Determination of sildenafil by preconcentration on surfactant coated polymeric resin followed by spectrofluorimetry

Autores
Wang, Chien Chun; Gomez, Maria Roxana Anabel; Fernandez, Liliana Patricia
Año de publicación
2013
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The illicit addition of phosphodiesterase type-5 (PDE-5) inhibitors like sildenafil (Viagra) in product offered as herbal medicine or dietary supplement for male erectile dysfunction has concerned authorities in recent times. In this paper, we proposed a sensitive surfactant-coated Amberlite XAD™ resin for sildenafil preconcentration method with spectrofluorimetric detection. Retention capacity of micellar coated XAD resin for sildenafil was studied and the obtained eluate was measured by spectrofluorometer at excitation and emission wavelengths of 350 and 430 nm, respectively. This method allowed the detection of sildenafil at 0.15 ng/mL with linear range of 0.0003–7.0 μg/mL. The method has been successfully applied to the analysis of some local commercially available herbal medicines and urine.
Fil: Wang, Chien Chun. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico San Luis. Instituto de Química de San Luis; Argentina
Fil: Gomez, Maria Roxana Anabel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico San Luis. Instituto de Química de San Luis; Argentina. Universidad Nacional de San Luis. Facultad de Quimica, Bioquimica y Farmacia. Departamento de Farmacia; Argentina
Fil: Fernandez, Liliana Patricia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico San Luis. Instituto de Química de San Luis; Argentina. Universidad Nacional de San Luis. Facultad de Quimica, Bioquimica y Farmacia. Departamento de Quimica. Area de Quimica Analitica; Argentina
Materia
Sildenafil
Herbal Medicine
Spectrofluorimetric Analysis
Surfactant
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/5770
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/5770
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Determination of sildenafil by preconcentration on surfactant coated polymeric resin followed by spectrofluorimetryWang, Chien ChunGomez, Maria Roxana AnabelFernandez, Liliana PatriciaSildenafilHerbal MedicineSpectrofluorimetric AnalysisSurfactanthttps://purl.org/becyt/ford/1.4https://purl.org/becyt/ford/1The illicit addition of phosphodiesterase type-5 (PDE-5) inhibitors like sildenafil (Viagra) in product offered as herbal medicine or dietary supplement for male erectile dysfunction has concerned authorities in recent times. In this paper, we proposed a sensitive surfactant-coated Amberlite XAD™ resin for sildenafil preconcentration method with spectrofluorimetric detection. Retention capacity of micellar coated XAD resin for sildenafil was studied and the obtained eluate was measured by spectrofluorometer at excitation and emission wavelengths of 350 and 430 nm, respectively. This method allowed the detection of sildenafil at 0.15 ng/mL with linear range of 0.0003–7.0 μg/mL. The method has been successfully applied to the analysis of some local commercially available herbal medicines and urine.Fil: Wang, Chien Chun. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico San Luis. Instituto de Química de San Luis; ArgentinaFil: Gomez, Maria Roxana Anabel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico San Luis. Instituto de Química de San Luis; Argentina. Universidad Nacional de San Luis. Facultad de Quimica, Bioquimica y Farmacia. Departamento de Farmacia; ArgentinaFil: Fernandez, Liliana Patricia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico San Luis. Instituto de Química de San Luis; Argentina. Universidad Nacional de San Luis. Facultad de Quimica, Bioquimica y Farmacia. Departamento de Quimica. Area de Quimica Analitica; ArgentinaElsevier2013-03info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/5770Wang, Chien Chun; Gomez, Maria Roxana Anabel; Fernandez, Liliana Patricia; Determination of sildenafil by preconcentration on surfactant coated polymeric resin followed by spectrofluorimetry; Elsevier; Journal of Pharmaceutical Analysis; 3; 3; 3-2013; 173-1792095-1779enginfo:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S2095177912001232info:eu-repo/semantics/altIdentifier/doi/info:eu-repo/semantics/altIdentifier/doi/10.1016/j.jpha.2012.11.001info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:53:04Zoai:ri.conicet.gov.ar:11336/5770instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:53:04.917CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Determination of sildenafil by preconcentration on surfactant coated polymeric resin followed by spectrofluorimetry
title Determination of sildenafil by preconcentration on surfactant coated polymeric resin followed by spectrofluorimetry
spellingShingle Determination of sildenafil by preconcentration on surfactant coated polymeric resin followed by spectrofluorimetry
Wang, Chien Chun
Sildenafil
Herbal Medicine
Spectrofluorimetric Analysis
Surfactant
title_short Determination of sildenafil by preconcentration on surfactant coated polymeric resin followed by spectrofluorimetry
title_full Determination of sildenafil by preconcentration on surfactant coated polymeric resin followed by spectrofluorimetry
title_fullStr Determination of sildenafil by preconcentration on surfactant coated polymeric resin followed by spectrofluorimetry
title_full_unstemmed Determination of sildenafil by preconcentration on surfactant coated polymeric resin followed by spectrofluorimetry
title_sort Determination of sildenafil by preconcentration on surfactant coated polymeric resin followed by spectrofluorimetry
dc.creator.none.fl_str_mv Wang, Chien Chun
Gomez, Maria Roxana Anabel
Fernandez, Liliana Patricia
author Wang, Chien Chun
author_facet Wang, Chien Chun
Gomez, Maria Roxana Anabel
Fernandez, Liliana Patricia
author_role author
author2 Gomez, Maria Roxana Anabel
Fernandez, Liliana Patricia
author2_role author
author
dc.subject.none.fl_str_mv Sildenafil
Herbal Medicine
Spectrofluorimetric Analysis
Surfactant
topic Sildenafil
Herbal Medicine
Spectrofluorimetric Analysis
Surfactant
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.4
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv The illicit addition of phosphodiesterase type-5 (PDE-5) inhibitors like sildenafil (Viagra) in product offered as herbal medicine or dietary supplement for male erectile dysfunction has concerned authorities in recent times. In this paper, we proposed a sensitive surfactant-coated Amberlite XAD™ resin for sildenafil preconcentration method with spectrofluorimetric detection. Retention capacity of micellar coated XAD resin for sildenafil was studied and the obtained eluate was measured by spectrofluorometer at excitation and emission wavelengths of 350 and 430 nm, respectively. This method allowed the detection of sildenafil at 0.15 ng/mL with linear range of 0.0003–7.0 μg/mL. The method has been successfully applied to the analysis of some local commercially available herbal medicines and urine.
Fil: Wang, Chien Chun. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico San Luis. Instituto de Química de San Luis; Argentina
Fil: Gomez, Maria Roxana Anabel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico San Luis. Instituto de Química de San Luis; Argentina. Universidad Nacional de San Luis. Facultad de Quimica, Bioquimica y Farmacia. Departamento de Farmacia; Argentina
Fil: Fernandez, Liliana Patricia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico San Luis. Instituto de Química de San Luis; Argentina. Universidad Nacional de San Luis. Facultad de Quimica, Bioquimica y Farmacia. Departamento de Quimica. Area de Quimica Analitica; Argentina
description The illicit addition of phosphodiesterase type-5 (PDE-5) inhibitors like sildenafil (Viagra) in product offered as herbal medicine or dietary supplement for male erectile dysfunction has concerned authorities in recent times. In this paper, we proposed a sensitive surfactant-coated Amberlite XAD™ resin for sildenafil preconcentration method with spectrofluorimetric detection. Retention capacity of micellar coated XAD resin for sildenafil was studied and the obtained eluate was measured by spectrofluorometer at excitation and emission wavelengths of 350 and 430 nm, respectively. This method allowed the detection of sildenafil at 0.15 ng/mL with linear range of 0.0003–7.0 μg/mL. The method has been successfully applied to the analysis of some local commercially available herbal medicines and urine.
publishDate 2013
dc.date.none.fl_str_mv 2013-03
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/5770
Wang, Chien Chun; Gomez, Maria Roxana Anabel; Fernandez, Liliana Patricia; Determination of sildenafil by preconcentration on surfactant coated polymeric resin followed by spectrofluorimetry; Elsevier; Journal of Pharmaceutical Analysis; 3; 3; 3-2013; 173-179
2095-1779
url http://hdl.handle.net/11336/5770
identifier_str_mv Wang, Chien Chun; Gomez, Maria Roxana Anabel; Fernandez, Liliana Patricia; Determination of sildenafil by preconcentration on surfactant coated polymeric resin followed by spectrofluorimetry; Elsevier; Journal of Pharmaceutical Analysis; 3; 3; 3-2013; 173-179
2095-1779
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S2095177912001232
info:eu-repo/semantics/altIdentifier/doi/
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.jpha.2012.11.001
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.13397

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