Poloxamine-based nanomaterials for drug delivery

Autores
Alvarez Lorenzo, Carmen; Rey Rico, Ana; Sosnik, Alejandro Dario; Taboada, Pablo; Concheiro, Ángel
Año de publicación
2010
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Poloxamines (Tetronic) are X-shaped amphiphilic block copolymers formed by four arms of poly(ethylene oxide)-poly(propylene oxide) (PEO-PPO) blocks bonded to a central ethylenediamine moiety. Such a structure confers multi-responsive behaviour, namely temperature and pH-sensitiveness. At relatively low concentrations but above the critical micellar concentration (CMC), poloxamines generate polymeric micelles. Due to the presence of a hydrophobic core, these nanocarriers are useful in the solubilization and stabilization of poorly water-soluble drugs. Moreover, chemical modification of the micellar core is feasible. These remarkable and unique features, compared to the well-known linear poloxamers, have motivated an increasing interest in the study and application of the branched derivatives in different emerging disciplines. The present review concisely overviews the most important developments comprising the application of poloxamines in drug delivery, mainly as micellar carriers capable of enhancing drug solubility and stability, and also as surface modifiers in the technology of stealth polymeric nanoparticles. Their potential for the administration of drugs by different routes and the improvement of the drug bioavailability and therapeutic effect are discussed.
Fil: Alvarez Lorenzo, Carmen. Universidad de Santiago de Compostela; España
Fil: Rey Rico, Ana. Universidad de Santiago de Compostela; España
Fil: Sosnik, Alejandro Dario. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Tecnología Farmacéutica; Argentina
Fil: Taboada, Pablo. Universidad de Santiago de Compostela; España
Fil: Concheiro, Ángel. Universidad de Santiago de Compostela; España
Materia
Nanotechnology
Polymeric Micelles
Drug Encapsulation And Delivery
Amphiphilic Copolymers
Drug Solubilization
Drug Stability
Peo-Ppo Block Copolymers
Poloxamines
Stealth Nanoparticles
Tetronics
Review
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/14273
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/14273
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Poloxamine-based nanomaterials for drug deliveryAlvarez Lorenzo, CarmenRey Rico, AnaSosnik, Alejandro DarioTaboada, PabloConcheiro, ÁngelNanotechnologyPolymeric MicellesDrug Encapsulation And DeliveryAmphiphilic CopolymersDrug SolubilizationDrug StabilityPeo-Ppo Block CopolymersPoloxaminesStealth NanoparticlesTetronicsReviewhttps://purl.org/becyt/ford/1.4https://purl.org/becyt/ford/1Poloxamines (Tetronic) are X-shaped amphiphilic block copolymers formed by four arms of poly(ethylene oxide)-poly(propylene oxide) (PEO-PPO) blocks bonded to a central ethylenediamine moiety. Such a structure confers multi-responsive behaviour, namely temperature and pH-sensitiveness. At relatively low concentrations but above the critical micellar concentration (CMC), poloxamines generate polymeric micelles. Due to the presence of a hydrophobic core, these nanocarriers are useful in the solubilization and stabilization of poorly water-soluble drugs. Moreover, chemical modification of the micellar core is feasible. These remarkable and unique features, compared to the well-known linear poloxamers, have motivated an increasing interest in the study and application of the branched derivatives in different emerging disciplines. The present review concisely overviews the most important developments comprising the application of poloxamines in drug delivery, mainly as micellar carriers capable of enhancing drug solubility and stability, and also as surface modifiers in the technology of stealth polymeric nanoparticles. Their potential for the administration of drugs by different routes and the improvement of the drug bioavailability and therapeutic effect are discussed.Fil: Alvarez Lorenzo, Carmen. Universidad de Santiago de Compostela; EspañaFil: Rey Rico, Ana. Universidad de Santiago de Compostela; EspañaFil: Sosnik, Alejandro Dario. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Tecnología Farmacéutica; ArgentinaFil: Taboada, Pablo. Universidad de Santiago de Compostela; EspañaFil: Concheiro, Ángel. Universidad de Santiago de Compostela; EspañaFrontiers In Bioscience Inc2010-12info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/14273Alvarez Lorenzo, Carmen; Rey Rico, Ana; Sosnik, Alejandro Dario; Taboada, Pablo; Concheiro, Ángel; Poloxamine-based nanomaterials for drug delivery; Frontiers In Bioscience Inc; Frontiers In Bioscience-landmark; E2; 102; 12-2010; 424-4401093-99461093-4715enginfo:eu-repo/semantics/altIdentifier/url/https://www.bioscience.org/2010/v2e/af/102/fulltext.php?bframe=2.htminfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T10:07:15Zoai:ri.conicet.gov.ar:11336/14273instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 10:07:16.0CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Poloxamine-based nanomaterials for drug delivery
title Poloxamine-based nanomaterials for drug delivery
spellingShingle Poloxamine-based nanomaterials for drug delivery
Alvarez Lorenzo, Carmen
Nanotechnology
Polymeric Micelles
Drug Encapsulation And Delivery
Amphiphilic Copolymers
Drug Solubilization
Drug Stability
Peo-Ppo Block Copolymers
Poloxamines
Stealth Nanoparticles
Tetronics
Review
title_short Poloxamine-based nanomaterials for drug delivery
title_full Poloxamine-based nanomaterials for drug delivery
title_fullStr Poloxamine-based nanomaterials for drug delivery
title_full_unstemmed Poloxamine-based nanomaterials for drug delivery
title_sort Poloxamine-based nanomaterials for drug delivery
dc.creator.none.fl_str_mv Alvarez Lorenzo, Carmen
Rey Rico, Ana
Sosnik, Alejandro Dario
Taboada, Pablo
Concheiro, Ángel
author Alvarez Lorenzo, Carmen
author_facet Alvarez Lorenzo, Carmen
Rey Rico, Ana
Sosnik, Alejandro Dario
Taboada, Pablo
Concheiro, Ángel
author_role author
author2 Rey Rico, Ana
Sosnik, Alejandro Dario
Taboada, Pablo
Concheiro, Ángel
author2_role author
author
author
author
dc.subject.none.fl_str_mv Nanotechnology
Polymeric Micelles
Drug Encapsulation And Delivery
Amphiphilic Copolymers
Drug Solubilization
Drug Stability
Peo-Ppo Block Copolymers
Poloxamines
Stealth Nanoparticles
Tetronics
Review
topic Nanotechnology
Polymeric Micelles
Drug Encapsulation And Delivery
Amphiphilic Copolymers
Drug Solubilization
Drug Stability
Peo-Ppo Block Copolymers
Poloxamines
Stealth Nanoparticles
Tetronics
Review
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.4
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Poloxamines (Tetronic) are X-shaped amphiphilic block copolymers formed by four arms of poly(ethylene oxide)-poly(propylene oxide) (PEO-PPO) blocks bonded to a central ethylenediamine moiety. Such a structure confers multi-responsive behaviour, namely temperature and pH-sensitiveness. At relatively low concentrations but above the critical micellar concentration (CMC), poloxamines generate polymeric micelles. Due to the presence of a hydrophobic core, these nanocarriers are useful in the solubilization and stabilization of poorly water-soluble drugs. Moreover, chemical modification of the micellar core is feasible. These remarkable and unique features, compared to the well-known linear poloxamers, have motivated an increasing interest in the study and application of the branched derivatives in different emerging disciplines. The present review concisely overviews the most important developments comprising the application of poloxamines in drug delivery, mainly as micellar carriers capable of enhancing drug solubility and stability, and also as surface modifiers in the technology of stealth polymeric nanoparticles. Their potential for the administration of drugs by different routes and the improvement of the drug bioavailability and therapeutic effect are discussed.
Fil: Alvarez Lorenzo, Carmen. Universidad de Santiago de Compostela; España
Fil: Rey Rico, Ana. Universidad de Santiago de Compostela; España
Fil: Sosnik, Alejandro Dario. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Tecnología Farmacéutica; Argentina
Fil: Taboada, Pablo. Universidad de Santiago de Compostela; España
Fil: Concheiro, Ángel. Universidad de Santiago de Compostela; España
description Poloxamines (Tetronic) are X-shaped amphiphilic block copolymers formed by four arms of poly(ethylene oxide)-poly(propylene oxide) (PEO-PPO) blocks bonded to a central ethylenediamine moiety. Such a structure confers multi-responsive behaviour, namely temperature and pH-sensitiveness. At relatively low concentrations but above the critical micellar concentration (CMC), poloxamines generate polymeric micelles. Due to the presence of a hydrophobic core, these nanocarriers are useful in the solubilization and stabilization of poorly water-soluble drugs. Moreover, chemical modification of the micellar core is feasible. These remarkable and unique features, compared to the well-known linear poloxamers, have motivated an increasing interest in the study and application of the branched derivatives in different emerging disciplines. The present review concisely overviews the most important developments comprising the application of poloxamines in drug delivery, mainly as micellar carriers capable of enhancing drug solubility and stability, and also as surface modifiers in the technology of stealth polymeric nanoparticles. Their potential for the administration of drugs by different routes and the improvement of the drug bioavailability and therapeutic effect are discussed.
publishDate 2010
dc.date.none.fl_str_mv 2010-12
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/14273
Alvarez Lorenzo, Carmen; Rey Rico, Ana; Sosnik, Alejandro Dario; Taboada, Pablo; Concheiro, Ángel; Poloxamine-based nanomaterials for drug delivery; Frontiers In Bioscience Inc; Frontiers In Bioscience-landmark; E2; 102; 12-2010; 424-440
1093-9946
1093-4715
url http://hdl.handle.net/11336/14273
identifier_str_mv Alvarez Lorenzo, Carmen; Rey Rico, Ana; Sosnik, Alejandro Dario; Taboada, Pablo; Concheiro, Ángel; Poloxamine-based nanomaterials for drug delivery; Frontiers In Bioscience Inc; Frontiers In Bioscience-landmark; E2; 102; 12-2010; 424-440
1093-9946
1093-4715
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.bioscience.org/2010/v2e/af/102/fulltext.php?bframe=2.htm
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Frontiers In Bioscience Inc
publisher.none.fl_str_mv Frontiers In Bioscience Inc
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1842269996143607808
score 13.13397

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