Cytotoxicity action of an oxidovanadium(IV)-DPPZ complex on MG-63 human osteosarcoma cell line

Autores
Leon, Ignacio Esteban; Etcheverry, Susana Beatriz; Baran, Enrique José
Año de publicación
2015
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The cytotoxicity activity of the recently reported [VO(H2O) 2(SO4)dppz]2H2O complex (dppz = dipyrido[3,2-a:2í,3í- c]phenazine) on MG-63 human osteosarcoma cell line was investigated. It was found that it caused a concentration related inhibitory effect in the concentration range between 5 and 25 µM and diminished the cell viability ca. 40% in the range from 25 to 100 ÏM, without dose/response effects in this range. These biological effects are, in general, similar to those previously reported for the related [VO(ODA)dppz].3H2O (ODA = dianion of oxodiacetic acid) and [VO(ODA)(phen)].1.5H2O (phen = o- phenanthroline) complexes. The importance of the presence of DNAintercalating ligands in these complexes is emphasized.
Fil: Leon, Ignacio Esteban. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Química Inorgánica ; Argentina
Fil: Etcheverry, Susana Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Química Inorgánica ; Argentina
Fil: Baran, Enrique José. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Química Inorgánica ; Argentina
Materia
Oxidovanadium(IV)
DPPZ
Metallointercalators
Human osteosarcoma cell line
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/50200
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/50200
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Cytotoxicity action of an oxidovanadium(IV)-DPPZ complex on MG-63 human osteosarcoma cell lineLeon, Ignacio EstebanEtcheverry, Susana BeatrizBaran, Enrique JoséOxidovanadium(IV)DPPZMetallointercalatorsHuman osteosarcoma cell linehttps://purl.org/becyt/ford/1.4https://purl.org/becyt/ford/1The cytotoxicity activity of the recently reported [VO(H2O) 2(SO4)dppz]2H2O complex (dppz = dipyrido[3,2-a:2í,3í- c]phenazine) on MG-63 human osteosarcoma cell line was investigated. It was found that it caused a concentration related inhibitory effect in the concentration range between 5 and 25 µM and diminished the cell viability ca. 40% in the range from 25 to 100 ÏM, without dose/response effects in this range. These biological effects are, in general, similar to those previously reported for the related [VO(ODA)dppz].3H2O (ODA = dianion of oxodiacetic acid) and [VO(ODA)(phen)].1.5H2O (phen = o- phenanthroline) complexes. The importance of the presence of DNAintercalating ligands in these complexes is emphasized.Fil: Leon, Ignacio Esteban. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Química Inorgánica ; ArgentinaFil: Etcheverry, Susana Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Química Inorgánica ; ArgentinaFil: Baran, Enrique José. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Química Inorgánica ; ArgentinaTrade Science Journals2015-04info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/50200Leon, Ignacio Esteban; Etcheverry, Susana Beatriz; Baran, Enrique José; Cytotoxicity action of an oxidovanadium(IV)-DPPZ complex on MG-63 human osteosarcoma cell line; Trade Science Journals; BioTechnology, An Indian Journal; 11; 12; 4-2015; 465-4680974-7435CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://www.tsijournals.com/abstract/cytotoxicity-action-of-an-oxidovanadiumivdppz-complex-on-mg63-human-osteosarcoma-cell-line-2208.htmlinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-22T12:01:46Zoai:ri.conicet.gov.ar:11336/50200instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-22 12:01:46.696CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Cytotoxicity action of an oxidovanadium(IV)-DPPZ complex on MG-63 human osteosarcoma cell line
title Cytotoxicity action of an oxidovanadium(IV)-DPPZ complex on MG-63 human osteosarcoma cell line
spellingShingle Cytotoxicity action of an oxidovanadium(IV)-DPPZ complex on MG-63 human osteosarcoma cell line
Leon, Ignacio Esteban
Oxidovanadium(IV)
DPPZ
Metallointercalators
Human osteosarcoma cell line
title_short Cytotoxicity action of an oxidovanadium(IV)-DPPZ complex on MG-63 human osteosarcoma cell line
title_full Cytotoxicity action of an oxidovanadium(IV)-DPPZ complex on MG-63 human osteosarcoma cell line
title_fullStr Cytotoxicity action of an oxidovanadium(IV)-DPPZ complex on MG-63 human osteosarcoma cell line
title_full_unstemmed Cytotoxicity action of an oxidovanadium(IV)-DPPZ complex on MG-63 human osteosarcoma cell line
title_sort Cytotoxicity action of an oxidovanadium(IV)-DPPZ complex on MG-63 human osteosarcoma cell line
dc.creator.none.fl_str_mv Leon, Ignacio Esteban
Etcheverry, Susana Beatriz
Baran, Enrique José
author Leon, Ignacio Esteban
author_facet Leon, Ignacio Esteban
Etcheverry, Susana Beatriz
Baran, Enrique José
author_role author
author2 Etcheverry, Susana Beatriz
Baran, Enrique José
author2_role author
author
dc.subject.none.fl_str_mv Oxidovanadium(IV)
DPPZ
Metallointercalators
Human osteosarcoma cell line
topic Oxidovanadium(IV)
DPPZ
Metallointercalators
Human osteosarcoma cell line
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.4
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv The cytotoxicity activity of the recently reported [VO(H2O) 2(SO4)dppz]2H2O complex (dppz = dipyrido[3,2-a:2í,3í- c]phenazine) on MG-63 human osteosarcoma cell line was investigated. It was found that it caused a concentration related inhibitory effect in the concentration range between 5 and 25 µM and diminished the cell viability ca. 40% in the range from 25 to 100 ÏM, without dose/response effects in this range. These biological effects are, in general, similar to those previously reported for the related [VO(ODA)dppz].3H2O (ODA = dianion of oxodiacetic acid) and [VO(ODA)(phen)].1.5H2O (phen = o- phenanthroline) complexes. The importance of the presence of DNAintercalating ligands in these complexes is emphasized.
Fil: Leon, Ignacio Esteban. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Química Inorgánica ; Argentina
Fil: Etcheverry, Susana Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Química Inorgánica ; Argentina
Fil: Baran, Enrique José. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Química Inorgánica ; Argentina
description The cytotoxicity activity of the recently reported [VO(H2O) 2(SO4)dppz]2H2O complex (dppz = dipyrido[3,2-a:2í,3í- c]phenazine) on MG-63 human osteosarcoma cell line was investigated. It was found that it caused a concentration related inhibitory effect in the concentration range between 5 and 25 µM and diminished the cell viability ca. 40% in the range from 25 to 100 ÏM, without dose/response effects in this range. These biological effects are, in general, similar to those previously reported for the related [VO(ODA)dppz].3H2O (ODA = dianion of oxodiacetic acid) and [VO(ODA)(phen)].1.5H2O (phen = o- phenanthroline) complexes. The importance of the presence of DNAintercalating ligands in these complexes is emphasized.
publishDate 2015
dc.date.none.fl_str_mv 2015-04
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/50200
Leon, Ignacio Esteban; Etcheverry, Susana Beatriz; Baran, Enrique José; Cytotoxicity action of an oxidovanadium(IV)-DPPZ complex on MG-63 human osteosarcoma cell line; Trade Science Journals; BioTechnology, An Indian Journal; 11; 12; 4-2015; 465-468
0974-7435
CONICET Digital
CONICET
url http://hdl.handle.net/11336/50200
identifier_str_mv Leon, Ignacio Esteban; Etcheverry, Susana Beatriz; Baran, Enrique José; Cytotoxicity action of an oxidovanadium(IV)-DPPZ complex on MG-63 human osteosarcoma cell line; Trade Science Journals; BioTechnology, An Indian Journal; 11; 12; 4-2015; 465-468
0974-7435
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://www.tsijournals.com/abstract/cytotoxicity-action-of-an-oxidovanadiumivdppz-complex-on-mg63-human-osteosarcoma-cell-line-2208.html
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Trade Science Journals
publisher.none.fl_str_mv Trade Science Journals
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 12.982451

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