Leptin action in normal and pathological pregnancies

Autores
Pérez Pérez, Antonio; Toro, Ayelen Rayen; Vilariño García, Teresa; Maymo, Julieta Lorena; Guadix, Pilar; Dueñas, José L.; Fernández Sánchez, Manuel; Varone, Cecilia Laura; Sánchez Margalet, Víctor
Año de publicación
2018
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Leptin is now considered an important signalling molecule of the reproductive system, as it regulates the production of gonadotrophins, the blastocyst formation and implantation, the normal placentation, as well as the foeto-placental communication. Leptin is a peptide hormone secreted mainly by adipose tissue, and the placenta is the second leptin-producing tissue in humans. Placental leptin is an important cytokine which regulates placental functions in an autocrine or paracrine manner. Leptin seems to play a crucial role during the first stages of pregnancy as it modulates critical processes such as proliferation, protein synthesis, invasion and apoptosis in placental cells. Furthermore, deregulation of leptin levels has been correlated with the pathogenesis of various disorders associated with reproduction and gestation, including polycystic ovary syndrome, recurrent miscarriage, gestational diabetes mellitus, pre-eclampsia and intrauterine growth restriction. Due to the relevant incidence of the mentioned diseases and the importance of leptin, we decided to review the latest information available about leptin action in normal and pathological pregnancies to support the idea of leptin as an important factor and/or predictor of diverse disorders associated with reproduction and pregnancy.
Fil: Pérez Pérez, Antonio. Universidad de Sevilla; España
Fil: Toro, Ayelen Rayen. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales; Argentina
Fil: Vilariño García, Teresa. Universidad de Sevilla; España
Fil: Maymo, Julieta Lorena. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales; Argentina
Fil: Guadix, Pilar. Universidad de Sevilla; España
Fil: Dueñas, José L.. Universidad de Sevilla; España
Fil: Fernández Sánchez, Manuel. Instituto Valenciano de Infertilidad; España
Fil: Varone, Cecilia Laura. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales; Argentina
Fil: Sánchez Margalet, Víctor. Universidad de Sevilla; España
Materia
GESTATIONAL DIABETES
GROWTH RESTRICTION
LEPTIN
PLACENTA
POLYCYSTIC OVARY SYNDROME
PRE-ECLAMPSIA
RECURRENT MISCARRIAGE
REPRODUCTION
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/53952
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/53952
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Leptin action in normal and pathological pregnanciesPérez Pérez, AntonioToro, Ayelen RayenVilariño García, TeresaMaymo, Julieta LorenaGuadix, PilarDueñas, José L.Fernández Sánchez, ManuelVarone, Cecilia LauraSánchez Margalet, VíctorGESTATIONAL DIABETESGROWTH RESTRICTIONLEPTINPLACENTAPOLYCYSTIC OVARY SYNDROMEPRE-ECLAMPSIARECURRENT MISCARRIAGEREPRODUCTIONhttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Leptin is now considered an important signalling molecule of the reproductive system, as it regulates the production of gonadotrophins, the blastocyst formation and implantation, the normal placentation, as well as the foeto-placental communication. Leptin is a peptide hormone secreted mainly by adipose tissue, and the placenta is the second leptin-producing tissue in humans. Placental leptin is an important cytokine which regulates placental functions in an autocrine or paracrine manner. Leptin seems to play a crucial role during the first stages of pregnancy as it modulates critical processes such as proliferation, protein synthesis, invasion and apoptosis in placental cells. Furthermore, deregulation of leptin levels has been correlated with the pathogenesis of various disorders associated with reproduction and gestation, including polycystic ovary syndrome, recurrent miscarriage, gestational diabetes mellitus, pre-eclampsia and intrauterine growth restriction. Due to the relevant incidence of the mentioned diseases and the importance of leptin, we decided to review the latest information available about leptin action in normal and pathological pregnancies to support the idea of leptin as an important factor and/or predictor of diverse disorders associated with reproduction and pregnancy.Fil: Pérez Pérez, Antonio. Universidad de Sevilla; EspañaFil: Toro, Ayelen Rayen. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales; ArgentinaFil: Vilariño García, Teresa. Universidad de Sevilla; EspañaFil: Maymo, Julieta Lorena. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales; ArgentinaFil: Guadix, Pilar. Universidad de Sevilla; EspañaFil: Dueñas, José L.. Universidad de Sevilla; EspañaFil: Fernández Sánchez, Manuel. Instituto Valenciano de Infertilidad; EspañaFil: Varone, Cecilia Laura. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales; ArgentinaFil: Sánchez Margalet, Víctor. Universidad de Sevilla; EspañaWiley Blackwell Publishing, Inc2018-02info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/53952Pérez Pérez, Antonio; Toro, Ayelen Rayen; Vilariño García, Teresa; Maymo, Julieta Lorena; Guadix, Pilar; et al.; Leptin action in normal and pathological pregnancies; Wiley Blackwell Publishing, Inc; Journal Of Cellular And Molecular Medicine (print); 22; 2; 2-2018; 716-7271582-1838CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1111/jcmm.13369info:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/abs/10.1111/jcmm.13369info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:00:57Zoai:ri.conicet.gov.ar:11336/53952instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:00:57.638CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Leptin action in normal and pathological pregnancies
title Leptin action in normal and pathological pregnancies
spellingShingle Leptin action in normal and pathological pregnancies
Pérez Pérez, Antonio
GESTATIONAL DIABETES
GROWTH RESTRICTION
LEPTIN
PLACENTA
POLYCYSTIC OVARY SYNDROME
PRE-ECLAMPSIA
RECURRENT MISCARRIAGE
REPRODUCTION
title_short Leptin action in normal and pathological pregnancies
title_full Leptin action in normal and pathological pregnancies
title_fullStr Leptin action in normal and pathological pregnancies
title_full_unstemmed Leptin action in normal and pathological pregnancies
title_sort Leptin action in normal and pathological pregnancies
dc.creator.none.fl_str_mv Pérez Pérez, Antonio
Toro, Ayelen Rayen
Vilariño García, Teresa
Maymo, Julieta Lorena
Guadix, Pilar
Dueñas, José L.
Fernández Sánchez, Manuel
Varone, Cecilia Laura
Sánchez Margalet, Víctor
author Pérez Pérez, Antonio
author_facet Pérez Pérez, Antonio
Toro, Ayelen Rayen
Vilariño García, Teresa
Maymo, Julieta Lorena
Guadix, Pilar
Dueñas, José L.
Fernández Sánchez, Manuel
Varone, Cecilia Laura
Sánchez Margalet, Víctor
author_role author
author2 Toro, Ayelen Rayen
Vilariño García, Teresa
Maymo, Julieta Lorena
Guadix, Pilar
Dueñas, José L.
Fernández Sánchez, Manuel
Varone, Cecilia Laura
Sánchez Margalet, Víctor
author2_role author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv GESTATIONAL DIABETES
GROWTH RESTRICTION
LEPTIN
PLACENTA
POLYCYSTIC OVARY SYNDROME
PRE-ECLAMPSIA
RECURRENT MISCARRIAGE
REPRODUCTION
topic GESTATIONAL DIABETES
GROWTH RESTRICTION
LEPTIN
PLACENTA
POLYCYSTIC OVARY SYNDROME
PRE-ECLAMPSIA
RECURRENT MISCARRIAGE
REPRODUCTION
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Leptin is now considered an important signalling molecule of the reproductive system, as it regulates the production of gonadotrophins, the blastocyst formation and implantation, the normal placentation, as well as the foeto-placental communication. Leptin is a peptide hormone secreted mainly by adipose tissue, and the placenta is the second leptin-producing tissue in humans. Placental leptin is an important cytokine which regulates placental functions in an autocrine or paracrine manner. Leptin seems to play a crucial role during the first stages of pregnancy as it modulates critical processes such as proliferation, protein synthesis, invasion and apoptosis in placental cells. Furthermore, deregulation of leptin levels has been correlated with the pathogenesis of various disorders associated with reproduction and gestation, including polycystic ovary syndrome, recurrent miscarriage, gestational diabetes mellitus, pre-eclampsia and intrauterine growth restriction. Due to the relevant incidence of the mentioned diseases and the importance of leptin, we decided to review the latest information available about leptin action in normal and pathological pregnancies to support the idea of leptin as an important factor and/or predictor of diverse disorders associated with reproduction and pregnancy.
Fil: Pérez Pérez, Antonio. Universidad de Sevilla; España
Fil: Toro, Ayelen Rayen. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales; Argentina
Fil: Vilariño García, Teresa. Universidad de Sevilla; España
Fil: Maymo, Julieta Lorena. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales; Argentina
Fil: Guadix, Pilar. Universidad de Sevilla; España
Fil: Dueñas, José L.. Universidad de Sevilla; España
Fil: Fernández Sánchez, Manuel. Instituto Valenciano de Infertilidad; España
Fil: Varone, Cecilia Laura. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales; Argentina
Fil: Sánchez Margalet, Víctor. Universidad de Sevilla; España
description Leptin is now considered an important signalling molecule of the reproductive system, as it regulates the production of gonadotrophins, the blastocyst formation and implantation, the normal placentation, as well as the foeto-placental communication. Leptin is a peptide hormone secreted mainly by adipose tissue, and the placenta is the second leptin-producing tissue in humans. Placental leptin is an important cytokine which regulates placental functions in an autocrine or paracrine manner. Leptin seems to play a crucial role during the first stages of pregnancy as it modulates critical processes such as proliferation, protein synthesis, invasion and apoptosis in placental cells. Furthermore, deregulation of leptin levels has been correlated with the pathogenesis of various disorders associated with reproduction and gestation, including polycystic ovary syndrome, recurrent miscarriage, gestational diabetes mellitus, pre-eclampsia and intrauterine growth restriction. Due to the relevant incidence of the mentioned diseases and the importance of leptin, we decided to review the latest information available about leptin action in normal and pathological pregnancies to support the idea of leptin as an important factor and/or predictor of diverse disorders associated with reproduction and pregnancy.
publishDate 2018
dc.date.none.fl_str_mv 2018-02
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/53952
Pérez Pérez, Antonio; Toro, Ayelen Rayen; Vilariño García, Teresa; Maymo, Julieta Lorena; Guadix, Pilar; et al.; Leptin action in normal and pathological pregnancies; Wiley Blackwell Publishing, Inc; Journal Of Cellular And Molecular Medicine (print); 22; 2; 2-2018; 716-727
1582-1838
CONICET Digital
CONICET
url http://hdl.handle.net/11336/53952
identifier_str_mv Pérez Pérez, Antonio; Toro, Ayelen Rayen; Vilariño García, Teresa; Maymo, Julieta Lorena; Guadix, Pilar; et al.; Leptin action in normal and pathological pregnancies; Wiley Blackwell Publishing, Inc; Journal Of Cellular And Molecular Medicine (print); 22; 2; 2-2018; 716-727
1582-1838
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1111/jcmm.13369
info:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/abs/10.1111/jcmm.13369
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Wiley Blackwell Publishing, Inc
publisher.none.fl_str_mv Wiley Blackwell Publishing, Inc
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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