Site and sex effects on tibia structure in distance runners and untrained people

Autores
Feldman, Sara; Capozza, Ricardo Francisco; Mortarino, Pablo A.; Reina, Paola Soledad; Ferretti, Jose Luis; Rittweger, Jörn; Cointry, Gustavo Roberto
Año de publicación
2012
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Purpose: The purpose was to study the relationship between mechanical environment and bone structure by comparing the tibia in people with different physical activities. Materials and Methods: Indicators of bone mass (bone mineral content), bone material "quality" (cortical volumetric mineral density (vBMD)), and diaphyseal design (endocortical and periosteal perimeters (EcPm and PoPm, respectively), cortical thickness (CtTh), circularity, and bending and torsion cross-sectional moments of inertia (CSMIs)) were determined in serial peripheral quantitative computed tomography scans taken at 5% steps of the tibia in 40 voluntary men and women age 25-40 yr who were either physically inactive or experienced distance runners (n = 10-12 per group). Results: Bone mass and design indicators were higher in runner than in nonrunner men, with a variable effect size along the tibia. In the distal tibia, runners had enhanced bone mineral content and CtTh (resistance to compression), but EcPm, PoPm, circularity, and CSMI were unaffected. In the midshaft, CSMIs (resistance to bending/torsion) were enhanced in runners, whereas bone mass was unaffected. In the proximal third, effects were observed for CtTh, EcPm, and PoPm. In female runners, these benefits were restricted to CSMIs only. Cortical vBMD, naturally lower in men than in women, was reduced in runners of either sex. DISCUSSION: Results are coherent with previous findings in physically inactive people and with Frost's mechanostat theory. The observed group differences in cortical vBMD could reflect an increase in intracortical porosity (enhanced remodeling for damage repair), eventually compensated biomechanically by CSMI improvements. The sex specificity of exercise effects may suggest the interference by the endocrine environment. Results confirm that the mechanical environment is a strong determinant of regional tibia structure and suggest that the endocrine environment may reduce the effects of physical interventions on bone health in fertile women.
Fil: Feldman, Sara. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario; Argentina. Universidad Nacional de Rosario; Argentina
Fil: Capozza, Ricardo Francisco. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario; Argentina. Universidad Nacional de Rosario; Argentina
Fil: Mortarino, Pablo A.. Universidad Nacional de Rosario; Argentina
Fil: Reina, Paola Soledad. Universidad Nacional de Rosario; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario; Argentina
Fil: Ferretti, Jose Luis. Universidad Nacional de Rosario; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario; Argentina
Fil: Rittweger, Jörn. University of Manchester; Reino Unido
Fil: Cointry, Gustavo Roberto. Universidad Nacional de Rosario; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario; Argentina
Materia
BONE STRENGTH
BONE STRUCTURE
EXERCISE AND BONE
OSTEOPENIA
OSTEOPOROSIS BONE BIOMECHANICS
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/196887
Acceder
id CONICETDig_c2b8a0d7073bd3b986275684aa1811ea
oai_identifier_str oai:ri.conicet.gov.ar:11336/196887
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Site and sex effects on tibia structure in distance runners and untrained peopleFeldman, SaraCapozza, Ricardo FranciscoMortarino, Pablo A.Reina, Paola SoledadFerretti, Jose LuisRittweger, JörnCointry, Gustavo RobertoBONE STRENGTHBONE STRUCTUREEXERCISE AND BONEOSTEOPENIAOSTEOPOROSIS BONE BIOMECHANICShttps://purl.org/becyt/ford/3.2https://purl.org/becyt/ford/3Purpose: The purpose was to study the relationship between mechanical environment and bone structure by comparing the tibia in people with different physical activities. Materials and Methods: Indicators of bone mass (bone mineral content), bone material "quality" (cortical volumetric mineral density (vBMD)), and diaphyseal design (endocortical and periosteal perimeters (EcPm and PoPm, respectively), cortical thickness (CtTh), circularity, and bending and torsion cross-sectional moments of inertia (CSMIs)) were determined in serial peripheral quantitative computed tomography scans taken at 5% steps of the tibia in 40 voluntary men and women age 25-40 yr who were either physically inactive or experienced distance runners (n = 10-12 per group). Results: Bone mass and design indicators were higher in runner than in nonrunner men, with a variable effect size along the tibia. In the distal tibia, runners had enhanced bone mineral content and CtTh (resistance to compression), but EcPm, PoPm, circularity, and CSMI were unaffected. In the midshaft, CSMIs (resistance to bending/torsion) were enhanced in runners, whereas bone mass was unaffected. In the proximal third, effects were observed for CtTh, EcPm, and PoPm. In female runners, these benefits were restricted to CSMIs only. Cortical vBMD, naturally lower in men than in women, was reduced in runners of either sex. DISCUSSION: Results are coherent with previous findings in physically inactive people and with Frost's mechanostat theory. The observed group differences in cortical vBMD could reflect an increase in intracortical porosity (enhanced remodeling for damage repair), eventually compensated biomechanically by CSMI improvements. The sex specificity of exercise effects may suggest the interference by the endocrine environment. Results confirm that the mechanical environment is a strong determinant of regional tibia structure and suggest that the endocrine environment may reduce the effects of physical interventions on bone health in fertile women.Fil: Feldman, Sara. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario; Argentina. Universidad Nacional de Rosario; ArgentinaFil: Capozza, Ricardo Francisco. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario; Argentina. Universidad Nacional de Rosario; ArgentinaFil: Mortarino, Pablo A.. Universidad Nacional de Rosario; ArgentinaFil: Reina, Paola Soledad. Universidad Nacional de Rosario; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario; ArgentinaFil: Ferretti, Jose Luis. Universidad Nacional de Rosario; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario; ArgentinaFil: Rittweger, Jörn. University of Manchester; Reino UnidoFil: Cointry, Gustavo Roberto. Universidad Nacional de Rosario; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario; ArgentinaLippincott Williams2012-08info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/196887Feldman, Sara; Capozza, Ricardo Francisco; Mortarino, Pablo A.; Reina, Paola Soledad; Ferretti, Jose Luis; et al.; Site and sex effects on tibia structure in distance runners and untrained people; Lippincott Williams; Medicine And Science In Sports And Exercise; 44; 8; 8-2012; 1580-15880195-9131CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://journals.lww.com/acsm-msse/Fulltext/2012/08000/Site_and_Sex_Effects_on_Tibia_Structure_in.22.aspxinfo:eu-repo/semantics/altIdentifier/doi/10.1249/MSS.0b013e31824e10b6info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-15T15:19:47Zoai:ri.conicet.gov.ar:11336/196887instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-15 15:19:48.115CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Site and sex effects on tibia structure in distance runners and untrained people
title Site and sex effects on tibia structure in distance runners and untrained people
spellingShingle Site and sex effects on tibia structure in distance runners and untrained people
Feldman, Sara
BONE STRENGTH
BONE STRUCTURE
EXERCISE AND BONE
OSTEOPENIA
OSTEOPOROSIS BONE BIOMECHANICS
title_short Site and sex effects on tibia structure in distance runners and untrained people
title_full Site and sex effects on tibia structure in distance runners and untrained people
title_fullStr Site and sex effects on tibia structure in distance runners and untrained people
title_full_unstemmed Site and sex effects on tibia structure in distance runners and untrained people
title_sort Site and sex effects on tibia structure in distance runners and untrained people
dc.creator.none.fl_str_mv Feldman, Sara
Capozza, Ricardo Francisco
Mortarino, Pablo A.
Reina, Paola Soledad
Ferretti, Jose Luis
Rittweger, Jörn
Cointry, Gustavo Roberto
author Feldman, Sara
author_facet Feldman, Sara
Capozza, Ricardo Francisco
Mortarino, Pablo A.
Reina, Paola Soledad
Ferretti, Jose Luis
Rittweger, Jörn
Cointry, Gustavo Roberto
author_role author
author2 Capozza, Ricardo Francisco
Mortarino, Pablo A.
Reina, Paola Soledad
Ferretti, Jose Luis
Rittweger, Jörn
Cointry, Gustavo Roberto
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv BONE STRENGTH
BONE STRUCTURE
EXERCISE AND BONE
OSTEOPENIA
OSTEOPOROSIS BONE BIOMECHANICS
topic BONE STRENGTH
BONE STRUCTURE
EXERCISE AND BONE
OSTEOPENIA
OSTEOPOROSIS BONE BIOMECHANICS
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.2
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Purpose: The purpose was to study the relationship between mechanical environment and bone structure by comparing the tibia in people with different physical activities. Materials and Methods: Indicators of bone mass (bone mineral content), bone material "quality" (cortical volumetric mineral density (vBMD)), and diaphyseal design (endocortical and periosteal perimeters (EcPm and PoPm, respectively), cortical thickness (CtTh), circularity, and bending and torsion cross-sectional moments of inertia (CSMIs)) were determined in serial peripheral quantitative computed tomography scans taken at 5% steps of the tibia in 40 voluntary men and women age 25-40 yr who were either physically inactive or experienced distance runners (n = 10-12 per group). Results: Bone mass and design indicators were higher in runner than in nonrunner men, with a variable effect size along the tibia. In the distal tibia, runners had enhanced bone mineral content and CtTh (resistance to compression), but EcPm, PoPm, circularity, and CSMI were unaffected. In the midshaft, CSMIs (resistance to bending/torsion) were enhanced in runners, whereas bone mass was unaffected. In the proximal third, effects were observed for CtTh, EcPm, and PoPm. In female runners, these benefits were restricted to CSMIs only. Cortical vBMD, naturally lower in men than in women, was reduced in runners of either sex. DISCUSSION: Results are coherent with previous findings in physically inactive people and with Frost's mechanostat theory. The observed group differences in cortical vBMD could reflect an increase in intracortical porosity (enhanced remodeling for damage repair), eventually compensated biomechanically by CSMI improvements. The sex specificity of exercise effects may suggest the interference by the endocrine environment. Results confirm that the mechanical environment is a strong determinant of regional tibia structure and suggest that the endocrine environment may reduce the effects of physical interventions on bone health in fertile women.
Fil: Feldman, Sara. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario; Argentina. Universidad Nacional de Rosario; Argentina
Fil: Capozza, Ricardo Francisco. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario; Argentina. Universidad Nacional de Rosario; Argentina
Fil: Mortarino, Pablo A.. Universidad Nacional de Rosario; Argentina
Fil: Reina, Paola Soledad. Universidad Nacional de Rosario; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario; Argentina
Fil: Ferretti, Jose Luis. Universidad Nacional de Rosario; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario; Argentina
Fil: Rittweger, Jörn. University of Manchester; Reino Unido
Fil: Cointry, Gustavo Roberto. Universidad Nacional de Rosario; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario; Argentina
description Purpose: The purpose was to study the relationship between mechanical environment and bone structure by comparing the tibia in people with different physical activities. Materials and Methods: Indicators of bone mass (bone mineral content), bone material "quality" (cortical volumetric mineral density (vBMD)), and diaphyseal design (endocortical and periosteal perimeters (EcPm and PoPm, respectively), cortical thickness (CtTh), circularity, and bending and torsion cross-sectional moments of inertia (CSMIs)) were determined in serial peripheral quantitative computed tomography scans taken at 5% steps of the tibia in 40 voluntary men and women age 25-40 yr who were either physically inactive or experienced distance runners (n = 10-12 per group). Results: Bone mass and design indicators were higher in runner than in nonrunner men, with a variable effect size along the tibia. In the distal tibia, runners had enhanced bone mineral content and CtTh (resistance to compression), but EcPm, PoPm, circularity, and CSMI were unaffected. In the midshaft, CSMIs (resistance to bending/torsion) were enhanced in runners, whereas bone mass was unaffected. In the proximal third, effects were observed for CtTh, EcPm, and PoPm. In female runners, these benefits were restricted to CSMIs only. Cortical vBMD, naturally lower in men than in women, was reduced in runners of either sex. DISCUSSION: Results are coherent with previous findings in physically inactive people and with Frost's mechanostat theory. The observed group differences in cortical vBMD could reflect an increase in intracortical porosity (enhanced remodeling for damage repair), eventually compensated biomechanically by CSMI improvements. The sex specificity of exercise effects may suggest the interference by the endocrine environment. Results confirm that the mechanical environment is a strong determinant of regional tibia structure and suggest that the endocrine environment may reduce the effects of physical interventions on bone health in fertile women.
publishDate 2012
dc.date.none.fl_str_mv 2012-08
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/196887
Feldman, Sara; Capozza, Ricardo Francisco; Mortarino, Pablo A.; Reina, Paola Soledad; Ferretti, Jose Luis; et al.; Site and sex effects on tibia structure in distance runners and untrained people; Lippincott Williams; Medicine And Science In Sports And Exercise; 44; 8; 8-2012; 1580-1588
0195-9131
CONICET Digital
CONICET
url http://hdl.handle.net/11336/196887
identifier_str_mv Feldman, Sara; Capozza, Ricardo Francisco; Mortarino, Pablo A.; Reina, Paola Soledad; Ferretti, Jose Luis; et al.; Site and sex effects on tibia structure in distance runners and untrained people; Lippincott Williams; Medicine And Science In Sports And Exercise; 44; 8; 8-2012; 1580-1588
0195-9131
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://journals.lww.com/acsm-msse/Fulltext/2012/08000/Site_and_Sex_Effects_on_Tibia_Structure_in.22.aspx
info:eu-repo/semantics/altIdentifier/doi/10.1249/MSS.0b013e31824e10b6
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Lippincott Williams
publisher.none.fl_str_mv Lippincott Williams
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.22299

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