Clinical-Pathological Analysis of 37 Oral Squamous Cell Carcinomas in Tucumán, Northwestern Province of Argentina: Immunohistochemical Study of p53 In Selected Cases

Autores
Blunda, S.; Carino, S.; Ortiz Mayor, M.; Aybar Odstrcil, Ana del Carmen; de Moreno, Maria Alejandra
Año de publicación
2024
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Oral squamous cell carcinoma (OSCC) represents 3% of all malignant neoplasms. Considering the bserved regional occurrence of OSCC, the aim of this study was to analyze the incidence and clinical characteristics of patients with primary carcinoma of the oral cavity diagnosed in the province of Tucumán, in the Northwestern of Argentina, where habits and lifestyle can play a central role in its incidence. A cross-sectional, descriptive and exploratory study was conducted with 37 clinical records of patients with OSCC. The study included the analysis of clinical and histological parameters, risk factors and the presence of p53 mutations in relation to the histopathological grade and the carcinoma in situ (CIS) component. OSCC is the most frequent oral malignancy in Tucumán. Most of the patients (81.1%) were male, and the mean age range was 65.5 years. The analysis of risk factors showed that 89.2% of the patients smoked. Most of the tumors (38%) were located on the tongue and the greater histological aggressiveness of OSCC was observed in this location. Overexpression of p53 was observed in OSCC with CIS component. OSCC is the most frequent oral malignancy in Tucumán. The data also agree with reports from other locations in terms of sex, age, location, and greater histological aggressiveness of OSCC in the tongue. The overexpression of p53 in OSCC with a CIS component could indicate the occurrence of its mutation in early lesions. The mutation in p53 in non-invasive lesions found in the adjacent surface epithelium could have predictive potential for progression or recurrences from inadequate surgical margins.
Fil: Blunda, S.. Universidad Nacional de Tucumán. Facultad de Odontología; Argentina
Fil: Carino, S.. Universidad Nacional de Tucumán. Facultad de Odontología; Argentina
Fil: Ortiz Mayor, M.. Universidad Nacional de Tucumán; Argentina
Fil: Aybar Odstrcil, Ana del Carmen. Universidad Nacional de Tucumán. Facultad de Odontología; Argentina
Fil: de Moreno, Maria Alejandra. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Centro de Referencia para Lactobacilos; Argentina
Materia
ORAL SQUAMOUS CELL CARCINOMA
ARGENTINA
TUCUMAN
RISK FACTORS
INCIDENCE
HISTOLOGICAL GRADE
P53
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/260816
Acceder
id CONICETDig_c222353a88b382972d01551eece6db13
oai_identifier_str oai:ri.conicet.gov.ar:11336/260816
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Clinical-Pathological Analysis of 37 Oral Squamous Cell Carcinomas in Tucumán, Northwestern Province of Argentina: Immunohistochemical Study of p53 In Selected CasesBlunda, S.Carino, S.Ortiz Mayor, M.Aybar Odstrcil, Ana del Carmende Moreno, Maria AlejandraORAL SQUAMOUS CELL CARCINOMAARGENTINATUCUMANRISK FACTORSINCIDENCEHISTOLOGICAL GRADEP53https://purl.org/becyt/ford/3.2https://purl.org/becyt/ford/3Oral squamous cell carcinoma (OSCC) represents 3% of all malignant neoplasms. Considering the bserved regional occurrence of OSCC, the aim of this study was to analyze the incidence and clinical characteristics of patients with primary carcinoma of the oral cavity diagnosed in the province of Tucumán, in the Northwestern of Argentina, where habits and lifestyle can play a central role in its incidence. A cross-sectional, descriptive and exploratory study was conducted with 37 clinical records of patients with OSCC. The study included the analysis of clinical and histological parameters, risk factors and the presence of p53 mutations in relation to the histopathological grade and the carcinoma in situ (CIS) component. OSCC is the most frequent oral malignancy in Tucumán. Most of the patients (81.1%) were male, and the mean age range was 65.5 years. The analysis of risk factors showed that 89.2% of the patients smoked. Most of the tumors (38%) were located on the tongue and the greater histological aggressiveness of OSCC was observed in this location. Overexpression of p53 was observed in OSCC with CIS component. OSCC is the most frequent oral malignancy in Tucumán. The data also agree with reports from other locations in terms of sex, age, location, and greater histological aggressiveness of OSCC in the tongue. The overexpression of p53 in OSCC with a CIS component could indicate the occurrence of its mutation in early lesions. The mutation in p53 in non-invasive lesions found in the adjacent surface epithelium could have predictive potential for progression or recurrences from inadequate surgical margins.Fil: Blunda, S.. Universidad Nacional de Tucumán. Facultad de Odontología; ArgentinaFil: Carino, S.. Universidad Nacional de Tucumán. Facultad de Odontología; ArgentinaFil: Ortiz Mayor, M.. Universidad Nacional de Tucumán; ArgentinaFil: Aybar Odstrcil, Ana del Carmen. Universidad Nacional de Tucumán. Facultad de Odontología; ArgentinaFil: de Moreno, Maria Alejandra. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Centro de Referencia para Lactobacilos; ArgentinaAnnals of Clinical and Medical Case Reports2024-02info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/260816Blunda, S.; Carino, S. ; Ortiz Mayor, M.; Aybar Odstrcil, Ana del Carmen; de Moreno, Maria Alejandra; Clinical-Pathological Analysis of 37 Oral Squamous Cell Carcinomas in Tucumán, Northwestern Province of Argentina: Immunohistochemical Study of p53 In Selected Cases; Annals of Clinical and Medical Case Reports; Annals of Clinical and Medical Case Reports; 12; 15; 2-2024; 1-92639-8109CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://acmcasereport.org/wp-content/uploads/2024/09/ACMCR-v12-2112.pdfinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-22T11:24:21Zoai:ri.conicet.gov.ar:11336/260816instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-22 11:24:22.087CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Clinical-Pathological Analysis of 37 Oral Squamous Cell Carcinomas in Tucumán, Northwestern Province of Argentina: Immunohistochemical Study of p53 In Selected Cases
title Clinical-Pathological Analysis of 37 Oral Squamous Cell Carcinomas in Tucumán, Northwestern Province of Argentina: Immunohistochemical Study of p53 In Selected Cases
spellingShingle Clinical-Pathological Analysis of 37 Oral Squamous Cell Carcinomas in Tucumán, Northwestern Province of Argentina: Immunohistochemical Study of p53 In Selected Cases
Blunda, S.
ORAL SQUAMOUS CELL CARCINOMA
ARGENTINA
TUCUMAN
RISK FACTORS
INCIDENCE
HISTOLOGICAL GRADE
P53
title_short Clinical-Pathological Analysis of 37 Oral Squamous Cell Carcinomas in Tucumán, Northwestern Province of Argentina: Immunohistochemical Study of p53 In Selected Cases
title_full Clinical-Pathological Analysis of 37 Oral Squamous Cell Carcinomas in Tucumán, Northwestern Province of Argentina: Immunohistochemical Study of p53 In Selected Cases
title_fullStr Clinical-Pathological Analysis of 37 Oral Squamous Cell Carcinomas in Tucumán, Northwestern Province of Argentina: Immunohistochemical Study of p53 In Selected Cases
title_full_unstemmed Clinical-Pathological Analysis of 37 Oral Squamous Cell Carcinomas in Tucumán, Northwestern Province of Argentina: Immunohistochemical Study of p53 In Selected Cases
title_sort Clinical-Pathological Analysis of 37 Oral Squamous Cell Carcinomas in Tucumán, Northwestern Province of Argentina: Immunohistochemical Study of p53 In Selected Cases
dc.creator.none.fl_str_mv Blunda, S.
Carino, S.
Ortiz Mayor, M.
Aybar Odstrcil, Ana del Carmen
de Moreno, Maria Alejandra
author Blunda, S.
author_facet Blunda, S.
Carino, S.
Ortiz Mayor, M.
Aybar Odstrcil, Ana del Carmen
de Moreno, Maria Alejandra
author_role author
author2 Carino, S.
Ortiz Mayor, M.
Aybar Odstrcil, Ana del Carmen
de Moreno, Maria Alejandra
author2_role author
author
author
author
dc.subject.none.fl_str_mv ORAL SQUAMOUS CELL CARCINOMA
ARGENTINA
TUCUMAN
RISK FACTORS
INCIDENCE
HISTOLOGICAL GRADE
P53
topic ORAL SQUAMOUS CELL CARCINOMA
ARGENTINA
TUCUMAN
RISK FACTORS
INCIDENCE
HISTOLOGICAL GRADE
P53
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.2
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Oral squamous cell carcinoma (OSCC) represents 3% of all malignant neoplasms. Considering the bserved regional occurrence of OSCC, the aim of this study was to analyze the incidence and clinical characteristics of patients with primary carcinoma of the oral cavity diagnosed in the province of Tucumán, in the Northwestern of Argentina, where habits and lifestyle can play a central role in its incidence. A cross-sectional, descriptive and exploratory study was conducted with 37 clinical records of patients with OSCC. The study included the analysis of clinical and histological parameters, risk factors and the presence of p53 mutations in relation to the histopathological grade and the carcinoma in situ (CIS) component. OSCC is the most frequent oral malignancy in Tucumán. Most of the patients (81.1%) were male, and the mean age range was 65.5 years. The analysis of risk factors showed that 89.2% of the patients smoked. Most of the tumors (38%) were located on the tongue and the greater histological aggressiveness of OSCC was observed in this location. Overexpression of p53 was observed in OSCC with CIS component. OSCC is the most frequent oral malignancy in Tucumán. The data also agree with reports from other locations in terms of sex, age, location, and greater histological aggressiveness of OSCC in the tongue. The overexpression of p53 in OSCC with a CIS component could indicate the occurrence of its mutation in early lesions. The mutation in p53 in non-invasive lesions found in the adjacent surface epithelium could have predictive potential for progression or recurrences from inadequate surgical margins.
Fil: Blunda, S.. Universidad Nacional de Tucumán. Facultad de Odontología; Argentina
Fil: Carino, S.. Universidad Nacional de Tucumán. Facultad de Odontología; Argentina
Fil: Ortiz Mayor, M.. Universidad Nacional de Tucumán; Argentina
Fil: Aybar Odstrcil, Ana del Carmen. Universidad Nacional de Tucumán. Facultad de Odontología; Argentina
Fil: de Moreno, Maria Alejandra. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Centro de Referencia para Lactobacilos; Argentina
description Oral squamous cell carcinoma (OSCC) represents 3% of all malignant neoplasms. Considering the bserved regional occurrence of OSCC, the aim of this study was to analyze the incidence and clinical characteristics of patients with primary carcinoma of the oral cavity diagnosed in the province of Tucumán, in the Northwestern of Argentina, where habits and lifestyle can play a central role in its incidence. A cross-sectional, descriptive and exploratory study was conducted with 37 clinical records of patients with OSCC. The study included the analysis of clinical and histological parameters, risk factors and the presence of p53 mutations in relation to the histopathological grade and the carcinoma in situ (CIS) component. OSCC is the most frequent oral malignancy in Tucumán. Most of the patients (81.1%) were male, and the mean age range was 65.5 years. The analysis of risk factors showed that 89.2% of the patients smoked. Most of the tumors (38%) were located on the tongue and the greater histological aggressiveness of OSCC was observed in this location. Overexpression of p53 was observed in OSCC with CIS component. OSCC is the most frequent oral malignancy in Tucumán. The data also agree with reports from other locations in terms of sex, age, location, and greater histological aggressiveness of OSCC in the tongue. The overexpression of p53 in OSCC with a CIS component could indicate the occurrence of its mutation in early lesions. The mutation in p53 in non-invasive lesions found in the adjacent surface epithelium could have predictive potential for progression or recurrences from inadequate surgical margins.
publishDate 2024
dc.date.none.fl_str_mv 2024-02
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/260816
Blunda, S.; Carino, S. ; Ortiz Mayor, M.; Aybar Odstrcil, Ana del Carmen; de Moreno, Maria Alejandra; Clinical-Pathological Analysis of 37 Oral Squamous Cell Carcinomas in Tucumán, Northwestern Province of Argentina: Immunohistochemical Study of p53 In Selected Cases; Annals of Clinical and Medical Case Reports; Annals of Clinical and Medical Case Reports; 12; 15; 2-2024; 1-9
2639-8109
CONICET Digital
CONICET
url http://hdl.handle.net/11336/260816
identifier_str_mv Blunda, S.; Carino, S. ; Ortiz Mayor, M.; Aybar Odstrcil, Ana del Carmen; de Moreno, Maria Alejandra; Clinical-Pathological Analysis of 37 Oral Squamous Cell Carcinomas in Tucumán, Northwestern Province of Argentina: Immunohistochemical Study of p53 In Selected Cases; Annals of Clinical and Medical Case Reports; Annals of Clinical and Medical Case Reports; 12; 15; 2-2024; 1-9
2639-8109
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://acmcasereport.org/wp-content/uploads/2024/09/ACMCR-v12-2112.pdf
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Annals of Clinical and Medical Case Reports
publisher.none.fl_str_mv Annals of Clinical and Medical Case Reports
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 12.982451

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