A Price to Pay for Adult Neurogenesis

Autores
Schinder, Alejandro Fabian; Mongiat, Lucas Alberto
Año de publicación
2014
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
We tend to believe that plasticity is what makes brain circuits adaptable to continuous changes in environmental demands and that greater brain plasticity should result in a better ability to cope with the surrounding world. To adapt to everyday life, animals explore, learn, and remember, and these tasks make use of various cortical structures, including the hippocampus. The dentate gyrus, part of the hippocampus, is a remarkable structure in that it is one of two areas of the adult mammalian brain, including the human brain, that continue to generate new neurons throughout postnatal life (1). It is well established that adult-born neurons integrate into preexisting neuronal networks and participate in information processing (2). Much evidence accumulated over the past decade supports the hypothesis that adult neurogenesis itself is a type of circuit plasticity required for hippocampus-dependent learning and memory recall. The work by Akers et al. on page 598 of this issue (3) now shows that adult hippocampal neurogenesis may also promote forgetting.
Fil: Schinder, Alejandro Fabian. Fundación Instituto Leloir; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquimicas de Buenos Aires; Argentina
Fil: Mongiat, Lucas Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Patagonia Norte. Instituto de Investigación En Biodiversidad y Medioambiente; Argentina
Materia
Adult Neurogenesis
Hypocampus
Memory
Dentate Gyrus
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/11815

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spelling A Price to Pay for Adult NeurogenesisSchinder, Alejandro FabianMongiat, Lucas AlbertoAdult NeurogenesisHypocampusMemoryDentate Gyrushttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1We tend to believe that plasticity is what makes brain circuits adaptable to continuous changes in environmental demands and that greater brain plasticity should result in a better ability to cope with the surrounding world. To adapt to everyday life, animals explore, learn, and remember, and these tasks make use of various cortical structures, including the hippocampus. The dentate gyrus, part of the hippocampus, is a remarkable structure in that it is one of two areas of the adult mammalian brain, including the human brain, that continue to generate new neurons throughout postnatal life (1). It is well established that adult-born neurons integrate into preexisting neuronal networks and participate in information processing (2). Much evidence accumulated over the past decade supports the hypothesis that adult neurogenesis itself is a type of circuit plasticity required for hippocampus-dependent learning and memory recall. The work by Akers et al. on page 598 of this issue (3) now shows that adult hippocampal neurogenesis may also promote forgetting.Fil: Schinder, Alejandro Fabian. Fundación Instituto Leloir; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquimicas de Buenos Aires; ArgentinaFil: Mongiat, Lucas Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Patagonia Norte. Instituto de Investigación En Biodiversidad y Medioambiente; ArgentinaAmerican Association For The Advancement Of Science2014-05info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/11815Schinder, Alejandro Fabian; Mongiat, Lucas Alberto; A Price to Pay for Adult Neurogenesis; American Association For The Advancement Of Science; Science; 344; 6184; 5-2014; 594-5950036-8075enginfo:eu-repo/semantics/altIdentifier/url/http://science.sciencemag.org/content/344/6184/594info:eu-repo/semantics/altIdentifier/url/http://dx.doi.org/10.1126/science.1254236info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:44:52Zoai:ri.conicet.gov.ar:11336/11815instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:44:52.902CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv A Price to Pay for Adult Neurogenesis
title A Price to Pay for Adult Neurogenesis
spellingShingle A Price to Pay for Adult Neurogenesis
Schinder, Alejandro Fabian
Adult Neurogenesis
Hypocampus
Memory
Dentate Gyrus
title_short A Price to Pay for Adult Neurogenesis
title_full A Price to Pay for Adult Neurogenesis
title_fullStr A Price to Pay for Adult Neurogenesis
title_full_unstemmed A Price to Pay for Adult Neurogenesis
title_sort A Price to Pay for Adult Neurogenesis
dc.creator.none.fl_str_mv Schinder, Alejandro Fabian
Mongiat, Lucas Alberto
author Schinder, Alejandro Fabian
author_facet Schinder, Alejandro Fabian
Mongiat, Lucas Alberto
author_role author
author2 Mongiat, Lucas Alberto
author2_role author
dc.subject.none.fl_str_mv Adult Neurogenesis
Hypocampus
Memory
Dentate Gyrus
topic Adult Neurogenesis
Hypocampus
Memory
Dentate Gyrus
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv We tend to believe that plasticity is what makes brain circuits adaptable to continuous changes in environmental demands and that greater brain plasticity should result in a better ability to cope with the surrounding world. To adapt to everyday life, animals explore, learn, and remember, and these tasks make use of various cortical structures, including the hippocampus. The dentate gyrus, part of the hippocampus, is a remarkable structure in that it is one of two areas of the adult mammalian brain, including the human brain, that continue to generate new neurons throughout postnatal life (1). It is well established that adult-born neurons integrate into preexisting neuronal networks and participate in information processing (2). Much evidence accumulated over the past decade supports the hypothesis that adult neurogenesis itself is a type of circuit plasticity required for hippocampus-dependent learning and memory recall. The work by Akers et al. on page 598 of this issue (3) now shows that adult hippocampal neurogenesis may also promote forgetting.
Fil: Schinder, Alejandro Fabian. Fundación Instituto Leloir; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquimicas de Buenos Aires; Argentina
Fil: Mongiat, Lucas Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Patagonia Norte. Instituto de Investigación En Biodiversidad y Medioambiente; Argentina
description We tend to believe that plasticity is what makes brain circuits adaptable to continuous changes in environmental demands and that greater brain plasticity should result in a better ability to cope with the surrounding world. To adapt to everyday life, animals explore, learn, and remember, and these tasks make use of various cortical structures, including the hippocampus. The dentate gyrus, part of the hippocampus, is a remarkable structure in that it is one of two areas of the adult mammalian brain, including the human brain, that continue to generate new neurons throughout postnatal life (1). It is well established that adult-born neurons integrate into preexisting neuronal networks and participate in information processing (2). Much evidence accumulated over the past decade supports the hypothesis that adult neurogenesis itself is a type of circuit plasticity required for hippocampus-dependent learning and memory recall. The work by Akers et al. on page 598 of this issue (3) now shows that adult hippocampal neurogenesis may also promote forgetting.
publishDate 2014
dc.date.none.fl_str_mv 2014-05
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/11815
Schinder, Alejandro Fabian; Mongiat, Lucas Alberto; A Price to Pay for Adult Neurogenesis; American Association For The Advancement Of Science; Science; 344; 6184; 5-2014; 594-595
0036-8075
url http://hdl.handle.net/11336/11815
identifier_str_mv Schinder, Alejandro Fabian; Mongiat, Lucas Alberto; A Price to Pay for Adult Neurogenesis; American Association For The Advancement Of Science; Science; 344; 6184; 5-2014; 594-595
0036-8075
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://science.sciencemag.org/content/344/6184/594
info:eu-repo/semantics/altIdentifier/url/http://dx.doi.org/10.1126/science.1254236
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv American Association For The Advancement Of Science
publisher.none.fl_str_mv American Association For The Advancement Of Science
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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