Community-associated methicillin-resistant Staphylococcus aureus in children treated in Uruguay

Autores
Pardo, Lorena; Vola, Magdalena; Macedo Viñas, Marina; Machado, Virginia; Cuello, Dianna; Mollerach, Marta Eugenia; Castro, Marta; Pirez, Catalina; Varela, Gustavo; Algorta, Gabriela
Año de publicación
2013
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Introduction: Staphylococcus aureus produces a variety of diseases among children, ranging from skin and soft tissue infections to invasive life-threatening diseases. Since 1990, an increasing number of diseases produced by community-associated methicillin-resistant S. aureus (CA-MRSA) isolates have been reported. The aim of this study was to describe the importance and the microbiological characteristics of S. aureus isolates recovered from children treated at the Hospital Pediátrico del Centro Hospitalario ?Pereira Rossell? (HP-CHPR); focusing on invasive diseases caused by CA-MRSA isolates, as well as some clinical aspects of the diseases they have produced. Methodology: One hundred and twenty-five S. aureus isolates recovered from the HP-CHPR between 2003 and 2006 from children with invasive (n=89) and superficial diseases (n=36) were included. Genotypic and phenotypic characteristics of S. aureus isolates and relevant clinical aspects of each child were studied. Results: CA-MRSA isolates accounted for 73% of all S. aureus recovered from invasive (mainly bone and joint) infections, pneumonia and bacteraemia. The most common CA-MRSA strain recovered from invasive (n=65) and superficial (n=36) diseases had the following features: pulsotype A (type USA1100), SCCmec cassette type IV, Panton-Valentine Leukocidin genes positive, susceptibility to trimethoprim-sulfamethoxazole without the inducible macrolide-lincosamide-streptogramin B (iMLSB) resistance phenotype. No association between genotypic characteristics of invasive CA-MRSA isolates and clinical outcomes was found. Conclusions: CA-MRSA isolates produced a wide spectrum of invasive diseases in a public paediatric hospital between 2003 and 2006. Microbiologic characterization suggests the spread of an adapted CA-MRSA clone lacking erm genes
Fil: Pardo, Lorena. Universidad de la Republica; Uruguay
Fil: Vola, Magdalena. Universidad de la Republica; Uruguay
Fil: Macedo Viñas, Marina. Universidad de la Republica; Uruguay
Fil: Machado, Virginia. Universidad de la Republica; Uruguay
Fil: Cuello, Dianna. Universidad de la Republica; Uruguay
Fil: Mollerach, Marta Eugenia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Inmunología, Genética y Metabolismo; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina
Fil: Castro, Marta. Universidad de la Republica; Uruguay
Fil: Pirez, Catalina. Universidad de la Republica; Uruguay
Fil: Varela, Gustavo. Universidad de la Republica; Uruguay
Fil: Algorta, Gabriela. Universidad de la Republica; Uruguay
Materia
Staphylococcus Aureus
Mrsa
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/12869
Acceder
id CONICETDig_a0ab4278bfc7907c98fbdac8a60f6057
oai_identifier_str oai:ri.conicet.gov.ar:11336/12869
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Community-associated methicillin-resistant Staphylococcus aureus in children treated in UruguayPardo, LorenaVola, MagdalenaMacedo Viñas, MarinaMachado, VirginiaCuello, DiannaMollerach, Marta EugeniaCastro, MartaPirez, CatalinaVarela, GustavoAlgorta, GabrielaStaphylococcus AureusMrsahttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3Introduction: Staphylococcus aureus produces a variety of diseases among children, ranging from skin and soft tissue infections to invasive life-threatening diseases. Since 1990, an increasing number of diseases produced by community-associated methicillin-resistant S. aureus (CA-MRSA) isolates have been reported. The aim of this study was to describe the importance and the microbiological characteristics of S. aureus isolates recovered from children treated at the Hospital Pediátrico del Centro Hospitalario ?Pereira Rossell? (HP-CHPR); focusing on invasive diseases caused by CA-MRSA isolates, as well as some clinical aspects of the diseases they have produced. Methodology: One hundred and twenty-five S. aureus isolates recovered from the HP-CHPR between 2003 and 2006 from children with invasive (n=89) and superficial diseases (n=36) were included. Genotypic and phenotypic characteristics of S. aureus isolates and relevant clinical aspects of each child were studied. Results: CA-MRSA isolates accounted for 73% of all S. aureus recovered from invasive (mainly bone and joint) infections, pneumonia and bacteraemia. The most common CA-MRSA strain recovered from invasive (n=65) and superficial (n=36) diseases had the following features: pulsotype A (type USA1100), SCCmec cassette type IV, Panton-Valentine Leukocidin genes positive, susceptibility to trimethoprim-sulfamethoxazole without the inducible macrolide-lincosamide-streptogramin B (iMLSB) resistance phenotype. No association between genotypic characteristics of invasive CA-MRSA isolates and clinical outcomes was found. Conclusions: CA-MRSA isolates produced a wide spectrum of invasive diseases in a public paediatric hospital between 2003 and 2006. Microbiologic characterization suggests the spread of an adapted CA-MRSA clone lacking erm genesFil: Pardo, Lorena. Universidad de la Republica; UruguayFil: Vola, Magdalena. Universidad de la Republica; UruguayFil: Macedo Viñas, Marina. Universidad de la Republica; UruguayFil: Machado, Virginia. Universidad de la Republica; UruguayFil: Cuello, Dianna. Universidad de la Republica; UruguayFil: Mollerach, Marta Eugenia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Inmunología, Genética y Metabolismo; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; ArgentinaFil: Castro, Marta. Universidad de la Republica; UruguayFil: Pirez, Catalina. Universidad de la Republica; UruguayFil: Varela, Gustavo. Universidad de la Republica; UruguayFil: Algorta, Gabriela. Universidad de la Republica; UruguayPorto Conte Ricerche Research Centre2013-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/12869Pardo, Lorena; Vola, Magdalena; Macedo Viñas, Marina; Machado, Virginia; Cuello, Dianna; et al.; Community-associated methicillin-resistant Staphylococcus aureus in children treated in Uruguay; Porto Conte Ricerche Research Centre; The Journal of Infection in Developing Countries; 7; 1; 1-2013; 10-162036-6590enginfo:eu-repo/semantics/altIdentifier/url/http://www.jidc.org/index.php/journal/article/view/23324815info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:41:03Zoai:ri.conicet.gov.ar:11336/12869instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:41:03.426CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Community-associated methicillin-resistant Staphylococcus aureus in children treated in Uruguay
title Community-associated methicillin-resistant Staphylococcus aureus in children treated in Uruguay
spellingShingle Community-associated methicillin-resistant Staphylococcus aureus in children treated in Uruguay
Pardo, Lorena
Staphylococcus Aureus
Mrsa
title_short Community-associated methicillin-resistant Staphylococcus aureus in children treated in Uruguay
title_full Community-associated methicillin-resistant Staphylococcus aureus in children treated in Uruguay
title_fullStr Community-associated methicillin-resistant Staphylococcus aureus in children treated in Uruguay
title_full_unstemmed Community-associated methicillin-resistant Staphylococcus aureus in children treated in Uruguay
title_sort Community-associated methicillin-resistant Staphylococcus aureus in children treated in Uruguay
dc.creator.none.fl_str_mv Pardo, Lorena
Vola, Magdalena
Macedo Viñas, Marina
Machado, Virginia
Cuello, Dianna
Mollerach, Marta Eugenia
Castro, Marta
Pirez, Catalina
Varela, Gustavo
Algorta, Gabriela
author Pardo, Lorena
author_facet Pardo, Lorena
Vola, Magdalena
Macedo Viñas, Marina
Machado, Virginia
Cuello, Dianna
Mollerach, Marta Eugenia
Castro, Marta
Pirez, Catalina
Varela, Gustavo
Algorta, Gabriela
author_role author
author2 Vola, Magdalena
Macedo Viñas, Marina
Machado, Virginia
Cuello, Dianna
Mollerach, Marta Eugenia
Castro, Marta
Pirez, Catalina
Varela, Gustavo
Algorta, Gabriela
author2_role author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Staphylococcus Aureus
Mrsa
topic Staphylococcus Aureus
Mrsa
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Introduction: Staphylococcus aureus produces a variety of diseases among children, ranging from skin and soft tissue infections to invasive life-threatening diseases. Since 1990, an increasing number of diseases produced by community-associated methicillin-resistant S. aureus (CA-MRSA) isolates have been reported. The aim of this study was to describe the importance and the microbiological characteristics of S. aureus isolates recovered from children treated at the Hospital Pediátrico del Centro Hospitalario ?Pereira Rossell? (HP-CHPR); focusing on invasive diseases caused by CA-MRSA isolates, as well as some clinical aspects of the diseases they have produced. Methodology: One hundred and twenty-five S. aureus isolates recovered from the HP-CHPR between 2003 and 2006 from children with invasive (n=89) and superficial diseases (n=36) were included. Genotypic and phenotypic characteristics of S. aureus isolates and relevant clinical aspects of each child were studied. Results: CA-MRSA isolates accounted for 73% of all S. aureus recovered from invasive (mainly bone and joint) infections, pneumonia and bacteraemia. The most common CA-MRSA strain recovered from invasive (n=65) and superficial (n=36) diseases had the following features: pulsotype A (type USA1100), SCCmec cassette type IV, Panton-Valentine Leukocidin genes positive, susceptibility to trimethoprim-sulfamethoxazole without the inducible macrolide-lincosamide-streptogramin B (iMLSB) resistance phenotype. No association between genotypic characteristics of invasive CA-MRSA isolates and clinical outcomes was found. Conclusions: CA-MRSA isolates produced a wide spectrum of invasive diseases in a public paediatric hospital between 2003 and 2006. Microbiologic characterization suggests the spread of an adapted CA-MRSA clone lacking erm genes
Fil: Pardo, Lorena. Universidad de la Republica; Uruguay
Fil: Vola, Magdalena. Universidad de la Republica; Uruguay
Fil: Macedo Viñas, Marina. Universidad de la Republica; Uruguay
Fil: Machado, Virginia. Universidad de la Republica; Uruguay
Fil: Cuello, Dianna. Universidad de la Republica; Uruguay
Fil: Mollerach, Marta Eugenia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Inmunología, Genética y Metabolismo; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina
Fil: Castro, Marta. Universidad de la Republica; Uruguay
Fil: Pirez, Catalina. Universidad de la Republica; Uruguay
Fil: Varela, Gustavo. Universidad de la Republica; Uruguay
Fil: Algorta, Gabriela. Universidad de la Republica; Uruguay
description Introduction: Staphylococcus aureus produces a variety of diseases among children, ranging from skin and soft tissue infections to invasive life-threatening diseases. Since 1990, an increasing number of diseases produced by community-associated methicillin-resistant S. aureus (CA-MRSA) isolates have been reported. The aim of this study was to describe the importance and the microbiological characteristics of S. aureus isolates recovered from children treated at the Hospital Pediátrico del Centro Hospitalario ?Pereira Rossell? (HP-CHPR); focusing on invasive diseases caused by CA-MRSA isolates, as well as some clinical aspects of the diseases they have produced. Methodology: One hundred and twenty-five S. aureus isolates recovered from the HP-CHPR between 2003 and 2006 from children with invasive (n=89) and superficial diseases (n=36) were included. Genotypic and phenotypic characteristics of S. aureus isolates and relevant clinical aspects of each child were studied. Results: CA-MRSA isolates accounted for 73% of all S. aureus recovered from invasive (mainly bone and joint) infections, pneumonia and bacteraemia. The most common CA-MRSA strain recovered from invasive (n=65) and superficial (n=36) diseases had the following features: pulsotype A (type USA1100), SCCmec cassette type IV, Panton-Valentine Leukocidin genes positive, susceptibility to trimethoprim-sulfamethoxazole without the inducible macrolide-lincosamide-streptogramin B (iMLSB) resistance phenotype. No association between genotypic characteristics of invasive CA-MRSA isolates and clinical outcomes was found. Conclusions: CA-MRSA isolates produced a wide spectrum of invasive diseases in a public paediatric hospital between 2003 and 2006. Microbiologic characterization suggests the spread of an adapted CA-MRSA clone lacking erm genes
publishDate 2013
dc.date.none.fl_str_mv 2013-01
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/12869
Pardo, Lorena; Vola, Magdalena; Macedo Viñas, Marina; Machado, Virginia; Cuello, Dianna; et al.; Community-associated methicillin-resistant Staphylococcus aureus in children treated in Uruguay; Porto Conte Ricerche Research Centre; The Journal of Infection in Developing Countries; 7; 1; 1-2013; 10-16
2036-6590
url http://hdl.handle.net/11336/12869
identifier_str_mv Pardo, Lorena; Vola, Magdalena; Macedo Viñas, Marina; Machado, Virginia; Cuello, Dianna; et al.; Community-associated methicillin-resistant Staphylococcus aureus in children treated in Uruguay; Porto Conte Ricerche Research Centre; The Journal of Infection in Developing Countries; 7; 1; 1-2013; 10-16
2036-6590
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://www.jidc.org/index.php/journal/article/view/23324815
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Porto Conte Ricerche Research Centre
publisher.none.fl_str_mv Porto Conte Ricerche Research Centre
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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