A longitudinal study of free leptin index in pre-eclamptic pregnancies
- Autores
- Garcés, María Fernanda; Buell Acosta, Julieth Daniela; Rodríguez Navarro, Haiver Antonio; Páez Leal, María Carolina; Maldonado Acosta, Luis Miguel; Peralta Franco, Jhon Jairo; Burgos Cardenas, Álvaro Javier; Ángel Müller, Edith; Parada Baños, Arturo José; Parra Pineda, Mario Orlando; Eslava Schmalbach, Javier; Escobar Sarmiento, Camilo Andrés; Lacunza, Ezequiel; Caminos Cepeda, Sofia Alexandra; Castaño, Justo P; Nogueiras, Rubén; Dieguez, Carlos; Ruiz Parra, Ariel Iván; Caminos, Jorge Eduardo
- Año de publicación
- 2023
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- The ratio between circulating levels of leptin and soluble leptin receptor (sOB-R), the free leptin index (FLI), is used as a marker of leptin resistance. Therefore, the aim of our study was to investigate the FLI in mild pre-eclamptic pregnancies in a nested case–control study within a prospective observational study. Circulating levels of leptin and sOB-R levels rise significantly during pregnancy in healthy (p < 0.05) (n = 46) and pre-eclamptic pregnancies (p < 0.05) (n = 20). Serum levels of leptin were significantly higher in pre-eclamptic compared to healthy pregnancies at second and third trimesters of pregnancy (p < 0.05). Additionally, serum levels of sOB-R were significantly lower in pre-eclamptic pregnancies during the second and third trimesters of pregnancy compared to healthy pregnancies (p < 0.05). Moreover, we found that FLI did not vary significantly during pregnancy in healthy women (p > 0.05), while it increases in pre-eclamptic pregnancies (p < 0.05). Indeed, FLI was significantly higher at second and third trimesters of pregnancy in pre-eclamptic compared to healthy pregnancies (p < 0.05). In addition, FLI was significantly higher in the luteal phase compared with the follicular phase of the menstrual cycle in eumenorrheic women (p < 0.05). Receiver operating characteristic (ROC) curve analysis revealed the ability of leptin (AUC = 0.72) and FLI (AUC = 0.67) as a reliable predictor for mild pre-eclampsia during the second trimester of pregnancy. In conclusion, our findings show that FLI were significantly increased in mild pre-eclamptic pregnancies and allowed us to hypothesize that this rise might alter leptin bioavailability and bioactivity which might lead to the sympathetic hyperactivity and the hypertensive disorders during pregnancy.
Fil: Garcés, María Fernanda. Universidad Nacional de Colombia. Facultad de Medicina; Colombia
Fil: Buell Acosta, Julieth Daniela. Universidad Nacional de Colombia. Facultad de Medicina; Colombia
Fil: Rodríguez Navarro, Haiver Antonio. Universidad Nacional de Colombia. Facultad de Medicina; Colombia
Fil: Páez Leal, María Carolina. Universidad Nacional de Colombia. Facultad de Medicina; Colombia
Fil: Maldonado Acosta, Luis Miguel. Universidad Nacional de Colombia. Facultad de Medicina; Colombia
Fil: Peralta Franco, Jhon Jairo. Universidad Nacional de Colombia. Facultad de Medicina; Colombia
Fil: Burgos Cardenas, Álvaro Javier. Universidad Nacional de Colombia. Facultad de Medicina; Colombia
Fil: Ángel Müller, Edith. Universidad Nacional de Colombia. Facultad de Medicina; Colombia
Fil: Parada Baños, Arturo José. Universidad Nacional de Colombia. Facultad de Medicina; Colombia
Fil: Parra Pineda, Mario Orlando. Universidad Nacional de Colombia. Facultad de Medicina; Colombia
Fil: Eslava Schmalbach, Javier. Universidad Nacional de Colombia. Facultad de Medicina; Colombia
Fil: Escobar Sarmiento, Camilo Andrés. Fundación Sueño Vigilia Colombiana; Colombia
Fil: Lacunza, Ezequiel. Universidad Nacional de La Plata. Facultad de Ciencias Médicas. Centro de Investigaciones Inmunológicas Básicas y Aplicadas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina
Fil: Caminos Cepeda, Sofia Alexandra. Universitat Pompeu Fabra; España
Fil: Castaño, Justo P. Universidad de Córdoba; España
Fil: Nogueiras, Rubén. Universidad de Santiago de Compostela; España
Fil: Dieguez, Carlos. Instituto de Salud Carlos Iii (isciii);
Fil: Ruiz Parra, Ariel Iván. Universidad Nacional de Colombia. Facultad de Medicina; Colombia
Fil: Caminos, Jorge Eduardo. Universidad Nacional de Colombia. Facultad de Medicina; Colombia - Materia
-
FREE LEPTIN INDEX
PREGNANCY AND PRE-ECLAMPSIA - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/218966
Ver los metadatos del registro completo
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A longitudinal study of free leptin index in pre-eclamptic pregnanciesGarcés, María FernandaBuell Acosta, Julieth DanielaRodríguez Navarro, Haiver AntonioPáez Leal, María CarolinaMaldonado Acosta, Luis MiguelPeralta Franco, Jhon JairoBurgos Cardenas, Álvaro JavierÁngel Müller, EdithParada Baños, Arturo JoséParra Pineda, Mario OrlandoEslava Schmalbach, JavierEscobar Sarmiento, Camilo AndrésLacunza, EzequielCaminos Cepeda, Sofia AlexandraCastaño, Justo PNogueiras, RubénDieguez, CarlosRuiz Parra, Ariel IvánCaminos, Jorge EduardoFREE LEPTIN INDEXPREGNANCY AND PRE-ECLAMPSIAhttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1The ratio between circulating levels of leptin and soluble leptin receptor (sOB-R), the free leptin index (FLI), is used as a marker of leptin resistance. Therefore, the aim of our study was to investigate the FLI in mild pre-eclamptic pregnancies in a nested case–control study within a prospective observational study. Circulating levels of leptin and sOB-R levels rise significantly during pregnancy in healthy (p < 0.05) (n = 46) and pre-eclamptic pregnancies (p < 0.05) (n = 20). Serum levels of leptin were significantly higher in pre-eclamptic compared to healthy pregnancies at second and third trimesters of pregnancy (p < 0.05). Additionally, serum levels of sOB-R were significantly lower in pre-eclamptic pregnancies during the second and third trimesters of pregnancy compared to healthy pregnancies (p < 0.05). Moreover, we found that FLI did not vary significantly during pregnancy in healthy women (p > 0.05), while it increases in pre-eclamptic pregnancies (p < 0.05). Indeed, FLI was significantly higher at second and third trimesters of pregnancy in pre-eclamptic compared to healthy pregnancies (p < 0.05). In addition, FLI was significantly higher in the luteal phase compared with the follicular phase of the menstrual cycle in eumenorrheic women (p < 0.05). Receiver operating characteristic (ROC) curve analysis revealed the ability of leptin (AUC = 0.72) and FLI (AUC = 0.67) as a reliable predictor for mild pre-eclampsia during the second trimester of pregnancy. In conclusion, our findings show that FLI were significantly increased in mild pre-eclamptic pregnancies and allowed us to hypothesize that this rise might alter leptin bioavailability and bioactivity which might lead to the sympathetic hyperactivity and the hypertensive disorders during pregnancy.Fil: Garcés, María Fernanda. Universidad Nacional de Colombia. Facultad de Medicina; ColombiaFil: Buell Acosta, Julieth Daniela. Universidad Nacional de Colombia. Facultad de Medicina; ColombiaFil: Rodríguez Navarro, Haiver Antonio. Universidad Nacional de Colombia. Facultad de Medicina; ColombiaFil: Páez Leal, María Carolina. Universidad Nacional de Colombia. Facultad de Medicina; ColombiaFil: Maldonado Acosta, Luis Miguel. Universidad Nacional de Colombia. Facultad de Medicina; ColombiaFil: Peralta Franco, Jhon Jairo. Universidad Nacional de Colombia. Facultad de Medicina; ColombiaFil: Burgos Cardenas, Álvaro Javier. Universidad Nacional de Colombia. Facultad de Medicina; ColombiaFil: Ángel Müller, Edith. Universidad Nacional de Colombia. Facultad de Medicina; ColombiaFil: Parada Baños, Arturo José. Universidad Nacional de Colombia. Facultad de Medicina; ColombiaFil: Parra Pineda, Mario Orlando. Universidad Nacional de Colombia. Facultad de Medicina; ColombiaFil: Eslava Schmalbach, Javier. Universidad Nacional de Colombia. Facultad de Medicina; ColombiaFil: Escobar Sarmiento, Camilo Andrés. Fundación Sueño Vigilia Colombiana; ColombiaFil: Lacunza, Ezequiel. Universidad Nacional de La Plata. Facultad de Ciencias Médicas. Centro de Investigaciones Inmunológicas Básicas y Aplicadas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; ArgentinaFil: Caminos Cepeda, Sofia Alexandra. Universitat Pompeu Fabra; EspañaFil: Castaño, Justo P. Universidad de Córdoba; EspañaFil: Nogueiras, Rubén. Universidad de Santiago de Compostela; EspañaFil: Dieguez, Carlos. Instituto de Salud Carlos Iii (isciii);Fil: Ruiz Parra, Ariel Iván. Universidad Nacional de Colombia. Facultad de Medicina; ColombiaFil: Caminos, Jorge Eduardo. Universidad Nacional de Colombia. Facultad de Medicina; ColombiaWiley Blackwell Publishing, Inc2023-04info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/218966Garcés, María Fernanda; Buell Acosta, Julieth Daniela; Rodríguez Navarro, Haiver Antonio; Páez Leal, María Carolina; Maldonado Acosta, Luis Miguel; et al.; A longitudinal study of free leptin index in pre-eclamptic pregnancies; Wiley Blackwell Publishing, Inc; Journal Of Cellular And Molecular Medicine (print); 27; 8; 4-2023; 1083-10941582-1838CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/10.1111/jcmm.17707info:eu-repo/semantics/altIdentifier/doi/10.1111/jcmm.17707info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:11:43Zoai:ri.conicet.gov.ar:11336/218966instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:11:43.642CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
A longitudinal study of free leptin index in pre-eclamptic pregnancies |
title |
A longitudinal study of free leptin index in pre-eclamptic pregnancies |
spellingShingle |
A longitudinal study of free leptin index in pre-eclamptic pregnancies Garcés, María Fernanda FREE LEPTIN INDEX PREGNANCY AND PRE-ECLAMPSIA |
title_short |
A longitudinal study of free leptin index in pre-eclamptic pregnancies |
title_full |
A longitudinal study of free leptin index in pre-eclamptic pregnancies |
title_fullStr |
A longitudinal study of free leptin index in pre-eclamptic pregnancies |
title_full_unstemmed |
A longitudinal study of free leptin index in pre-eclamptic pregnancies |
title_sort |
A longitudinal study of free leptin index in pre-eclamptic pregnancies |
dc.creator.none.fl_str_mv |
Garcés, María Fernanda Buell Acosta, Julieth Daniela Rodríguez Navarro, Haiver Antonio Páez Leal, María Carolina Maldonado Acosta, Luis Miguel Peralta Franco, Jhon Jairo Burgos Cardenas, Álvaro Javier Ángel Müller, Edith Parada Baños, Arturo José Parra Pineda, Mario Orlando Eslava Schmalbach, Javier Escobar Sarmiento, Camilo Andrés Lacunza, Ezequiel Caminos Cepeda, Sofia Alexandra Castaño, Justo P Nogueiras, Rubén Dieguez, Carlos Ruiz Parra, Ariel Iván Caminos, Jorge Eduardo |
author |
Garcés, María Fernanda |
author_facet |
Garcés, María Fernanda Buell Acosta, Julieth Daniela Rodríguez Navarro, Haiver Antonio Páez Leal, María Carolina Maldonado Acosta, Luis Miguel Peralta Franco, Jhon Jairo Burgos Cardenas, Álvaro Javier Ángel Müller, Edith Parada Baños, Arturo José Parra Pineda, Mario Orlando Eslava Schmalbach, Javier Escobar Sarmiento, Camilo Andrés Lacunza, Ezequiel Caminos Cepeda, Sofia Alexandra Castaño, Justo P Nogueiras, Rubén Dieguez, Carlos Ruiz Parra, Ariel Iván Caminos, Jorge Eduardo |
author_role |
author |
author2 |
Buell Acosta, Julieth Daniela Rodríguez Navarro, Haiver Antonio Páez Leal, María Carolina Maldonado Acosta, Luis Miguel Peralta Franco, Jhon Jairo Burgos Cardenas, Álvaro Javier Ángel Müller, Edith Parada Baños, Arturo José Parra Pineda, Mario Orlando Eslava Schmalbach, Javier Escobar Sarmiento, Camilo Andrés Lacunza, Ezequiel Caminos Cepeda, Sofia Alexandra Castaño, Justo P Nogueiras, Rubén Dieguez, Carlos Ruiz Parra, Ariel Iván Caminos, Jorge Eduardo |
author2_role |
author author author author author author author author author author author author author author author author author author |
dc.subject.none.fl_str_mv |
FREE LEPTIN INDEX PREGNANCY AND PRE-ECLAMPSIA |
topic |
FREE LEPTIN INDEX PREGNANCY AND PRE-ECLAMPSIA |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/1.6 https://purl.org/becyt/ford/1 |
dc.description.none.fl_txt_mv |
The ratio between circulating levels of leptin and soluble leptin receptor (sOB-R), the free leptin index (FLI), is used as a marker of leptin resistance. Therefore, the aim of our study was to investigate the FLI in mild pre-eclamptic pregnancies in a nested case–control study within a prospective observational study. Circulating levels of leptin and sOB-R levels rise significantly during pregnancy in healthy (p < 0.05) (n = 46) and pre-eclamptic pregnancies (p < 0.05) (n = 20). Serum levels of leptin were significantly higher in pre-eclamptic compared to healthy pregnancies at second and third trimesters of pregnancy (p < 0.05). Additionally, serum levels of sOB-R were significantly lower in pre-eclamptic pregnancies during the second and third trimesters of pregnancy compared to healthy pregnancies (p < 0.05). Moreover, we found that FLI did not vary significantly during pregnancy in healthy women (p > 0.05), while it increases in pre-eclamptic pregnancies (p < 0.05). Indeed, FLI was significantly higher at second and third trimesters of pregnancy in pre-eclamptic compared to healthy pregnancies (p < 0.05). In addition, FLI was significantly higher in the luteal phase compared with the follicular phase of the menstrual cycle in eumenorrheic women (p < 0.05). Receiver operating characteristic (ROC) curve analysis revealed the ability of leptin (AUC = 0.72) and FLI (AUC = 0.67) as a reliable predictor for mild pre-eclampsia during the second trimester of pregnancy. In conclusion, our findings show that FLI were significantly increased in mild pre-eclamptic pregnancies and allowed us to hypothesize that this rise might alter leptin bioavailability and bioactivity which might lead to the sympathetic hyperactivity and the hypertensive disorders during pregnancy. Fil: Garcés, María Fernanda. Universidad Nacional de Colombia. Facultad de Medicina; Colombia Fil: Buell Acosta, Julieth Daniela. Universidad Nacional de Colombia. Facultad de Medicina; Colombia Fil: Rodríguez Navarro, Haiver Antonio. Universidad Nacional de Colombia. Facultad de Medicina; Colombia Fil: Páez Leal, María Carolina. Universidad Nacional de Colombia. Facultad de Medicina; Colombia Fil: Maldonado Acosta, Luis Miguel. Universidad Nacional de Colombia. Facultad de Medicina; Colombia Fil: Peralta Franco, Jhon Jairo. Universidad Nacional de Colombia. Facultad de Medicina; Colombia Fil: Burgos Cardenas, Álvaro Javier. Universidad Nacional de Colombia. Facultad de Medicina; Colombia Fil: Ángel Müller, Edith. Universidad Nacional de Colombia. Facultad de Medicina; Colombia Fil: Parada Baños, Arturo José. Universidad Nacional de Colombia. Facultad de Medicina; Colombia Fil: Parra Pineda, Mario Orlando. Universidad Nacional de Colombia. Facultad de Medicina; Colombia Fil: Eslava Schmalbach, Javier. Universidad Nacional de Colombia. Facultad de Medicina; Colombia Fil: Escobar Sarmiento, Camilo Andrés. Fundación Sueño Vigilia Colombiana; Colombia Fil: Lacunza, Ezequiel. Universidad Nacional de La Plata. Facultad de Ciencias Médicas. Centro de Investigaciones Inmunológicas Básicas y Aplicadas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina Fil: Caminos Cepeda, Sofia Alexandra. Universitat Pompeu Fabra; España Fil: Castaño, Justo P. Universidad de Córdoba; España Fil: Nogueiras, Rubén. Universidad de Santiago de Compostela; España Fil: Dieguez, Carlos. Instituto de Salud Carlos Iii (isciii); Fil: Ruiz Parra, Ariel Iván. Universidad Nacional de Colombia. Facultad de Medicina; Colombia Fil: Caminos, Jorge Eduardo. Universidad Nacional de Colombia. Facultad de Medicina; Colombia |
description |
The ratio between circulating levels of leptin and soluble leptin receptor (sOB-R), the free leptin index (FLI), is used as a marker of leptin resistance. Therefore, the aim of our study was to investigate the FLI in mild pre-eclamptic pregnancies in a nested case–control study within a prospective observational study. Circulating levels of leptin and sOB-R levels rise significantly during pregnancy in healthy (p < 0.05) (n = 46) and pre-eclamptic pregnancies (p < 0.05) (n = 20). Serum levels of leptin were significantly higher in pre-eclamptic compared to healthy pregnancies at second and third trimesters of pregnancy (p < 0.05). Additionally, serum levels of sOB-R were significantly lower in pre-eclamptic pregnancies during the second and third trimesters of pregnancy compared to healthy pregnancies (p < 0.05). Moreover, we found that FLI did not vary significantly during pregnancy in healthy women (p > 0.05), while it increases in pre-eclamptic pregnancies (p < 0.05). Indeed, FLI was significantly higher at second and third trimesters of pregnancy in pre-eclamptic compared to healthy pregnancies (p < 0.05). In addition, FLI was significantly higher in the luteal phase compared with the follicular phase of the menstrual cycle in eumenorrheic women (p < 0.05). Receiver operating characteristic (ROC) curve analysis revealed the ability of leptin (AUC = 0.72) and FLI (AUC = 0.67) as a reliable predictor for mild pre-eclampsia during the second trimester of pregnancy. In conclusion, our findings show that FLI were significantly increased in mild pre-eclamptic pregnancies and allowed us to hypothesize that this rise might alter leptin bioavailability and bioactivity which might lead to the sympathetic hyperactivity and the hypertensive disorders during pregnancy. |
publishDate |
2023 |
dc.date.none.fl_str_mv |
2023-04 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/218966 Garcés, María Fernanda; Buell Acosta, Julieth Daniela; Rodríguez Navarro, Haiver Antonio; Páez Leal, María Carolina; Maldonado Acosta, Luis Miguel; et al.; A longitudinal study of free leptin index in pre-eclamptic pregnancies; Wiley Blackwell Publishing, Inc; Journal Of Cellular And Molecular Medicine (print); 27; 8; 4-2023; 1083-1094 1582-1838 CONICET Digital CONICET |
url |
http://hdl.handle.net/11336/218966 |
identifier_str_mv |
Garcés, María Fernanda; Buell Acosta, Julieth Daniela; Rodríguez Navarro, Haiver Antonio; Páez Leal, María Carolina; Maldonado Acosta, Luis Miguel; et al.; A longitudinal study of free leptin index in pre-eclamptic pregnancies; Wiley Blackwell Publishing, Inc; Journal Of Cellular And Molecular Medicine (print); 27; 8; 4-2023; 1083-1094 1582-1838 CONICET Digital CONICET |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/10.1111/jcmm.17707 info:eu-repo/semantics/altIdentifier/doi/10.1111/jcmm.17707 |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
Wiley Blackwell Publishing, Inc |
publisher.none.fl_str_mv |
Wiley Blackwell Publishing, Inc |
dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
reponame_str |
CONICET Digital (CONICET) |
collection |
CONICET Digital (CONICET) |
instname_str |
Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.name.fl_str_mv |
CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
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1844614018515337216 |
score |
13.070432 |