Cytotoxicity action of an oxidovanadium(IV)-DPPZ complex on MG-63 human osteosarcoma cell line
- Autores
- León, Ignacio Esteban; Etcheverry, Susana Beatriz; Baran, Enrique José
- Año de publicación
- 2015
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- The cytotoxicity activity of the recently reported [VO(H2O)2(SO4)dppz]·2H2O complex (dppz = dipyrido[3,2-a:2',3'- c]phenazine) on MG-63 human osteosarcoma cell line was investigated. It was found that it caused a concentration related inhibitory effect in the concentration range between 5 and 25 µM and diminished the cell viability ca. 40% in the range from 25 to 100 µM, without dose/response effects in this range. These biological effects are, in general, similar to those previously reported for the related [VO(ODA)dppz]·3H2O (ODA = dianion of oxodiacetic acid) and [VO(ODA)(phen)]·1.5H2O (phen = o- phenanthroline) complexes. The importance of the presence of DNAintercalating ligands in these complexes is emphasized.
Facultad de Ciencias Exactas
Centro de Química Inorgánica - Materia
-
Ciencias Exactas
Química
oxidovanadium(IV)
dipyrido[3,2-a:2',3'-c]phenazine (dppz)
metallointercalators
human osteosarcoma cell line - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- http://creativecommons.org/licenses/by-nc-sa/4.0/
- Repositorio
.jpg)
- Institución
- Universidad Nacional de La Plata
- OAI Identificador
- oai:sedici.unlp.edu.ar:10915/104747
Ver los metadatos del registro completo
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Cytotoxicity action of an oxidovanadium(IV)-DPPZ complex on MG-63 human osteosarcoma cell lineLeón, Ignacio EstebanEtcheverry, Susana BeatrizBaran, Enrique JoséCiencias ExactasQuímicaoxidovanadium(IV)dipyrido[3,2-a:2',3'-c]phenazine (dppz)metallointercalatorshuman osteosarcoma cell lineThe cytotoxicity activity of the recently reported [VO(H<sub>2</sub>O)<sub>2</sub>(SO<sub>4</sub>)dppz]·2H<sub>2</sub>O complex (dppz = dipyrido[3,2-a:2',3'- c]phenazine) on MG-63 human osteosarcoma cell line was investigated. It was found that it caused a concentration related inhibitory effect in the concentration range between 5 and 25 µM and diminished the cell viability ca. 40% in the range from 25 to 100 µM, without dose/response effects in this range. These biological effects are, in general, similar to those previously reported for the related [VO(ODA)dppz]·3H<sub>2</sub>O (ODA = dianion of oxodiacetic acid) and [VO(ODA)(phen)]·1.5H<sub>2</sub>O (phen = o- phenanthroline) complexes. The importance of the presence of DNAintercalating ligands in these complexes is emphasized.Facultad de Ciencias ExactasCentro de Química Inorgánica2015info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionArticulohttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdf465-468http://sedici.unlp.edu.ar/handle/10915/104747enginfo:eu-repo/semantics/altIdentifier/url/http://hdl.handle.net/11336/50200info:eu-repo/semantics/altIdentifier/url/https://www.tsijournals.com/abstract/cytotoxicity-action-of-an-oxidovanadiumivdppz-complex-on-mg63-human-osteosarcoma-cell-line-2208.htmlinfo:eu-repo/semantics/altIdentifier/issn/0974-7435info:eu-repo/semantics/altIdentifier/hdl/11336/50200info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by-nc-sa/4.0/Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)reponame:SEDICI (UNLP)instname:Universidad Nacional de La Platainstacron:UNLP2025-10-22T17:03:35Zoai:sedici.unlp.edu.ar:10915/104747Institucionalhttp://sedici.unlp.edu.ar/Universidad públicaNo correspondehttp://sedici.unlp.edu.ar/oai/snrdalira@sedici.unlp.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:13292025-10-22 17:03:36.142SEDICI (UNLP) - Universidad Nacional de La Platafalse |
| dc.title.none.fl_str_mv |
Cytotoxicity action of an oxidovanadium(IV)-DPPZ complex on MG-63 human osteosarcoma cell line |
| title |
Cytotoxicity action of an oxidovanadium(IV)-DPPZ complex on MG-63 human osteosarcoma cell line |
| spellingShingle |
Cytotoxicity action of an oxidovanadium(IV)-DPPZ complex on MG-63 human osteosarcoma cell line León, Ignacio Esteban Ciencias Exactas Química oxidovanadium(IV) dipyrido[3,2-a:2',3'-c]phenazine (dppz) metallointercalators human osteosarcoma cell line |
| title_short |
Cytotoxicity action of an oxidovanadium(IV)-DPPZ complex on MG-63 human osteosarcoma cell line |
| title_full |
Cytotoxicity action of an oxidovanadium(IV)-DPPZ complex on MG-63 human osteosarcoma cell line |
| title_fullStr |
Cytotoxicity action of an oxidovanadium(IV)-DPPZ complex on MG-63 human osteosarcoma cell line |
| title_full_unstemmed |
Cytotoxicity action of an oxidovanadium(IV)-DPPZ complex on MG-63 human osteosarcoma cell line |
| title_sort |
Cytotoxicity action of an oxidovanadium(IV)-DPPZ complex on MG-63 human osteosarcoma cell line |
| dc.creator.none.fl_str_mv |
León, Ignacio Esteban Etcheverry, Susana Beatriz Baran, Enrique José |
| author |
León, Ignacio Esteban |
| author_facet |
León, Ignacio Esteban Etcheverry, Susana Beatriz Baran, Enrique José |
| author_role |
author |
| author2 |
Etcheverry, Susana Beatriz Baran, Enrique José |
| author2_role |
author author |
| dc.subject.none.fl_str_mv |
Ciencias Exactas Química oxidovanadium(IV) dipyrido[3,2-a:2',3'-c]phenazine (dppz) metallointercalators human osteosarcoma cell line |
| topic |
Ciencias Exactas Química oxidovanadium(IV) dipyrido[3,2-a:2',3'-c]phenazine (dppz) metallointercalators human osteosarcoma cell line |
| dc.description.none.fl_txt_mv |
The cytotoxicity activity of the recently reported [VO(H<sub>2</sub>O)<sub>2</sub>(SO<sub>4</sub>)dppz]·2H<sub>2</sub>O complex (dppz = dipyrido[3,2-a:2',3'- c]phenazine) on MG-63 human osteosarcoma cell line was investigated. It was found that it caused a concentration related inhibitory effect in the concentration range between 5 and 25 µM and diminished the cell viability ca. 40% in the range from 25 to 100 µM, without dose/response effects in this range. These biological effects are, in general, similar to those previously reported for the related [VO(ODA)dppz]·3H<sub>2</sub>O (ODA = dianion of oxodiacetic acid) and [VO(ODA)(phen)]·1.5H<sub>2</sub>O (phen = o- phenanthroline) complexes. The importance of the presence of DNAintercalating ligands in these complexes is emphasized. Facultad de Ciencias Exactas Centro de Química Inorgánica |
| description |
The cytotoxicity activity of the recently reported [VO(H<sub>2</sub>O)<sub>2</sub>(SO<sub>4</sub>)dppz]·2H<sub>2</sub>O complex (dppz = dipyrido[3,2-a:2',3'- c]phenazine) on MG-63 human osteosarcoma cell line was investigated. It was found that it caused a concentration related inhibitory effect in the concentration range between 5 and 25 µM and diminished the cell viability ca. 40% in the range from 25 to 100 µM, without dose/response effects in this range. These biological effects are, in general, similar to those previously reported for the related [VO(ODA)dppz]·3H<sub>2</sub>O (ODA = dianion of oxodiacetic acid) and [VO(ODA)(phen)]·1.5H<sub>2</sub>O (phen = o- phenanthroline) complexes. The importance of the presence of DNAintercalating ligands in these complexes is emphasized. |
| publishDate |
2015 |
| dc.date.none.fl_str_mv |
2015 |
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info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Articulo http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
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article |
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publishedVersion |
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http://sedici.unlp.edu.ar/handle/10915/104747 |
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eng |
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eng |
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