A New Oxidovanadium(IV) Complex of Oxodiacetic Acid and dppz : Spectroscopic and DFT Study. Antitumor Action on MG-63 Human Osteosarcoma Cell Line

Autores
León, Ignacio Esteban; Parajón Costa, Beatriz Susana; Franca, Carlos Alberto; Etcheverry, Susana Beatriz; Baran, Enrique José
Año de publicación
2015
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The oxidovanadium(IV) complex of oxodiacetic acid (H2ODA) and dppz (dipyrido[3,2-a:2′,3′-c] phenazine) of stoichiometry [VO(ODA)(dppz)]⋅3H2O could be synthesized for the first time by reaction between [VO(ODA)(H2O)2] and dppz. It was characterized by infrared and electronic spectroscopies. Its optimized molecular structure was obtained by DFT calculations, as it was impossible to grow single crystals adequate for crystallographic studies. The antitumor action of the complex on MG-63 human osteosarcoma cell line was also investigated. It was found that it caused a concentration-related inhibitory effect in the concentration range between 5 and 25 μM and diminished the cell viability ca. 45 % in the range from 25 to 100 μM, without dose/response effects in this range. These biological effects are, in general, similar to those previously reported for the related [VO(ODA)(ophen)]⋅1.5H2O complex.
Centro de Química Inorgánica
Materia
Ciencias Exactas
Química
Oxidovanadium(IV)
Oxodiacetic acid
Dppz
DFT calculations
FTIR spectrum
Electronic spectrum
Human osteosarcoma cell line
Nivel de accesibilidad
acceso abierto
Condiciones de uso
http://creativecommons.org/licenses/by-nc-sa/4.0/
Repositorio
SEDICI (UNLP)
Institución
Universidad Nacional de La Plata
OAI Identificador
oai:sedici.unlp.edu.ar:10915/108517
Acceder
id SEDICI_dfb02cdb40125913ab7fb45716f6d9dd
oai_identifier_str oai:sedici.unlp.edu.ar:10915/108517
network_acronym_str SEDICI
repository_id_str 1329
network_name_str SEDICI (UNLP)
spelling A New Oxidovanadium(IV) Complex of Oxodiacetic Acid and dppz : Spectroscopic and DFT Study. Antitumor Action on MG-63 Human Osteosarcoma Cell LineLeón, Ignacio EstebanParajón Costa, Beatriz SusanaFranca, Carlos AlbertoEtcheverry, Susana BeatrizBaran, Enrique JoséCiencias ExactasQuímicaOxidovanadium(IV)Oxodiacetic acidDppzDFT calculationsFTIR spectrumElectronic spectrumHuman osteosarcoma cell lineThe oxidovanadium(IV) complex of oxodiacetic acid (H<sub>2</sub>ODA) and dppz (dipyrido[3,2-a:2′,3′-c] phenazine) of stoichiometry [VO(ODA)(dppz)]⋅3H<sub>2</sub>O could be synthesized for the first time by reaction between [VO(ODA)(H<sub>2</sub>O)<sub>2</sub>] and dppz. It was characterized by infrared and electronic spectroscopies. Its optimized molecular structure was obtained by DFT calculations, as it was impossible to grow single crystals adequate for crystallographic studies. The antitumor action of the complex on MG-63 human osteosarcoma cell line was also investigated. It was found that it caused a concentration-related inhibitory effect in the concentration range between 5 and 25 μM and diminished the cell viability ca. 45 % in the range from 25 to 100 μM, without dose/response effects in this range. These biological effects are, in general, similar to those previously reported for the related [VO(ODA)(ophen)]⋅1.5H<sub>2</sub>O complex.Centro de Química Inorgánica2015info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionArticulohttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdf198-204http://sedici.unlp.edu.ar/handle/10915/108517enginfo:eu-repo/semantics/altIdentifier/issn/1559-0720info:eu-repo/semantics/altIdentifier/doi/10.1007/s12011-014-0206-2info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by-nc-sa/4.0/Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)reponame:SEDICI (UNLP)instname:Universidad Nacional de La Platainstacron:UNLP2025-10-22T17:05:30Zoai:sedici.unlp.edu.ar:10915/108517Institucionalhttp://sedici.unlp.edu.ar/Universidad públicaNo correspondehttp://sedici.unlp.edu.ar/oai/snrdalira@sedici.unlp.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:13292025-10-22 17:05:30.748SEDICI (UNLP) - Universidad Nacional de La Platafalse
dc.title.none.fl_str_mv A New Oxidovanadium(IV) Complex of Oxodiacetic Acid and dppz : Spectroscopic and DFT Study. Antitumor Action on MG-63 Human Osteosarcoma Cell Line
title A New Oxidovanadium(IV) Complex of Oxodiacetic Acid and dppz : Spectroscopic and DFT Study. Antitumor Action on MG-63 Human Osteosarcoma Cell Line
spellingShingle A New Oxidovanadium(IV) Complex of Oxodiacetic Acid and dppz : Spectroscopic and DFT Study. Antitumor Action on MG-63 Human Osteosarcoma Cell Line
León, Ignacio Esteban
Ciencias Exactas
Química
Oxidovanadium(IV)
Oxodiacetic acid
Dppz
DFT calculations
FTIR spectrum
Electronic spectrum
Human osteosarcoma cell line
title_short A New Oxidovanadium(IV) Complex of Oxodiacetic Acid and dppz : Spectroscopic and DFT Study. Antitumor Action on MG-63 Human Osteosarcoma Cell Line
title_full A New Oxidovanadium(IV) Complex of Oxodiacetic Acid and dppz : Spectroscopic and DFT Study. Antitumor Action on MG-63 Human Osteosarcoma Cell Line
title_fullStr A New Oxidovanadium(IV) Complex of Oxodiacetic Acid and dppz : Spectroscopic and DFT Study. Antitumor Action on MG-63 Human Osteosarcoma Cell Line
title_full_unstemmed A New Oxidovanadium(IV) Complex of Oxodiacetic Acid and dppz : Spectroscopic and DFT Study. Antitumor Action on MG-63 Human Osteosarcoma Cell Line
title_sort A New Oxidovanadium(IV) Complex of Oxodiacetic Acid and dppz : Spectroscopic and DFT Study. Antitumor Action on MG-63 Human Osteosarcoma Cell Line
dc.creator.none.fl_str_mv León, Ignacio Esteban
Parajón Costa, Beatriz Susana
Franca, Carlos Alberto
Etcheverry, Susana Beatriz
Baran, Enrique José
author León, Ignacio Esteban
author_facet León, Ignacio Esteban
Parajón Costa, Beatriz Susana
Franca, Carlos Alberto
Etcheverry, Susana Beatriz
Baran, Enrique José
author_role author
author2 Parajón Costa, Beatriz Susana
Franca, Carlos Alberto
Etcheverry, Susana Beatriz
Baran, Enrique José
author2_role author
author
author
author
dc.subject.none.fl_str_mv Ciencias Exactas
Química
Oxidovanadium(IV)
Oxodiacetic acid
Dppz
DFT calculations
FTIR spectrum
Electronic spectrum
Human osteosarcoma cell line
topic Ciencias Exactas
Química
Oxidovanadium(IV)
Oxodiacetic acid
Dppz
DFT calculations
FTIR spectrum
Electronic spectrum
Human osteosarcoma cell line
dc.description.none.fl_txt_mv The oxidovanadium(IV) complex of oxodiacetic acid (H<sub>2</sub>ODA) and dppz (dipyrido[3,2-a:2′,3′-c] phenazine) of stoichiometry [VO(ODA)(dppz)]⋅3H<sub>2</sub>O could be synthesized for the first time by reaction between [VO(ODA)(H<sub>2</sub>O)<sub>2</sub>] and dppz. It was characterized by infrared and electronic spectroscopies. Its optimized molecular structure was obtained by DFT calculations, as it was impossible to grow single crystals adequate for crystallographic studies. The antitumor action of the complex on MG-63 human osteosarcoma cell line was also investigated. It was found that it caused a concentration-related inhibitory effect in the concentration range between 5 and 25 μM and diminished the cell viability ca. 45 % in the range from 25 to 100 μM, without dose/response effects in this range. These biological effects are, in general, similar to those previously reported for the related [VO(ODA)(ophen)]⋅1.5H<sub>2</sub>O complex.
Centro de Química Inorgánica
description The oxidovanadium(IV) complex of oxodiacetic acid (H<sub>2</sub>ODA) and dppz (dipyrido[3,2-a:2′,3′-c] phenazine) of stoichiometry [VO(ODA)(dppz)]⋅3H<sub>2</sub>O could be synthesized for the first time by reaction between [VO(ODA)(H<sub>2</sub>O)<sub>2</sub>] and dppz. It was characterized by infrared and electronic spectroscopies. Its optimized molecular structure was obtained by DFT calculations, as it was impossible to grow single crystals adequate for crystallographic studies. The antitumor action of the complex on MG-63 human osteosarcoma cell line was also investigated. It was found that it caused a concentration-related inhibitory effect in the concentration range between 5 and 25 μM and diminished the cell viability ca. 45 % in the range from 25 to 100 μM, without dose/response effects in this range. These biological effects are, in general, similar to those previously reported for the related [VO(ODA)(ophen)]⋅1.5H<sub>2</sub>O complex.
publishDate 2015
dc.date.none.fl_str_mv 2015
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Articulo
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://sedici.unlp.edu.ar/handle/10915/108517
url http://sedici.unlp.edu.ar/handle/10915/108517
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/issn/1559-0720
info:eu-repo/semantics/altIdentifier/doi/10.1007/s12011-014-0206-2
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by-nc-sa/4.0/
Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by-nc-sa/4.0/
Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
dc.format.none.fl_str_mv application/pdf
198-204
dc.source.none.fl_str_mv reponame:SEDICI (UNLP)
instname:Universidad Nacional de La Plata
instacron:UNLP
reponame_str SEDICI (UNLP)
collection SEDICI (UNLP)
instname_str Universidad Nacional de La Plata
instacron_str UNLP
institution UNLP
repository.name.fl_str_mv SEDICI (UNLP) - Universidad Nacional de La Plata
repository.mail.fl_str_mv alira@sedici.unlp.edu.ar
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score 12.982451

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