspects of the diseases they have produced. Methodology: One hundred and twenty-five S. aureus isolates recovered from the HP-CHPR between 2003 and 2006 from children with invasive (n=89) and superficial diseases (n=36) were included. Genotypic and phenotypic characteristics of S. aureus isolates and relevant clinical aspects of each child were studied. Results: CA-MRSA isolates accounted for 73% of all S. aureus recovered from invasive (mainly bone and joint) infections, pneumonia and bacteraemia. The most common CA-MRSA strain recovered from invasive (n=65) and superficial (n=36) diseases had the following features: pulsotype A (type USA1100), SCCmec cassette type IV, Panton-Valentine Leukocidin genes positive, susceptibility to trimethoprim-sulfamethoxazole without the inducible macrolide-lincosamide-streptogramin B (iMLSB) resistance phenotype. No association between genotypic characteristics of invasive CA-MRSA isolates and clinical outcomes was found. Conclusions: CA-MRSA isolates produced a wide spectrum of invasive diseases in a public paediatric hospital between 2003 and 2006. Microbiologic characterization suggests the spread of an adapted CA-MRSA clone lacking erm genes
Fil: Pardo, Lorena. Universidad de la Republica; Uruguay
Fil: Vola, Magdalena. Universidad de la Republica; Uruguay
Fil: Macedo Viñas, Marina. Universidad de la Republica; Uruguay
Fil: Machado, Virginia. Universidad de la Republica; Uruguay
Fil: Cuello, Dianna. Universidad de la Republica; Uruguay
Fil: Mollerach, Marta Eugenia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Inmunología, Genética y Metabolismo; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina
Fil: Castro, Marta. Universidad de la Republica; Uruguay
Fil: Pirez, Catalina. Universidad de la Republica; Uruguay
Fil: Varela, Gustavo. Universidad de la Republica; Uruguay
Fil: Algorta, Gabriela. Universidad de la Republica; Uruguay - Materia
-
Staphylococcus Aureus
Mrsa - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/12869
Ver los metadatos del registro completo
id |
CONICETDig_a0ab4278bfc7907c98fbdac8a60f6057 |
---|---|
oai_identifier_str |
oai:ri.conicet.gov.ar:11336/12869 |
network_acronym_str |
CONICETDig |
repository_id_str |
3498 |
network_name_str |
CONICET Digital (CONICET) |
spelling |
Community-associated methicillin-resistant Staphylococcus aureus in children treated in UruguayPardo, LorenaVola, MagdalenaMacedo Viñas, MarinaMachado, VirginiaCuello, DiannaMollerach, Marta EugeniaCastro, MartaPirez, CatalinaVarela, GustavoAlgorta, GabrielaStaphylococcus AureusMrsahttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3Introduction: Staphylococcus aureus produces a variety of diseases among children, ranging from skin and soft tissue infections to invasive life-threatening diseases. Since 1990, an increasing number of diseases produced by community-associated methicillin-resistant S. aureus (CA-MRSA) isolates have been reported. The aim of this study was to describe the importance and the microbiological characteristics of S. aureus isolates recovered from children treated at the Hospital Pediátrico del Centro Hospitalario ?Pereira Rossell? (HP-CHPR); focusing on invasive diseases caused by CA-MRSA isolates, as well as some clinical aspects of the diseases they have produced. Methodology: One hundred and twenty-five S. aureus isolates recovered from the HP-CHPR between 2003 and 2006 from children with invasive (n=89) and superficial diseases (n=36) were included. Genotypic and phenotypic characteristics of S. aureus isolates and relevant clinical aspects of each child were studied. Results: CA-MRSA isolates accounted for 73% of all S. aureus recovered from invasive (mainly bone and joint) infections, pneumonia and bacteraemia. The most common CA-MRSA strain recovered from invasive (n=65) and superficial (n=36) diseases had the following features: pulsotype A (type USA1100), SCCmec cassette type IV, Panton-Valentine Leukocidin genes positive, susceptibility to trimethoprim-sulfamethoxazole without the inducible macrolide-lincosamide-streptogramin B (iMLSB) resistance phenotype. No association between genotypic characteristics of invasive CA-MRSA isolates and clinical outcomes was found. Conclusions: CA-MRSA isolates produced a wide spectrum of invasive diseases in a public paediatric hospital between 2003 and 2006. Microbiologic characterization suggests the spread of an adapted CA-MRSA clone lacking erm genesFil: Pardo, Lorena. Universidad de la Republica; UruguayFil: Vola, Magdalena. Universidad de la Republica; UruguayFil: Macedo Viñas, Marina. Universidad de la Republica; UruguayFil: Machado, Virginia. Universidad de la Republica; UruguayFil: Cuello, Dianna. Universidad de la Republica; UruguayFil: Mollerach, Marta Eugenia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Inmunología, Genética y Metabolismo; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; ArgentinaFil: Castro, Marta. Universidad de la Republica; UruguayFil: Pirez, Catalina. Universidad de la Republica; UruguayFil: Varela, Gustavo. Universidad de la Republica; UruguayFil: Algorta, Gabriela. Universidad de la Republica; UruguayPorto Conte Ricerche Research Centre2013-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/12869Pardo, Lorena; Vola, Magdalena; Macedo Viñas, Marina; Machado, Virginia; Cuello, Dianna; et al.; Community-associated methicillin-resistant Staphylococcus aureus in children treated in Uruguay; Porto Conte Ricerche Research Centre; The Journal of Infection in Developing Countries; 7; 1; 1-2013; 10-162036-6590enginfo:eu-repo/semantics/altIdentifier/url/http://www.jidc.org/index.php/journal/article/view/23324815info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T10:09:50Zoai:ri.conicet.gov.ar:11336/12869instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 10:09:51.289CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
Community-associated methicillin-resistant Staphylococcus aureus in children treated in Uruguay |
title |
Community-associated methicillin-resistant Staphylococcus aureus in children treated in Uruguay |
spellingShingle |
Community-associated methicillin-resistant Staphylococcus aureus in children treated in Uruguay Pardo, Lorena Staphylococcus Aureus Mrsa |
title_short |
Community-associated methicillin-resistant Staphylococcus aureus in children treated in Uruguay |
title_full |
Community-associated methicillin-resistant Staphylococcus aureus in children treated in Uruguay |
title_fullStr |
Community-associated methicillin-resistant Staphylococcus aureus in children treated in Uruguay |
title_full_unstemmed |
Community-associated methicillin-resistant Staphylococcus aureus in children treated in Uruguay |
title_sort |
Community-associated methicillin-resistant Staphylococcus aureus in children treated in Uruguay |
dc.creator.none.fl_str_mv |
Pardo, Lorena Vola, Magdalena Macedo Viñas, Marina Machado, Virginia Cuello, Dianna Mollerach, Marta Eugenia Castro, Marta Pirez, Catalina Varela, Gustavo Algorta, Gabriela |
author |
Pardo, Lorena |
author_facet |
Pardo, Lorena Vola, Magdalena Macedo Viñas, Marina Machado, Virginia Cuello, Dianna Mollerach, Marta Eugenia Castro, Marta Pirez, Catalina Varela, Gustavo Algorta, Gabriela |
author_role |
author |
author2 |
Vola, Magdalena Macedo Viñas, Marina Machado, Virginia Cuello, Dianna Mollerach, Marta Eugenia Castro, Marta Pirez, Catalina Varela, Gustavo Algorta, Gabriela |
author2_role |
author author author author author author author author author |
dc.subject.none.fl_str_mv |
Staphylococcus Aureus Mrsa |
topic |
Staphylococcus Aureus Mrsa |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/3.3 https://purl.org/becyt/ford/3 |
dc.description.none.fl_txt_mv |
Introduction: Staphylococcus aureus produces a variety of diseases among children, ranging from skin and soft tissue infections to invasive life-threatening diseases. Since 1990, an increasing number of diseases produced by community-associated methicillin-resistant S. aureus (CA-MRSA) isolates have been reported. The aim of this study was to describe the importance and the microbiological characteristics of S. aureus isolates recovered from children treated at the Hospital Pediátrico del Centro Hospitalario ?Pereira Rossell? (HP-CHPR); focusing on invasive diseases caused by CA-MRSA isolates, as well as some clinical aspects of the diseases they have produced. Methodology: One hundred and twenty-five S. aureus isolates recovered from the HP-CHPR between 2003 and 2006 from children with invasive (n=89) and superficial diseases (n=36) were included. Genotypic and phenotypic characteristics of S. aureus isolates and relevant clinical aspects of each child were studied. Results: CA-MRSA isolates accounted for 73% of all S. aureus recovered from invasive (mainly bone and joint) infections, pneumonia and bacteraemia. The most common CA-MRSA strain recovered from invasive (n=65) and superficial (n=36) diseases had the following features: pulsotype A (type USA1100), SCCmec cassette type IV, Panton-Valentine Leukocidin genes positive, susceptibility to trimethoprim-sulfamethoxazole without the inducible macrolide-lincosamide-streptogramin B (iMLSB) resistance phenotype. No association between genotypic characteristics of invasive CA-MRSA isolates and clinical outcomes was found. Conclusions: CA-MRSA isolates produced a wide spectrum of invasive diseases in a public paediatric hospital between 2003 and 2006. Microbiologic characterization suggests the spread of an adapted CA-MRSA clone lacking erm genes Fil: Pardo, Lorena. Universidad de la Republica; Uruguay Fil: Vola, Magdalena. Universidad de la Republica; Uruguay Fil: Macedo Viñas, Marina. Universidad de la Republica; Uruguay Fil: Machado, Virginia. Universidad de la Republica; Uruguay Fil: Cuello, Dianna. Universidad de la Republica; Uruguay Fil: Mollerach, Marta Eugenia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Inmunología, Genética y Metabolismo; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina Fil: Castro, Marta. Universidad de la Republica; Uruguay Fil: Pirez, Catalina. Universidad de la Republica; Uruguay Fil: Varela, Gustavo. Universidad de la Republica; Uruguay Fil: Algorta, Gabriela. Universidad de la Republica; Uruguay |
description |
Introduction: Staphylococcus aureus produces a variety of diseases among children, ranging from skin and soft tissue infections to invasive life-threatening diseases. Since 1990, an increasing number of diseases produced by community-associated methicillin-resistant S. aureus (CA-MRSA) isolates have been reported. The aim of this study was to describe the importance and the microbiological characteristics of S. aureus isolates recovered from children treated at the Hospital Pediátrico del Centro Hospitalario ?Pereira Rossell? (HP-CHPR); focusing on invasive diseases caused by CA-MRSA isolates, as well as some clinical aspects of the diseases they have produced. Methodology: One hundred and twenty-five S. aureus isolates recovered from the HP-CHPR between 2003 and 2006 from children with invasive (n=89) and superficial diseases (n=36) were included. Genotypic and phenotypic characteristics of S. aureus isolates and relevant clinical aspects of each child were studied. Results: CA-MRSA isolates accounted for 73% of all S. aureus recovered from invasive (mainly bone and joint) infections, pneumonia and bacteraemia. The most common CA-MRSA strain recovered from invasive (n=65) and superficial (n=36) diseases had the following features: pulsotype A (type USA1100), SCCmec cassette type IV, Panton-Valentine Leukocidin genes positive, susceptibility to trimethoprim-sulfamethoxazole without the inducible macrolide-lincosamide-streptogramin B (iMLSB) resistance phenotype. No association between genotypic characteristics of invasive CA-MRSA isolates and clinical outcomes was found. Conclusions: CA-MRSA isolates produced a wide spectrum of invasive diseases in a public paediatric hospital between 2003 and 2006. Microbiologic characterization suggests the spread of an adapted CA-MRSA clone lacking erm genes |
publishDate |
2013 |
dc.date.none.fl_str_mv |
2013-01 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/12869 Pardo, Lorena; Vola, Magdalena; Macedo Viñas, Marina; Machado, Virginia; Cuello, Dianna; et al.; Community-associated methicillin-resistant Staphylococcus aureus in children treated in Uruguay; Porto Conte Ricerche Research Centre; The Journal of Infection in Developing Countries; 7; 1; 1-2013; 10-16 2036-6590 |
url |
http://hdl.handle.net/11336/12869 |
identifier_str_mv |
Pardo, Lorena; Vola, Magdalena; Macedo Viñas, Marina; Machado, Virginia; Cuello, Dianna; et al.; Community-associated methicillin-resistant Staphylococcus aureus in children treated in Uruguay; Porto Conte Ricerche Research Centre; The Journal of Infection in Developing Countries; 7; 1; 1-2013; 10-16 2036-6590 |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/url/http://www.jidc.org/index.php/journal/article/view/23324815 |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
Porto Conte Ricerche Research Centre |
publisher.none.fl_str_mv |
Porto Conte Ricerche Research Centre |
dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
reponame_str |
CONICET Digital (CONICET) |
collection |
CONICET Digital (CONICET) |
instname_str |
Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.name.fl_str_mv |
CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
_version_ |
1842270096717774848 |
score |
13.13397 |