The effect of ethyl-lactate and ethyl-acetate plasticizers on PCL and PCL-HA composites foamed with supercritical CO2
- Autores
- Salerno, A.; Fanovich, Maria Alejandra; Domingo Pascual, C.
- Año de publicación
- 2014
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- The present study reports foaming of polycaprolactone (PCL) and PCL nano- and micro-composites with dispersed hydroxyapatite (HA) particles by means of binary mixtures of supercritical CO2 (scCO2) and either ethyl lactate (EL) or ethyl acetate (EA) as plasticizer. The effect of the size and concentration of HA particles, as well as the effects of the plasticizer type and the incorporation route were investigated aiming to fabricate porous scaffolds with uniform morphology and controlled pore size distribution. For this purpose, foaming experiments were carried out by selecting two operating temperatures, 40 and 45 °C, and two soaking times, 1 and 17 h. Furthermore, a double step of depressurization was used to promote the development of a double-scale pore size structure in porous scaffolds useful for tissue engineering. The results of this study indicated that supercritical foaming of PCL and PCL-HA composites is enhanced when the selected operating temperature and time are 45 °C and 17 h, respectively. Furthermore, although both EL and EA plasticizers enhanced the low temperature foaming of the materials, we demonstrated that the route of incorporation of the plasticizer is a critical aspect for enhancing composite foaming and scaffold fabrication. From this point of view, the best results were achieved when EA was pre-mixed with the polymeric powder for preparing a dough for the foaming process.
Fil: Salerno, A.. Institut de Ciència de Materials de Barcelona; España
Fil: Fanovich, Maria Alejandra. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Mar del Plata. Instituto de Investigación en Ciencia y Tecnología de Materiales (i); Argentina. Universidad Nacional de Mar del Plata. Facultad de Ingeniería; Argentina
Fil: Domingo Pascual, C.. Institut de Ciència de Materials de Barcelona; España - Materia
-
CO2
FOAMING
HYDROXYAPATITE
PLASTICIZER
POLYCAPROLACTONE
SCAFFOLD
SUPERCRITICAL - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/4497
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The effect of ethyl-lactate and ethyl-acetate plasticizers on PCL and PCL-HA composites foamed with supercritical CO2Salerno, A.Fanovich, Maria AlejandraDomingo Pascual, C.CO2FOAMINGHYDROXYAPATITEPLASTICIZERPOLYCAPROLACTONESCAFFOLDSUPERCRITICALhttps://purl.org/becyt/ford/2.5https://purl.org/becyt/ford/2https://purl.org/becyt/ford/1.4https://purl.org/becyt/ford/1The present study reports foaming of polycaprolactone (PCL) and PCL nano- and micro-composites with dispersed hydroxyapatite (HA) particles by means of binary mixtures of supercritical CO2 (scCO2) and either ethyl lactate (EL) or ethyl acetate (EA) as plasticizer. The effect of the size and concentration of HA particles, as well as the effects of the plasticizer type and the incorporation route were investigated aiming to fabricate porous scaffolds with uniform morphology and controlled pore size distribution. For this purpose, foaming experiments were carried out by selecting two operating temperatures, 40 and 45 °C, and two soaking times, 1 and 17 h. Furthermore, a double step of depressurization was used to promote the development of a double-scale pore size structure in porous scaffolds useful for tissue engineering. The results of this study indicated that supercritical foaming of PCL and PCL-HA composites is enhanced when the selected operating temperature and time are 45 °C and 17 h, respectively. Furthermore, although both EL and EA plasticizers enhanced the low temperature foaming of the materials, we demonstrated that the route of incorporation of the plasticizer is a critical aspect for enhancing composite foaming and scaffold fabrication. From this point of view, the best results were achieved when EA was pre-mixed with the polymeric powder for preparing a dough for the foaming process.Fil: Salerno, A.. Institut de Ciència de Materials de Barcelona; EspañaFil: Fanovich, Maria Alejandra. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Mar del Plata. Instituto de Investigación en Ciencia y Tecnología de Materiales (i); Argentina. Universidad Nacional de Mar del Plata. Facultad de Ingeniería; ArgentinaFil: Domingo Pascual, C.. Institut de Ciència de Materials de Barcelona; EspañaElsevier Science2014-10-22info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/4497Salerno, A.; Fanovich, Maria Alejandra; Domingo Pascual, C.; The effect of ethyl-lactate and ethyl-acetate plasticizers on PCL and PCL-HA composites foamed with supercritical CO2; Elsevier Science; Journal of Supercritical Fluids; 95; 22-10-2014; 394-4060896-8446enginfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.supflu.2014.10.007info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S089684461400343Xinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:52:04Zoai:ri.conicet.gov.ar:11336/4497instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:52:04.718CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
The effect of ethyl-lactate and ethyl-acetate plasticizers on PCL and PCL-HA composites foamed with supercritical CO2 |
title |
The effect of ethyl-lactate and ethyl-acetate plasticizers on PCL and PCL-HA composites foamed with supercritical CO2 |
spellingShingle |
The effect of ethyl-lactate and ethyl-acetate plasticizers on PCL and PCL-HA composites foamed with supercritical CO2 Salerno, A. CO2 FOAMING HYDROXYAPATITE PLASTICIZER POLYCAPROLACTONE SCAFFOLD SUPERCRITICAL |
title_short |
The effect of ethyl-lactate and ethyl-acetate plasticizers on PCL and PCL-HA composites foamed with supercritical CO2 |
title_full |
The effect of ethyl-lactate and ethyl-acetate plasticizers on PCL and PCL-HA composites foamed with supercritical CO2 |
title_fullStr |
The effect of ethyl-lactate and ethyl-acetate plasticizers on PCL and PCL-HA composites foamed with supercritical CO2 |
title_full_unstemmed |
The effect of ethyl-lactate and ethyl-acetate plasticizers on PCL and PCL-HA composites foamed with supercritical CO2 |
title_sort |
The effect of ethyl-lactate and ethyl-acetate plasticizers on PCL and PCL-HA composites foamed with supercritical CO2 |
dc.creator.none.fl_str_mv |
Salerno, A. Fanovich, Maria Alejandra Domingo Pascual, C. |
author |
Salerno, A. |
author_facet |
Salerno, A. Fanovich, Maria Alejandra Domingo Pascual, C. |
author_role |
author |
author2 |
Fanovich, Maria Alejandra Domingo Pascual, C. |
author2_role |
author author |
dc.subject.none.fl_str_mv |
CO2 FOAMING HYDROXYAPATITE PLASTICIZER POLYCAPROLACTONE SCAFFOLD SUPERCRITICAL |
topic |
CO2 FOAMING HYDROXYAPATITE PLASTICIZER POLYCAPROLACTONE SCAFFOLD SUPERCRITICAL |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/2.5 https://purl.org/becyt/ford/2 https://purl.org/becyt/ford/1.4 https://purl.org/becyt/ford/1 |
dc.description.none.fl_txt_mv |
The present study reports foaming of polycaprolactone (PCL) and PCL nano- and micro-composites with dispersed hydroxyapatite (HA) particles by means of binary mixtures of supercritical CO2 (scCO2) and either ethyl lactate (EL) or ethyl acetate (EA) as plasticizer. The effect of the size and concentration of HA particles, as well as the effects of the plasticizer type and the incorporation route were investigated aiming to fabricate porous scaffolds with uniform morphology and controlled pore size distribution. For this purpose, foaming experiments were carried out by selecting two operating temperatures, 40 and 45 °C, and two soaking times, 1 and 17 h. Furthermore, a double step of depressurization was used to promote the development of a double-scale pore size structure in porous scaffolds useful for tissue engineering. The results of this study indicated that supercritical foaming of PCL and PCL-HA composites is enhanced when the selected operating temperature and time are 45 °C and 17 h, respectively. Furthermore, although both EL and EA plasticizers enhanced the low temperature foaming of the materials, we demonstrated that the route of incorporation of the plasticizer is a critical aspect for enhancing composite foaming and scaffold fabrication. From this point of view, the best results were achieved when EA was pre-mixed with the polymeric powder for preparing a dough for the foaming process. Fil: Salerno, A.. Institut de Ciència de Materials de Barcelona; España Fil: Fanovich, Maria Alejandra. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Mar del Plata. Instituto de Investigación en Ciencia y Tecnología de Materiales (i); Argentina. Universidad Nacional de Mar del Plata. Facultad de Ingeniería; Argentina Fil: Domingo Pascual, C.. Institut de Ciència de Materials de Barcelona; España |
description |
The present study reports foaming of polycaprolactone (PCL) and PCL nano- and micro-composites with dispersed hydroxyapatite (HA) particles by means of binary mixtures of supercritical CO2 (scCO2) and either ethyl lactate (EL) or ethyl acetate (EA) as plasticizer. The effect of the size and concentration of HA particles, as well as the effects of the plasticizer type and the incorporation route were investigated aiming to fabricate porous scaffolds with uniform morphology and controlled pore size distribution. For this purpose, foaming experiments were carried out by selecting two operating temperatures, 40 and 45 °C, and two soaking times, 1 and 17 h. Furthermore, a double step of depressurization was used to promote the development of a double-scale pore size structure in porous scaffolds useful for tissue engineering. The results of this study indicated that supercritical foaming of PCL and PCL-HA composites is enhanced when the selected operating temperature and time are 45 °C and 17 h, respectively. Furthermore, although both EL and EA plasticizers enhanced the low temperature foaming of the materials, we demonstrated that the route of incorporation of the plasticizer is a critical aspect for enhancing composite foaming and scaffold fabrication. From this point of view, the best results were achieved when EA was pre-mixed with the polymeric powder for preparing a dough for the foaming process. |
publishDate |
2014 |
dc.date.none.fl_str_mv |
2014-10-22 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/4497 Salerno, A.; Fanovich, Maria Alejandra; Domingo Pascual, C.; The effect of ethyl-lactate and ethyl-acetate plasticizers on PCL and PCL-HA composites foamed with supercritical CO2; Elsevier Science; Journal of Supercritical Fluids; 95; 22-10-2014; 394-406 0896-8446 |
url |
http://hdl.handle.net/11336/4497 |
identifier_str_mv |
Salerno, A.; Fanovich, Maria Alejandra; Domingo Pascual, C.; The effect of ethyl-lactate and ethyl-acetate plasticizers on PCL and PCL-HA composites foamed with supercritical CO2; Elsevier Science; Journal of Supercritical Fluids; 95; 22-10-2014; 394-406 0896-8446 |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.supflu.2014.10.007 info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S089684461400343X |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-nd/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
Elsevier Science |
publisher.none.fl_str_mv |
Elsevier Science |
dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
reponame_str |
CONICET Digital (CONICET) |
collection |
CONICET Digital (CONICET) |
instname_str |
Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.name.fl_str_mv |
CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
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1844613598427480064 |
score |
13.070432 |