Analysis of the independent power of age-related, anthropometric and mechanical factors as determinants of the structure of radius and tibia in normal adults: a pQCT study

Autores
Reina, Paola Soledad; Cointry, Gustavo Roberto; Nocciolino, L.; Feldman, Sara; Ferretti, Jose Luis; Rittweger, J.; Capozza, Ricardo Francisco
Año de publicación
2015
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
To compare the independent influence of mechanical and non-mechanical factors on bone features, multiple regression analyses were performed between pQCT indicators of radius and tibia bone mass, mineralization, design and strength as determined variables, and age or time since menopause (TMP), body mass, bone length and regional muscles’ areas as selected determinant factors, in Caucasian, physically active, untrained healthy men and pre- and post-menopausal women. In men and pre-menopausal women, the strongest influences were exerted by muscle area on radial features and by both muscle area and bone length on the tibia. Only for women, was body mass a significant factor for tibia traits. In men and pre-menopausal women, mass/design/strength indicators depended more strongly on the selected determinants than the cortical vBMD did (p<0.01-0.001 vs n.s.), regardless of age. However, TMP was an additional factor for both bones (p<0.01-0.001). The selected mechanical factors (muscle size, bone lengths) were more relevant than age/TMP or body weight to the development of allometrically-related bone properties (mass/design/strength), yet not to bone tissue “quality” (cortical vBMD), suggesting a determinant, rather than determined role for cortical stiffness. While the mechanical impacts of muscles and bone levers on bone structure were comparable in men and pre-menopausal women, TMP exerted a stronger impact than allometric or mechanical factors on bone properties, including cortical vBMD.
Fil: Reina, Paola Soledad. Universidad Nacional de Rosario. Facultad de Cs.medicas. Centro de Est.de Metabolismo Fosfocalcico; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Cointry, Gustavo Roberto. Universidad Nacional de Rosario. Facultad de Cs.medicas. Centro de Est.de Metabolismo Fosfocalcico; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Nocciolino, L.. Universidad Nacional de Rosario. Facultad de Cs.medicas. Centro de Est.de Metabolismo Fosfocalcico; Argentina
Fil: Feldman, Sara. Universidad Nacional de Rosario. Facultad de Cs.medicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Ferretti, Jose Luis. Universidad Nacional de Rosario. Facultad de Cs.medicas. Centro de Est.de Metabolismo Fosfocalcico; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Rittweger, J.. German Space Center. Institute of Aerospace Medicine; Alemania
Fil: Capozza, Ricardo Francisco. Universidad Nacional de Rosario. Facultad de Cs.medicas. Centro de Est.de Metabolismo Fosfocalcico; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Materia
Muscle-Bone Interactions
Bone Biomechanics
Bone Tomography
QCT
pQCT
Osteoporosis
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/13523
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/13523
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Analysis of the independent power of age-related, anthropometric and mechanical factors as determinants of the structure of radius and tibia in normal adults: a pQCT studyReina, Paola SoledadCointry, Gustavo RobertoNocciolino, L.Feldman, SaraFerretti, Jose LuisRittweger, J.Capozza, Ricardo FranciscoMuscle-Bone InteractionsBone BiomechanicsBone TomographyQCTpQCTOsteoporosishttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3To compare the independent influence of mechanical and non-mechanical factors on bone features, multiple regression analyses were performed between pQCT indicators of radius and tibia bone mass, mineralization, design and strength as determined variables, and age or time since menopause (TMP), body mass, bone length and regional muscles’ areas as selected determinant factors, in Caucasian, physically active, untrained healthy men and pre- and post-menopausal women. In men and pre-menopausal women, the strongest influences were exerted by muscle area on radial features and by both muscle area and bone length on the tibia. Only for women, was body mass a significant factor for tibia traits. In men and pre-menopausal women, mass/design/strength indicators depended more strongly on the selected determinants than the cortical vBMD did (p<0.01-0.001 vs n.s.), regardless of age. However, TMP was an additional factor for both bones (p<0.01-0.001). The selected mechanical factors (muscle size, bone lengths) were more relevant than age/TMP or body weight to the development of allometrically-related bone properties (mass/design/strength), yet not to bone tissue “quality” (cortical vBMD), suggesting a determinant, rather than determined role for cortical stiffness. While the mechanical impacts of muscles and bone levers on bone structure were comparable in men and pre-menopausal women, TMP exerted a stronger impact than allometric or mechanical factors on bone properties, including cortical vBMD.Fil: Reina, Paola Soledad. Universidad Nacional de Rosario. Facultad de Cs.medicas. Centro de Est.de Metabolismo Fosfocalcico; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Cointry, Gustavo Roberto. Universidad Nacional de Rosario. Facultad de Cs.medicas. Centro de Est.de Metabolismo Fosfocalcico; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Nocciolino, L.. Universidad Nacional de Rosario. Facultad de Cs.medicas. Centro de Est.de Metabolismo Fosfocalcico; ArgentinaFil: Feldman, Sara. Universidad Nacional de Rosario. Facultad de Cs.medicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Ferretti, Jose Luis. Universidad Nacional de Rosario. Facultad de Cs.medicas. Centro de Est.de Metabolismo Fosfocalcico; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Rittweger, J.. German Space Center. Institute of Aerospace Medicine; AlemaniaFil: Capozza, Ricardo Francisco. Universidad Nacional de Rosario. Facultad de Cs.medicas. Centro de Est.de Metabolismo Fosfocalcico; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaISMNI2015-03info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/13523Reina, Paola Soledad; Cointry, Gustavo Roberto; Nocciolino, L.; Feldman, Sara; Ferretti, Jose Luis; et al.; Analysis of the independent power of age-related, anthropometric and mechanical factors as determinants of the structure of radius and tibia in normal adults: a pQCT study; ISMNI; Journal of Musculoskeletal and Neuronal Interactions; 15; 1; 3-2015; 10-221108-7161enginfo:eu-repo/semantics/altIdentifier/url/http://www.ismni.org/jmni/pdf/59/02REINA.pdfinfo:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5123604/info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T10:10:41Zoai:ri.conicet.gov.ar:11336/13523instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 10:10:42.036CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Analysis of the independent power of age-related, anthropometric and mechanical factors as determinants of the structure of radius and tibia in normal adults: a pQCT study
title Analysis of the independent power of age-related, anthropometric and mechanical factors as determinants of the structure of radius and tibia in normal adults: a pQCT study
spellingShingle Analysis of the independent power of age-related, anthropometric and mechanical factors as determinants of the structure of radius and tibia in normal adults: a pQCT study
Reina, Paola Soledad
Muscle-Bone Interactions
Bone Biomechanics
Bone Tomography
QCT
pQCT
Osteoporosis
title_short Analysis of the independent power of age-related, anthropometric and mechanical factors as determinants of the structure of radius and tibia in normal adults: a pQCT study
title_full Analysis of the independent power of age-related, anthropometric and mechanical factors as determinants of the structure of radius and tibia in normal adults: a pQCT study
title_fullStr Analysis of the independent power of age-related, anthropometric and mechanical factors as determinants of the structure of radius and tibia in normal adults: a pQCT study
title_full_unstemmed Analysis of the independent power of age-related, anthropometric and mechanical factors as determinants of the structure of radius and tibia in normal adults: a pQCT study
title_sort Analysis of the independent power of age-related, anthropometric and mechanical factors as determinants of the structure of radius and tibia in normal adults: a pQCT study
dc.creator.none.fl_str_mv Reina, Paola Soledad
Cointry, Gustavo Roberto
Nocciolino, L.
Feldman, Sara
Ferretti, Jose Luis
Rittweger, J.
Capozza, Ricardo Francisco
author Reina, Paola Soledad
author_facet Reina, Paola Soledad
Cointry, Gustavo Roberto
Nocciolino, L.
Feldman, Sara
Ferretti, Jose Luis
Rittweger, J.
Capozza, Ricardo Francisco
author_role author
author2 Cointry, Gustavo Roberto
Nocciolino, L.
Feldman, Sara
Ferretti, Jose Luis
Rittweger, J.
Capozza, Ricardo Francisco
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv Muscle-Bone Interactions
Bone Biomechanics
Bone Tomography
QCT
pQCT
Osteoporosis
topic Muscle-Bone Interactions
Bone Biomechanics
Bone Tomography
QCT
pQCT
Osteoporosis
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv To compare the independent influence of mechanical and non-mechanical factors on bone features, multiple regression analyses were performed between pQCT indicators of radius and tibia bone mass, mineralization, design and strength as determined variables, and age or time since menopause (TMP), body mass, bone length and regional muscles’ areas as selected determinant factors, in Caucasian, physically active, untrained healthy men and pre- and post-menopausal women. In men and pre-menopausal women, the strongest influences were exerted by muscle area on radial features and by both muscle area and bone length on the tibia. Only for women, was body mass a significant factor for tibia traits. In men and pre-menopausal women, mass/design/strength indicators depended more strongly on the selected determinants than the cortical vBMD did (p<0.01-0.001 vs n.s.), regardless of age. However, TMP was an additional factor for both bones (p<0.01-0.001). The selected mechanical factors (muscle size, bone lengths) were more relevant than age/TMP or body weight to the development of allometrically-related bone properties (mass/design/strength), yet not to bone tissue “quality” (cortical vBMD), suggesting a determinant, rather than determined role for cortical stiffness. While the mechanical impacts of muscles and bone levers on bone structure were comparable in men and pre-menopausal women, TMP exerted a stronger impact than allometric or mechanical factors on bone properties, including cortical vBMD.
Fil: Reina, Paola Soledad. Universidad Nacional de Rosario. Facultad de Cs.medicas. Centro de Est.de Metabolismo Fosfocalcico; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Cointry, Gustavo Roberto. Universidad Nacional de Rosario. Facultad de Cs.medicas. Centro de Est.de Metabolismo Fosfocalcico; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Nocciolino, L.. Universidad Nacional de Rosario. Facultad de Cs.medicas. Centro de Est.de Metabolismo Fosfocalcico; Argentina
Fil: Feldman, Sara. Universidad Nacional de Rosario. Facultad de Cs.medicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Ferretti, Jose Luis. Universidad Nacional de Rosario. Facultad de Cs.medicas. Centro de Est.de Metabolismo Fosfocalcico; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Rittweger, J.. German Space Center. Institute of Aerospace Medicine; Alemania
Fil: Capozza, Ricardo Francisco. Universidad Nacional de Rosario. Facultad de Cs.medicas. Centro de Est.de Metabolismo Fosfocalcico; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
description To compare the independent influence of mechanical and non-mechanical factors on bone features, multiple regression analyses were performed between pQCT indicators of radius and tibia bone mass, mineralization, design and strength as determined variables, and age or time since menopause (TMP), body mass, bone length and regional muscles’ areas as selected determinant factors, in Caucasian, physically active, untrained healthy men and pre- and post-menopausal women. In men and pre-menopausal women, the strongest influences were exerted by muscle area on radial features and by both muscle area and bone length on the tibia. Only for women, was body mass a significant factor for tibia traits. In men and pre-menopausal women, mass/design/strength indicators depended more strongly on the selected determinants than the cortical vBMD did (p<0.01-0.001 vs n.s.), regardless of age. However, TMP was an additional factor for both bones (p<0.01-0.001). The selected mechanical factors (muscle size, bone lengths) were more relevant than age/TMP or body weight to the development of allometrically-related bone properties (mass/design/strength), yet not to bone tissue “quality” (cortical vBMD), suggesting a determinant, rather than determined role for cortical stiffness. While the mechanical impacts of muscles and bone levers on bone structure were comparable in men and pre-menopausal women, TMP exerted a stronger impact than allometric or mechanical factors on bone properties, including cortical vBMD.
publishDate 2015
dc.date.none.fl_str_mv 2015-03
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/13523
Reina, Paola Soledad; Cointry, Gustavo Roberto; Nocciolino, L.; Feldman, Sara; Ferretti, Jose Luis; et al.; Analysis of the independent power of age-related, anthropometric and mechanical factors as determinants of the structure of radius and tibia in normal adults: a pQCT study; ISMNI; Journal of Musculoskeletal and Neuronal Interactions; 15; 1; 3-2015; 10-22
1108-7161
url http://hdl.handle.net/11336/13523
identifier_str_mv Reina, Paola Soledad; Cointry, Gustavo Roberto; Nocciolino, L.; Feldman, Sara; Ferretti, Jose Luis; et al.; Analysis of the independent power of age-related, anthropometric and mechanical factors as determinants of the structure of radius and tibia in normal adults: a pQCT study; ISMNI; Journal of Musculoskeletal and Neuronal Interactions; 15; 1; 3-2015; 10-22
1108-7161
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://www.ismni.org/jmni/pdf/59/02REINA.pdf
info:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5123604/
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv ISMNI
publisher.none.fl_str_mv ISMNI
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.13397

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