Sensitive surfactant-mediated spectrofluorimetric determination of sildenafil

Autores
Wang, Chien Chun; Silva, Raúl Alejandro; Masi, Adriana Noemi; Fernandez, Liliana Patricia
Año de publicación
2010
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Two simple and sensitive surfactant-mediated spectrofluorimetric methods for the determination of sildenafil are proposed in this paper. These methods are based on the interaction of sildenafil with normal micelles of HTAB (hexadecyltrimethylammonium bromide, method A) and the formation of ion-association complexes of sildenafil with SDS (sodium dodecyl sulfate, method B). In both methods, the formed species produce considerable fluorescence enhancement, which allows sildenafil to be quantitatively determined. Linearity was obtained for sildenafil in the concentration range 0.004 to 25 μg mL -1 with a detection limit of 0.0012 μg mL-1 by method A; and a linearity range of 0.005 to 50.0 μg mL-1 with a detection limit of 0.0016 μg mL-1 by method B. The proposed methods have been applied to the analysis of bulk drug, tablets, herbal medicine and beverages. Validation processes were performed by recovery studies and statistical analysis with satisfactory results.
Fil: Wang, Chien Chun. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto de Química de San Luis. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Instituto de Química de San Luis; Argentina
Fil: Silva, Raúl Alejandro. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia; Argentina
Fil: Masi, Adriana Noemi. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto de Química de San Luis. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Instituto de Química de San Luis; Argentina
Fil: Fernandez, Liliana Patricia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto de Química de San Luis. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Instituto de Química de San Luis; Argentina
Materia
SILDENAFIL
SPECTROFLUORIMETRY
SURFACTANT ENHANCEMENT
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/92874
Acceder
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repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Sensitive surfactant-mediated spectrofluorimetric determination of sildenafilWang, Chien ChunSilva, Raúl AlejandroMasi, Adriana NoemiFernandez, Liliana PatriciaSILDENAFILSPECTROFLUORIMETRYSURFACTANT ENHANCEMENThttps://purl.org/becyt/ford/1.4https://purl.org/becyt/ford/1Two simple and sensitive surfactant-mediated spectrofluorimetric methods for the determination of sildenafil are proposed in this paper. These methods are based on the interaction of sildenafil with normal micelles of HTAB (hexadecyltrimethylammonium bromide, method A) and the formation of ion-association complexes of sildenafil with SDS (sodium dodecyl sulfate, method B). In both methods, the formed species produce considerable fluorescence enhancement, which allows sildenafil to be quantitatively determined. Linearity was obtained for sildenafil in the concentration range 0.004 to 25 μg mL -1 with a detection limit of 0.0012 μg mL-1 by method A; and a linearity range of 0.005 to 50.0 μg mL-1 with a detection limit of 0.0016 μg mL-1 by method B. The proposed methods have been applied to the analysis of bulk drug, tablets, herbal medicine and beverages. Validation processes were performed by recovery studies and statistical analysis with satisfactory results.Fil: Wang, Chien Chun. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto de Química de San Luis. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Instituto de Química de San Luis; ArgentinaFil: Silva, Raúl Alejandro. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia; ArgentinaFil: Masi, Adriana Noemi. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto de Química de San Luis. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Instituto de Química de San Luis; ArgentinaFil: Fernandez, Liliana Patricia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto de Química de San Luis. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Instituto de Química de San Luis; ArgentinaRoyal Society of Chemistry2010-05info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/92874Wang, Chien Chun; Silva, Raúl Alejandro; Masi, Adriana Noemi; Fernandez, Liliana Patricia; Sensitive surfactant-mediated spectrofluorimetric determination of sildenafil; Royal Society of Chemistry; Analytical Methods; 2; 5; 5-2010; 519-5241759-9679CONICET DigitalCONICETenginfo:eu-repo/semantics/reference/url/http://www.rsc.org/suppdata/ay/b9/b9ay00208a/b9ay00208a.pdfinfo:eu-repo/semantics/altIdentifier/doi/10.1039/b9ay00208ainfo:eu-repo/semantics/altIdentifier/url/https://pubs.rsc.org/en/content/articlelanding/2010/AY/b9ay00208ainfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T10:03:05Zoai:ri.conicet.gov.ar:11336/92874instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 10:03:05.655CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Sensitive surfactant-mediated spectrofluorimetric determination of sildenafil
title Sensitive surfactant-mediated spectrofluorimetric determination of sildenafil
spellingShingle Sensitive surfactant-mediated spectrofluorimetric determination of sildenafil
Wang, Chien Chun
SILDENAFIL
SPECTROFLUORIMETRY
SURFACTANT ENHANCEMENT
title_short Sensitive surfactant-mediated spectrofluorimetric determination of sildenafil
title_full Sensitive surfactant-mediated spectrofluorimetric determination of sildenafil
title_fullStr Sensitive surfactant-mediated spectrofluorimetric determination of sildenafil
title_full_unstemmed Sensitive surfactant-mediated spectrofluorimetric determination of sildenafil
title_sort Sensitive surfactant-mediated spectrofluorimetric determination of sildenafil
dc.creator.none.fl_str_mv Wang, Chien Chun
Silva, Raúl Alejandro
Masi, Adriana Noemi
Fernandez, Liliana Patricia
author Wang, Chien Chun
author_facet Wang, Chien Chun
Silva, Raúl Alejandro
Masi, Adriana Noemi
Fernandez, Liliana Patricia
author_role author
author2 Silva, Raúl Alejandro
Masi, Adriana Noemi
Fernandez, Liliana Patricia
author2_role author
author
author
dc.subject.none.fl_str_mv SILDENAFIL
SPECTROFLUORIMETRY
SURFACTANT ENHANCEMENT
topic SILDENAFIL
SPECTROFLUORIMETRY
SURFACTANT ENHANCEMENT
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.4
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Two simple and sensitive surfactant-mediated spectrofluorimetric methods for the determination of sildenafil are proposed in this paper. These methods are based on the interaction of sildenafil with normal micelles of HTAB (hexadecyltrimethylammonium bromide, method A) and the formation of ion-association complexes of sildenafil with SDS (sodium dodecyl sulfate, method B). In both methods, the formed species produce considerable fluorescence enhancement, which allows sildenafil to be quantitatively determined. Linearity was obtained for sildenafil in the concentration range 0.004 to 25 μg mL -1 with a detection limit of 0.0012 μg mL-1 by method A; and a linearity range of 0.005 to 50.0 μg mL-1 with a detection limit of 0.0016 μg mL-1 by method B. The proposed methods have been applied to the analysis of bulk drug, tablets, herbal medicine and beverages. Validation processes were performed by recovery studies and statistical analysis with satisfactory results.
Fil: Wang, Chien Chun. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto de Química de San Luis. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Instituto de Química de San Luis; Argentina
Fil: Silva, Raúl Alejandro. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia; Argentina
Fil: Masi, Adriana Noemi. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto de Química de San Luis. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Instituto de Química de San Luis; Argentina
Fil: Fernandez, Liliana Patricia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto de Química de San Luis. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Instituto de Química de San Luis; Argentina
description Two simple and sensitive surfactant-mediated spectrofluorimetric methods for the determination of sildenafil are proposed in this paper. These methods are based on the interaction of sildenafil with normal micelles of HTAB (hexadecyltrimethylammonium bromide, method A) and the formation of ion-association complexes of sildenafil with SDS (sodium dodecyl sulfate, method B). In both methods, the formed species produce considerable fluorescence enhancement, which allows sildenafil to be quantitatively determined. Linearity was obtained for sildenafil in the concentration range 0.004 to 25 μg mL -1 with a detection limit of 0.0012 μg mL-1 by method A; and a linearity range of 0.005 to 50.0 μg mL-1 with a detection limit of 0.0016 μg mL-1 by method B. The proposed methods have been applied to the analysis of bulk drug, tablets, herbal medicine and beverages. Validation processes were performed by recovery studies and statistical analysis with satisfactory results.
publishDate 2010
dc.date.none.fl_str_mv 2010-05
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/92874
Wang, Chien Chun; Silva, Raúl Alejandro; Masi, Adriana Noemi; Fernandez, Liliana Patricia; Sensitive surfactant-mediated spectrofluorimetric determination of sildenafil; Royal Society of Chemistry; Analytical Methods; 2; 5; 5-2010; 519-524
1759-9679
CONICET Digital
CONICET
url http://hdl.handle.net/11336/92874
identifier_str_mv Wang, Chien Chun; Silva, Raúl Alejandro; Masi, Adriana Noemi; Fernandez, Liliana Patricia; Sensitive surfactant-mediated spectrofluorimetric determination of sildenafil; Royal Society of Chemistry; Analytical Methods; 2; 5; 5-2010; 519-524
1759-9679
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
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info:eu-repo/semantics/altIdentifier/doi/10.1039/b9ay00208a
info:eu-repo/semantics/altIdentifier/url/https://pubs.rsc.org/en/content/articlelanding/2010/AY/b9ay00208a
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Royal Society of Chemistry
publisher.none.fl_str_mv Royal Society of Chemistry
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.13397

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