Injectable thermosensitive gels based in Poloxamer as modified drug release systems for veterinary use

Autores
Bermudez, Jose Maria; Grau, Ricardo Jose Antonio
Año de publicación
2010
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The purpose of this work is to explore the potential of combining poloxamer 407 and carrageenan for its utilization in an injectable depot drug release system. Reverse thermal gelation of these formulations allow the local injection in liquid form, gelling in situ after its administration. Carrageenan reinforces the structure of poloxamer gels (after 50 h of testing only 20 % of the system is eroding) and allows to modulate the release rate of progesterone as a function of formulations composition. The elastic modulus of sole poloxamer gels (G’ = 56 Pa) increases significantly in presence of carrageenan (G’ = 1 347 Pa) at 10 °C. The gelation temperature of tested formulations is between 17 and 22 °C and the gelation process is very quick. Poloxamer-carrageenan systems offer a promissory alternative approach to development of injectable depot systems for veterinary use.
Fil: Bermudez, Jose Maria. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Salta. Instituto de Investigación para la Industria Química (i); Argentina. Universidad Nacional de Salta; Argentina
Fil: Grau, Ricardo Jose Antonio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química (i); Argentina. Universidad Nacional del Litoral; Argentina
Materia
Injectable Depot
Modified Release
Thermosensitive Gel
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/14257
Acceder
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network_name_str CONICET Digital (CONICET)
spelling Injectable thermosensitive gels based in Poloxamer as modified drug release systems for veterinary useBermudez, Jose MariaGrau, Ricardo Jose AntonioInjectable DepotModified ReleaseThermosensitive Gelhttps://purl.org/becyt/ford/2.5https://purl.org/becyt/ford/2The purpose of this work is to explore the potential of combining poloxamer 407 and carrageenan for its utilization in an injectable depot drug release system. Reverse thermal gelation of these formulations allow the local injection in liquid form, gelling in situ after its administration. Carrageenan reinforces the structure of poloxamer gels (after 50 h of testing only 20 % of the system is eroding) and allows to modulate the release rate of progesterone as a function of formulations composition. The elastic modulus of sole poloxamer gels (G’ = 56 Pa) increases significantly in presence of carrageenan (G’ = 1 347 Pa) at 10 °C. The gelation temperature of tested formulations is between 17 and 22 °C and the gelation process is very quick. Poloxamer-carrageenan systems offer a promissory alternative approach to development of injectable depot systems for veterinary use.Fil: Bermudez, Jose Maria. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Salta. Instituto de Investigación para la Industria Química (i); Argentina. Universidad Nacional de Salta; ArgentinaFil: Grau, Ricardo Jose Antonio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química (i); Argentina. Universidad Nacional del Litoral; ArgentinaColegio Farmaceuticos Provincia de Buenos Aires2010-12info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/14257Bermudez, Jose Maria; Grau, Ricardo Jose Antonio; Injectable thermosensitive gels based in Poloxamer as modified drug release systems for veterinary use; Colegio Farmaceuticos Provincia de Buenos Aires; Acta Farm. Bonaerense; 29; 8; 12-2010; 1377-13820326-2383enginfo:eu-repo/semantics/altIdentifier/url/http://www.latamjpharm.org/previous_issue.php?vol=29&num=8info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-15T14:23:59Zoai:ri.conicet.gov.ar:11336/14257instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-15 14:23:59.779CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Injectable thermosensitive gels based in Poloxamer as modified drug release systems for veterinary use
title Injectable thermosensitive gels based in Poloxamer as modified drug release systems for veterinary use
spellingShingle Injectable thermosensitive gels based in Poloxamer as modified drug release systems for veterinary use
Bermudez, Jose Maria
Injectable Depot
Modified Release
Thermosensitive Gel
title_short Injectable thermosensitive gels based in Poloxamer as modified drug release systems for veterinary use
title_full Injectable thermosensitive gels based in Poloxamer as modified drug release systems for veterinary use
title_fullStr Injectable thermosensitive gels based in Poloxamer as modified drug release systems for veterinary use
title_full_unstemmed Injectable thermosensitive gels based in Poloxamer as modified drug release systems for veterinary use
title_sort Injectable thermosensitive gels based in Poloxamer as modified drug release systems for veterinary use
dc.creator.none.fl_str_mv Bermudez, Jose Maria
Grau, Ricardo Jose Antonio
author Bermudez, Jose Maria
author_facet Bermudez, Jose Maria
Grau, Ricardo Jose Antonio
author_role author
author2 Grau, Ricardo Jose Antonio
author2_role author
dc.subject.none.fl_str_mv Injectable Depot
Modified Release
Thermosensitive Gel
topic Injectable Depot
Modified Release
Thermosensitive Gel
purl_subject.fl_str_mv https://purl.org/becyt/ford/2.5
https://purl.org/becyt/ford/2
dc.description.none.fl_txt_mv The purpose of this work is to explore the potential of combining poloxamer 407 and carrageenan for its utilization in an injectable depot drug release system. Reverse thermal gelation of these formulations allow the local injection in liquid form, gelling in situ after its administration. Carrageenan reinforces the structure of poloxamer gels (after 50 h of testing only 20 % of the system is eroding) and allows to modulate the release rate of progesterone as a function of formulations composition. The elastic modulus of sole poloxamer gels (G’ = 56 Pa) increases significantly in presence of carrageenan (G’ = 1 347 Pa) at 10 °C. The gelation temperature of tested formulations is between 17 and 22 °C and the gelation process is very quick. Poloxamer-carrageenan systems offer a promissory alternative approach to development of injectable depot systems for veterinary use.
Fil: Bermudez, Jose Maria. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Salta. Instituto de Investigación para la Industria Química (i); Argentina. Universidad Nacional de Salta; Argentina
Fil: Grau, Ricardo Jose Antonio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química (i); Argentina. Universidad Nacional del Litoral; Argentina
description The purpose of this work is to explore the potential of combining poloxamer 407 and carrageenan for its utilization in an injectable depot drug release system. Reverse thermal gelation of these formulations allow the local injection in liquid form, gelling in situ after its administration. Carrageenan reinforces the structure of poloxamer gels (after 50 h of testing only 20 % of the system is eroding) and allows to modulate the release rate of progesterone as a function of formulations composition. The elastic modulus of sole poloxamer gels (G’ = 56 Pa) increases significantly in presence of carrageenan (G’ = 1 347 Pa) at 10 °C. The gelation temperature of tested formulations is between 17 and 22 °C and the gelation process is very quick. Poloxamer-carrageenan systems offer a promissory alternative approach to development of injectable depot systems for veterinary use.
publishDate 2010
dc.date.none.fl_str_mv 2010-12
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/14257
Bermudez, Jose Maria; Grau, Ricardo Jose Antonio; Injectable thermosensitive gels based in Poloxamer as modified drug release systems for veterinary use; Colegio Farmaceuticos Provincia de Buenos Aires; Acta Farm. Bonaerense; 29; 8; 12-2010; 1377-1382
0326-2383
url http://hdl.handle.net/11336/14257
identifier_str_mv Bermudez, Jose Maria; Grau, Ricardo Jose Antonio; Injectable thermosensitive gels based in Poloxamer as modified drug release systems for veterinary use; Colegio Farmaceuticos Provincia de Buenos Aires; Acta Farm. Bonaerense; 29; 8; 12-2010; 1377-1382
0326-2383
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://www.latamjpharm.org/previous_issue.php?vol=29&num=8
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Colegio Farmaceuticos Provincia de Buenos Aires
publisher.none.fl_str_mv Colegio Farmaceuticos Provincia de Buenos Aires
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.22299

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