A longitudinal study of free leptin index in pre-eclamptic pregnancies

Autores
Garcés, María Fernanda; Buell Acosta, Julieth Daniela; Rodríguez Navarro, Haiver Antonio; Páez Leal, María Carolina; Maldonado Acosta, Luis Miguel; Peralta Franco, Jhon Jairo; Burgos Cardenas, Álvaro Javier; Ángel Müller, Edith; Parada Baños, Arturo José; Parra Pineda, Mario Orlando; Eslava Schmalbach, Javier; Escobar Sarmiento, Camilo Andrés; Lacunza, Ezequiel; Caminos Cepeda, Sofia Alexandra; Castaño, Justo P; Nogueiras, Rubén; Dieguez, Carlos; Ruiz Parra, Ariel Iván; Caminos, Jorge Eduardo
Año de publicación
2023
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The ratio between circulating levels of leptin and soluble leptin receptor (sOB-R), the free leptin index (FLI), is used as a marker of leptin resistance. Therefore, the aim of our study was to investigate the FLI in mild pre-eclamptic pregnancies in a nested case–control study within a prospective observational study. Circulating levels of leptin and sOB-R levels rise significantly during pregnancy in healthy (p < 0.05) (n = 46) and pre-eclamptic pregnancies (p < 0.05) (n = 20). Serum levels of leptin were significantly higher in pre-eclamptic compared to healthy pregnancies at second and third trimesters of pregnancy (p < 0.05). Additionally, serum levels of sOB-R were significantly lower in pre-eclamptic pregnancies during the second and third trimesters of pregnancy compared to healthy pregnancies (p < 0.05). Moreover, we found that FLI did not vary significantly during pregnancy in healthy women (p > 0.05), while it increases in pre-eclamptic pregnancies (p < 0.05). Indeed, FLI was significantly higher at second and third trimesters of pregnancy in pre-eclamptic compared to healthy pregnancies (p < 0.05). In addition, FLI was significantly higher in the luteal phase compared with the follicular phase of the menstrual cycle in eumenorrheic women (p < 0.05). Receiver operating characteristic (ROC) curve analysis revealed the ability of leptin (AUC = 0.72) and FLI (AUC = 0.67) as a reliable predictor for mild pre-eclampsia during the second trimester of pregnancy. In conclusion, our findings show that FLI were significantly increased in mild pre-eclamptic pregnancies and allowed us to hypothesize that this rise might alter leptin bioavailability and bioactivity which might lead to the sympathetic hyperactivity and the hypertensive disorders during pregnancy.
Fil: Garcés, María Fernanda. Universidad Nacional de Colombia. Facultad de Medicina; Colombia
Fil: Buell Acosta, Julieth Daniela. Universidad Nacional de Colombia. Facultad de Medicina; Colombia
Fil: Rodríguez Navarro, Haiver Antonio. Universidad Nacional de Colombia. Facultad de Medicina; Colombia
Fil: Páez Leal, María Carolina. Universidad Nacional de Colombia. Facultad de Medicina; Colombia
Fil: Maldonado Acosta, Luis Miguel. Universidad Nacional de Colombia. Facultad de Medicina; Colombia
Fil: Peralta Franco, Jhon Jairo. Universidad Nacional de Colombia. Facultad de Medicina; Colombia
Fil: Burgos Cardenas, Álvaro Javier. Universidad Nacional de Colombia. Facultad de Medicina; Colombia
Fil: Ángel Müller, Edith. Universidad Nacional de Colombia. Facultad de Medicina; Colombia
Fil: Parada Baños, Arturo José. Universidad Nacional de Colombia. Facultad de Medicina; Colombia
Fil: Parra Pineda, Mario Orlando. Universidad Nacional de Colombia. Facultad de Medicina; Colombia
Fil: Eslava Schmalbach, Javier. Universidad Nacional de Colombia. Facultad de Medicina; Colombia
Fil: Escobar Sarmiento, Camilo Andrés. Fundación Sueño Vigilia Colombiana; Colombia
Fil: Lacunza, Ezequiel. Universidad Nacional de La Plata. Facultad de Ciencias Médicas. Centro de Investigaciones Inmunológicas Básicas y Aplicadas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina
Fil: Caminos Cepeda, Sofia Alexandra. Universitat Pompeu Fabra; España
Fil: Castaño, Justo P. Universidad de Córdoba; España
Fil: Nogueiras, Rubén. Universidad de Santiago de Compostela; España
Fil: Dieguez, Carlos. Instituto de Salud Carlos Iii (isciii);
Fil: Ruiz Parra, Ariel Iván. Universidad Nacional de Colombia. Facultad de Medicina; Colombia
Fil: Caminos, Jorge Eduardo. Universidad Nacional de Colombia. Facultad de Medicina; Colombia
Materia
FREE LEPTIN INDEX
PREGNANCY AND PRE-ECLAMPSIA
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/218966

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network_name_str CONICET Digital (CONICET)
spelling A longitudinal study of free leptin index in pre-eclamptic pregnanciesGarcés, María FernandaBuell Acosta, Julieth DanielaRodríguez Navarro, Haiver AntonioPáez Leal, María CarolinaMaldonado Acosta, Luis MiguelPeralta Franco, Jhon JairoBurgos Cardenas, Álvaro JavierÁngel Müller, EdithParada Baños, Arturo JoséParra Pineda, Mario OrlandoEslava Schmalbach, JavierEscobar Sarmiento, Camilo AndrésLacunza, EzequielCaminos Cepeda, Sofia AlexandraCastaño, Justo PNogueiras, RubénDieguez, CarlosRuiz Parra, Ariel IvánCaminos, Jorge EduardoFREE LEPTIN INDEXPREGNANCY AND PRE-ECLAMPSIAhttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1The ratio between circulating levels of leptin and soluble leptin receptor (sOB-R), the free leptin index (FLI), is used as a marker of leptin resistance. Therefore, the aim of our study was to investigate the FLI in mild pre-eclamptic pregnancies in a nested case–control study within a prospective observational study. Circulating levels of leptin and sOB-R levels rise significantly during pregnancy in healthy (p < 0.05) (n = 46) and pre-eclamptic pregnancies (p < 0.05) (n = 20). Serum levels of leptin were significantly higher in pre-eclamptic compared to healthy pregnancies at second and third trimesters of pregnancy (p < 0.05). Additionally, serum levels of sOB-R were significantly lower in pre-eclamptic pregnancies during the second and third trimesters of pregnancy compared to healthy pregnancies (p < 0.05). Moreover, we found that FLI did not vary significantly during pregnancy in healthy women (p > 0.05), while it increases in pre-eclamptic pregnancies (p < 0.05). Indeed, FLI was significantly higher at second and third trimesters of pregnancy in pre-eclamptic compared to healthy pregnancies (p < 0.05). In addition, FLI was significantly higher in the luteal phase compared with the follicular phase of the menstrual cycle in eumenorrheic women (p < 0.05). Receiver operating characteristic (ROC) curve analysis revealed the ability of leptin (AUC = 0.72) and FLI (AUC = 0.67) as a reliable predictor for mild pre-eclampsia during the second trimester of pregnancy. In conclusion, our findings show that FLI were significantly increased in mild pre-eclamptic pregnancies and allowed us to hypothesize that this rise might alter leptin bioavailability and bioactivity which might lead to the sympathetic hyperactivity and the hypertensive disorders during pregnancy.Fil: Garcés, María Fernanda. Universidad Nacional de Colombia. Facultad de Medicina; ColombiaFil: Buell Acosta, Julieth Daniela. Universidad Nacional de Colombia. Facultad de Medicina; ColombiaFil: Rodríguez Navarro, Haiver Antonio. Universidad Nacional de Colombia. Facultad de Medicina; ColombiaFil: Páez Leal, María Carolina. Universidad Nacional de Colombia. Facultad de Medicina; ColombiaFil: Maldonado Acosta, Luis Miguel. Universidad Nacional de Colombia. Facultad de Medicina; ColombiaFil: Peralta Franco, Jhon Jairo. Universidad Nacional de Colombia. Facultad de Medicina; ColombiaFil: Burgos Cardenas, Álvaro Javier. Universidad Nacional de Colombia. Facultad de Medicina; ColombiaFil: Ángel Müller, Edith. Universidad Nacional de Colombia. Facultad de Medicina; ColombiaFil: Parada Baños, Arturo José. Universidad Nacional de Colombia. Facultad de Medicina; ColombiaFil: Parra Pineda, Mario Orlando. Universidad Nacional de Colombia. Facultad de Medicina; ColombiaFil: Eslava Schmalbach, Javier. Universidad Nacional de Colombia. Facultad de Medicina; ColombiaFil: Escobar Sarmiento, Camilo Andrés. Fundación Sueño Vigilia Colombiana; ColombiaFil: Lacunza, Ezequiel. Universidad Nacional de La Plata. Facultad de Ciencias Médicas. Centro de Investigaciones Inmunológicas Básicas y Aplicadas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; ArgentinaFil: Caminos Cepeda, Sofia Alexandra. Universitat Pompeu Fabra; EspañaFil: Castaño, Justo P. Universidad de Córdoba; EspañaFil: Nogueiras, Rubén. Universidad de Santiago de Compostela; EspañaFil: Dieguez, Carlos. Instituto de Salud Carlos Iii (isciii);Fil: Ruiz Parra, Ariel Iván. Universidad Nacional de Colombia. Facultad de Medicina; ColombiaFil: Caminos, Jorge Eduardo. Universidad Nacional de Colombia. Facultad de Medicina; ColombiaWiley Blackwell Publishing, Inc2023-04info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/218966Garcés, María Fernanda; Buell Acosta, Julieth Daniela; Rodríguez Navarro, Haiver Antonio; Páez Leal, María Carolina; Maldonado Acosta, Luis Miguel; et al.; A longitudinal study of free leptin index in pre-eclamptic pregnancies; Wiley Blackwell Publishing, Inc; Journal Of Cellular And Molecular Medicine (print); 27; 8; 4-2023; 1083-10941582-1838CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/10.1111/jcmm.17707info:eu-repo/semantics/altIdentifier/doi/10.1111/jcmm.17707info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:11:43Zoai:ri.conicet.gov.ar:11336/218966instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:11:43.642CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv A longitudinal study of free leptin index in pre-eclamptic pregnancies
title A longitudinal study of free leptin index in pre-eclamptic pregnancies
spellingShingle A longitudinal study of free leptin index in pre-eclamptic pregnancies
Garcés, María Fernanda
FREE LEPTIN INDEX
PREGNANCY AND PRE-ECLAMPSIA
title_short A longitudinal study of free leptin index in pre-eclamptic pregnancies
title_full A longitudinal study of free leptin index in pre-eclamptic pregnancies
title_fullStr A longitudinal study of free leptin index in pre-eclamptic pregnancies
title_full_unstemmed A longitudinal study of free leptin index in pre-eclamptic pregnancies
title_sort A longitudinal study of free leptin index in pre-eclamptic pregnancies
dc.creator.none.fl_str_mv Garcés, María Fernanda
Buell Acosta, Julieth Daniela
Rodríguez Navarro, Haiver Antonio
Páez Leal, María Carolina
Maldonado Acosta, Luis Miguel
Peralta Franco, Jhon Jairo
Burgos Cardenas, Álvaro Javier
Ángel Müller, Edith
Parada Baños, Arturo José
Parra Pineda, Mario Orlando
Eslava Schmalbach, Javier
Escobar Sarmiento, Camilo Andrés
Lacunza, Ezequiel
Caminos Cepeda, Sofia Alexandra
Castaño, Justo P
Nogueiras, Rubén
Dieguez, Carlos
Ruiz Parra, Ariel Iván
Caminos, Jorge Eduardo
author Garcés, María Fernanda
author_facet Garcés, María Fernanda
Buell Acosta, Julieth Daniela
Rodríguez Navarro, Haiver Antonio
Páez Leal, María Carolina
Maldonado Acosta, Luis Miguel
Peralta Franco, Jhon Jairo
Burgos Cardenas, Álvaro Javier
Ángel Müller, Edith
Parada Baños, Arturo José
Parra Pineda, Mario Orlando
Eslava Schmalbach, Javier
Escobar Sarmiento, Camilo Andrés
Lacunza, Ezequiel
Caminos Cepeda, Sofia Alexandra
Castaño, Justo P
Nogueiras, Rubén
Dieguez, Carlos
Ruiz Parra, Ariel Iván
Caminos, Jorge Eduardo
author_role author
author2 Buell Acosta, Julieth Daniela
Rodríguez Navarro, Haiver Antonio
Páez Leal, María Carolina
Maldonado Acosta, Luis Miguel
Peralta Franco, Jhon Jairo
Burgos Cardenas, Álvaro Javier
Ángel Müller, Edith
Parada Baños, Arturo José
Parra Pineda, Mario Orlando
Eslava Schmalbach, Javier
Escobar Sarmiento, Camilo Andrés
Lacunza, Ezequiel
Caminos Cepeda, Sofia Alexandra
Castaño, Justo P
Nogueiras, Rubén
Dieguez, Carlos
Ruiz Parra, Ariel Iván
Caminos, Jorge Eduardo
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv FREE LEPTIN INDEX
PREGNANCY AND PRE-ECLAMPSIA
topic FREE LEPTIN INDEX
PREGNANCY AND PRE-ECLAMPSIA
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv The ratio between circulating levels of leptin and soluble leptin receptor (sOB-R), the free leptin index (FLI), is used as a marker of leptin resistance. Therefore, the aim of our study was to investigate the FLI in mild pre-eclamptic pregnancies in a nested case–control study within a prospective observational study. Circulating levels of leptin and sOB-R levels rise significantly during pregnancy in healthy (p < 0.05) (n = 46) and pre-eclamptic pregnancies (p < 0.05) (n = 20). Serum levels of leptin were significantly higher in pre-eclamptic compared to healthy pregnancies at second and third trimesters of pregnancy (p < 0.05). Additionally, serum levels of sOB-R were significantly lower in pre-eclamptic pregnancies during the second and third trimesters of pregnancy compared to healthy pregnancies (p < 0.05). Moreover, we found that FLI did not vary significantly during pregnancy in healthy women (p > 0.05), while it increases in pre-eclamptic pregnancies (p < 0.05). Indeed, FLI was significantly higher at second and third trimesters of pregnancy in pre-eclamptic compared to healthy pregnancies (p < 0.05). In addition, FLI was significantly higher in the luteal phase compared with the follicular phase of the menstrual cycle in eumenorrheic women (p < 0.05). Receiver operating characteristic (ROC) curve analysis revealed the ability of leptin (AUC = 0.72) and FLI (AUC = 0.67) as a reliable predictor for mild pre-eclampsia during the second trimester of pregnancy. In conclusion, our findings show that FLI were significantly increased in mild pre-eclamptic pregnancies and allowed us to hypothesize that this rise might alter leptin bioavailability and bioactivity which might lead to the sympathetic hyperactivity and the hypertensive disorders during pregnancy.
Fil: Garcés, María Fernanda. Universidad Nacional de Colombia. Facultad de Medicina; Colombia
Fil: Buell Acosta, Julieth Daniela. Universidad Nacional de Colombia. Facultad de Medicina; Colombia
Fil: Rodríguez Navarro, Haiver Antonio. Universidad Nacional de Colombia. Facultad de Medicina; Colombia
Fil: Páez Leal, María Carolina. Universidad Nacional de Colombia. Facultad de Medicina; Colombia
Fil: Maldonado Acosta, Luis Miguel. Universidad Nacional de Colombia. Facultad de Medicina; Colombia
Fil: Peralta Franco, Jhon Jairo. Universidad Nacional de Colombia. Facultad de Medicina; Colombia
Fil: Burgos Cardenas, Álvaro Javier. Universidad Nacional de Colombia. Facultad de Medicina; Colombia
Fil: Ángel Müller, Edith. Universidad Nacional de Colombia. Facultad de Medicina; Colombia
Fil: Parada Baños, Arturo José. Universidad Nacional de Colombia. Facultad de Medicina; Colombia
Fil: Parra Pineda, Mario Orlando. Universidad Nacional de Colombia. Facultad de Medicina; Colombia
Fil: Eslava Schmalbach, Javier. Universidad Nacional de Colombia. Facultad de Medicina; Colombia
Fil: Escobar Sarmiento, Camilo Andrés. Fundación Sueño Vigilia Colombiana; Colombia
Fil: Lacunza, Ezequiel. Universidad Nacional de La Plata. Facultad de Ciencias Médicas. Centro de Investigaciones Inmunológicas Básicas y Aplicadas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina
Fil: Caminos Cepeda, Sofia Alexandra. Universitat Pompeu Fabra; España
Fil: Castaño, Justo P. Universidad de Córdoba; España
Fil: Nogueiras, Rubén. Universidad de Santiago de Compostela; España
Fil: Dieguez, Carlos. Instituto de Salud Carlos Iii (isciii);
Fil: Ruiz Parra, Ariel Iván. Universidad Nacional de Colombia. Facultad de Medicina; Colombia
Fil: Caminos, Jorge Eduardo. Universidad Nacional de Colombia. Facultad de Medicina; Colombia
description The ratio between circulating levels of leptin and soluble leptin receptor (sOB-R), the free leptin index (FLI), is used as a marker of leptin resistance. Therefore, the aim of our study was to investigate the FLI in mild pre-eclamptic pregnancies in a nested case–control study within a prospective observational study. Circulating levels of leptin and sOB-R levels rise significantly during pregnancy in healthy (p < 0.05) (n = 46) and pre-eclamptic pregnancies (p < 0.05) (n = 20). Serum levels of leptin were significantly higher in pre-eclamptic compared to healthy pregnancies at second and third trimesters of pregnancy (p < 0.05). Additionally, serum levels of sOB-R were significantly lower in pre-eclamptic pregnancies during the second and third trimesters of pregnancy compared to healthy pregnancies (p < 0.05). Moreover, we found that FLI did not vary significantly during pregnancy in healthy women (p > 0.05), while it increases in pre-eclamptic pregnancies (p < 0.05). Indeed, FLI was significantly higher at second and third trimesters of pregnancy in pre-eclamptic compared to healthy pregnancies (p < 0.05). In addition, FLI was significantly higher in the luteal phase compared with the follicular phase of the menstrual cycle in eumenorrheic women (p < 0.05). Receiver operating characteristic (ROC) curve analysis revealed the ability of leptin (AUC = 0.72) and FLI (AUC = 0.67) as a reliable predictor for mild pre-eclampsia during the second trimester of pregnancy. In conclusion, our findings show that FLI were significantly increased in mild pre-eclamptic pregnancies and allowed us to hypothesize that this rise might alter leptin bioavailability and bioactivity which might lead to the sympathetic hyperactivity and the hypertensive disorders during pregnancy.
publishDate 2023
dc.date.none.fl_str_mv 2023-04
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/218966
Garcés, María Fernanda; Buell Acosta, Julieth Daniela; Rodríguez Navarro, Haiver Antonio; Páez Leal, María Carolina; Maldonado Acosta, Luis Miguel; et al.; A longitudinal study of free leptin index in pre-eclamptic pregnancies; Wiley Blackwell Publishing, Inc; Journal Of Cellular And Molecular Medicine (print); 27; 8; 4-2023; 1083-1094
1582-1838
CONICET Digital
CONICET
url http://hdl.handle.net/11336/218966
identifier_str_mv Garcés, María Fernanda; Buell Acosta, Julieth Daniela; Rodríguez Navarro, Haiver Antonio; Páez Leal, María Carolina; Maldonado Acosta, Luis Miguel; et al.; A longitudinal study of free leptin index in pre-eclamptic pregnancies; Wiley Blackwell Publishing, Inc; Journal Of Cellular And Molecular Medicine (print); 27; 8; 4-2023; 1083-1094
1582-1838
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/10.1111/jcmm.17707
info:eu-repo/semantics/altIdentifier/doi/10.1111/jcmm.17707
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Wiley Blackwell Publishing, Inc
publisher.none.fl_str_mv Wiley Blackwell Publishing, Inc
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
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instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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