Current strategies to prevent ishcemia reperfusion injury in organ transplantation

Autores
Stringa, Pablo Luis; Rumbo, Martín
Año de publicación
2014
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Solid organ transplantation is inherently associated to ischemia reperfusion injury (IRI) since the operative procedure always impliesthe harvesting, preservation and implantation of the organ,whichresult in several hours of ischemia followed by reperfusion. Several strategies have been proposed to mitigate IRI in organ transplantation.However, most of them are in experimental phases and currently few are implemented in the clinical field. These strategies can be applied in 3 different stages of the transplantation procedure: on the organ donor, known as donor pre-treatment; during preservation, when ischemic organ is waiting to be implanted in the recipient or on the transplant recipient. In the present review, we will discuss the different approaches to control IRI damage in solid organ transplantation and the rationale behind them.
Fil: Stringa, Pablo Luis. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Estudios Inmunológicos y Fisiopatológicos. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Estudios Inmunológicos y Fisiopatológicos; Argentina. Universidad Favaloro; Argentina
Fil: Rumbo, Martín. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Estudios Inmunológicos y Fisiopatológicos. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Estudios Inmunológicos y Fisiopatológicos; Argentina
Materia
solid organ transplantation
ischemia
reperfusion
prevention
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/33219
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/33219
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Current strategies to prevent ishcemia reperfusion injury in organ transplantationStringa, Pablo LuisRumbo, Martínsolid organ transplantationischemiareperfusionpreventionhttps://purl.org/becyt/ford/3.2https://purl.org/becyt/ford/3Solid organ transplantation is inherently associated to ischemia reperfusion injury (IRI) since the operative procedure always impliesthe harvesting, preservation and implantation of the organ,whichresult in several hours of ischemia followed by reperfusion. Several strategies have been proposed to mitigate IRI in organ transplantation.However, most of them are in experimental phases and currently few are implemented in the clinical field. These strategies can be applied in 3 different stages of the transplantation procedure: on the organ donor, known as donor pre-treatment; during preservation, when ischemic organ is waiting to be implanted in the recipient or on the transplant recipient. In the present review, we will discuss the different approaches to control IRI damage in solid organ transplantation and the rationale behind them.Fil: Stringa, Pablo Luis. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Estudios Inmunológicos y Fisiopatológicos. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Estudios Inmunológicos y Fisiopatológicos; Argentina. Universidad Favaloro; ArgentinaFil: Rumbo, Martín. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Estudios Inmunológicos y Fisiopatológicos. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Estudios Inmunológicos y Fisiopatológicos; ArgentinaSociedad Argentina de Fisiología2014-07info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/33219Stringa, Pablo Luis; Rumbo, Martín; Current strategies to prevent ishcemia reperfusion injury in organ transplantation; Sociedad Argentina de Fisiología; Physiological mini-reviews; 7; 4; 7-2014; 44-591669-5410CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://pmr.safisiol.org.ar/archive/id/65info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T10:10:22Zoai:ri.conicet.gov.ar:11336/33219instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 10:10:22.87CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Current strategies to prevent ishcemia reperfusion injury in organ transplantation
title Current strategies to prevent ishcemia reperfusion injury in organ transplantation
spellingShingle Current strategies to prevent ishcemia reperfusion injury in organ transplantation
Stringa, Pablo Luis
solid organ transplantation
ischemia
reperfusion
prevention
title_short Current strategies to prevent ishcemia reperfusion injury in organ transplantation
title_full Current strategies to prevent ishcemia reperfusion injury in organ transplantation
title_fullStr Current strategies to prevent ishcemia reperfusion injury in organ transplantation
title_full_unstemmed Current strategies to prevent ishcemia reperfusion injury in organ transplantation
title_sort Current strategies to prevent ishcemia reperfusion injury in organ transplantation
dc.creator.none.fl_str_mv Stringa, Pablo Luis
Rumbo, Martín
author Stringa, Pablo Luis
author_facet Stringa, Pablo Luis
Rumbo, Martín
author_role author
author2 Rumbo, Martín
author2_role author
dc.subject.none.fl_str_mv solid organ transplantation
ischemia
reperfusion
prevention
topic solid organ transplantation
ischemia
reperfusion
prevention
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.2
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Solid organ transplantation is inherently associated to ischemia reperfusion injury (IRI) since the operative procedure always impliesthe harvesting, preservation and implantation of the organ,whichresult in several hours of ischemia followed by reperfusion. Several strategies have been proposed to mitigate IRI in organ transplantation.However, most of them are in experimental phases and currently few are implemented in the clinical field. These strategies can be applied in 3 different stages of the transplantation procedure: on the organ donor, known as donor pre-treatment; during preservation, when ischemic organ is waiting to be implanted in the recipient or on the transplant recipient. In the present review, we will discuss the different approaches to control IRI damage in solid organ transplantation and the rationale behind them.
Fil: Stringa, Pablo Luis. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Estudios Inmunológicos y Fisiopatológicos. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Estudios Inmunológicos y Fisiopatológicos; Argentina. Universidad Favaloro; Argentina
Fil: Rumbo, Martín. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Estudios Inmunológicos y Fisiopatológicos. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Estudios Inmunológicos y Fisiopatológicos; Argentina
description Solid organ transplantation is inherently associated to ischemia reperfusion injury (IRI) since the operative procedure always impliesthe harvesting, preservation and implantation of the organ,whichresult in several hours of ischemia followed by reperfusion. Several strategies have been proposed to mitigate IRI in organ transplantation.However, most of them are in experimental phases and currently few are implemented in the clinical field. These strategies can be applied in 3 different stages of the transplantation procedure: on the organ donor, known as donor pre-treatment; during preservation, when ischemic organ is waiting to be implanted in the recipient or on the transplant recipient. In the present review, we will discuss the different approaches to control IRI damage in solid organ transplantation and the rationale behind them.
publishDate 2014
dc.date.none.fl_str_mv 2014-07
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/33219
Stringa, Pablo Luis; Rumbo, Martín; Current strategies to prevent ishcemia reperfusion injury in organ transplantation; Sociedad Argentina de Fisiología; Physiological mini-reviews; 7; 4; 7-2014; 44-59
1669-5410
CONICET Digital
CONICET
url http://hdl.handle.net/11336/33219
identifier_str_mv Stringa, Pablo Luis; Rumbo, Martín; Current strategies to prevent ishcemia reperfusion injury in organ transplantation; Sociedad Argentina de Fisiología; Physiological mini-reviews; 7; 4; 7-2014; 44-59
1669-5410
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://pmr.safisiol.org.ar/archive/id/65
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Sociedad Argentina de Fisiología
publisher.none.fl_str_mv Sociedad Argentina de Fisiología
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1842270117174444032
score 13.13397

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