Porous hydroxyapatite-titanium dioxide composites prepared by a sol-gel / supercritical CO2-drying combined process

Autores
Hernández Ortiz, Gloria Mercedes; Parra, Rodrigo; Fraile Sainz, Julio; Domingo, Concepción; Fanovich, Maria Alejandra
Año de publicación
2024
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
In this work, porous nanostructured materials based on hydroxyapatite (HA) and titanium dioxide (TiO2) were prepared by integrating the sol-gel process and supercritical CO2 drying. These combined processes constitute a synergistic methodology that allows modulating the porosity generated in the gel and preserving it after drying. HA nanoparticles and a pore-generating agent (Polyvinylpyrrolidone) were included without significant modifications to gel consolidation times or integrity by using this methodology. The presence of HA nanoparticles within the TiO2 matrix helped preserving the anatase phase after the calcination stage. No reactivity between the present phases was detected, indicating their successful integration in the final composite material structure, which was one of the most challenging aspects of the research. This allowed HA-TiO2 composites to improve the adhesion of MG63 osteoblast-like cells and their proliferation, being the sample with high HA content (∼37 % wt/wt) the one that presented the best response. The present work puts forward a new way for the synthesis of scaffolds composed of HA and TiO2 with retention of the anatase phase for applications in bone tissue engineering.
Fil: Hernández Ortiz, Gloria Mercedes. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones en Ciencia y Tecnología de Materiales. Universidad Nacional de Mar del Plata. Facultad de Ingeniería. Instituto de Investigaciones en Ciencia y Tecnología de Materiales; Argentina
Fil: Parra, Rodrigo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones en Ciencia y Tecnología de Materiales. Universidad Nacional de Mar del Plata. Facultad de Ingeniería. Instituto de Investigaciones en Ciencia y Tecnología de Materiales; Argentina
Fil: Fraile Sainz, Julio. Consejo Superior de Investigaciones Científicas. Instituto de Ciencia de los Materiales de Barcelona; España
Fil: Domingo, Concepción. Consejo Superior de Investigaciones Científicas. Instituto de Ciencia de los Materiales de Barcelona; España
Fil: Fanovich, Maria Alejandra. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones en Ciencia y Tecnología de Materiales. Universidad Nacional de Mar del Plata. Facultad de Ingeniería. Instituto de Investigaciones en Ciencia y Tecnología de Materiales; Argentina
Materia
HYDROXYAPATITE
TiO2
SOL_GEL
SUPERCRITICAL CO2
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/267515
Acceder
id CONICETDig_1bc2df8296c7357c9689cceceb4e8a86
oai_identifier_str oai:ri.conicet.gov.ar:11336/267515
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Porous hydroxyapatite-titanium dioxide composites prepared by a sol-gel / supercritical CO2-drying combined processHernández Ortiz, Gloria MercedesParra, RodrigoFraile Sainz, JulioDomingo, ConcepciónFanovich, Maria AlejandraHYDROXYAPATITETiO2SOL_GELSUPERCRITICAL CO2https://purl.org/becyt/ford/2.5https://purl.org/becyt/ford/2In this work, porous nanostructured materials based on hydroxyapatite (HA) and titanium dioxide (TiO2) were prepared by integrating the sol-gel process and supercritical CO2 drying. These combined processes constitute a synergistic methodology that allows modulating the porosity generated in the gel and preserving it after drying. HA nanoparticles and a pore-generating agent (Polyvinylpyrrolidone) were included without significant modifications to gel consolidation times or integrity by using this methodology. The presence of HA nanoparticles within the TiO2 matrix helped preserving the anatase phase after the calcination stage. No reactivity between the present phases was detected, indicating their successful integration in the final composite material structure, which was one of the most challenging aspects of the research. This allowed HA-TiO2 composites to improve the adhesion of MG63 osteoblast-like cells and their proliferation, being the sample with high HA content (∼37 % wt/wt) the one that presented the best response. The present work puts forward a new way for the synthesis of scaffolds composed of HA and TiO2 with retention of the anatase phase for applications in bone tissue engineering.Fil: Hernández Ortiz, Gloria Mercedes. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones en Ciencia y Tecnología de Materiales. Universidad Nacional de Mar del Plata. Facultad de Ingeniería. Instituto de Investigaciones en Ciencia y Tecnología de Materiales; ArgentinaFil: Parra, Rodrigo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones en Ciencia y Tecnología de Materiales. Universidad Nacional de Mar del Plata. Facultad de Ingeniería. Instituto de Investigaciones en Ciencia y Tecnología de Materiales; ArgentinaFil: Fraile Sainz, Julio. Consejo Superior de Investigaciones Científicas. Instituto de Ciencia de los Materiales de Barcelona; EspañaFil: Domingo, Concepción. Consejo Superior de Investigaciones Científicas. Instituto de Ciencia de los Materiales de Barcelona; EspañaFil: Fanovich, Maria Alejandra. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones en Ciencia y Tecnología de Materiales. Universidad Nacional de Mar del Plata. Facultad de Ingeniería. Instituto de Investigaciones en Ciencia y Tecnología de Materiales; ArgentinaElsevier2024-04info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/267515Hernández Ortiz, Gloria Mercedes; Parra, Rodrigo; Fraile Sainz, Julio; Domingo, Concepción; Fanovich, Maria Alejandra; Porous hydroxyapatite-titanium dioxide composites prepared by a sol-gel / supercritical CO2-drying combined process; Elsevier; Ceramics International; 50; 8; 4-2024; 1-450272-8842CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.ceramint.2024.01.242info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/abs/pii/S0272884224002578info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-15T15:08:05Zoai:ri.conicet.gov.ar:11336/267515instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-15 15:08:06.079CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Porous hydroxyapatite-titanium dioxide composites prepared by a sol-gel / supercritical CO2-drying combined process
title Porous hydroxyapatite-titanium dioxide composites prepared by a sol-gel / supercritical CO2-drying combined process
spellingShingle Porous hydroxyapatite-titanium dioxide composites prepared by a sol-gel / supercritical CO2-drying combined process
Hernández Ortiz, Gloria Mercedes
HYDROXYAPATITE
TiO2
SOL_GEL
SUPERCRITICAL CO2
title_short Porous hydroxyapatite-titanium dioxide composites prepared by a sol-gel / supercritical CO2-drying combined process
title_full Porous hydroxyapatite-titanium dioxide composites prepared by a sol-gel / supercritical CO2-drying combined process
title_fullStr Porous hydroxyapatite-titanium dioxide composites prepared by a sol-gel / supercritical CO2-drying combined process
title_full_unstemmed Porous hydroxyapatite-titanium dioxide composites prepared by a sol-gel / supercritical CO2-drying combined process
title_sort Porous hydroxyapatite-titanium dioxide composites prepared by a sol-gel / supercritical CO2-drying combined process
dc.creator.none.fl_str_mv Hernández Ortiz, Gloria Mercedes
Parra, Rodrigo
Fraile Sainz, Julio
Domingo, Concepción
Fanovich, Maria Alejandra
author Hernández Ortiz, Gloria Mercedes
author_facet Hernández Ortiz, Gloria Mercedes
Parra, Rodrigo
Fraile Sainz, Julio
Domingo, Concepción
Fanovich, Maria Alejandra
author_role author
author2 Parra, Rodrigo
Fraile Sainz, Julio
Domingo, Concepción
Fanovich, Maria Alejandra
author2_role author
author
author
author
dc.subject.none.fl_str_mv HYDROXYAPATITE
TiO2
SOL_GEL
SUPERCRITICAL CO2
topic HYDROXYAPATITE
TiO2
SOL_GEL
SUPERCRITICAL CO2
purl_subject.fl_str_mv https://purl.org/becyt/ford/2.5
https://purl.org/becyt/ford/2
dc.description.none.fl_txt_mv In this work, porous nanostructured materials based on hydroxyapatite (HA) and titanium dioxide (TiO2) were prepared by integrating the sol-gel process and supercritical CO2 drying. These combined processes constitute a synergistic methodology that allows modulating the porosity generated in the gel and preserving it after drying. HA nanoparticles and a pore-generating agent (Polyvinylpyrrolidone) were included without significant modifications to gel consolidation times or integrity by using this methodology. The presence of HA nanoparticles within the TiO2 matrix helped preserving the anatase phase after the calcination stage. No reactivity between the present phases was detected, indicating their successful integration in the final composite material structure, which was one of the most challenging aspects of the research. This allowed HA-TiO2 composites to improve the adhesion of MG63 osteoblast-like cells and their proliferation, being the sample with high HA content (∼37 % wt/wt) the one that presented the best response. The present work puts forward a new way for the synthesis of scaffolds composed of HA and TiO2 with retention of the anatase phase for applications in bone tissue engineering.
Fil: Hernández Ortiz, Gloria Mercedes. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones en Ciencia y Tecnología de Materiales. Universidad Nacional de Mar del Plata. Facultad de Ingeniería. Instituto de Investigaciones en Ciencia y Tecnología de Materiales; Argentina
Fil: Parra, Rodrigo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones en Ciencia y Tecnología de Materiales. Universidad Nacional de Mar del Plata. Facultad de Ingeniería. Instituto de Investigaciones en Ciencia y Tecnología de Materiales; Argentina
Fil: Fraile Sainz, Julio. Consejo Superior de Investigaciones Científicas. Instituto de Ciencia de los Materiales de Barcelona; España
Fil: Domingo, Concepción. Consejo Superior de Investigaciones Científicas. Instituto de Ciencia de los Materiales de Barcelona; España
Fil: Fanovich, Maria Alejandra. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones en Ciencia y Tecnología de Materiales. Universidad Nacional de Mar del Plata. Facultad de Ingeniería. Instituto de Investigaciones en Ciencia y Tecnología de Materiales; Argentina
description In this work, porous nanostructured materials based on hydroxyapatite (HA) and titanium dioxide (TiO2) were prepared by integrating the sol-gel process and supercritical CO2 drying. These combined processes constitute a synergistic methodology that allows modulating the porosity generated in the gel and preserving it after drying. HA nanoparticles and a pore-generating agent (Polyvinylpyrrolidone) were included without significant modifications to gel consolidation times or integrity by using this methodology. The presence of HA nanoparticles within the TiO2 matrix helped preserving the anatase phase after the calcination stage. No reactivity between the present phases was detected, indicating their successful integration in the final composite material structure, which was one of the most challenging aspects of the research. This allowed HA-TiO2 composites to improve the adhesion of MG63 osteoblast-like cells and their proliferation, being the sample with high HA content (∼37 % wt/wt) the one that presented the best response. The present work puts forward a new way for the synthesis of scaffolds composed of HA and TiO2 with retention of the anatase phase for applications in bone tissue engineering.
publishDate 2024
dc.date.none.fl_str_mv 2024-04
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/267515
Hernández Ortiz, Gloria Mercedes; Parra, Rodrigo; Fraile Sainz, Julio; Domingo, Concepción; Fanovich, Maria Alejandra; Porous hydroxyapatite-titanium dioxide composites prepared by a sol-gel / supercritical CO2-drying combined process; Elsevier; Ceramics International; 50; 8; 4-2024; 1-45
0272-8842
CONICET Digital
CONICET
url http://hdl.handle.net/11336/267515
identifier_str_mv Hernández Ortiz, Gloria Mercedes; Parra, Rodrigo; Fraile Sainz, Julio; Domingo, Concepción; Fanovich, Maria Alejandra; Porous hydroxyapatite-titanium dioxide composites prepared by a sol-gel / supercritical CO2-drying combined process; Elsevier; Ceramics International; 50; 8; 4-2024; 1-45
0272-8842
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1016/j.ceramint.2024.01.242
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/abs/pii/S0272884224002578
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1846083226920026112
score 13.22299

Publicaciones similares