Recent advances in thermosensitive hydrogels as drug delivery systems: A review
- Autores
- Bermudez, Jose Maria; Quinteros, Daniela Alejandra; Grau, Ricardo José Antonio; Allemandi, Daniel Alberto; Palma, Santiago Daniel
- Año de publicación
- 2011
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Polymers that exhibit physicochemical responses to stimuli have been widely explored as potential drug delivery systems. Different kind of stimuli investigated to date includes, for example, chemical substances and changes in temperature, pH and electric fields. Polymers that exhibit dramatic changes in their behavior in an aqueous solution at temperatures close to the body temperature are of particular interest in drug delivery and biomedical applications. Thermosensitive polymers have a wide range of applications, specially, the thermosensitive triblock copolymers because they exhibit unique aqueous solution properties, biodegradability and biocompatibility. These copolymers can be designed to be used as potential drug delivery systems for therapeutic protein drugs or poorly water soluble drugs. This article reviews the applications of polymer solutions with the ability to form in situ implants under temperature changes, in areas of interest to biomedical, pharmacist and engineer scientists. Recent advantages on thermosensitive and biodegradable polymers are discussed to give a wide overview of the available strategies to modify them in order to make them suitable for potential applications in health products.
Fil: Bermudez, Jose Maria. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Salta. Instituto de Investigaciones para la Industria Química. Universidad Nacional de Salta. Facultad de Ingeniería. Instituto de Investigaciones para la Industria Química; Argentina
Fil: Quinteros, Daniela Alejandra. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica; Argentina
Fil: Grau, Ricardo José Antonio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; Argentina
Fil: Allemandi, Daniel Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica; Argentina
Fil: Palma, Santiago Daniel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica; Argentina - Materia
-
Drug delivery
Gelation temperature
Triblock copolymers
Thermosensitive - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
- Repositorio
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- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/195661
Ver los metadatos del registro completo
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Recent advances in thermosensitive hydrogels as drug delivery systems: A reviewBermudez, Jose MariaQuinteros, Daniela AlejandraGrau, Ricardo José AntonioAllemandi, Daniel AlbertoPalma, Santiago DanielDrug deliveryGelation temperatureTriblock copolymersThermosensitivehttps://purl.org/becyt/ford/2.11https://purl.org/becyt/ford/2Polymers that exhibit physicochemical responses to stimuli have been widely explored as potential drug delivery systems. Different kind of stimuli investigated to date includes, for example, chemical substances and changes in temperature, pH and electric fields. Polymers that exhibit dramatic changes in their behavior in an aqueous solution at temperatures close to the body temperature are of particular interest in drug delivery and biomedical applications. Thermosensitive polymers have a wide range of applications, specially, the thermosensitive triblock copolymers because they exhibit unique aqueous solution properties, biodegradability and biocompatibility. These copolymers can be designed to be used as potential drug delivery systems for therapeutic protein drugs or poorly water soluble drugs. This article reviews the applications of polymer solutions with the ability to form in situ implants under temperature changes, in areas of interest to biomedical, pharmacist and engineer scientists. Recent advantages on thermosensitive and biodegradable polymers are discussed to give a wide overview of the available strategies to modify them in order to make them suitable for potential applications in health products.Fil: Bermudez, Jose Maria. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Salta. Instituto de Investigaciones para la Industria Química. Universidad Nacional de Salta. Facultad de Ingeniería. Instituto de Investigaciones para la Industria Química; ArgentinaFil: Quinteros, Daniela Alejandra. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica; ArgentinaFil: Grau, Ricardo José Antonio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; ArgentinaFil: Allemandi, Daniel Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica; ArgentinaFil: Palma, Santiago Daniel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica; ArgentinaBentham Science Publishers2011-11info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/195661Bermudez, Jose Maria; Quinteros, Daniela Alejandra; Grau, Ricardo José Antonio; Allemandi, Daniel Alberto; Palma, Santiago Daniel; Recent advances in thermosensitive hydrogels as drug delivery systems: A review; Bentham Science Publishers; Drug Delivery Letters; 1; 2; 11-2011; 135-1492210-30312210-304XCONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://benthamscience.com/issue/4242info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:55:46Zoai:ri.conicet.gov.ar:11336/195661instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:55:46.841CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
| dc.title.none.fl_str_mv |
Recent advances in thermosensitive hydrogels as drug delivery systems: A review |
| title |
Recent advances in thermosensitive hydrogels as drug delivery systems: A review |
| spellingShingle |
Recent advances in thermosensitive hydrogels as drug delivery systems: A review Bermudez, Jose Maria Drug delivery Gelation temperature Triblock copolymers Thermosensitive |
| title_short |
Recent advances in thermosensitive hydrogels as drug delivery systems: A review |
| title_full |
Recent advances in thermosensitive hydrogels as drug delivery systems: A review |
| title_fullStr |
Recent advances in thermosensitive hydrogels as drug delivery systems: A review |
| title_full_unstemmed |
Recent advances in thermosensitive hydrogels as drug delivery systems: A review |
| title_sort |
Recent advances in thermosensitive hydrogels as drug delivery systems: A review |
| dc.creator.none.fl_str_mv |
Bermudez, Jose Maria Quinteros, Daniela Alejandra Grau, Ricardo José Antonio Allemandi, Daniel Alberto Palma, Santiago Daniel |
| author |
Bermudez, Jose Maria |
| author_facet |
Bermudez, Jose Maria Quinteros, Daniela Alejandra Grau, Ricardo José Antonio Allemandi, Daniel Alberto Palma, Santiago Daniel |
| author_role |
author |
| author2 |
Quinteros, Daniela Alejandra Grau, Ricardo José Antonio Allemandi, Daniel Alberto Palma, Santiago Daniel |
| author2_role |
author author author author |
| dc.subject.none.fl_str_mv |
Drug delivery Gelation temperature Triblock copolymers Thermosensitive |
| topic |
Drug delivery Gelation temperature Triblock copolymers Thermosensitive |
| purl_subject.fl_str_mv |
https://purl.org/becyt/ford/2.11 https://purl.org/becyt/ford/2 |
| dc.description.none.fl_txt_mv |
Polymers that exhibit physicochemical responses to stimuli have been widely explored as potential drug delivery systems. Different kind of stimuli investigated to date includes, for example, chemical substances and changes in temperature, pH and electric fields. Polymers that exhibit dramatic changes in their behavior in an aqueous solution at temperatures close to the body temperature are of particular interest in drug delivery and biomedical applications. Thermosensitive polymers have a wide range of applications, specially, the thermosensitive triblock copolymers because they exhibit unique aqueous solution properties, biodegradability and biocompatibility. These copolymers can be designed to be used as potential drug delivery systems for therapeutic protein drugs or poorly water soluble drugs. This article reviews the applications of polymer solutions with the ability to form in situ implants under temperature changes, in areas of interest to biomedical, pharmacist and engineer scientists. Recent advantages on thermosensitive and biodegradable polymers are discussed to give a wide overview of the available strategies to modify them in order to make them suitable for potential applications in health products. Fil: Bermudez, Jose Maria. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Salta. Instituto de Investigaciones para la Industria Química. Universidad Nacional de Salta. Facultad de Ingeniería. Instituto de Investigaciones para la Industria Química; Argentina Fil: Quinteros, Daniela Alejandra. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica; Argentina Fil: Grau, Ricardo José Antonio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; Argentina Fil: Allemandi, Daniel Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica; Argentina Fil: Palma, Santiago Daniel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica; Argentina |
| description |
Polymers that exhibit physicochemical responses to stimuli have been widely explored as potential drug delivery systems. Different kind of stimuli investigated to date includes, for example, chemical substances and changes in temperature, pH and electric fields. Polymers that exhibit dramatic changes in their behavior in an aqueous solution at temperatures close to the body temperature are of particular interest in drug delivery and biomedical applications. Thermosensitive polymers have a wide range of applications, specially, the thermosensitive triblock copolymers because they exhibit unique aqueous solution properties, biodegradability and biocompatibility. These copolymers can be designed to be used as potential drug delivery systems for therapeutic protein drugs or poorly water soluble drugs. This article reviews the applications of polymer solutions with the ability to form in situ implants under temperature changes, in areas of interest to biomedical, pharmacist and engineer scientists. Recent advantages on thermosensitive and biodegradable polymers are discussed to give a wide overview of the available strategies to modify them in order to make them suitable for potential applications in health products. |
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2011 |
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2011-11 |
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http://hdl.handle.net/11336/195661 Bermudez, Jose Maria; Quinteros, Daniela Alejandra; Grau, Ricardo José Antonio; Allemandi, Daniel Alberto; Palma, Santiago Daniel; Recent advances in thermosensitive hydrogels as drug delivery systems: A review; Bentham Science Publishers; Drug Delivery Letters; 1; 2; 11-2011; 135-149 2210-3031 2210-304X CONICET Digital CONICET |
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http://hdl.handle.net/11336/195661 |
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Bermudez, Jose Maria; Quinteros, Daniela Alejandra; Grau, Ricardo José Antonio; Allemandi, Daniel Alberto; Palma, Santiago Daniel; Recent advances in thermosensitive hydrogels as drug delivery systems: A review; Bentham Science Publishers; Drug Delivery Letters; 1; 2; 11-2011; 135-149 2210-3031 2210-304X CONICET Digital CONICET |
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eng |
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eng |
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info:eu-repo/semantics/altIdentifier/url/https://benthamscience.com/issue/4242 |
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Bentham Science Publishers |
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