A New Oxidovanadium(IV) Complex of Oxodiacetic Acid and dppz : Spectroscopic and DFT Study. Antitumor Action on MG-63 Human Osteosarcoma Cell Line
- Autores
- León, Ignacio Esteban; Parajón Costa, Beatriz Susana; Franca, Carlos Alberto; Etcheverry, Susana Beatriz; Baran, Enrique José
- Año de publicación
- 2015
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- The oxidovanadium(IV) complex of oxodiacetic acid (H2ODA) and dppz (dipyrido[3,2-a:2′,3′-c] phenazine) of stoichiometry [VO(ODA)(dppz)]⋅3H2O could be synthesized for the first time by reaction between [VO(ODA)(H2O)2] and dppz. It was characterized by infrared and electronic spectroscopies. Its optimized molecular structure was obtained by DFT calculations, as it was impossible to grow single crystals adequate for crystallographic studies. The antitumor action of the complex on MG-63 human osteosarcoma cell line was also investigated. It was found that it caused a concentration-related inhibitory effect in the concentration range between 5 and 25 μM and diminished the cell viability ca. 45 % in the range from 25 to 100 μM, without dose/response effects in this range. These biological effects are, in general, similar to those previously reported for the related [VO(ODA)(ophen)]⋅1.5H2O complex.
Centro de Química Inorgánica - Materia
-
Ciencias Exactas
Química
Oxidovanadium(IV)
Oxodiacetic acid
Dppz
DFT calculations
FTIR spectrum
Electronic spectrum
Human osteosarcoma cell line - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- http://creativecommons.org/licenses/by-nc-sa/4.0/
- Repositorio
- Institución
- Universidad Nacional de La Plata
- OAI Identificador
- oai:sedici.unlp.edu.ar:10915/108517
Ver los metadatos del registro completo
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A New Oxidovanadium(IV) Complex of Oxodiacetic Acid and dppz : Spectroscopic and DFT Study. Antitumor Action on MG-63 Human Osteosarcoma Cell LineLeón, Ignacio EstebanParajón Costa, Beatriz SusanaFranca, Carlos AlbertoEtcheverry, Susana BeatrizBaran, Enrique JoséCiencias ExactasQuímicaOxidovanadium(IV)Oxodiacetic acidDppzDFT calculationsFTIR spectrumElectronic spectrumHuman osteosarcoma cell lineThe oxidovanadium(IV) complex of oxodiacetic acid (H<sub>2</sub>ODA) and dppz (dipyrido[3,2-a:2′,3′-c] phenazine) of stoichiometry [VO(ODA)(dppz)]⋅3H<sub>2</sub>O could be synthesized for the first time by reaction between [VO(ODA)(H<sub>2</sub>O)<sub>2</sub>] and dppz. It was characterized by infrared and electronic spectroscopies. Its optimized molecular structure was obtained by DFT calculations, as it was impossible to grow single crystals adequate for crystallographic studies. The antitumor action of the complex on MG-63 human osteosarcoma cell line was also investigated. It was found that it caused a concentration-related inhibitory effect in the concentration range between 5 and 25 μM and diminished the cell viability ca. 45 % in the range from 25 to 100 μM, without dose/response effects in this range. These biological effects are, in general, similar to those previously reported for the related [VO(ODA)(ophen)]⋅1.5H<sub>2</sub>O complex.Centro de Química Inorgánica2015info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionArticulohttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdf198-204http://sedici.unlp.edu.ar/handle/10915/108517enginfo:eu-repo/semantics/altIdentifier/issn/1559-0720info:eu-repo/semantics/altIdentifier/doi/10.1007/s12011-014-0206-2info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by-nc-sa/4.0/Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)reponame:SEDICI (UNLP)instname:Universidad Nacional de La Platainstacron:UNLP2025-09-29T11:24:36Zoai:sedici.unlp.edu.ar:10915/108517Institucionalhttp://sedici.unlp.edu.ar/Universidad públicaNo correspondehttp://sedici.unlp.edu.ar/oai/snrdalira@sedici.unlp.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:13292025-09-29 11:24:37.153SEDICI (UNLP) - Universidad Nacional de La Platafalse |
dc.title.none.fl_str_mv |
A New Oxidovanadium(IV) Complex of Oxodiacetic Acid and dppz : Spectroscopic and DFT Study. Antitumor Action on MG-63 Human Osteosarcoma Cell Line |
title |
A New Oxidovanadium(IV) Complex of Oxodiacetic Acid and dppz : Spectroscopic and DFT Study. Antitumor Action on MG-63 Human Osteosarcoma Cell Line |
spellingShingle |
A New Oxidovanadium(IV) Complex of Oxodiacetic Acid and dppz : Spectroscopic and DFT Study. Antitumor Action on MG-63 Human Osteosarcoma Cell Line León, Ignacio Esteban Ciencias Exactas Química Oxidovanadium(IV) Oxodiacetic acid Dppz DFT calculations FTIR spectrum Electronic spectrum Human osteosarcoma cell line |
title_short |
A New Oxidovanadium(IV) Complex of Oxodiacetic Acid and dppz : Spectroscopic and DFT Study. Antitumor Action on MG-63 Human Osteosarcoma Cell Line |
title_full |
A New Oxidovanadium(IV) Complex of Oxodiacetic Acid and dppz : Spectroscopic and DFT Study. Antitumor Action on MG-63 Human Osteosarcoma Cell Line |
title_fullStr |
A New Oxidovanadium(IV) Complex of Oxodiacetic Acid and dppz : Spectroscopic and DFT Study. Antitumor Action on MG-63 Human Osteosarcoma Cell Line |
title_full_unstemmed |
A New Oxidovanadium(IV) Complex of Oxodiacetic Acid and dppz : Spectroscopic and DFT Study. Antitumor Action on MG-63 Human Osteosarcoma Cell Line |
title_sort |
A New Oxidovanadium(IV) Complex of Oxodiacetic Acid and dppz : Spectroscopic and DFT Study. Antitumor Action on MG-63 Human Osteosarcoma Cell Line |
dc.creator.none.fl_str_mv |
León, Ignacio Esteban Parajón Costa, Beatriz Susana Franca, Carlos Alberto Etcheverry, Susana Beatriz Baran, Enrique José |
author |
León, Ignacio Esteban |
author_facet |
León, Ignacio Esteban Parajón Costa, Beatriz Susana Franca, Carlos Alberto Etcheverry, Susana Beatriz Baran, Enrique José |
author_role |
author |
author2 |
Parajón Costa, Beatriz Susana Franca, Carlos Alberto Etcheverry, Susana Beatriz Baran, Enrique José |
author2_role |
author author author author |
dc.subject.none.fl_str_mv |
Ciencias Exactas Química Oxidovanadium(IV) Oxodiacetic acid Dppz DFT calculations FTIR spectrum Electronic spectrum Human osteosarcoma cell line |
topic |
Ciencias Exactas Química Oxidovanadium(IV) Oxodiacetic acid Dppz DFT calculations FTIR spectrum Electronic spectrum Human osteosarcoma cell line |
dc.description.none.fl_txt_mv |
The oxidovanadium(IV) complex of oxodiacetic acid (H<sub>2</sub>ODA) and dppz (dipyrido[3,2-a:2′,3′-c] phenazine) of stoichiometry [VO(ODA)(dppz)]⋅3H<sub>2</sub>O could be synthesized for the first time by reaction between [VO(ODA)(H<sub>2</sub>O)<sub>2</sub>] and dppz. It was characterized by infrared and electronic spectroscopies. Its optimized molecular structure was obtained by DFT calculations, as it was impossible to grow single crystals adequate for crystallographic studies. The antitumor action of the complex on MG-63 human osteosarcoma cell line was also investigated. It was found that it caused a concentration-related inhibitory effect in the concentration range between 5 and 25 μM and diminished the cell viability ca. 45 % in the range from 25 to 100 μM, without dose/response effects in this range. These biological effects are, in general, similar to those previously reported for the related [VO(ODA)(ophen)]⋅1.5H<sub>2</sub>O complex. Centro de Química Inorgánica |
description |
The oxidovanadium(IV) complex of oxodiacetic acid (H<sub>2</sub>ODA) and dppz (dipyrido[3,2-a:2′,3′-c] phenazine) of stoichiometry [VO(ODA)(dppz)]⋅3H<sub>2</sub>O could be synthesized for the first time by reaction between [VO(ODA)(H<sub>2</sub>O)<sub>2</sub>] and dppz. It was characterized by infrared and electronic spectroscopies. Its optimized molecular structure was obtained by DFT calculations, as it was impossible to grow single crystals adequate for crystallographic studies. The antitumor action of the complex on MG-63 human osteosarcoma cell line was also investigated. It was found that it caused a concentration-related inhibitory effect in the concentration range between 5 and 25 μM and diminished the cell viability ca. 45 % in the range from 25 to 100 μM, without dose/response effects in this range. These biological effects are, in general, similar to those previously reported for the related [VO(ODA)(ophen)]⋅1.5H<sub>2</sub>O complex. |
publishDate |
2015 |
dc.date.none.fl_str_mv |
2015 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Articulo http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://sedici.unlp.edu.ar/handle/10915/108517 |
url |
http://sedici.unlp.edu.ar/handle/10915/108517 |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/issn/1559-0720 info:eu-repo/semantics/altIdentifier/doi/10.1007/s12011-014-0206-2 |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by-nc-sa/4.0/ Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) |
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openAccess |
rights_invalid_str_mv |
http://creativecommons.org/licenses/by-nc-sa/4.0/ Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) |
dc.format.none.fl_str_mv |
application/pdf 198-204 |
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