Spectrofluorimetric determination of sildenafil: a new analytical alternative for its analysis

Autores
Wang, Chien Chun; Fernandez, Liliana Patricia
Año de publicación
2012
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
In aqueous solutions, sildenafil presents a very low fluorescence emission and a limited linear range. In presence of a cationic surfactant hexadecyltrim ethylammonium bromide (HTAB, method A) and anionic surfactant sodium dodecyl sulfate (SDS, method B) a great fluorescence enhancement was observed and the linearity range was enlarged. These surfactants-drug interactions lead to the development of two sensitive methods for sildenafil spectrofluorimetric determination. Nature of interactions between sildenafil and surfactants were studied and different parameters which influence these associations were discussed. Sildenafil was quantitatively determined at an emission wavelength of 435 nm and 415 nm by method A and B respectively with detection limit of 0.0012 µg mL-1 and 0.0016 µg mL-1. The methods have been successfully applied to the analysis of bulk drug, tablets and herbal medicines.
Fil: Wang, Chien Chun. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico San Luis. Instituto de Química de San Luis; Argentina. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia; Argentina
Fil: Fernandez, Liliana Patricia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico San Luis. Instituto de Química de San Luis; Argentina. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia; Argentina
Materia
PHARMACEUTICAL ANALYSIS
FLUORIMETRIC ANALYSIS
SURFACTANT
SILDENAFIL
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/14483
Acceder
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network_name_str CONICET Digital (CONICET)
spelling Spectrofluorimetric determination of sildenafil: a new analytical alternative for its analysisWang, Chien ChunFernandez, Liliana PatriciaPHARMACEUTICAL ANALYSISFLUORIMETRIC ANALYSISSURFACTANTSILDENAFILhttps://purl.org/becyt/ford/1.4https://purl.org/becyt/ford/1In aqueous solutions, sildenafil presents a very low fluorescence emission and a limited linear range. In presence of a cationic surfactant hexadecyltrim ethylammonium bromide (HTAB, method A) and anionic surfactant sodium dodecyl sulfate (SDS, method B) a great fluorescence enhancement was observed and the linearity range was enlarged. These surfactants-drug interactions lead to the development of two sensitive methods for sildenafil spectrofluorimetric determination. Nature of interactions between sildenafil and surfactants were studied and different parameters which influence these associations were discussed. Sildenafil was quantitatively determined at an emission wavelength of 435 nm and 415 nm by method A and B respectively with detection limit of 0.0012 µg mL-1 and 0.0016 µg mL-1. The methods have been successfully applied to the analysis of bulk drug, tablets and herbal medicines.Fil: Wang, Chien Chun. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico San Luis. Instituto de Química de San Luis; Argentina. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia; ArgentinaFil: Fernandez, Liliana Patricia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico San Luis. Instituto de Química de San Luis; Argentina. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia; ArgentinaWorld Academic Publishing2012-06info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/14483Wang, Chien Chun; Fernandez, Liliana Patricia; Spectrofluorimetric determination of sildenafil: a new analytical alternative for its analysis; World Academic Publishing; Journal of Chinese Medicine Research and Development; 1; 2; 6-2012; 54-602303-93452303-9353enginfo:eu-repo/semantics/altIdentifier/url/http://www.academicpub.org/jmrd/paperInfo.aspx?paperid=1643info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:44:15Zoai:ri.conicet.gov.ar:11336/14483instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:44:15.708CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Spectrofluorimetric determination of sildenafil: a new analytical alternative for its analysis
title Spectrofluorimetric determination of sildenafil: a new analytical alternative for its analysis
spellingShingle Spectrofluorimetric determination of sildenafil: a new analytical alternative for its analysis
Wang, Chien Chun
PHARMACEUTICAL ANALYSIS
FLUORIMETRIC ANALYSIS
SURFACTANT
SILDENAFIL
title_short Spectrofluorimetric determination of sildenafil: a new analytical alternative for its analysis
title_full Spectrofluorimetric determination of sildenafil: a new analytical alternative for its analysis
title_fullStr Spectrofluorimetric determination of sildenafil: a new analytical alternative for its analysis
title_full_unstemmed Spectrofluorimetric determination of sildenafil: a new analytical alternative for its analysis
title_sort Spectrofluorimetric determination of sildenafil: a new analytical alternative for its analysis
dc.creator.none.fl_str_mv Wang, Chien Chun
Fernandez, Liliana Patricia
author Wang, Chien Chun
author_facet Wang, Chien Chun
Fernandez, Liliana Patricia
author_role author
author2 Fernandez, Liliana Patricia
author2_role author
dc.subject.none.fl_str_mv PHARMACEUTICAL ANALYSIS
FLUORIMETRIC ANALYSIS
SURFACTANT
SILDENAFIL
topic PHARMACEUTICAL ANALYSIS
FLUORIMETRIC ANALYSIS
SURFACTANT
SILDENAFIL
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.4
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv In aqueous solutions, sildenafil presents a very low fluorescence emission and a limited linear range. In presence of a cationic surfactant hexadecyltrim ethylammonium bromide (HTAB, method A) and anionic surfactant sodium dodecyl sulfate (SDS, method B) a great fluorescence enhancement was observed and the linearity range was enlarged. These surfactants-drug interactions lead to the development of two sensitive methods for sildenafil spectrofluorimetric determination. Nature of interactions between sildenafil and surfactants were studied and different parameters which influence these associations were discussed. Sildenafil was quantitatively determined at an emission wavelength of 435 nm and 415 nm by method A and B respectively with detection limit of 0.0012 µg mL-1 and 0.0016 µg mL-1. The methods have been successfully applied to the analysis of bulk drug, tablets and herbal medicines.
Fil: Wang, Chien Chun. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico San Luis. Instituto de Química de San Luis; Argentina. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia; Argentina
Fil: Fernandez, Liliana Patricia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico San Luis. Instituto de Química de San Luis; Argentina. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia; Argentina
description In aqueous solutions, sildenafil presents a very low fluorescence emission and a limited linear range. In presence of a cationic surfactant hexadecyltrim ethylammonium bromide (HTAB, method A) and anionic surfactant sodium dodecyl sulfate (SDS, method B) a great fluorescence enhancement was observed and the linearity range was enlarged. These surfactants-drug interactions lead to the development of two sensitive methods for sildenafil spectrofluorimetric determination. Nature of interactions between sildenafil and surfactants were studied and different parameters which influence these associations were discussed. Sildenafil was quantitatively determined at an emission wavelength of 435 nm and 415 nm by method A and B respectively with detection limit of 0.0012 µg mL-1 and 0.0016 µg mL-1. The methods have been successfully applied to the analysis of bulk drug, tablets and herbal medicines.
publishDate 2012
dc.date.none.fl_str_mv 2012-06
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/14483
Wang, Chien Chun; Fernandez, Liliana Patricia; Spectrofluorimetric determination of sildenafil: a new analytical alternative for its analysis; World Academic Publishing; Journal of Chinese Medicine Research and Development; 1; 2; 6-2012; 54-60
2303-9345
2303-9353
url http://hdl.handle.net/11336/14483
identifier_str_mv Wang, Chien Chun; Fernandez, Liliana Patricia; Spectrofluorimetric determination of sildenafil: a new analytical alternative for its analysis; World Academic Publishing; Journal of Chinese Medicine Research and Development; 1; 2; 6-2012; 54-60
2303-9345
2303-9353
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://www.academicpub.org/jmrd/paperInfo.aspx?paperid=1643
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv World Academic Publishing
publisher.none.fl_str_mv World Academic Publishing
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1842268653322502144
score 13.13397

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