Differences in the Cortical Structure of the Whole Fibula and Tibia Between Long-Distance Runners and Untrained Controls: Toward a Wider Conception of the Biomechanical Regulation...

Autores: Luscher, Sergio Hugo; Nocciolino, Laura Marcela; Pilot, Nicolas Carlos; Pisani, Leonardo; Ireland, Alex; Rittweger, Jörn; Ferretti, Jose Luis; Cointry, Gustavo Roberto; Capozza, Ricardo Francisco
Año de publicación: 2019
Idioma: inglés
Tipo de recurso: artículo
Estado: versión publicada
Descripción: The cortical structure of human fibula varies widely throughout the bone suggesting a more selective adaptation to different mechanical environments with respect to the adjacent tibia. To test this hypothesis, serial-pQCT scans of the dominant fibulae and tibiae of 15/15 men/women chronically trained in long-distance running were compared with those of 15/15 untrained controls. When compared to controls, the fibulae of trained individuals had similar (distally) or lower (proximally) cortical area, similar moments of inertia (MI) for anterior-posterior bending (xMI) and lower for lateral bending (yMI) with a lower “shape-index” (yMI/xMI ratio) throughout, and higher resistance to buckling distally. These group differences were more evident in men and independent of group differences in bone mass. These results contrast with those observed in the tibia, where, as expected, structural indicators of bone strength were greater in trained than untrained individuals. Proximally, the larger lateral flexibility of runners' fibulae could improve the ability to store energy, and thereby contribute to fast-running optimization. Distally, the greater lateral fibular flexibility could reduce bending strength. The latter appears to have been compensated by a higher buckling strength. Assuming that these differences could be ascribed to training effects, this suggests that usage-derived strains in some bones may modify their relative structural resistance to different kinds of deformation in different regions, not only regarding strength, but also concerning other physiological roles of the skeleton.
Fil: Luscher, Sergio Hugo. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Centro de Estudios de Metabolismo Fosfocálcico; Argentina
Fil: Nocciolino, Laura Marcela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario; Argentina. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Centro de Estudios de Metabolismo Fosfocálcico; Argentina
Fil: Pilot, Nicolas Carlos. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Centro de Estudios de Metabolismo Fosfocálcico; Argentina
Fil: Pisani, Leonardo. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Centro de Estudios de Metabolismo Fosfocálcico; Argentina
Fil: Ireland, Alex. Manchester Metropolitan University; Reino Unido
Fil: Rittweger, Jörn. Centro Aero Espacial Aleman; Alemania. Universitat zu Köln; Alemania
Fil: Ferretti, Jose Luis. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario; Argentina. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Centro de Estudios de Metabolismo Fosfocálcico; Argentina
Fil: Cointry, Gustavo Roberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario; Argentina. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Centro de Estudios de Metabolismo Fosfocálcico; Argentina
Fil: Capozza, Ricardo Francisco. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario; Argentina. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Centro de Estudios de Metabolismo Fosfocálcico; Argentina
Materia: PQCT
FIBULA
BONE MECHANOSTAT
RUNNERS
CORTICAL BONE
BONE GEOMETRY
DINAMOMETRY
BONE BIOMECHANICS
Nivel de accesibilidad: acceso abierto
Condiciones de uso: https://creativecommons.org/licenses/by/2.5/ar/
Repositorio
Institución: Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador: oai:ri.conicet.gov.ar:11336/150604

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spelling	Differences in the Cortical Structure of the Whole Fibula and Tibia Between Long-Distance Runners and Untrained Controls: Toward a Wider Conception of the Biomechanical Regulation of Cortical Bone StructureLuscher, Sergio HugoNocciolino, Laura MarcelaPilot, Nicolas CarlosPisani, LeonardoIreland, AlexRittweger, JörnFerretti, Jose LuisCointry, Gustavo RobertoCapozza, Ricardo FranciscoPQCTFIBULABONE MECHANOSTATRUNNERSCORTICAL BONEBONE GEOMETRYDINAMOMETRYBONE BIOMECHANICShttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3The cortical structure of human fibula varies widely throughout the bone suggesting a more selective adaptation to different mechanical environments with respect to the adjacent tibia. To test this hypothesis, serial-pQCT scans of the dominant fibulae and tibiae of 15/15 men/women chronically trained in long-distance running were compared with those of 15/15 untrained controls. When compared to controls, the fibulae of trained individuals had similar (distally) or lower (proximally) cortical area, similar moments of inertia (MI) for anterior-posterior bending (xMI) and lower for lateral bending (yMI) with a lower “shape-index” (yMI/xMI ratio) throughout, and higher resistance to buckling distally. These group differences were more evident in men and independent of group differences in bone mass. These results contrast with those observed in the tibia, where, as expected, structural indicators of bone strength were greater in trained than untrained individuals. Proximally, the larger lateral flexibility of runners' fibulae could improve the ability to store energy, and thereby contribute to fast-running optimization. Distally, the greater lateral fibular flexibility could reduce bending strength. The latter appears to have been compensated by a higher buckling strength. Assuming that these differences could be ascribed to training effects, this suggests that usage-derived strains in some bones may modify their relative structural resistance to different kinds of deformation in different regions, not only regarding strength, but also concerning other physiological roles of the skeleton.Fil: Luscher, Sergio Hugo. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Centro de Estudios de Metabolismo Fosfocálcico; ArgentinaFil: Nocciolino, Laura Marcela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario; Argentina. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Centro de Estudios de Metabolismo Fosfocálcico; ArgentinaFil: Pilot, Nicolas Carlos. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Centro de Estudios de Metabolismo Fosfocálcico; ArgentinaFil: Pisani, Leonardo. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Centro de Estudios de Metabolismo Fosfocálcico; ArgentinaFil: Ireland, Alex. Manchester Metropolitan University; Reino UnidoFil: Rittweger, Jörn. Centro Aero Espacial Aleman; Alemania. Universitat zu Köln; AlemaniaFil: Ferretti, Jose Luis. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario; Argentina. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Centro de Estudios de Metabolismo Fosfocálcico; ArgentinaFil: Cointry, Gustavo Roberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario; Argentina. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Centro de Estudios de Metabolismo Fosfocálcico; ArgentinaFil: Capozza, Ricardo Francisco. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario; Argentina. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Centro de Estudios de Metabolismo Fosfocálcico; ArgentinaFrontiers Media2019-11info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/150604Luscher, Sergio Hugo; Nocciolino, Laura Marcela; Pilot, Nicolas Carlos; Pisani, Leonardo; Ireland, Alex; et al.; Differences in the Cortical Structure of the Whole Fibula and Tibia Between Long-Distance Runners and Untrained Controls: Toward a Wider Conception of the Biomechanical Regulation of Cortical Bone Structure; Frontiers Media; Frontiers in Endocrinology; 10; 11-2019; 1-131664-2392CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.frontiersin.org/article/10.3389/fendo.2019.00833/fullinfo:eu-repo/semantics/altIdentifier/doi/10.3389/fendo.2019.00833info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-17T11:02:14Zoai:ri.conicet.gov.ar:11336/150604instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-17 11:02:15.102CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv	Differences in the Cortical Structure of the Whole Fibula and Tibia Between Long-Distance Runners and Untrained Controls: Toward a Wider Conception of the Biomechanical Regulation of Cortical Bone Structure
title	Differences in the Cortical Structure of the Whole Fibula and Tibia Between Long-Distance Runners and Untrained Controls: Toward a Wider Conception of the Biomechanical Regulation of Cortical Bone Structure
spellingShingle	Differences in the Cortical Structure of the Whole Fibula and Tibia Between Long-Distance Runners and Untrained Controls: Toward a Wider Conception of the Biomechanical Regulation of Cortical Bone Structure Luscher, Sergio Hugo PQCT FIBULA BONE MECHANOSTAT RUNNERS CORTICAL BONE BONE GEOMETRY DINAMOMETRY BONE BIOMECHANICS
title_short	Differences in the Cortical Structure of the Whole Fibula and Tibia Between Long-Distance Runners and Untrained Controls: Toward a Wider Conception of the Biomechanical Regulation of Cortical Bone Structure
title_full	Differences in the Cortical Structure of the Whole Fibula and Tibia Between Long-Distance Runners and Untrained Controls: Toward a Wider Conception of the Biomechanical Regulation of Cortical Bone Structure
title_fullStr	Differences in the Cortical Structure of the Whole Fibula and Tibia Between Long-Distance Runners and Untrained Controls: Toward a Wider Conception of the Biomechanical Regulation of Cortical Bone Structure
title_full_unstemmed	Differences in the Cortical Structure of the Whole Fibula and Tibia Between Long-Distance Runners and Untrained Controls: Toward a Wider Conception of the Biomechanical Regulation of Cortical Bone Structure
title_sort	Differences in the Cortical Structure of the Whole Fibula and Tibia Between Long-Distance Runners and Untrained Controls: Toward a Wider Conception of the Biomechanical Regulation of Cortical Bone Structure
dc.creator.none.fl_str_mv	Luscher, Sergio Hugo Nocciolino, Laura Marcela Pilot, Nicolas Carlos Pisani, Leonardo Ireland, Alex Rittweger, Jörn Ferretti, Jose Luis Cointry, Gustavo Roberto Capozza, Ricardo Francisco
author	Luscher, Sergio Hugo
author_facet	Luscher, Sergio Hugo Nocciolino, Laura Marcela Pilot, Nicolas Carlos Pisani, Leonardo Ireland, Alex Rittweger, Jörn Ferretti, Jose Luis Cointry, Gustavo Roberto Capozza, Ricardo Francisco
author_role	author
author2	Nocciolino, Laura Marcela Pilot, Nicolas Carlos Pisani, Leonardo Ireland, Alex Rittweger, Jörn Ferretti, Jose Luis Cointry, Gustavo Roberto Capozza, Ricardo Francisco
author2_role	author author author author author author author author
dc.subject.none.fl_str_mv	PQCT FIBULA BONE MECHANOSTAT RUNNERS CORTICAL BONE BONE GEOMETRY DINAMOMETRY BONE BIOMECHANICS
topic	PQCT FIBULA BONE MECHANOSTAT RUNNERS CORTICAL BONE BONE GEOMETRY DINAMOMETRY BONE BIOMECHANICS
purl_subject.fl_str_mv	https://purl.org/becyt/ford/3.3 https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv	The cortical structure of human fibula varies widely throughout the bone suggesting a more selective adaptation to different mechanical environments with respect to the adjacent tibia. To test this hypothesis, serial-pQCT scans of the dominant fibulae and tibiae of 15/15 men/women chronically trained in long-distance running were compared with those of 15/15 untrained controls. When compared to controls, the fibulae of trained individuals had similar (distally) or lower (proximally) cortical area, similar moments of inertia (MI) for anterior-posterior bending (xMI) and lower for lateral bending (yMI) with a lower “shape-index” (yMI/xMI ratio) throughout, and higher resistance to buckling distally. These group differences were more evident in men and independent of group differences in bone mass. These results contrast with those observed in the tibia, where, as expected, structural indicators of bone strength were greater in trained than untrained individuals. Proximally, the larger lateral flexibility of runners' fibulae could improve the ability to store energy, and thereby contribute to fast-running optimization. Distally, the greater lateral fibular flexibility could reduce bending strength. The latter appears to have been compensated by a higher buckling strength. Assuming that these differences could be ascribed to training effects, this suggests that usage-derived strains in some bones may modify their relative structural resistance to different kinds of deformation in different regions, not only regarding strength, but also concerning other physiological roles of the skeleton. Fil: Luscher, Sergio Hugo. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Centro de Estudios de Metabolismo Fosfocálcico; Argentina Fil: Nocciolino, Laura Marcela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario; Argentina. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Centro de Estudios de Metabolismo Fosfocálcico; Argentina Fil: Pilot, Nicolas Carlos. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Centro de Estudios de Metabolismo Fosfocálcico; Argentina Fil: Pisani, Leonardo. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Centro de Estudios de Metabolismo Fosfocálcico; Argentina Fil: Ireland, Alex. Manchester Metropolitan University; Reino Unido Fil: Rittweger, Jörn. Centro Aero Espacial Aleman; Alemania. Universitat zu Köln; Alemania Fil: Ferretti, Jose Luis. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario; Argentina. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Centro de Estudios de Metabolismo Fosfocálcico; Argentina Fil: Cointry, Gustavo Roberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario; Argentina. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Centro de Estudios de Metabolismo Fosfocálcico; Argentina Fil: Capozza, Ricardo Francisco. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario; Argentina. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Centro de Estudios de Metabolismo Fosfocálcico; Argentina
description	The cortical structure of human fibula varies widely throughout the bone suggesting a more selective adaptation to different mechanical environments with respect to the adjacent tibia. To test this hypothesis, serial-pQCT scans of the dominant fibulae and tibiae of 15/15 men/women chronically trained in long-distance running were compared with those of 15/15 untrained controls. When compared to controls, the fibulae of trained individuals had similar (distally) or lower (proximally) cortical area, similar moments of inertia (MI) for anterior-posterior bending (xMI) and lower for lateral bending (yMI) with a lower “shape-index” (yMI/xMI ratio) throughout, and higher resistance to buckling distally. These group differences were more evident in men and independent of group differences in bone mass. These results contrast with those observed in the tibia, where, as expected, structural indicators of bone strength were greater in trained than untrained individuals. Proximally, the larger lateral flexibility of runners' fibulae could improve the ability to store energy, and thereby contribute to fast-running optimization. Distally, the greater lateral fibular flexibility could reduce bending strength. The latter appears to have been compensated by a higher buckling strength. Assuming that these differences could be ascribed to training effects, this suggests that usage-derived strains in some bones may modify their relative structural resistance to different kinds of deformation in different regions, not only regarding strength, but also concerning other physiological roles of the skeleton.
publishDate	2019
dc.date.none.fl_str_mv	2019-11
dc.type.none.fl_str_mv	info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo
format	article
status_str	publishedVersion
dc.identifier.none.fl_str_mv	http://hdl.handle.net/11336/150604 Luscher, Sergio Hugo; Nocciolino, Laura Marcela; Pilot, Nicolas Carlos; Pisani, Leonardo; Ireland, Alex; et al.; Differences in the Cortical Structure of the Whole Fibula and Tibia Between Long-Distance Runners and Untrained Controls: Toward a Wider Conception of the Biomechanical Regulation of Cortical Bone Structure; Frontiers Media; Frontiers in Endocrinology; 10; 11-2019; 1-13 1664-2392 CONICET Digital CONICET
url	http://hdl.handle.net/11336/150604
identifier_str_mv	Luscher, Sergio Hugo; Nocciolino, Laura Marcela; Pilot, Nicolas Carlos; Pisani, Leonardo; Ireland, Alex; et al.; Differences in the Cortical Structure of the Whole Fibula and Tibia Between Long-Distance Runners and Untrained Controls: Toward a Wider Conception of the Biomechanical Regulation of Cortical Bone Structure; Frontiers Media; Frontiers in Endocrinology; 10; 11-2019; 1-13 1664-2392 CONICET Digital CONICET
dc.language.none.fl_str_mv	eng
language	eng
dc.relation.none.fl_str_mv	info:eu-repo/semantics/altIdentifier/url/https://www.frontiersin.org/article/10.3389/fendo.2019.00833/full info:eu-repo/semantics/altIdentifier/doi/10.3389/fendo.2019.00833
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dc.publisher.none.fl_str_mv	Frontiers Media
publisher.none.fl_str_mv	Frontiers Media
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repository.mail.fl_str_mv	dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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Differences in the Cortical Structure of the Whole Fibula and Tibia Between Long-Distance Runners and Untrained Controls: Toward a Wider Conception of the Biomechanical Regulation...

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