Leptin and Gestational Diabetes Mellitus

Autores
Guádix, Pilar; Pérez Pérez, Antonio; Vilariño, Teresa; Dueñas, Jose L.; Maymo, Julieta Lorena; Varone, Cecilia Laura; Sánchez Margalet, Victor
Año de publicación
2019
Idioma
inglés
Tipo de recurso
parte de libro
Estado
versión publicada
Descripción
Emerging research has highlighted the importance of leptin in fetal growth anddevelopment, independent of its essential role in the regulation of feeding andenergy metabolism. Leptin is now considered an important signaling molecule ofthe reproductive system, since it regulates the production of gonadotropins, theblastocyst formation and implantation, the normal placentation, as well as the feto-placental communication. Placental leptin is an important cytokine which regulatesplacental functions in an autocrine or paracrine manner. Leptin seems to play acrucial role during the first stages of pregnancy as it modulates critical processes likeproliferation, protein synthesis, invasion, and apoptosis in placental cells. Further-more, deregulation of leptin levels has been correlated with the pathogenesis ofvarious disorders associated with reproduction and gestation, including gestationaldiabetes mellitus (GDM). Due to the relevant incidence of the GDM and theimportance of leptin, we decided to review the latest information available aboutleptin action in normal and GDM pregnancies to support the idea of leptin as animportant factor and/or predictor of diverse disorders associated with reproductionand pregnancy.
Fil: Guádix, Pilar. No especifíca;
Fil: Pérez Pérez, Antonio. No especifíca;
Fil: Vilariño, Teresa. No especifíca;
Fil: Dueñas, Jose L.. No especifíca;
Fil: Maymo, Julieta Lorena. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales; Argentina
Fil: Varone, Cecilia Laura. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales; Argentina
Fil: Sánchez Margalet, Victor. No especifíca;
Materia
LEPTINA
PLACENTA
DIABETES
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/123571
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/123571
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Leptin and Gestational Diabetes MellitusGuádix, PilarPérez Pérez, AntonioVilariño, TeresaDueñas, Jose L.Maymo, Julieta LorenaVarone, Cecilia LauraSánchez Margalet, VictorLEPTINAPLACENTADIABETEShttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Emerging research has highlighted the importance of leptin in fetal growth anddevelopment, independent of its essential role in the regulation of feeding andenergy metabolism. Leptin is now considered an important signaling molecule ofthe reproductive system, since it regulates the production of gonadotropins, theblastocyst formation and implantation, the normal placentation, as well as the feto-placental communication. Placental leptin is an important cytokine which regulatesplacental functions in an autocrine or paracrine manner. Leptin seems to play acrucial role during the first stages of pregnancy as it modulates critical processes likeproliferation, protein synthesis, invasion, and apoptosis in placental cells. Further-more, deregulation of leptin levels has been correlated with the pathogenesis ofvarious disorders associated with reproduction and gestation, including gestationaldiabetes mellitus (GDM). Due to the relevant incidence of the GDM and theimportance of leptin, we decided to review the latest information available aboutleptin action in normal and GDM pregnancies to support the idea of leptin as animportant factor and/or predictor of diverse disorders associated with reproductionand pregnancy.Fil: Guádix, Pilar. No especifíca;Fil: Pérez Pérez, Antonio. No especifíca;Fil: Vilariño, Teresa. No especifíca;Fil: Dueñas, Jose L.. No especifíca;Fil: Maymo, Julieta Lorena. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales; ArgentinaFil: Varone, Cecilia Laura. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales; ArgentinaFil: Sánchez Margalet, Victor. No especifíca;IntechOpenAmita Ray2019info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/bookParthttp://purl.org/coar/resource_type/c_3248info:ar-repo/semantics/parteDeLibroapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/123571Guádix, Pilar; Pérez Pérez, Antonio; Vilariño, Teresa; Dueñas, Jose L.; Maymo, Julieta Lorena; et al.; Leptin and Gestational Diabetes Mellitus; IntechOpen; 2019; 55-70978-1-78985-187-8CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.intechopen.com/chapters/65886info:eu-repo/semantics/altIdentifier/doi/10.5772/intechopen.84885info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:45:11Zoai:ri.conicet.gov.ar:11336/123571instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:45:13.239CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Leptin and Gestational Diabetes Mellitus
title Leptin and Gestational Diabetes Mellitus
spellingShingle Leptin and Gestational Diabetes Mellitus
Guádix, Pilar
LEPTINA
PLACENTA
DIABETES
title_short Leptin and Gestational Diabetes Mellitus
title_full Leptin and Gestational Diabetes Mellitus
title_fullStr Leptin and Gestational Diabetes Mellitus
title_full_unstemmed Leptin and Gestational Diabetes Mellitus
title_sort Leptin and Gestational Diabetes Mellitus
dc.creator.none.fl_str_mv Guádix, Pilar
Pérez Pérez, Antonio
Vilariño, Teresa
Dueñas, Jose L.
Maymo, Julieta Lorena
Varone, Cecilia Laura
Sánchez Margalet, Victor
author Guádix, Pilar
author_facet Guádix, Pilar
Pérez Pérez, Antonio
Vilariño, Teresa
Dueñas, Jose L.
Maymo, Julieta Lorena
Varone, Cecilia Laura
Sánchez Margalet, Victor
author_role author
author2 Pérez Pérez, Antonio
Vilariño, Teresa
Dueñas, Jose L.
Maymo, Julieta Lorena
Varone, Cecilia Laura
Sánchez Margalet, Victor
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv Amita Ray
dc.subject.none.fl_str_mv LEPTINA
PLACENTA
DIABETES
topic LEPTINA
PLACENTA
DIABETES
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Emerging research has highlighted the importance of leptin in fetal growth anddevelopment, independent of its essential role in the regulation of feeding andenergy metabolism. Leptin is now considered an important signaling molecule ofthe reproductive system, since it regulates the production of gonadotropins, theblastocyst formation and implantation, the normal placentation, as well as the feto-placental communication. Placental leptin is an important cytokine which regulatesplacental functions in an autocrine or paracrine manner. Leptin seems to play acrucial role during the first stages of pregnancy as it modulates critical processes likeproliferation, protein synthesis, invasion, and apoptosis in placental cells. Further-more, deregulation of leptin levels has been correlated with the pathogenesis ofvarious disorders associated with reproduction and gestation, including gestationaldiabetes mellitus (GDM). Due to the relevant incidence of the GDM and theimportance of leptin, we decided to review the latest information available aboutleptin action in normal and GDM pregnancies to support the idea of leptin as animportant factor and/or predictor of diverse disorders associated with reproductionand pregnancy.
Fil: Guádix, Pilar. No especifíca;
Fil: Pérez Pérez, Antonio. No especifíca;
Fil: Vilariño, Teresa. No especifíca;
Fil: Dueñas, Jose L.. No especifíca;
Fil: Maymo, Julieta Lorena. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales; Argentina
Fil: Varone, Cecilia Laura. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales; Argentina
Fil: Sánchez Margalet, Victor. No especifíca;
description Emerging research has highlighted the importance of leptin in fetal growth anddevelopment, independent of its essential role in the regulation of feeding andenergy metabolism. Leptin is now considered an important signaling molecule ofthe reproductive system, since it regulates the production of gonadotropins, theblastocyst formation and implantation, the normal placentation, as well as the feto-placental communication. Placental leptin is an important cytokine which regulatesplacental functions in an autocrine or paracrine manner. Leptin seems to play acrucial role during the first stages of pregnancy as it modulates critical processes likeproliferation, protein synthesis, invasion, and apoptosis in placental cells. Further-more, deregulation of leptin levels has been correlated with the pathogenesis ofvarious disorders associated with reproduction and gestation, including gestationaldiabetes mellitus (GDM). Due to the relevant incidence of the GDM and theimportance of leptin, we decided to review the latest information available aboutleptin action in normal and GDM pregnancies to support the idea of leptin as animportant factor and/or predictor of diverse disorders associated with reproductionand pregnancy.
publishDate 2019
dc.date.none.fl_str_mv 2019
dc.type.none.fl_str_mv info:eu-repo/semantics/publishedVersion
info:eu-repo/semantics/bookPart
http://purl.org/coar/resource_type/c_3248
info:ar-repo/semantics/parteDeLibro
status_str publishedVersion
format bookPart
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/123571
Guádix, Pilar; Pérez Pérez, Antonio; Vilariño, Teresa; Dueñas, Jose L.; Maymo, Julieta Lorena; et al.; Leptin and Gestational Diabetes Mellitus; IntechOpen; 2019; 55-70
978-1-78985-187-8
CONICET Digital
CONICET
url http://hdl.handle.net/11336/123571
identifier_str_mv Guádix, Pilar; Pérez Pérez, Antonio; Vilariño, Teresa; Dueñas, Jose L.; Maymo, Julieta Lorena; et al.; Leptin and Gestational Diabetes Mellitus; IntechOpen; 2019; 55-70
978-1-78985-187-8
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.intechopen.com/chapters/65886
info:eu-repo/semantics/altIdentifier/doi/10.5772/intechopen.84885
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv IntechOpen
publisher.none.fl_str_mv IntechOpen
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1842268715133960192
score 13.13397

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