Flow injection spectrofluorimetric determination of carvedilol mediated by micelles
- Autores
- Silva, Raúl Alejandro; Wang, Chien Chun; Fernandez, Liliana Patricia; Masi, Adriana Noemi
- Año de publicación
- 2008
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- A novel flow injection (FI)-spectrofluorimetric methodology for the determination of carvedilol in microheterogeneous medium has been developed. In the sodium dodecyl sulfate (SDS) surfactant medium, an additional fluorescence enhancement was produced by the electrolyte NaCl. A total enhancement of 3.1-fold in the native fluorescent response was achieved respect to aqueous medium. Using an excitation and emission wavelength of 286 and 341 nm, respectively, a good linear relationship was obtained in the range of 9 × 10-8 to 1 × 10-6 mol L-1 with a detection limit of 3.63 × 10-9 mol L-1 (S/N = 3). This method was applied to determine carvedilol in commercial pharmaceutical formulations. Good concordance was found between the nominal (6.25, 12.5 and 25.0 mg) and experimental values. The new methodology developed showed high selectivity respect to the common excipients used in pharmaceuticals. The sampling rate was 30 samples h-1. From the fluorescent properties, binding constant for carvedilol-SDS determined was 3.2 × 102 L mol-1.
Fil: Silva, Raúl Alejandro. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia; Argentina
Fil: Wang, Chien Chun. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto de Química de San Luis. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Instituto de Química de San Luis; Argentina
Fil: Fernandez, Liliana Patricia. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Departamento de Química. Área de Química Analítica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto de Química de San Luis. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Instituto de Química de San Luis; Argentina
Fil: Masi, Adriana Noemi. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Departamento de Farmacia. Laboratorio de Bromatología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto de Química de San Luis. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Instituto de Química de San Luis; Argentina - Materia
-
CARVEDILOL DETERMINATION
FLOW INJECTION SPECTROFLUORIMETRY
MICELLAR ENHANCEMENT
PHARMACEUTICALS - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/93226
Ver los metadatos del registro completo
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oai:ri.conicet.gov.ar:11336/93226 |
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CONICET Digital (CONICET) |
spelling |
Flow injection spectrofluorimetric determination of carvedilol mediated by micellesSilva, Raúl AlejandroWang, Chien ChunFernandez, Liliana PatriciaMasi, Adriana NoemiCARVEDILOL DETERMINATIONFLOW INJECTION SPECTROFLUORIMETRYMICELLAR ENHANCEMENTPHARMACEUTICALShttps://purl.org/becyt/ford/1.4https://purl.org/becyt/ford/1A novel flow injection (FI)-spectrofluorimetric methodology for the determination of carvedilol in microheterogeneous medium has been developed. In the sodium dodecyl sulfate (SDS) surfactant medium, an additional fluorescence enhancement was produced by the electrolyte NaCl. A total enhancement of 3.1-fold in the native fluorescent response was achieved respect to aqueous medium. Using an excitation and emission wavelength of 286 and 341 nm, respectively, a good linear relationship was obtained in the range of 9 × 10-8 to 1 × 10-6 mol L-1 with a detection limit of 3.63 × 10-9 mol L-1 (S/N = 3). This method was applied to determine carvedilol in commercial pharmaceutical formulations. Good concordance was found between the nominal (6.25, 12.5 and 25.0 mg) and experimental values. The new methodology developed showed high selectivity respect to the common excipients used in pharmaceuticals. The sampling rate was 30 samples h-1. From the fluorescent properties, binding constant for carvedilol-SDS determined was 3.2 × 102 L mol-1.Fil: Silva, Raúl Alejandro. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia; ArgentinaFil: Wang, Chien Chun. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto de Química de San Luis. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Instituto de Química de San Luis; ArgentinaFil: Fernandez, Liliana Patricia. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Departamento de Química. Área de Química Analítica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto de Química de San Luis. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Instituto de Química de San Luis; ArgentinaFil: Masi, Adriana Noemi. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Departamento de Farmacia. Laboratorio de Bromatología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto de Química de San Luis. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Instituto de Química de San Luis; ArgentinaElsevier Science2008-06info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/93226Silva, Raúl Alejandro; Wang, Chien Chun; Fernandez, Liliana Patricia; Masi, Adriana Noemi; Flow injection spectrofluorimetric determination of carvedilol mediated by micelles; Elsevier Science; Talanta; 76; 1; 6-2008; 166-1710039-9140CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.talanta.2008.02.029info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/abs/pii/S0039914008001227info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:47:41Zoai:ri.conicet.gov.ar:11336/93226instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:47:41.909CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
Flow injection spectrofluorimetric determination of carvedilol mediated by micelles |
title |
Flow injection spectrofluorimetric determination of carvedilol mediated by micelles |
spellingShingle |
Flow injection spectrofluorimetric determination of carvedilol mediated by micelles Silva, Raúl Alejandro CARVEDILOL DETERMINATION FLOW INJECTION SPECTROFLUORIMETRY MICELLAR ENHANCEMENT PHARMACEUTICALS |
title_short |
Flow injection spectrofluorimetric determination of carvedilol mediated by micelles |
title_full |
Flow injection spectrofluorimetric determination of carvedilol mediated by micelles |
title_fullStr |
Flow injection spectrofluorimetric determination of carvedilol mediated by micelles |
title_full_unstemmed |
Flow injection spectrofluorimetric determination of carvedilol mediated by micelles |
title_sort |
Flow injection spectrofluorimetric determination of carvedilol mediated by micelles |
dc.creator.none.fl_str_mv |
Silva, Raúl Alejandro Wang, Chien Chun Fernandez, Liliana Patricia Masi, Adriana Noemi |
author |
Silva, Raúl Alejandro |
author_facet |
Silva, Raúl Alejandro Wang, Chien Chun Fernandez, Liliana Patricia Masi, Adriana Noemi |
author_role |
author |
author2 |
Wang, Chien Chun Fernandez, Liliana Patricia Masi, Adriana Noemi |
author2_role |
author author author |
dc.subject.none.fl_str_mv |
CARVEDILOL DETERMINATION FLOW INJECTION SPECTROFLUORIMETRY MICELLAR ENHANCEMENT PHARMACEUTICALS |
topic |
CARVEDILOL DETERMINATION FLOW INJECTION SPECTROFLUORIMETRY MICELLAR ENHANCEMENT PHARMACEUTICALS |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/1.4 https://purl.org/becyt/ford/1 |
dc.description.none.fl_txt_mv |
A novel flow injection (FI)-spectrofluorimetric methodology for the determination of carvedilol in microheterogeneous medium has been developed. In the sodium dodecyl sulfate (SDS) surfactant medium, an additional fluorescence enhancement was produced by the electrolyte NaCl. A total enhancement of 3.1-fold in the native fluorescent response was achieved respect to aqueous medium. Using an excitation and emission wavelength of 286 and 341 nm, respectively, a good linear relationship was obtained in the range of 9 × 10-8 to 1 × 10-6 mol L-1 with a detection limit of 3.63 × 10-9 mol L-1 (S/N = 3). This method was applied to determine carvedilol in commercial pharmaceutical formulations. Good concordance was found between the nominal (6.25, 12.5 and 25.0 mg) and experimental values. The new methodology developed showed high selectivity respect to the common excipients used in pharmaceuticals. The sampling rate was 30 samples h-1. From the fluorescent properties, binding constant for carvedilol-SDS determined was 3.2 × 102 L mol-1. Fil: Silva, Raúl Alejandro. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia; Argentina Fil: Wang, Chien Chun. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto de Química de San Luis. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Instituto de Química de San Luis; Argentina Fil: Fernandez, Liliana Patricia. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Departamento de Química. Área de Química Analítica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto de Química de San Luis. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Instituto de Química de San Luis; Argentina Fil: Masi, Adriana Noemi. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Departamento de Farmacia. Laboratorio de Bromatología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto de Química de San Luis. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Instituto de Química de San Luis; Argentina |
description |
A novel flow injection (FI)-spectrofluorimetric methodology for the determination of carvedilol in microheterogeneous medium has been developed. In the sodium dodecyl sulfate (SDS) surfactant medium, an additional fluorescence enhancement was produced by the electrolyte NaCl. A total enhancement of 3.1-fold in the native fluorescent response was achieved respect to aqueous medium. Using an excitation and emission wavelength of 286 and 341 nm, respectively, a good linear relationship was obtained in the range of 9 × 10-8 to 1 × 10-6 mol L-1 with a detection limit of 3.63 × 10-9 mol L-1 (S/N = 3). This method was applied to determine carvedilol in commercial pharmaceutical formulations. Good concordance was found between the nominal (6.25, 12.5 and 25.0 mg) and experimental values. The new methodology developed showed high selectivity respect to the common excipients used in pharmaceuticals. The sampling rate was 30 samples h-1. From the fluorescent properties, binding constant for carvedilol-SDS determined was 3.2 × 102 L mol-1. |
publishDate |
2008 |
dc.date.none.fl_str_mv |
2008-06 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/93226 Silva, Raúl Alejandro; Wang, Chien Chun; Fernandez, Liliana Patricia; Masi, Adriana Noemi; Flow injection spectrofluorimetric determination of carvedilol mediated by micelles; Elsevier Science; Talanta; 76; 1; 6-2008; 166-171 0039-9140 CONICET Digital CONICET |
url |
http://hdl.handle.net/11336/93226 |
identifier_str_mv |
Silva, Raúl Alejandro; Wang, Chien Chun; Fernandez, Liliana Patricia; Masi, Adriana Noemi; Flow injection spectrofluorimetric determination of carvedilol mediated by micelles; Elsevier Science; Talanta; 76; 1; 6-2008; 166-171 0039-9140 CONICET Digital CONICET |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.talanta.2008.02.029 info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/abs/pii/S0039914008001227 |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf application/pdf application/pdf application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
Elsevier Science |
publisher.none.fl_str_mv |
Elsevier Science |
dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
reponame_str |
CONICET Digital (CONICET) |
collection |
CONICET Digital (CONICET) |
instname_str |
Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.name.fl_str_mv |
CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
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1842268874586718208 |
score |
13.13397 |